Research

Publications

Below you can find a list of our published research.

9618 results

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

Teaching and learning in medicine, Volume 35, Issue 5, 24 4 2022, Pages 565-576 Comprehensive Assessment of Clinical Learning Environments to Drive Improvement: Lessons Learned from a Pilot Program. Bernal J, Cresalia N, Fuller J, Gin B, Laves E, Lupton K, Malkina A, Marmor A, Wheeler D, Williams M, van Schaik S

Problem: Recognition of the importance of clinical learning environments (CLEs) in health professions education has led to calls to evaluate and improve the quality of such learning environments. As CLEs sit at the crossroads of education and healthcare delivery, leadership from both entities should share the responsibility and accountability for this work. Current data collection about the experience and outcomes for learners, faculty, staff, and patients tends to occur in fragmented and siloed... Abstract

Cited 9 times since 2022 (3 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 38, Issue 12, 24 4 2022, Pages 2781-2789 Vessel and sex differences in pericoronary adipose tissue attenuation obtained with coronary CT in individuals without coronary atherosclerosis. van Rosendael SE, Kuneman JH, van den Hoogen IJ, Kitslaar PH, van Rosendael AR, van der Bijl P, Reiber JHC, Ajmone Marsan N, Jukema JW, Knuuti J, Bax JJ

Pericoronary adipose tissue (PCAT) attenuation, derived from coronary computed tomography angiography (CCTA), is associated with coronary artery inflammation. Values for PCAT attenuation in men and women without atherosclerosis on CCTA are lacking. The aim of the current study was to assess the mean PCAT attenuation in individuals without coronary artery atherosclerosis on CCTA. Data on PCAT attenuation in men and women without coronary artery atherosclerosis on CCTA were included in this retros... Abstract

Journal of clinical lipidology, Volume 16, Issue 5, 23 4 2022, Pages 747-756 Relation of red blood cell distribution width to risk of major adverse cardiovascular events, death, and effect of alirocumab after acute coronary syndromes. Moriarty PM, Steg PG, McGinniss J, Zeiher AM, White HD, Manvelian G, Pordy R, Loy M, Jukema JW, Harrington RA, Gray JV, Gorby LK, Goodman SG, Diaz R, Bittner VA, Bhatt DL, Szarek M, Schwartz GG, ODYSSEY OUTCOMES Investigators

Elevated red blood cell distribution width (RDW) is associated with increased risk for major adverse cardiovascular events (MACE) and death in patients with cardiovascular disease. The ODYSSEY OUTCOMES trial compared alirocumab with placebo in 18,924 patients with recent acute coronary syndrome (ACS) and elevated atherogenic lipoproteins despite optimized statin treatment. This post hoc analysis determined whether RDW independently predicts risk of MACE and death in patients after recent ACS, wh... Abstract

Cited 4 times since 2022 (1.3 per year) source: EuropePMC

Scientific reports, Volume 12, Issue 1, 22 4 2022, Pages 14275 Profiling of humoral immune responses to norovirus in children across Europe. Villabruna N, Izquierdo-Lara RW, Schapendonk CME, de Bruin E, Chandler F, Thao TTN, Westerhuis BM, van Beek J, Sigfrid L, Giaquinto C, Goossens H, Bielicki JA, Kohns Vasconcelos M, Fraaij PLA, Koopmans MPG, de Graaf M

Norovirus is a leading cause of epidemic acute gastroenteritis. More than 30 genotypes circulate in humans, some are common, and others are only sporadically detected. Here, we investigated whether serology can be used to determine which genotypes infect children. We established a multiplex protein microarray with structural and non-structural norovirus antigens that allowed simultaneous antibody testing against 30 human GI and GII genotypes. Antibody responses of sera obtained from 287 children... Abstract

Cited 12 times since 2022 (4 per year) source: EuropePMC

Teaching and learning in medicine, Volume 35, Issue 5, 22 4 2022, Pages 550-564 "It's All About the Trust And Building A Foundation:" Evaluation of a Longitudinal Medical Student Coaching Program. Hauer KE, Chang A, van Schaik SM, Lucey C, Cowell T, Teherani A

Coaching is increasingly implemented in medical education to support learners' growth, learning, and wellbeing. Data demonstrating the impact of longitudinal coaching programs are needed.We developed and evaluated a comprehensive longitudinal medical student coaching program designed to achieve three aims for students: fostering personal and professional development, advancing physician skills with a growth mindset, and promoting student wellbeing and belonging within an inclusive learning... Abstract

Cited 9 times since 2022 (3 per year) source: EuropePMC

Micromachines, Volume 13, Issue 8, 20 3 2022, Pages 1359 Pressure-Driven Perfusion System to Control, Multiplex and Recirculate Cell Culture Medium for Organs-on-Chips. de Graaf MNS, Vivas A, van der Meer AD, Mummery CL, Orlova VV

Organ-on-chip (OoC) devices are increasingly used to mimic the tissue microenvironment of cells in intact organs. This includes microchannels to mimic, for example, fluidic flow through blood vessels. Present methods for controlling microfluidic flow in these systems rely on gravity, rocker systems or external pressure pumps. For many purposes, pressure pumps give the most consistent flow profiles, but they are not well-suited for high throughput as might be required for testing drug responses.... Abstract

The American journal of emergency medicine, Volume 61, 19 3 2022, Pages 68-73 Potentially avoidable interfacility transfers following reduced emergency department volumes due to COVID-19 "Safer-at-Home" orders. Van Schaik G, Self WH, Hennessy C, Ward MJ

Objectives: We sought to assess if a state-wide lockdown implemented due to COVID-19 was associated with increased odds of being a potentially avoidable transfer (PAT). Methods: We conducted a retrospective observational analysis using hospital administrative data of interfacility ED-to-ED transfers to a single, quaternary care adult ED after "Safer at Home" orders were issued March 23rd, 2020 in [Blinded for submission]. Using the PAT classification to identify transfers rapidly disch... Abstract

Cited 16 times since 2022 (5.3 per year) source: EuropePMC

European journal of internal medicine, Volume 105, 18 3 2022, Pages 69-76 Angiographic and clinical outcome of SARS-CoV-2 positive patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: A collaborative, individual patient data meta-analysis of six registry-based studies. De Luca G, Silverio A, Verdoia M, Siudak Z, Tokarek T, Kite TA, Gershlick AH, Rodriguez-Leor O, Cid-Alvarez B, Jones DA, Rathod KS, Montero-Cabezas JM, Jurado-Roman A, Nardin M, Galasso G

Background: The characteristics and outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients with ST-Elevation Myocardial Infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) are still poorly known. Methods: The PANDEMIC study was an investigator-initiated, collaborative, individual patient data (IPD) meta-analysis of registry-based studies. MEDLINE, ScienceDirect, Web of Sciences, and SCOPUS were searched to identify all registry-based... Abstract

Vascular biology (Bristol, England), Volume 4, Issue 1, 18 3 2022, Pages E1-E2 Go with the flow….. Quax PHA, Goumans MTH

Abstract

International journal of cardiology. Congenital heart disease, Volume 10, 17 3 2022, Pages 100417 Cardiac autonomic nervous activity in patients with transposition of the great arteries after arterial switch operation. Terol Espinosa de Los Monteros C, van der Palen RLF, Nederend I, de Geus EJC, Kuipers IM, Hazekamp MG, Blom NA, Ten Harkel ADJ

Background: A chronic imbalance of the autonomic nervous system(ANS) may contribute to long term complications in different congenital heart diseases. The purpose of this study was to determine whether the ANS plays a role in the long-term outcome of patients with Transposition of great arteries(TGA) after arterial switch operation(ASO) as its contribution is as yet not clear. Methods: The ANS activity was evaluated non-invasively in 26 TGA patients and 52 age-appropriate healthy subjects combin... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

PEC innovation, Volume 1, 17 3 2022, Pages 100071 Lifestyle support preferences of patients with cardiovascular diseases: What lifestyle support might work best for whom? Cohen Rodrigues TR, Reijnders T, de Buisonjé DR, Breeman LD, van den Broek I, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AWM, BENEFIT consortium

Background: Lifestyle support is essential in preventing and treating cardiovascular diseases (CVD), and eHealth may be an easy and affordable solution to provide this support. However, CVD patients vary in their ability and interest to use eHealth. This study investigates demographic characteristics determining CVD patients' online and offline lifestyle support preferences. Methods: We used a cross-sectional study design. 659 CVD patients (Harteraad panel) completed our questionnaire. We a... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

NPJ microgravity, Volume 8, Issue 1, 17 3 2022, Pages 36 The influence of interparticle cohesion on rebounding slow impacts on rubble pile asteroids. Joeris K, Schönau L, Keulen M, Born P, Kollmer JE

The ballistic sorting effect has been proposed to be a driver behind the observed size sorting on the rubble pile asteroid Itokawa. This effect depends on the inelasticity of slow collisions with granular materials. The inelasticity of a collision with a granular material, in turn, depends on grain size. Here we argue that determining the inelasticity of such collisions in an asteroid-like environment is a nontrivial task. We show non-monotonic dependency of the coefficient of restitution (COR)... Abstract

Cited 5 times since 2022 (1.7 per year) source: EuropePMC

European heart journal. Case reports, Volume 6, Issue 8, 16 3 2022, Pages ytac345 Anomalous coronary artery from the pulmonary artery diagnosed in adulthood: a case series on variations of coronary anatomy and the diagnostic value of cardiac magnetic resonance imaging. Talebian Yazdi M, Robbers-Visser D, van der Bilt IAC, Boekholdt SM, Koolbergen DR, Planken RN, Groenink M

Background: Anomalous coronary artery from the pulmonary artery is a rare congenital disorder with high mortality rates in infancy. Adult cases can present with life-threatening arrhythmias and sudden cardiac death. Case summary: We report three cases of adults with anomalous pulmonary origin of each of the main coronary branches. The first patient with an anomalous left coronary artery from the pulmonary artery presented with an out-of-hospital cardiac arrest. The second patient with an anomalo... Abstract

Cited 4 times since 2022 (1.3 per year) source: EuropePMC

Journal of pediatric hematology/oncology, Volume 45, Issue 3, 16 3 2022, Pages e298-e303 Roles of Vitamin-K-dependent Factors Protein S and GAS6 With TAM Receptors and HMGB1 in Pediatric COVID-19 Disease. Şik N, Duman M, Küme T, Gürsoy Doruk Ö, Yilmaz D, Ören H

Objective: This study was designed to evaluate serum high-mobility group box 1 (HMGB1), protein S (PS), growth arrest-specific gene 6 (GAS6), and TAM receptor (TYRO3, AXL, and MERTK) levels in children with COVID-19 disease. Methods: A prospective case-control study was conducted in our pediatric emergency department and 57 patients with SARS-CoV-2 polymerase chain reaction (PCR) positivity, 6 patients with multisystem inflammatory syndrome in children (MIS-C), and 17 healthy children were inclu... Abstract

Cited 11 times since 2022 (3.7 per year) source: EuropePMC

Molecular psychiatry, Volume 27, Issue 11, 16 3 2022, Pages 4419-4431 Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Lahti J, Tuominen S, Yang Q, Pergola G, Ahmad S, Amin N, Armstrong NJ, Beiser A, Bey K, Bis JC, Boerwinkle E, Bressler J, Campbell A, Campbell H, Chen Q, Corley J, Cox SR, Davies G, De Jager PL, Derks EM, Faul JD, Fitzpatrick AL, Fohner AE, Ford I, Fornage M, Gerring Z, Grabe HJ, Grodstein F, Gudnason V, Simonsick E, Holliday EG, Joshi PK, Kajantie E, Kaprio J, Karell P, Kleineidam L, Knol MJ, Kochan NA, Kwok JB, Leber M, Lam M, Lee T, Li S, Loukola A, Luck T, Marioni RE, Mather KA, Medland S, Mirza SS, Nalls MA, Nho K, O'Donnell A, Oldmeadow C, Painter J, Pattie A, Reppermund S, Risacher SL, Rose RJ, Sadashivaiah V, Scholz M, Satizabal CL, Schofield PW, Schraut KE, Scott RJ, Simino J, Smith AV, Smith JA, Stott DJ, Surakka I, Teumer A, Thalamuthu A, Trompet S, Turner ST, van der Lee SJ, Villringer A, Völker U, Wilson RS, Wittfeld K, Vuoksimaa E, Xia R, Yaffe K, Yu L, Zare H, Zhao W, Ames D, Attia J, Bennett DA, Brodaty H, Chasman DI, Goldman AL, Hayward C, Ikram MA, Jukema JW, Kardia SLR, Lencz T, Loeffler M,

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyse... Abstract

Cited 9 times since 2022 (3 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 36, Issue 2, 14 2 2022, Pages 163-171 Effects of Atrial Ischemia on Left Atrial Remodeling in Patients with ST-Segment Elevation Myocardial Infarction. Montero-Cabezas JM, Abou R, Chimed S, Fortuni F, Goedemans L, Ajmone Marsan N, Bax JJ, Delgado V

Background: Adverse left atrial (LA) remodeling after ST-segment elevation myocardial infarction (STEMI) has been associated with poor prognosis. Flow impairment in the dominant coronary atrial branch (CAB) may affect large areas of LA myocardium, potentially leading to adverse LA remodeling during follow-up. The aim of this study was to assess echocardiographic LA remodeling in patients with STEMI with impaired coronary flow in the dominant CAB. Methods: Of 897 patients with STEMI, 69 patients... Abstract

Cited 8 times since 2022 (2.7 per year) source: EuropePMC

Animal frontiers : the review magazine of animal agriculture, Volume 12, Issue 4, 12 2 2022, Pages 61-70 Nutritional values and health benefits of dromedary camel meat. Kadim IT, Al-Amri IS, Alkindi AY, Haq QMI

Abstract

Cited 12 times since 2022 (4 per year) source: EuropePMC

Prehospital and disaster medicine, Volume 37, Issue 5, 11 2 2022, Pages 600-608 Managing Hospital Capacity: Achievements and Lessons from the COVID-19 Pandemic. de Koning ER, Boogers MJ, Beeres SL, Kramer ID, Dannenberg WJ, Schalij MJ

Introduction: The coronavirus disease 2019 (COVID-19) pandemic challenged health care systems in an unprecedented way. Due to the enormous amount of hospital ward and intensive care unit (ICU) admissions, regular care came to a standstill, thereby overcrowding ICUs and endangering (regular and COVID-19-related) critical care. Acute care coordination centers were set up to safely manage the influx of COVID-19 patients. Furthermore, treatments requiring ICU surveillance were postponed leading to i... Abstract

Cited 8 times since 2022 (2.7 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 108, Issue 17, 11 2 2022, Pages 1401-1407 Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis. Stassen J, Ewe SH, Butcher SC, Amanullah MR, Mertens BJ, Hirasawa K, Singh GK, Sin KY, Ding ZP, Pio SM, Sia CH, Chew N, Kong W, Poh KK, Cohen D, Généreux P, Leon MB, Ajmone Marsan N, Delgado V, Bax JJ

Objective: To investigate the prognostic impact of left ventricular (LV) diastolic dysfunction in patients with moderate aortic stenosis (AS) and preserved LV systolic function. Methods: Patients with a first diagnosis of moderate AS (aortic valve area >1.0 and ≤1.5 cm2) and preserved LV systolic function (LV ejection fraction ≥50%) were identified. LV diastolic function was evaluated using echocardiographic criteria according to the 2016 American Society of Echocardiography/European Associat... Abstract

Cited 8 times since 2022 (2.6 per year) source: EuropePMC

Frontiers in physiology, Volume 13, 9 2 2022, Pages 870154 Both caffeine and <i>Capsicum annuum</i> fruit powder lower blood glucose levels and increase brown adipose tissue temperature in healthy adult males. Van Schaik L, Kettle C, Green R, Wundersitz D, Gordon B, Irving HR, Rathner JA

Using a combination of respiratory gas exchange, infrared thermography, and blood glucose (BGL) analysis, we have investigated the impact of Capsicum annuum (C. annuum) fruit powder (475 mg) or caffeine (100 mg) on metabolic activity in a placebo controlled (lactose, 100 mg) double-blinded three-way cross-over-design experiment. Metabolic measurements were made on day 1 and day 7 of supplementation in eight adult male participants (22.2 ± 2 years of age, BMI 23 ± 2 kg/m2, x̅ ± SD). Participants... Abstract