Research

Publications

Below you can find a list of our published research.

6132 results

Cited 7 times since 2006 (0.4 per year) source: EuropePMC

Vascular pharmacology, Volume 44, Issue 5, 9 2 2006, Pages 257-264 Drug-eluting stents studies in mice: do we need atherosclerosis to study restenosis? Pires NM, Jukema JW, Daemen MJ, Quax PH

In 2001, the first human study with drug-eluting stents (DES) was published showing a nearly complete abolition of restenosis by using a sirolimus-eluting stent. This success was very encouraging to test new compounds in combination with the DES platform. Nevertheless, several other anti-restenotic compounds have been used in human clinical trials with disappointing outcomes. Little is known concerning potential adverse effects on vessel wall integrity and (re)healing, atherosclerotic lesion for... Abstract

Cited 29 times since 2006 (1.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 33, Issue 6, 8 2 2006, Pages 716-723 Prediction of functional recovery after revascularization in patients with chronic ischaemic left ventricular dysfunction: head-to-head comparison between 99mTc-sestamibi/18F-FDG DISA SPECT and 13N-ammonia/ 18F-FDG PET. Slart RH, Bax JJ, van Veldhuisen DJ, van der Wall EE, Irwan R, Sluiter WJ, Dierckx RA, de Boer J, Jager PL

Purpose: (18)F-FDG PET is an important modality for myocardial viability assessment in patients with left ventricular (LV) dysfunction. Dual-isotope simultaneous acquisition (DISA) SPECT may be an alternative to PET. The aim of this study was to compare the diagnostic performance of PET and DISA SPECT for the prediction of improvement in regional and global LV function as well as LV reverse remodelling after revascularization. Methods: Patients (n=47) with chronic coronary artery disease and LV... Abstract

Cited 17 times since 2006 (0.9 per year) source: EuropePMC

Journal of biomechanics, Volume 40, Issue 2, 6 1 2006, Pages 289-295 Development of fibrinous thrombus analogue for in-vitro abdominal aortic aneurysm studies. Hinnen JW, Rixen DJ, Koning OH, van Bockel JH, Hamming JF

Purpose: To develop different thrombus analogues, with mechanical properties similar to those of human fibrinous thrombus, for in-vitro aneurysm sac pressure studies. Methods: Using dynamic mechanical analysis we determined the E-modulus (/E(*)/) at 0.8, 1.0, 1.5 and 3.9 Hz of ten different human fibrinous thrombus samples. We also determined loss and storage modulus to quantify the visco-elastic properties. For comparison, we measured the E-modulus (|E(*)|), loss and storage modulus of gelatin,... Abstract

Cited 112 times since 2006 (5.9 per year) source: EuropePMC

Circulation, Volume 113, Issue 10, 6 1 2006, Pages 1295-1304 Hemodynamic effects of long-term cardiac resynchronization therapy: analysis by pressure-volume loops. Steendijk P, Tulner SA, Bax JJ, Oemrawsingh PV, Bleeker GB, van Erven L, Putter H, Verwey HF, van der Wall EE, Schalij MJ

Background: Acute hemodynamic effects of cardiac resynchronization therapy (CRT) were reported previously, but detailed invasive studies showing hemodynamic consequences of long-term CRT are not available. Methods and results: We studied 22 patients scheduled for implantation of a CRT device based on conventional criteria (New York Heart Association class III or IV, left ventricular [LV] ejection fraction 120 ms). During diagnostic catheterization before CRT, we acquired pressure-volume loops us... Abstract

Cited 66 times since 2006 (3.5 per year) source: EuropePMC

The American journal of cardiology, Volume 97, Issue 8, 2 1 2006, Pages 1220-1222 Effect of radiofrequency catheter ablation for atrial fibrillation on left atrial cavity size. Tops LF, Bax JJ, Zeppenfeld K, Jongbloed MR, van der Wall EE, Schalij MJ

Left atrial (LA) remodeling is associated with atrial fibrillation (AF). Radiofrequency catheter ablation offers a good treatment option for AF, with reasonable long-term results. The purpose of the present study was to assess whether LA reverse remodeling occurs after successful catheter ablation. Fifty-seven consecutive patients (45 men; age 53 +/- 8 years) with symptomatic drug-refractory AF were treated with radiofrequency catheter ablation. The patients were divided into 2 groups on the bas... Abstract

Cited 29 times since 2006 (1.5 per year) source: EuropePMC

Clinical genetics, Volume 69, Issue 3, 1 1 2006, Pages 263-270 Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels. Boekholdt SM, Souverein OW, Tanck MW, Hovingh GK, Kuivenhoven JA, Peters RI, Jansen H, Schiffers PM, van der Wall EE, Doevendans PA, Reitsma PH, Zwinderman AH, Kastelein JJ, Jukema JW

It is assumed that the combined effects of multiple common genetic variants explain a large part of variation of high-density lipoprotein cholesterol (HDL-C) plasma levels, but little evidence exists to corroborate this assumption. It was our objective to study the contribution of multiple common genetic variants of HDL-C-related genes to variation of HDL-C plasma levels. A well-characterized cohort of 546 Caucasian men with documented coronary artery disease was genotyped for common functional... Abstract

Cited 8 times since 2006 (0.4 per year) source: EuropePMC

Inflammopharmacology, Volume 14, Issue 1-2, 1 1 2006, Pages 36-41 Chronic effects of celecoxib, a cyclooxygenase-2 inhibitor, cause enhanced alcohol-induced liver steatosis in rats. Bykov IL, Palmen M, Rainsford KD, Lindros KO

Background: The pathogenetic role of prostaglandins in steatosis, the first stage of alcoholic liver injury, is not well understood, especially that involving the inflammatory reactions controlled by prostaglandins and pro-inflammatory cytokines in the liver. We, therefore, studied the chronic effects of the COX-2 inhibitor, celecoxib, given to ethanol-treated rats. Methods: Rats were fed ethanol and a low dose of celecoxib (approximately 20 mg/kg daily) in a high-fat/low-carbohydrate liquid die... Abstract

Cited 11 times since 2006 (0.6 per year) source: EuropePMC

Journal of clinical microbiology, Volume 44, Issue 3, 1 1 2006, Pages 1197-1201 Use of enzyme-linked immunospot assay with Mycobacterium tuberculosis-specific peptides for diagnosis of recent infection with M. tuberculosis after accidental laboratory exposure. Leyten EM, Mulder B, Prins C, Weldingh K, Andersen P, Ottenhoff TH, van Dissel JT, Arend SM

This report of an accidental exposure to Mycobacterium tuberculosis in a microbiological laboratory illustrates the value of gamma interferon enzyme-linked immunospot assay using peptides of ESAT-6, CFP-10, TB37.6, and TB7.7 for the diagnosis of latent infection. In particular, positive responses to peptides 2 to 6 of TB37.6 were observed exclusively in recently infected persons. Abstract

Cited 18 times since 2006 (0.9 per year) source: EuropePMC

Nature clinical practice. Cardiovascular medicine, Volume 3 Suppl 1, 1 1 2006, Pages S94-100 Intramyocardial injection of skeletal myoblasts: long-term follow-up with pressure-volume loops. Steendijk P, Smits PC, Valgimigli M, van der Giessen WJ, Onderwater EE, Serruys PW

The human heart has a limited capacity for self-repair because, unlike most other cells, cardiomyocytes do not regenerate. Therefore, if a substantial number of myocytes is lost after a myocardial infarction, the performance of the heart may become severely limited, leading to a condition of heart failure. Recently, cell transplantation has emerged as a potential therapy for patients with end-stage heart failure. Of the various cell types being investigated for this purpose, skeletal myoblasts a... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 150, Issue 11, 1 1 2006, Pages 597-600 [Screening of asymptomatic individuals for coronary disease using CT-calcium measurement in the coronary arteries]. Schuijf JD, Bax JJ, Jukema JW, van der Wall EE

Coronary calcification is a specific marker for coronary atherosclerosis. It is therefore reasonable to assume that the risk ofcardiac events can be assessed by the quantification of the extent of coronary calcium. Until now, the predictive value of coronary calcium and its advantage over conventional risk factors has not been proven by any of the available prospective cohort studies. It is particularly likely that assessment of coronary atherosclerosis will help in the decision to initiate or d... Abstract

Cited 31 times since 2006 (1.6 per year) source: EuropePMC

Coronary artery disease, Volume 17, Issue 2, 1 1 2006, Pages 173-179 A meta-analysis of safety and effectiveness of perioperative beta-blocker use for the prevention of cardiac events in different types of noncardiac surgery. Schouten O, Shaw LJ, Boersma E, Bax JJ, Kertai MD, Feringa HH, Biagini E, Kok NF, Urk Hv, Elhendy A, Poldermans D

Objective: Perioperative beta-blocker therapy has been proposed to improve outcome. Most of the trials conducted, however, lacked statistical power to evaluate the incidence of hard cardiac events and the relationship to the type of surgery. Therefore, we conducted a meta-analysis of all randomized controlled trials in which beta-blocker therapy was evaluated. Methods: An electronic search of published reports on Medline was undertaken to identify studies published between January 1980 and Novem... Abstract

Cited 16 times since 2006 (0.8 per year) source: EuropePMC

Seminars in cardiothoracic and vascular anesthesia, Volume 10, Issue 1, 1 1 2006, Pages 25-31 Protecting the heart with cardiac medication in patients with left ventricular dysfunction undergoing major noncardiac vascular surgery. Feringa HH, Bax JJ, Schouten O, Poldermans D

Patients with left ventricular dysfunction who are undergoing major noncardiac vascular surgery are at increased risk of adverse postoperative events. We sought to evaluate whether perioperative medication use, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, statins, and aspirin, was associated with a reduced incidence of postoperative in-hospital mortality in these high-risk patients. The study enrolled 511 patients with left ventricular dysfunction (left ventricular ej... Abstract

Cited 75 times since 2006 (3.9 per year) source: EuropePMC

Archives of internal medicine, Volume 166, Issue 5, 1 1 2006, Pages 529-535 The long-term prognostic value of the resting and postexercise ankle-brachial index. Feringa HH, Bax JJ, van Waning VH, Boersma E, Elhendy A, Schouten O, Tangelder MJ, van Sambeek MH, van den Meiracker AH, Poldermans D

Background: Peripheral arterial disease is associated with a high incidence of cardiovascular mortality. Peripheral arterial disease can be detected by using the ankle-brachial index (ABI). This study assessed the prognostic value of the postexercise ABI in addition to the resting ABI on long-term mortality in patients with suspected peripheral arterial disease. Methods: In this prospective cohort study of 3209 patients (mean +/- SD age, 63 +/- 12 years; 71.1% male), resting and postexercise ABI... Abstract

Cited 28 times since 2006 (1.5 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 13, Issue 2, 1 1 2006, Pages 210-219 Prediction of functional recovery after revascularization in patients with coronary artery disease and left ventricular dysfunction by gated FDG-PET. Slart RH, Bax JJ, van Veldhuisen DJ, van der Wall EE, Dierckx RA, de Boer J, Jager PL

Background: Traditionally, cardiac fluorodeoxyglucose (FDG) uptake is combined with regional perfusion for optimal evaluation of viability. Gated FDG-positron emission tomography (PET) may be an alternative technique for detection of viability because it permits combined assessment of glucose metabolism uptake and wall thickening (WT). In this study the value of FDG uptake and WT (analyzed from a stand-alone gated FDG-PET study) for the prediction of recovery of regional and global left ventricu... Abstract

Cited 1 times since 2006 (0.1 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 33, Issue 3, 1 1 2006, Pages 353-355 MSCT is better than stress perfusion imaging for detecting CAD--For. Cademartiri F, Bax JJ

Abstract

Cited 66 times since 2006 (3.5 per year) source: EuropePMC

Heart rhythm, Volume 3, Issue 5, 28 4 2006, Pages 526-535 Ablation of focal atrial arrhythmia in patients with congenital heart defects after surgery: role of circumscribed areas with heterogeneous conduction. de Groot NM, Zeppenfeld K, Wijffels MC, Chan WK, Blom NA, Van der Wall EE, Schalij MJ

Background: In patients late after surgical repair of congenital heart disease (CHD), areas with abnormal electrophysiologic properties may serve as slow conducting pathways within a macroreentrant circuit or may be the source of focal atrial tachycardia. Objectives: The purpose of this study was to evaluate the role of abnormal areas during focal atrial tachycardia prior to ablation. Methods: Electroanatomic activation mapping of 62 atrial tachycardias was performed in 43 consecutive patients (... Abstract

Cited 10 times since 2006 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 97, Issue 8, 28 4 2006, Pages 1146-1150 Relation of B-type natriuretic peptide early after acute myocardial infarction to left ventricular diastolic function and extent of myocardial damage determined by magnetic resonance imaging. Paelinck BP, Vrints CJ, Bax JJ, Bosmans JM, De Hert SG, de Roos A, Lamb HJ

Early after acute myocardial infarction, the relation between plasma B-type natriuretic peptide (BNP) and extent of myocardial scar formation and diastolic dysfunction remains unclear. In 32 consecutive patients early (5 +/- 3 days) after a first acute myocardial infarction, delayed contrast-enhanced magnetic resonance (MR) imaging was performed to define myocardial scar. Diastolic function was assessed using phase-contrast MR measurements of mitral flow and septal tissue velocities (tissue MR i... Abstract

Cited 45 times since 2006 (2.4 per year) source: EuropePMC

The American journal of cardiology, Volume 97, Issue 7, 28 4 2006, Pages 1103-1106 Prognostic value of routine preoperative electrocardiography in patients undergoing noncardiac surgery. Noordzij PG, Boersma E, Bax JJ, Feringa HH, Schreiner F, Schouten O, Kertai MD, Klein J, van Urk H, Elhendy A, Poldermans D

Electrocardiography is commonly performed as part of preoperative cardiovascular risk assessment in patients undergoing noncardiac surgery. However, the prognostic value of such electrocardiography is still not clear. This study retrospectively studied 23,036 patients who underwent 28,457 surgical procedures at Erasmus Medical Center from 1991 to 2000. Patients were screened before surgery by type of surgery, cardiovascular risk factors (history of coronary heart disease, heart failure, diabetes... Abstract

Cited 88 times since 2006 (4.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 47, Issue 6, 23 4 2006, Pages 1182-1187 Cardioprotective medication is associated with improved survival in patients with peripheral arterial disease. Feringa HH, van Waning VH, Bax JJ, Elhendy A, Boersma E, Schouten O, Galal W, Vidakovic RV, Tangelder MJ, Poldermans D

Objectives: We sought to investigate the effect of cardiac medication on long-term mortality in patients with peripheral arterial disease (PAD). Background: Peripheral arterial disease is associated with increased cardiovascular morbidity and mortality. Treatment guidelines recommend aggressive management of risk factors and lifestyle modifications. However, the potential benefit of cardiac medication in patients with PAD remains ill defined. Methods: In this prospective observational cohort stu... Abstract

Cited 5 times since 2006 (0.3 per year) source: EuropePMC

European heart journal, Volume 27, Issue 6, 23 4 2006, Pages 631-632 Assessment of coronary artery disease in patients with (a)symptomatic diabetes. Bax JJ, van der Wall EE

Abstract