6136 results
Cited 11 times since 2016 (1.3 per year)
source: EuropePMC
Congenital heart disease,
Volume 12, Issue 1, 18 3 2016, Pages 40-48
Comparative Evaluation of Flow Quantification across the Atrioventricular Valve in Patients with Functional Univentricular Heart after Fontan's Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization.
She HL, Roest AA, Calkoen EE, van den Boogaard PJ, van der Geest RJ, Hazekamp MG, de Roos A, Westenberg JJ
Purpose: To evaluate the inflow pattern and flow quantification in patients with functional univentricular heart after Fontan's operation using 4D flow magnetic resonance imaging (MRI) with streamline visualization when compared with the conventional 2D flow approach. Method: Seven patients with functional univentricular heart after Fontan's operation and twenty-three healthy controls underwent 4D flow MRI. In two orthogonal two-chamber planes, streamline visualization was applied, and...
Abstract
Cited 10 times since 2016 (1.2 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 32, Issue 10, 12 2 2016, Pages 1567-1575
Incidence of persistent renal dysfunction after contrast enhanced coronary CT angiography in patients with suspected coronary artery disease.
Maaniitty T, Stenström I, Uusitalo V, Ukkonen H, Kajander S, Bax JJ, Saraste A, Knuuti J
Contrast-induced nephropathy (CIN) is a potentially serious complication of contrast agents used in computed tomography angiography (CTA). The aim of this study was to evaluate whether persistent renal dysfunction occurs in patients undergoing coronary CTA for suspected stable coronary artery disease (CAD). From a cohort of 957 patients undergone coronary CTA, we identified 402 patients with plasma creatinine levels collected before and within 6 months after CTA. According to the definition of C...
Abstract
International journal of cardiology,
Volume 221, 9 2 2016, Pages 682-687
Haptoglobin polymorphism in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and near-infrared spectroscopy in patients with coronary artery disease.
Buljubasic N, Oemrawsingh RM, Smeets MB, Cheng JM, Regar E, van Geuns RJ, Serruys PW, Boersma E, Akkerhuis KM, Kardys I, Arslan F
Background: Conflicting results exist regarding the association between a common Haptoglobin (Hp) polymorphism and risk of coronary artery disease. We investigated the association of three functionally different anti-oxidant and anti-inflammatory Hp phenotypes (Hp1-1, Hp2-1, Hp2-2) with invasively measured degree and composition of coronary atherosclerosis as determined by intravascular ultrasound (-virtual histology) (IVUS(-VH)) as well as near-infrared spectroscopy (NIRS). Methods: Non-culprit...
Abstract
Cited 3 times since 2016 (0.3 per year)
source: EuropePMC
African journal of traditional, complementary, and alternative medicines : AJTCAM,
Volume 13, Issue 4, 3 1 2016, Pages 191-198
EFFECT OF HARVEST DATE AND STALK SECTION ON SELECTED STRENGTH CHARACTERISTICS OF TURKISH OREGANO (<i>Origanum onites</i> L).
Yilmaz D, Jasinskas A
Background: The time required to harvest plant crops is important to the plant properties. It is affected by design of the harvest equipment and the desire for high-quality products with low energy usage. Materials and methods: Strength characteristics of Origanum onites L., an important medicinal aromatic plant, harvested on 2, 9, 16 and 23 July, 2012-2014 (H1, H2, H3 and H4, respectively) were measured at the bottom and top sections of the stalk. Measurements included maximum force, bio-yield...
Abstract
Cited 71 times since 2016 (8.2 per year)
source: EuropePMC
Lab on a chip,
Volume 16, Issue 14, 1 1 2016, Pages 2644-2653
Engineering a perfusable 3D human liver platform from iPS cells.
Schepers A, Li C, Chhabra A, Seney BT, Bhatia S
In vitro models of human tissue are crucial to our ability to study human disease as well as develop safe and effective drug therapies. Models of single organs in static and microfluidic culture have been established and shown utility for modeling some aspects of health and disease; however, these systems lack multi-organ interactions that are critical to some aspects of drug metabolism and toxicity. Thus, as part of a consortium of researchers, we have developed a liver chip that meets the foll...
Abstract
Cited 47 times since 2016 (5.4 per year)
source: EuropePMC
Circulation,
Volume 134, Issue 3, 1 1 2016, Pages 212-221
Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects.
Smit RA, Trompet S, Sabayan B, le Cessie S, van der Grond J, van Buchem MA, de Craen AJ, Jukema JW
Background: Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy. Methods: We investigated the association between LDL-C variability and 4 cognitive domains at month 30 in 4428 participants of PROSPER (PROspective Study of Pravastatin in the Elderly at Risk...
Abstract
Cited 4 times since 2016 (0.5 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 24, Issue 7, 1 1 2016, Pages 1096
Genome-wide association studies identify genetic loci for low von Willebrand factor levels.
van Loon J, Dehghan A, Weihong T, Trompet S, McArdle WL, Asselbergs FW, Chen MH, Lopez LM, Huffman JE, Leebeek FW, Basu S, Stott DJ, Rumley A, Gansevoort RT, Davies G, Wilson JJ, Witteman JC, Cao X, de Craen AJ, Bakker SJ, Psaty BM, Starr JM, Hofman A, Jukema JW, Deary IJ, Hayward C, van der Harst P, Lowe GD, Folsom AR, Strachan DP, Smith N, de Maat MP, O'Donnell C
Abstract
Cited 4 times since 2016 (0.5 per year)
source: EuropePMC
Archives of medical science : AMS,
Volume 12, Issue 4, 1 1 2016, Pages 697-703
Serum paraoxonase 1 activity in patients with iron deficiency anemia.
Okuturlar Y, Gedikbasi A, Akalin N, Gunaldi M, Yilmaz D, Mert M, Harmankaya O, Soylu A, Karakaya P, Kumbasar A
Introduction: In this study we aimed to detect paraoxonase 1 (PON-1) activity in iron deficiency anemia (IDA) and to compare it with healthy controls by observing the change after iron therapy. Material and methods: In this study, 50 adult patients with IDA and 40 healthy subjects were enrolled. All patients were analyzed at the beginning and after treatment according to laboratory assessments. Results: Mean paraoxonase and arylesterase activities in the iron deficiency anemia group were signifi...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 7-8, 1 1 2016, Pages 441-446
Redesigning healthcare: The 2.4 billion euro question? : Connecting smart technology to improve outcome of patients.
Treskes RW, Van Der Velde ET, Atsma DE, Schalij MJ
Although it has been possible to transfer electrocardiograms via a phone line for more than 100 years, use of internet-based patient monitoring and communication systems in daily care is uncommon. Despite the introduction of numerous health-monitoring devices, and despite most patients having internet access, the implementation of individualised healthcare services is still limited. On the other hand, hospitals have invested heavily in massive information systems offering limited value for money...
Abstract
Cited 18 times since 2016 (2.1 per year)
source: EuropePMC
The Journal of general virology,
Volume 97, Issue 9, 30 5 2016, Pages 2255-2264
Comparison of norovirus genogroup I, II and IV seroprevalence among children in the Netherlands, 1963, 1983 and 2006.
van Beek J, de Graaf M, Xia M, Jiang X, Vinjé J, Beersma M, de Bruin E, van de Vijver D, Holwerda M, van Houten M, Buisman AM, van Binnendijk R, Osterhaus ADME, van der Klis F, Vennema H, Koopmans MPG
Noroviruses are a major cause of acute gastroenteritis worldwide and are a genetically diverse group of viruses. Since 2002, an increasing number of norovirus outbreaks have been reported globally, but it is not clear whether this increase has been caused by a higher awareness or reflects the emergence of new genogroup II genotype 4 (GII.4) variants. The hypothesis that norovirus prevalence has increased post-2002 and is related to the emergence of GII.4 is tested in this study. Sera collected f...
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
PLoS genetics,
Volume 12, Issue 6, 29 5 2016, Pages e1006166
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Sc
[This corrects the article DOI: 10.1371/journal.pgen.1005378.].
Abstract
Cited 111 times since 2016 (12.7 per year)
source: EuropePMC
Genome biology,
Volume 17, Issue 1, 27 4 2016, Pages 138
Blood lipids influence DNA methylation in circulating cells.
Dekkers KF, van Iterson M, Slieker RC, Moed MH, Bonder MJ, van Galen M, Mei H, Zhernakova DV, van den Berg LH, Deelen J, van Dongen J, van Heemst D, Hofman A, Hottenga JJ, van der Kallen CJ, Schalkwijk CG, Stehouwer CD, Tigchelaar EF, Uitterlinden AG, Willemsen G, Zhernakova A, Franke L, 't Hoen PA, Jansen R, van Meurs J, Boomsma DI, van Duijn CM, van Greevenbroek MM, Veldink JH, Wijmenga C, BIOS Consortium, van Zwet EW, Slagboom PE, Jukema JW, Heijmans BT
Background: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the development of atherosclerosis. To interrogate the causal relationship between triglyceride, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels and genome-wide DNA methylation while excludi...
Abstract
Cited 12 times since 2016 (1.4 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 33, Issue 10, 25 4 2016, Pages 1458-1464
Left ventricular reverse remodeling after aortic valve surgery for acute versus chronic aortic regurgitation.
Regeer MV, Versteegh MI, Ajmone Marsan N, Schalij MJ, Klautz RJ, Bax JJ, Delgado V
Aims: Extent of left ventricular (LV) reverse remodeling after aortic valve repair or replacement (AVR) may differ between patients operated for acute aortic regurgitation (AR) and chronic AR. The aim of this study was to compare changes in LV volumes and function between patients with acute and chronic AR who underwent AVR. Methods and results: A total of 98 patients (54±15 years, 61% men) with acute (n=21) or chronic AR (n=77) were included in the present retrospective evaluation. LV volumes,...
Abstract
Cited 33 times since 2016 (3.8 per year)
source: EuropePMC
ACS biomaterials science & engineering,
Volume 3, Issue 9, 20 3 2016, Pages 1964-1971
Oxygen-Generating Photo-Cross-Linkable Hydrogels Support Cardiac Progenitor Cell Survival by Reducing Hypoxia-Induced Necrosis.
Alemdar N, Leijten J, Camci-Unal G, Hjortnaes J, Ribas J, Paul A, Mostafalu P, Gaharwar AK, Qiu Y, Sonkusale S, Liao R, Khademhosseini A
Oxygen is essential to cell survival and tissue function. Not surprisingly, ischemia resulting from myocardial infarction induces cell death and tissue necrosis. Attempts to regenerate myocardial tissue with cell based therapies exacerbate the hypoxic stress by further increasing the metabolic burden. In consequence, implanted tissue engineered cardiac tissues suffer from hypoxia-induced cell death. Here, we report on the generation of oxygen-generating hydrogels composed of calcium peroxide (CP...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 33, Issue 10, 16 3 2016, Pages 1532-1538
Assessment of global left ventricular excursion using three-dimensional dobutamine stress echocardiography to identify significant coronary artery disease.
Hoogslag GE, Joyce E, Bax JJ, Ajmone Marsan N, Delgado V
Background: Quantitative three-dimensional (3D) dobutamine stress echocardiography (DSE) for myocardial ischemia detection may be an adjuvant to left ventricular (LV) wall-motion analysis. The aim of the current study was to assess the association between global 3D LV excursion during DSE and the presence of significant coronary artery disease (CAD) on coronary angiography. Methods: Three-dimensional DSE was performed in 40 patients (67±12 years, 68% male) who underwent subsequent coronary angio...
Abstract
Cited 29 times since 2016 (3.3 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 5, Issue 6, 16 3 2016, Pages e002860
Systematic Evaluation of the Cellular Innate Immune Response During the Process of Human Atherosclerosis.
van Dijk RA, Rijs K, Wezel A, Hamming JF, Kolodgie FD, Virmani R, Schaapherder AF, Lindeman JH
Background: The concept of innate immunity is well recognized within the spectrum of atherosclerosis, which is primarily dictated by macrophages. Although current insights to this process are largely based on murine models, there are fundamental differences in the atherosclerotic microenvironment and associated inflammatory response relative to humans. In this light, we characterized the cellular aspects of innate immune response in normal, nonprogressive, and progressive human atherosclerotic p...
Abstract
Dermatology online journal,
Volume 22, Issue 6, 15 3 2016, Pages 13030/qt4f48g7jc
Unusual location of median raphe cyst presenting as perianal polyp: a case report.
Arer IM, Yilmaz D, Ozek OC, Yabanoglu H, Caliskan K
Median raphe cysts (MRC) are uncommon, benign congenital lesions that may present anywhere in the midline between the urinary meatus and the anus, with the shaft of the penis and the glans penis being the most common sites. We report a 52-year-old man with median raphe cyst unusually located in perianal region and treated by surgical excision.
Abstract
Cited 15 times since 2016 (1.7 per year)
source: EuropePMC
Atherosclerosis,
Volume 251, 11 2 2016, Pages 139-146
IL-6: A Janus-like factor in abdominal aortic aneurysm disease.
Kokje VBC, Gäbel G, Koole D, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN
Background and aims: An abdominal aortic aneurysm (AAA) is part of the atherosclerotic spectrum of diseases. The disease is hallmarked by a comprehensive localized inflammatory response with striking IL-6 hyperexpression. IL-6 is a multifaceted cytokine that, depending on the context, acts as a pro- or anti-inflammatory factor. In this study, we explore a putative role for IL-6 in AAA disease. Methods: ELISA's, Western blot analysis, real time PCR and array analysis were used to investigate...
Abstract
Cited 37 times since 2016 (4.2 per year)
source: EuropePMC
Journal of virology,
Volume 90, Issue 13, 10 2 2016, Pages 5928-5938
Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells.
Mänz B, de Graaf M, Mögling R, Richard M, Bestebroer TM, Rimmelzwaan GF, Fouchier RAM
Unlabelled: A strong restriction of the avian influenza A virus polymerase in mammalian cells generally limits viral host-range switching. Although substitutions like E627K in the PB2 polymerase subunit can facilitate polymerase activity to allow replication in mammals, many human H5N1 and H7N9 viruses lack this adaptive substitution. Here, several previously unknown, naturally occurring, adaptive substitutions in PB2 were identified by bioinformatics, and their enhancing activity was verified u...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 18, Issue 6, 1 1 2016, Pages 727
Erratum to "Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency" [Eur J Heart Fail 2016;18:482-489].
Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani HA, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Floch CL, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F
Abstract
