7368 results
Cited 5 times since 2024 (4.4 per year)
source: EuropePMC
Acta physiologica (Oxford, England),
Volume 240, Issue 8, 17 3 2024, Pages e14190
Immunosuppression with cyclosporine versus tacrolimus shows distinctive nephrotoxicity profiles within renal compartments.
Demirci H, Popovic S, Dittmayer C, Yilmaz DE, El-Shimy IA, Mülleder M, Hinze C, Su M, Mertins P, Kirchner M, Osmanodja B, Paliege A, Budde K, Amann K, Persson PB, Mutig K, Bachmann S
Aim: Calcineurin inhibitors (CNIs) are the backbone for immunosuppression after solid organ transplantation. Although successful in preventing kidney transplant rejection, their nephrotoxic side effects contribute to allograft injury. Renal parenchymal lesions occur for cyclosporine A (CsA) as well as for the currently favored tacrolimus (Tac). We aimed to study whether chronic CsA and Tac exposures, before reaching irreversible nephrotoxic damage, affect renal compartments differentially and wh...
Abstract
Cited 2 times since 2024 (1.8 per year)
source: EuropePMC
Journal of neurology, neurosurgery, and psychiatry,
Volume 95, Issue 7, 17 3 2024, Pages 595-604
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy.
Wieske L, Michael MR, In 't Veld SGJG, Visser A, van Schaik IN, Eftimov F, Teunissen CE
Background: Objective disease activity biomarkers are lacking in chronic inflammatory demyelinating polyneuropathy (CIDP), impacting treatment decisions in clinical care and outcomes in clinical trials. Using a proximity extension assay, we aimed to identify candidate serum protein biomarkers for disease activity in CIDP. Method: We collected clinical data and serum of 106 patients with CIDP. Patients starting induction treatment (n=53) and patients on maintenance treatment starting treatment wi...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Journal of surgical education,
Volume 81, Issue 8, 14 2 2024, Pages 1034-1043
How to Support Communication Between Nurses and Residents During Shift Work: A Mixed-Methods Study Into Local Practices and Perceptions.
Verhagen MJ, Frouws MA, Timmer RA, Schepers A, Brunsveld-Reinders AH, de Vos MS, Hamming JF
Objective: The aim of this study was to explore local practices and perceptions of effective nurse-resident communication during shifts. Subsequently, effective communication was sought to be reinforced by implementing an initiative for improvement. Design: A mixed-methods study was performed, combining a questionnaire with focus groups. Following qualitative analysis, 3 initiatives for improvement of nurse-resident communication were scrutinized, after which 1 initiative was implemented. Overal...
Abstract
Cited 7 times since 2024 (6.1 per year)
source: EuropePMC
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
Volume 43, Issue 8, 14 2 2024, Pages 1199-1234
An ISHLT consensus statement on strategies to prevent and manage hemocompatibility related adverse events in patients with a durable, continuous-flow ventricular assist device.
Hollis IB, Jennings DL, Krim S, Ton VK, Ducharme A, Cowger J, Looby M, Eulert-Green JJ, Bansal N, Horn E, Byku M, Katz J, Michaud CJ, Rajapreyar I, Campbell P, Vale C, Cosgrove R, Hernandez-Montfort J, Otero J, Ingemi A, Raj S, Weeks P, Agarwal R, Martinez ES, Tops LF, Ahmed MM, Kiskaddon A, Kremer J, Keebler M, Ratnagiri RK
Life expectancy of patients with a durable, continuous-flow left ventricular assist device (CF-LVAD) continues to increase. Despite significant improvements in the delivery of care for patients with these devices, hemocompatability-related adverse events (HRAEs) are still a concern and contribute to significant morbility and mortality when they occur. As such, dissemination of current best evidence and practices is of critical importance. This ISHLT Consensus Statement is a summative assessment...
Abstract
Cited 4 times since 2024 (3.5 per year)
source: EuropePMC
Heliyon,
Volume 10, Issue 12, 13 2 2024, Pages e32949
Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice.
Yılmaz D, Marques FC, Fischer Y, Zimmermann S, Hwang G, Atkins PR, Mathavan N, Singh A, de Souza PPC, Kuhn GA, Wehrle E, Müller R
Osteoclasts are essential for bone remodeling by adapting their resorptive activity in response to their mechanical in vivo environment. However, the molecular mechanisms underlying this process remain unclear. Here, we demonstrated the role of tartrate-resistant acid phosphatase (TRAP, Acp5), a key enzyme secreted by osteoclasts, in bone remodeling and mechanosensitivity. Using CRISPR/Cas9 reporter mice, we demonstrated bone cell reporter (BCRIbsp/Acp5) mice feature fluorescent TRAP-deficient o...
Abstract
International journal of tryptophan research : IJTR,
Volume 17, 12 2 2024, Pages 11786469241257816
Periconceptional Non-medical Maternal Determinants Influence the Tryptophan Metabolism: The Rotterdam Periconceptional Cohort (Predict Study).
van Zundert SK, van Rossem L, Mirzaian M, Griffioen PH, Willemsen SP, van Schaik RH, Steegers-Theunissen RP
Background: The vital role of the maternal tryptophan (TRP) metabolism in maternal health and pregnancy is well established. However, non-medical maternal determinants influencing the TRP metabolism have been poorly investigated. We hypothesise that periconceptional maternal non-medical determinants alter the TRP metabolism, affecting both kynurenine (KP) and serotonin pathway (SP) metabolite concentrations. Therefore, we investigated the influence of non-medical maternal determinants on the TRP...
Abstract
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery,
Volume 40, Issue 9, 10 2 2024, Pages 2775-2780
Evaluation of traumatic spinal injuries: a pediatric perspective.
Şık N, Bulut SK, Şalbaş ÖY, Yılmaz D, Duman M
Purpose: The aim of the present study is to provide information about pediatric patients with spinal trauma. Methods: A single-center retrospective chart review was carried out. Children who arrived at the pediatric emergency department due to trauma and those with spinal pathology confirmed by radiological assessment were included. Demographics, mechanisms of trauma, clinical findings, radiological investigations, applied treatments, hospital stay and prognosis were recorded. Results: A total o...
Abstract
Cited 8 times since 2024 (6.9 per year)
source: EuropePMC
European journal of heart failure,
Volume 26, Issue 11, 10 2 2024, Pages 2304-2322
Right heart failure with left ventricular assist devices: Preoperative, perioperative and postoperative management strategies. A clinical consensus statement of the Heart Failure Association (HFA) of the ESC.
Adamopoulos S, Bonios M, Ben Gal T, Gustafsson F, Abdelhamid M, Adamo M, Bayes-Genis A, Böhm M, Chioncel O, Cohen-Solal A, Damman K, Di Nora C, Hashmani S, Hill L, Jaarsma T, Jankowska E, Lopatin Y, Masetti M, Mehra MR, Milicic D, Moura B, Mullens W, Nalbantgil S, Panagiotou C, Piepoli M, Rakisheva A, Ristic A, Rivinius R, Savarese G, Thum T, Tocchetti CG, Tops LF, Van Laake LW, Volterrani M, Seferovic P, Coats A, Metra M, Rosano G
Right heart failure (RHF) following implantation of a left ventricular assist device (LVAD) is a common and potentially serious condition with a wide spectrum of clinical presentations with an unfavourable effect on patient outcomes. Clinical scores that predict the occurrence of right ventricular (RV) failure have included multiple clinical, biochemical, imaging and haemodynamic parameters. However, unless the right ventricle is overtly dysfunctional with end-organ involvement, prediction of RH...
Abstract
The Pediatric infectious disease journal,
Volume 43, Issue 9, 10 2 2024, Pages e338-e339
Brain Abscess Developing After Lobar Pneumonia: A Rare Complication in Unvaccinated Child Caused by Streptococcus pneumoniae Serotype 14.
Kuş S, Kuş S, Elvan-Tuz A, Aslan-Saritas U, Yilmaz D
Abstract
Cited 3 times since 2024 (2.6 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 25, Issue 12, 9 2 2024, Pages 6376
The Intriguing World of Vascular Remodeling, Angiogenesis, and Arteriogenesis.
Quax PHA, Deindl E
Vascular remodeling is a very general feature related to angiogenesis and arteriogenesis, which are involved in neovascularization processes [...].
Abstract
Cited 2 times since 2024 (1.7 per year)
source: EuropePMC
Frontiers in sports and active living,
Volume 6, 6 1 2024, Pages 1389565
Exploring the impact of sleep on emotional and physical well-being in professional cricketers: a cohort study over an in-season training period.
Grewal S, Theijse RT, Dunlop G, van Deurzen DFP, van den Bekerom MPJ, Klautz RJM, Lefebvre RP, Munsami D, Grewal N
Background: Professional athletes navigate a multitude of unique challenges associated to sport-specific factors (e.g., training, travel and competition) and non-sport factors (e.g., performance pressure, stress and anxiety) that can interfere with healthy sleep behaviors. Sleep plays a key role in proper biopsychosocial development as well as short- and long-term biological, physical, psychological, and cognitive health. As poor sleep quality is known to impair proper brain function, this study...
Abstract
Cited 12 times since 2024 (10.3 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 51, Issue 12, 5 1 2024, Pages 3585-3595
Cost-effectiveness of one-stop-shop [<sup>18</sup>F]Fluorocholine PET/CT to localise parathyroid adenomas in patients suffering from primary hyperparathyroidism.
van Mossel S, Saing S, Appelman-Dijkstra N, Quak E, Schepers A, Smit F, de Geus-Oei LF, Vriens D
Purpose: We conducted a cost-effectiveness analysis in which we compared a preoperative [18F]Fluorocholine PET/CT-based one-stop-shop imaging strategy with current best practice in which [18F]Fluorocholine PET/CT is only recommended after negative or inconclusive [99mTc]Tc-methoxy isobutyl isonitrile SPECT/CT for patients suffering from primary hyperparathyroidism. We investigated whether the one-stop-shop strategy performs as well as current best practice but at lower costs. Methods: We develop...
Abstract
Sensors (Basel, Switzerland),
Volume 24, Issue 11, 5 1 2024, Pages 3664
Efficacy of the Cardiac Implantable Electronic Device Multisensory Triage-HF Algorithm in Heart Failure Care: A Real-World Clinical Experience.
Aslan U, Beeres SLMA, Feijen M, Mulder GM, Jukema JW, Egorova AD
Heart failure (HF) admissions are burdensome, and the mainstay of prevention is the timely detection of impending fluid retention, creating a window for medical treatment intensification. This study evaluated the accuracy and performance of a Triage-HF-guided carepath in real-world ambulatory HF patients in daily clinical practice. In this prospective, observational study, 92 adult HF patients (71 males (78%), with a median age of 69 [IQR 59-75] years) with the Triage-HF algorithm activated in t...
Abstract
Cited 2 times since 2024 (1.7 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 13, Issue 11, 5 1 2024, Pages 3327
Practical Considerations of Remote Care in Thoracic Aortopathy in India.
Grewal N, Idhrees M, Velayudhan B, Klautz RJM, Grewal S
Background: Thoracic aortopathy includes conditions like aortic aneurysms and dissections, posing significant management challenges. In India, care delivery is complicated by geographic vastness, financial constraints, and healthcare resource disparities. Telemedicine and digital health technologies offer promising solutions. Methods: A comprehensive review of literature and clinical experiences was conducted to explore the implementation of remote care strategies for thoracic aortopathy in Indi...
Abstract
Journal of surgical case reports,
Volume 2024, Issue 6, 3 1 2024, Pages rjae383
First use of a new extended reality tool for preoperative planning in coronary artery bypass surgery: a case-report.
El Mathari S, Broersen A, Dijkstra J, Sadeghi AH, Grisèl B, de Lind van Wijngaarden RAF, Klautz RJM, Kluin J
A 73-year-old male presented with angina symptoms and was diagnosed with three-vessel coronary artery disease by use of computed tomography angiography and coronary angiography. This diagnosis necessitated coronary artery bypass grafting (CABG) surgery. A custom made AI-driven algorithm was used to generate a patient-specific three-dimensional coronary artery model from computed tomography angiography imaging data. This framework enabled precise segmentation and reconstruction of the coronary va...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Journal of scleroderma and related disorders,
Volume 9, Issue 3, 3 1 2024, Pages 185-191
Troponin I levels in systemic sclerosis patients with myocardial involvement.
Hoekstra EM, Liem SI, Ahmed S, Levarht N, Fehres CM, Giuca A, Ajmone Marsan N, Huizinga TW, de Vries-Bouwstra JK
Objectives: Troponin I has been suggested as a more specific diagnostic biomarker for myocardial involvement in systemic sclerosis than the frequently used troponin T. The aim of this study is to evaluate the additive value of troponin I to detect myocardial involvement in systemic sclerosis. To this end, we evaluated the association between troponin I levels and myocardial involvement in systemic sclerosis patients. Methods: A cross-sectional observational study was performed, including 20 heal...
Abstract
Cited 3 times since 2024 (2.5 per year)
source: EuropePMC
European journal of heart failure,
Volume 26, Issue 8, 2 1 2024, Pages 1736-1744
Serial cardiac biomarkers, pulmonary artery pressures and traditional parameters of fluid status in relation to prognosis in patients with chronic heart failure: Design and rationale of the BioMEMS study.
Allach Y, Barry-Loncq de Jong M, Clephas PRD, van Gent MWF, Brunner-La Rocca HP, Szymanski MK, van Halm VP, Handoko ML, Kok WEM, Asselbergs FW, van Kimmenade RRJ, Manintveld OC, van Mieghem NMDA, Beeres SLMA, Rienstra M, Post MC, van Heerebeek L, Borleffs CJW, Tukkie R, Mosterd A, Linssen GCM, Spee RF, Emans ME, Smilde TDJ, van Ramshorst J, Kirchhof CJHJ, Feenema-Aardema MW, da Fonseca CA, van den Heuvel M, Hazeleger R, van Eck JWM, Boersma E, Kardys I, de Boer RA, Brugts JJ
Aims: Heart failure (HF), a global pandemic affecting millions of individuals, calls for adequate predictive guidance for improved therapy. Congestion, a key factor in HF-related hospitalizations, further underscores the need for timely interventions. Proactive monitoring of intracardiac pressures, guided by pulmonary artery (PA) pressure, offers opportunities for efficient early-stage intervention, since haemodynamic congestion precedes clinical symptoms. Methods: The BioMEMS study, a substudy...
Abstract
Cited 1 times since 2024 (0.8 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 31, Issue 8, 1 1 2024, Pages 945-953
The potential benefit of statin prescription based on prediction of treatment responsiveness in older individuals: an application to the PROSPER randomized controlled trial.
Nguyen TL, Trompet S, Brodersen JB, Hoogland J, Debray TPA, Sattar N, Jukema JW, Westendorp RGJ
Aims: Clinical guidelines often recommend treating individuals based on their cardiovascular risk. We revisit this paradigm and quantify the efficacy of three treatment strategies: (i) overall prescription, i.e. treatment to all individuals sharing the eligibility criteria of a trial; (ii) risk-stratified prescription, i.e. treatment only to those at an elevated outcome risk; and (iii) prescription based on predicted treatment responsiveness. Methods and results: We reanalysed the PROSPER random...
Abstract
Cited 5 times since 2024 (4.2 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 26, Issue 6, 1 1 2024, Pages euae157
Body mass index and pulmonary vein isolation: real-world data on outcomes and quality of life.
Vermeer J, Houterman S, Medendorp N, van der Voort P, Dekker L, Ablation Registration Committee of the Netherlands Heart Registration
Aims: Increasing numbers of overweight and obese patients undergo pulmonary vein isolation (PVI), despite the association between higher body mass index (BMI) and adverse PVI outcomes. Evidence on complications and quality of life in different bodyweight groups is limited. This study aims to clarify the impact of BMI on repeat ablations, periprocedural complications, and changes in quality of life. Methods and results: This multi-centre study analysed prospectively collected data from 15 ablatio...
Abstract
JACC. Cardiovascular imaging,
Volume 17, Issue 6, 1 1 2024, Pages 713-714
Tricuspid Regurgitation: What Is Missing?
Bax JJ, Chandrashekhar Y
Abstract
