Research

Publications

Below you can find a list of our published research.

6424 results

eLife, Volume 14, 7 1 2026, Pages RP107072 Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics. Teplenin AS, Kudryashova NN, Majumder R, de Vries AAF, Panfilov AV, Pijnappels DA, De Coster T

Many biological processes emerge as frequency-dependent responses to trains of external stimuli. Heart rhythm disturbances, that is cardiac arrhythmias, are important examples as they are often triggered by specific patterns of preceding stimuli. In this study, we investigated how ectopic arrhythmias can be induced by external stimuli in cardiac tissue containing a localised area of depolarisation. Using optogenetic in vitro experiments and in silico modelling, we systematically explored the dyn... Abstract

Pathology international, 5 1 2026 The Occurrence of Gene Fusions in Thyroid Lesions and the Relation With Chronic Lymphocytic Thyroiditis. Jentus MM, van Wezel T, Ruano D, Snel M, Schepers A, Crobach S, Morreau H

Previously, we concluded that thyroid resections with multifocal, genetically distinct lesions more often showed florid chronic lymphocytic thyroiditis (CLT) than thyroids with clonally related multiple lesions. In this study, we characterized a consecutive cohort of thyroid lesions for molecular drivers and investigated the relationship between the molecular alteration type and florid CLT. Molecular diagnostic data from 414 patients (2016-2025) were retrospectively reviewed, including clinical... Abstract

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 5 1 2026 Preoperative Extracorporeal Membrane Oxygenation in Children With Dextro-Transposition of the Great Arteries: Extracorporeal Life Support Organization Registry Study, 2000-2022. Koers L, Thiagarajan RR, van der Palen RLF, Willems AMA, Liebenberg L, Rycus P, Hazekamp MG, Roeleveld PP

Objective: To describe those neonates with dextro-transposition of the great arteries (d-TGA) who undergo preoperative support with extracorporeal membrane oxygenation (ECMO) and to compare outcomes in those undergoing the arterial switch operation (ASO) on-ECMO vs. those who undergo ASO after weaning from ECMO. Design: Retrospective analysis of the Extracorporeal Life Support Organization (ELSO) Registry data, 2000-2022. Patients: Neonates aged up to 21 days with d-TGA supported by ECMO before... Abstract

International journal of biometeorology, Volume 70, Issue 1, 3 1 2026, Pages 8 Quantifying associations between local climate zones on land surface temperature: new insights from coastal areas of Italy. Isinkaralar O, Isinkaralar K, Yilmaz D, Yeboah E, Sarfo I, Öztürk S

Coastal regions across Europe face rising sea levels and climate change-related extreme weather conditions such as more frequent and intense heat waves, floods, droughts, and storms. As climate change and rapid urbanization continue to pose significant challenges to the resilience of cities, knowledge from LCZ studies has the potential to generate targeted adaptation strategies that address the unique thermal performance characteristics of different urban areas. A range of physical characteristi... Abstract

Kidney international, Volume 109, Issue 1, 1 1 2026, Pages 37-40 Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling. Baker AH, de Vries MR

Single-cell transcriptomics of arteriovenous fistulas reveal that failure is likely driven less by smooth muscle proliferation than by continuous inflammation, endothelial dysfunction, and fibroblast-driven fibrosis. These insights reframe current knowledge and highlight mechanistic pathways as to where future therapies could be targeted to improve arteriovenous fistula maturation kinetics and associated patency rates. Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 68, Issue 1, 1 1 2026, Pages ezaf461 Mitral Annular Disjunction: A Roadmap for the Surgeon. Bonaros N, Gollmann-Tepeköylü C, Palmen M, Ajmone N, Delgado V, Garbi M, Mayr A, Pölzl L, Marin-Cuartas M, Ascione G, Azzola Guicciardi N, Troger F, Pereda D, Klautz R, De Bonis M, Borger MA, Perier P

Objectives: Mitral annular disjunction (MAD) is a structural abnormality of the mitral annulus fibrosus, associated with myxomatous leaflet degeneration, mitral valve prolapse (MVP), and ventricular arrhythmias. The combination of annular dilatation and abnormal annular motion increases mechanical stress on the mitral leaflets, triggering the degenerative process. Methods: This review summarizes the major pathophysiologic, diagnostic and therapeutic measures for the treatment of patients with MA... Abstract

European heart journal. Cardiovascular Imaging, 29 5 2026, Pages jeaf372 Outcomes with Revascularization vs. Medical Therapy According to Plaque Burden from Coronary Computed Tomography Angiography. Bär S, Knuuti J, Saraste A, Nurmohamed NS, Jukema RA, Klén R, Bax JJ, Knaapen P, Danad I, Maaniitty T

Aims: We aimed to investigate, whether plaque burden from coronary computed tomography angiography (CCTA) could be used to identify patients potentially benefitting from revascularization. Methods and results: We assessed consecutive patients undergoing CCTA and selective 15O-water perfusion positron emission tomography for evaluation of coronary artery disease (CAD) at two tertiary care centers in Finland and the Netherlands. Per-patient percent atheroma volume (PAV) and maximum per-vessel PAV... Abstract

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 27 4 2025, Pages 15266028251397339 A 15-Year Single-Center Experience Treating Complex Aortic Aneurysms: Transitioning From Open to Complex Endovascular Repair. Warmerdam BWCM, Hjortnaes J, Driessen AHG, Eefting D, Hamming JF, Klautz RJM, Van der Meer RW, Van Rijswijk CSP, Van der Vorst JR, van Schaik J

Introduction: This is a descriptive study analyzing all surgically treated complex aneurysm patients in a tertiary referral center, during a 15-year time period in which complex endovascular aortic repair (complex EVAR) was introduced alongside open surgical repair (OSR). The goal was to present the real-world clinical profiles and surgical outcomes of complex (thoraco-)abdominal aneurysm patients, based on the current decision-making process. Methods: Patients undergoing OSR and complex EVAR be... Abstract

Molecular biology of the cell, 24 4 2025, Pages mbcE24090405T The RhoGEF Trio regulates the formation of tensile linear endothelial junctions to improve barrier function. van Rijssel J, Sluiter TJ, van der Krogt JMA, Bart CI, Zhang J, de Vries AAF, van Alphen FPJ, Janssen H, van den Biggelaar M, Wubbolts RW, Quax PHA, de Vries MR, van Buul JD

The vascular endothelium serves as a selectively permeable barrier, tightly regulating transendothelial transport of small molecules, macromolecules, and immune cells. In the context of cardiovascular and inflammatory pathologies, the integrity of this barrier is often markedly compromised, contributing to tissue dysfunction, multi-organ failure, and, ultimately, mortality. Therapeutic strategies aimed at mitigating endothelial barrier dysfunction primarily focus on enhancing the stability of en... Abstract

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20 3 2025, Pages S1198-743X(25)00618-4 CefiderocolFinder: a tool for detecting genetic adaptations implicated in cefiderocol resistance. van den Brand B, Notermans DW, Verkaik NJ, Lansu S, Rossen JWA, Hendrickx APA, Dutch CPE surveillance study group, van Arkel ALE, Leversteijn-van Hall MA, van den Bijllaardt W, van Mansfeld R, van Dijk K, Zwart B, Diederen BMW, Berkhout H, Ott A, Waar K, Ang W, da Silva J, Vlek ALM, Stohr JJJM, Bode LGM, Jansz A, Paltansing S, van Griethuysen AJ, Lo Ten Foe JR, van Trijp MJCA, Wong M, Muller AE, van der Linden MPM, van Rijn M, Debast SB, Kolwijck E, Al Naiemi N, Schulin T, Dinant S, van Mens SP, Melles DC, Stuart JWTC, Gruteke P, van Dam AP, Rahamat-Langendoen J, Maraha B, Sinnige JC, van der Vorm E, van Meer MPA, de Graaf M, de Jong E, Vainio SJ, Heikens E, Reijer MD, Dorigo-Zetsma JW, Troelstra A, Bathoorn E, de Vries J, van Dam DW, de Brauwer EIGB, Steingrover R, Oliveira Dos Santos C

Objectives: Cefiderocol is a novel last-resort cephalosporin antimicrobial increasingly used for difficult-to-treat infections by multidrug-resistant microorganisms (MDRO), and is effective against carbapenem-resistant Enterobacterales and Pseudomonas species. Multiple chromosomally encoded genetic determinants have been implicated in cefiderocol resistance, including mutations, deletions and/or frameshifts. However, identification of these determinants remains labour-intensive and time-consumin... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 169, 18 3 2025, Pages D8577 [The role of clinical practice guidelines in the assessment by the disciplinary board]. Weller FS, van Bodegom-Vos L, Repping S, Hamming JF

Objective: To examine how often disciplinary complaints against physicians are upheld explicitly on the grounds of deviation from clinical practice guidelines. Design: Retrospective document analysis of publicly available medical disciplinary rulings in the Netherlands between January 1, 2019, and December 31, 2023. Methods: We analysed rulings from the official Dutch disciplinary law database (tuchtrecht.nl). All upheld complaints were reviewed to determine whether the disciplinary board explic... Abstract

Nature, 17 3 2025 An integrated view of the structure and function of the human 4D nucleome. Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N, Rando OJ, Xu J, Janssens DH, Henikoff S, Kukalev A, Andréa W, Winick-Ng W, Kempfer R, Pombo A, Yu M, Kumar P, Zhang L, Belmont AS, Sasaki T, van Schaik T, Brueckner L, Peric-Hupkes D, van Steensel B, Wang P, Chai H, Kim M, Ruan Y, Zhang R, Quinodoz SA, Bhat P, Guttman M, Zhao W, Chien S, Liu Y, Venev SV, Plewczynski D, Azcarate II, Szabó D, Thieme CJ, Szczepińska T, Chiliński M, Sengupta K, Conte M, Esposito A, Abraham A, Zhang R, Wang Y, Wen X, Wu Q, Yang Y, Liu J, Boninsegna L, Yildirim A, Zhan Y, Chiariello AM, Bianco S, Lee L, Hu M, Li Y, Barnett RJ, Cook AL, Emerson DJ, Marchal C, Zhao P, Park PJ, Alver BH, Schroeder AJ, Navelkar R, Bakker C, Ronchetti W, Ehmsen S, Veit AD, Gehlenborg N, Wang T, Li D, Wang X, Nicodemi M, Ren B, Zhong S, Phillips-Cremins JE, Gilbert DM, Pollard KS, Alber F, Ma J, Noble WS, Yue F

The dynamic three-dimensional (3D) organization of the human genome (the 4D nucleome) is linked to genome function. Here we describe efforts by the 4D Nucleome Project1 to map and analyse the 4D nucleome in widely used H1 human embryonic stem cells and immortalized fibroblasts (HFFc6). We produced and integrated diverse genomic datasets of the 4D nucleome, each contributing unique observations, which enabled us to assemble extensive catalogues of more than 140,000 looping interactions per cell t... Abstract

JACC. Advances, Volume 5, Issue 1, 17 3 2025, Pages 102424 Activation of the Anrep Effect in Aortic Stenosis Pre-TAVR and Post-TAVR: An Echocardiographic Pressure-Volume Analysis. Reil JC, Sequeira V, Lucas P, Tadros L, Reil GH, Federspiel JM, Scholtz S, Omran H, Steendijk P, Marquetand C, Scholtz W, Piper C, Rudolph T, Rudolph V

Background: In aortic stenosis (AS), chronic pressure overload of the left ventricle (LV) may sustain an intrinsic, afterload-dependent adaptive response known as the Anrep effect, characterized by increased myocardial contractility and prolonged systolic duration. Whether this response resolves following transcatheter aortic valve replacement (TAVR) remains unknown. Objectives: The objective of the study was to determine whether the Anrep is chronically activated in severe AS and acutely revers... Abstract

Journal of cardiovascular development and disease, Volume 12, Issue 12, 17 3 2025, Pages 498 Echocardiographic Assessment of Patients Undergoing Mitral Valve Repair. Rolando M, Elmasry N, Gobbi F, Moreo A, Ajmone Marsan N, Carluccio E, Fortuni F

Mitral regurgitation (MR) is one of the most prevalent valvular disorders worldwide, with a growing burden driven by population aging and improved diagnostic capabilities. Understanding the mechanism of MR, whether primary, due to intrinsic valve abnormalities, or secondary, resulting from atrial or ventricular remodeling, is essential for optimal management. Echocardiography, particularly advanced modalities such as three-dimensional imaging and strain analysis, plays a central role in this pro... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 34, Issue 1, 16 3 2025, Pages 18-26 Left atrial appendage occlusion vs standard of care in high stroke risk atrial fibrillation patients ineligible for anticoagulation: COMPARE-LAAO. Aarnink EW, Huijboom MFM, van der Kley F, Folkeringa R, de Groot JR, van der Voort PH, Blaauw Y, Chaldoupi M, Stevenhagen J, Vlachojannis GJ, van Mieghem NM, Swaans MJ, van Dijk VF, Dijkgraaf MG, van Dijk EJ, Tijssen JGP, Boersma LVA

Introduction: The left atrial appendage is the dominant source of cardioembolic stroke in patients with atrial fibrillation (AF). Contemporary guidelines recommend considering left atrial appendage occlusion (LAAO) in AF patients contraindicated to oral anticoagulation therapy (OAC), but randomized controlled trial (RCT) data for this subpopulation are lacking. Methods: COMPARE LAAO was designed as an event-driven, multicenter, prospective, randomized, open, blinded endpoint (PROBE) trial that r... Abstract

JACC. Advances, Volume 5, Issue 1, 11 2 2025, Pages 102415 Prognostic Value of NT-proBNP in Patients Treated With Allogeneic Stem Cell Transplantation. Polomski EAS, von dem Borne PA, Veelken H, Heemelaar JC, Jukema JW, Antoni ML

Background: As survival rates after allogeneic stem cell transplantation (alloSCT) continue to grow, cardiovascular disease is becoming a major complication after alloSCT. However, the prognostic value of cardiac biomarkers has not been widely investigated. Objectives: This study aims to investigate the association between baseline N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in patients treated with alloSCT and mortality. Methods: Patients who were referred for alloSCT between... Abstract

Journal of cardiothoracic and vascular anesthesia, 11 2 2025, Pages S1053-0770(25)01219-4 Ultrafast Track Pathway After Low-Risk Cardiac Surgery Enables Intensive Care Unit Stepdown Within 6 Hours: A Feasible Model for Anesthesia-Led Recovery. Cotovanu AGM, Berendsen RR, van Dorp ELA, Okkerse P, de Weger A, de Blok ACJ, Janson JA, Boogers MJ, Braun J, Hjortnaes J, Wink J

Objective: The aim of this study was to assess the feasibility and safety of the ultrafast track (UFT) integrated care pathway in cardiac surgery patients defined as intensive care unit (ICU) discharge within 6 hours. Design: A prospective cohort study. Setting: University Medical Center, the Netherlands. Participants: A total of 261 adults (median age 70 [62-75], 72.4% male) with EuroSCORE II Abstract

JACC. Case reports, 10 2 2025, Pages 106227 Severe Aortic Stenosis and Dual Valve Vegetations: An Uncommon Presentation of Primary Antiphospholipid Syndrome. van der Woude SFS, Valentijn FA, Antoni ML, Huisman SJ, van Vliet M

Background: Primary antiphospholipid syndrome (PAPS) may cause thromboembolic events and valvular heart disease. Case summary: A 42-year-old woman with a history of pre-eclampsia, epilepsy, and thrombocytopenia presented with acute chest pain and shortness of breath. Investigations revealed vegetation on both the aortic and mitral valves, severe aortic stenosis, and a non-ST-segment elevation myocardial infarction. Autoimmune testing confirmed antiphospholipid antibodies, which led to a diagnosi... Abstract

Journal of cardiovascular medicine (Hagerstown, Md.), Volume 26, Issue 12, 10 2 2025, Pages 703-711 Intravascular lithotripsy in eccentric and concentric coronary calcifications: a post-hoc analysis of the BENELUX-IVL registry. Oliveri F, Van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) has demonstrated excellent results in treating calcified coronary lesions. However, specific focus on different calcification patterns is still limited. The aim of our study was to evaluate the procedural and clinical outcomes of IVL in treating concentric vs. eccentric calcifications. Methods: The BENELUX-IVL prospective registry enrolled patients aged ≥18 years who underwent IVL. For this study, patients who underwent both IVL and intravascular ultra... Abstract

Allergy, 9 2 2025 Drug Survival in Atopic Dermatitis: Comparison of Biologics and JAK Inhibitors in the BioDay Registry. van der Gang LF, Boesjes CM, Zuithoff NPA, Haeck I, Bacoş-Cosma O, Loman L, Atash K, Harbers V, Stadhouders S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynski A, Christoffers WA, Garritsen FM, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, Galimont-Collen AFS, Schuttelaar MA, de Graaf M, de Bruin-Weller MS

Abstract