7971 results
Cited 64 times since 2020 (12.8 per year)
source: EuropePMC
JAMA cardiology,
Volume 5, Issue 6, 1 1 2020, Pages 709-713
An Exploratory Analysis of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Aortic Stenosis in the FOURIER Trial.
Bergmark BA, O'Donoghue ML, Murphy SA, Kuder JF, Ezhov MV, Ceška R, Gouni-Berthold I, Jensen HK, Tokgozoglu SL, Mach F, Huber K, Gaciong Z, Lewis BS, Schiele F, Jukema JW, Pedersen TR, Giugliano RP, Sabatine MS
Importance: Despite recent advances in treatment of severe aortic valve stenosis (AS), AS remains a life-threatening condition with no proven disease-modifying therapy. Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) have been implicated in the pathobiology of AS. The proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab reduces circulating LDL-C concentrations by 50% to 60% and Lp(a) by 20% to 30%. Objective: To determine whether evolocumab reduces the risk o...
Abstract
Cited 24 times since 2020 (4.8 per year)
source: EuropePMC
Bioinformatics (Oxford, England),
Volume 36, Issue 12, 1 1 2020, Pages 3874-3876
gplas: a comprehensive tool for plasmid analysis using short-read graphs.
Arredondo-Alonso S, Bootsma M, Hein Y, Rogers MRC, Corander J, Willems RJL, Schürch AC
Summary: Plasmids can horizontally transmit genetic traits, enabling rapid bacterial adaptation to new environments and hosts. Short-read whole-genome sequencing data are often applied to large-scale bacterial comparative genomics projects but the reconstruction of plasmids from these data is facing severe limitations, such as the inability to distinguish plasmids from each other in a bacterial genome. We developed gplas, a new approach to reliably separate plasmid contigs into discrete componen...
Abstract
Cited 37 times since 2020 (7.4 per year)
source: EuropePMC
European heart journal,
Volume 41, Issue 24, 1 1 2020, Pages 2248-2258
Effect of alirocumab on cardiovascular outcomes after acute coronary syndromes according to age: an ODYSSEY OUTCOMES trial analysis.
Sinnaeve PR, Schwartz GG, Wojdyla DM, Alings M, Bhatt DL, Bittner VA, Chiang CE, Correa Flores RM, Diaz R, Dorobantu M, Goodman SG, Jukema JW, Kim YU, Pordy R, Roe MT, Sy RG, Szarek M, White HD, Zeiher AM, Steg PG, ODYSSEY OUTCOMES Investigators
Aims: Lowering low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular risk irrespective of age, but the evidence is less strong for older patients. Methods and results: This prespecified analysis from ODYSSEY OUTCOMES compared the effect of alirocumab vs. placebo in 18 924 patients with recent acute coronary syndrome (ACS) according to age. We examined the effect of assigned treatment on occurrence of the primary study outcome, a composite of coronary heart disease death, myocardial...
Abstract
Journal of religion and health,
Volume 59, Issue 3, 1 1 2020, Pages 1189-1200
Determination of the Personal Values of the University Students in Different Departments.
Tunç GÇ, Yılmaz D, Özyazıcıoğlu N
This research aims to examine the personal values of the first-year university students studying in different departments. This is a descriptive cross-sectional survey study. Research population is composed of first-grade students approving to participate and studying in the Nursing Department in the School of Health, Biology Department in the Faculty of Science and Letters and the Department of Early Childhood Education in the Faculty of Education of Uludağ University. "Student Information...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 30, Issue 6, 1 1 2020, Pages 846-853
Treatment and outcome of plastic bronchitis in single ventricle patients: a systematic review.
Harteveld LM, Blom NA, Hazekamp MG, Ten Harkel ADJ
Plastic bronchitis (PB) is a life-threatening complication in single ventricle (SV) patients of which the exact pathophysiology, outcome and optimal treatment are still unclear. This study aims to systematically review the literature to give insight into the characteristics, outcome and management options of SV patients with PB. A systematic review was conducted, using the electronic database PubMed to find records published up to August 2018, describing SV patients and PB in which characteristi...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
Clinical rehabilitation,
Volume 34, Issue 7, 31 5 2020, Pages 901-915
A multicomponent intervention to decrease sedentary time during hospitalization: a quasi-experimental pilot study.
Conijn D, van Bodegom-Vos L, Volker WG, Mertens B, Vermeulen HM, Huurman V, van Schaik J, Vliet Vlieland T, Meesters J
Objective: The aim of this study was to evaluate the feasibility and preliminary effects of a multicomponent intervention to decrease sedentary time during and shortly after hospitalization. Design: This is a quasi-experimental pilot study comparing outcomes in patients admitted before and after the implementation of the intervention. Setting: The study was conducted in a university hospital. Subjects: Participants were adult patients undergoing elective organ transplantation or vascular surgery...
Abstract
Cited 14 times since 2020 (2.8 per year)
source: EuropePMC
Progress in cardiovascular diseases,
Volume 63, Issue 4, 30 5 2020, Pages 434-441
Clinical presentation and outcomes of adults with bicuspid aortic valves: 2020 update.
Yang LT, Tribouilloy C, Masri A, Bax JJ, Delgado V, Girdauskas E, Evangelista A, Sundt TM, Svensson LG, Enriquez-Sarano M, Michelena HI
The congenital bicuspid aortic valve (BAV) is a heterogeneous condition that is better understood considering 3 types of valvulo-aortopathy presentations: A typical-presentation valvulo-aortopathy, a complex-presentation valvulo-aortopathy and an uncomplicated/undiagnosed-presentation. The burden of BAV-related complications has been elucidated in patients with the typical-presentation valvulo-aortopathy and is discussed in this review. These patients enjoy an overall normal expected long-term s...
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
Forensic science international,
Volume 313, 29 5 2020, Pages 110344
Chemical attribution of the homemade explosive ETN - Part II: Isotope ratio mass spectrometry analysis of ETN and its precursors.
Bezemer K, McLennan L, Hessels R, Schoorl J, van den Elshout J, van der Heijden A, Hulsbergen A, Koeberg M, Busby T, Yevdokimov A, de Rijke E, Schoenmakers P, Smith J, Oxley J, van Asten A
In this follow-up study the collaboration between two research groups from the USA and the Netherlands was continued to expand the framework of chemical attribution for the homemade explosive erythritol tetranitrate (ETN). Isotope ratio mass spectrometry (IRMS) analysis was performed to predict possible links between ETN samples and its precursors. Carbon, nitrogen, hydrogen and oxygen isotope ratios were determined for a wide variety of precursor sources and for ETN samples that were prepared w...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Cardiovascular revascularization medicine : including molecular interventions,
Volume 21, Issue 12, 29 5 2020, Pages 1493-1499
Association Between Flow Impairment in Dominant Coronary Atrial Branches and Atrial Arrhythmias in Patients With ST-Segment Elevation Myocardial Infarction.
Montero Cabezas JM, Abou R, Goedemans L, Ajmone Marsan N, Bax JJ, Delgado V
Objectives: The impact of atrial ischemia in the occurrence of atrial arrhythmias may vary based on the amount of jeopardized myocardium. We sought to determine the association between coronary flow impairment in dominant coronary atrial branches (CAB) and atrial arrhythmias at 1-year follow-up in ST-segment elevation myocardial infarction (STEMI) patients. Methods: Patients with STEMI involving the right or circumflex coronary artery were included. Dominant CAB was defined as the most developed...
Abstract
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
Journal of aging and health,
Volume 32, Issue 9, 27 4 2020, Pages 1267-1274
Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk.
Grasset L, Smit RAJ, Caunca MR, Elfassy T, Odden MC, van der Grond J, van Buchem MA, Stott DJ, Sattar N, Trompet S, Jukema JW, Zeki Al Hazzouri A
Objective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviat...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
European journal of orthopaedic surgery & traumatology : orthopedie traumatologie,
Volume 30, Issue 8, 26 4 2020, Pages 1357-1362
Long-term follow-up of distal radius fractures, an evaluation of the current guideline: the relation between malunion, osteoarthritis and functional outcome.
Visser D, Mathijssen NMC, van Outeren MV, Colaris JW, de Vries MR, Kraan GA
Background: Last decades there is an increased tendency of performing surgery on displaced distal radius fractures. However, it is unclear whether this affects the development of osteoarthritis. This study aims to determine the relation between anatomical position, radiological osteoarthritis and functional outcome of the elderly wrist, 10-15 years after a distal radius fracture. Patients and methods: 173 patients between the age of 50 and 70 at time of trauma were included in this retrospective...
Abstract
Cited 328 times since 2020 (65.5 per year)
source: EuropePMC
Cell stem cell,
Volume 26, Issue 6, 26 4 2020, Pages 862-879.e11
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.
Giacomelli E, Meraviglia V, Campostrini G, Cochrane A, Cao X, van Helden RWJ, Krotenberg Garcia A, Mircea M, Kostidis S, Davis RP, van Meer BJ, Jost CR, Koster AJ, Mei H, Míguez DG, Mulder AA, Ledesma-Terrón M, Pompilio G, Sala L, Salvatori DCF, Slieker RC, Sommariva E, de Vries AAF, Giera M, Semrau S, Tertoolen LGJ, Orlova VV, Bellin M, Mummery CL
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally immature, but this is improved by incorporation into engineered tissues or forced contraction. Here, we showed that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts (CFs), and cardiac endothelial cells also enhance maturation in easily constructed, scaffold-free, three-dimensional microtissues (MTs). hiPSC-CMs in MTs with CFs showed improved sarcomeric structures with T-tubules, enhanced c...
Abstract
Cited 22 times since 2020 (4.4 per year)
source: EuropePMC
Critical care (London, England),
Volume 24, Issue 1, 26 4 2020, Pages 263
COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients.
Kox M, Frenzel T, Schouten J, van de Veerdonk FL, Koenen HJPM, Pickkers P, , on behalf of the RCI-COVID-19 study group
Abstract
International journal of molecular sciences,
Volume 21, Issue 10, 25 4 2020, Pages E3707
From Increased Fluid Shear Stress to Natural Bypass Growth.
Deindl E, Quax PHA
This Special Issue enqueues a series of publications dealing with arteriogenesis, which is the growth of a natural bypass from pre-existing arteriolar connections, as defined by Wolfgang Schaper, Werner Risau and Ramon Munoz-Chapuli in the late nineties of the last century [...].
Abstract
Cited 8 times since 2020 (1.6 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 36, Issue 9, 25 4 2020, Pages 1771-1780
Left ventricular global longitudinal strain in bicupsid aortic valve patients: head-to-head comparison between computed tomography, 4D flow cardiovascular magnetic resonance and speckle-tracking echocardiography.
van den Hoven AT, Yilmazer S, Chelu RG, van Grootel RWJ, Minderhoud SCS, Bons LR, van Berendoncks AM, Duijnhouwer AL, Siebelink HJ, van den Bosch AE, Budde RPJ, Roos-Hesselink JW, Hirsch A
Left ventricular global longitudinal strain (LVGLS) analysis is a sensitive measurement of myocardial deformation most often done using speckle-tracking transthoracic echocardiography (TTE). We propose a novel approach to measure LVGLS using feature-tracking software on the magnitude dataset of 4D flow cardiovascular magnetic resonance (CMR) and compare it to dynamic computed tomography (CT) and speckle tracking TTE derived measurements. In this prospective cohort study 59 consecutive adult pati...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
Journal of affective disorders,
Volume 274, 23 4 2020, Pages 1013-1021
Getting under the skin: Does biology help predict chronicity of depression?
Verhoeven JE, Verduijn J, van Oppen P, van Schaik A, Vinkers CH, Penninx BWJH
Background: Depressed patients are at risk of an unfavourable course including chronic episodes. Various psychiatric characteristics have shown to be predictive of depression's course trajectory, but whether indicators of somatic health further contribute to course prediction remains unclear. This study aimed to identify somatic health indicators (i.e. biomarkers, health status and lifestyle) that predict 2-year chronicity above and beyond an extensive list of sociodemographic and psychiatr...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
European urology,
Volume 78, Issue 1, 21 3 2020, Pages e48-e50
Corrigendum to 'EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort Under the Auspices of the EAU-ESMO Guidelines Committees' [European Urology 77 (2020) 223-250].
Witjes JA, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Van Der Kwast T, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis I, Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Compérat E, Crabb S, Culine S, De Bari B, De Blok W, De Visschere PJL, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne V, Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmüller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez V, Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo V, Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinós E, Løgager V, Lorch A, Loriot Y, Meijer R, Mir MC, Moschini M, Mostafid H, Müller AC, Müller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, Oyen WJG, Pacheco-Figueiredo L, Pappot H, Patel MI, Pieters BR, Plass
Abstract
Cited 20 times since 2020 (4 per year)
source: EuropePMC
BMC cancer,
Volume 20, Issue 1, 20 3 2020, Pages 455
Insight into bladder cancer care: study protocol of a large nationwide prospective cohort study (BlaZIB).
Ripping TM, Kiemeney LA, van Hoogstraten LMC, Witjes JA, Aben KKH, BlaZIB study group
Background: Despite the embedding of bladder cancer management in European guidelines, large variation in clinical practice exists for applied diagnostics and treatments. This variation may affect patients' outcomes including complications, disease recurrence, progression, survival, and health-related quality of life (HRQL). Lack of detailed clinical data and HRQL data hampers a comprehensive evaluation of bladder cancer care. Through prospective data registration, this study aims to provid...
Abstract
Cited 69 times since 2020 (13.7 per year)
source: EuropePMC
European urology,
Volume 78, Issue 5, 20 3 2020, Pages 690-698
Treatment of High-grade Non-muscle-invasive Bladder Carcinoma by Standard Number and Dose of BCG Instillations Versus Reduced Number and Standard Dose of BCG Instillations: Results of the European Association of Urology Research Foundation Randomised Phase III Clinical Trial "NIMBUS".
Grimm MO, van der Heijden AG, Colombel M, Muilwijk T, Martínez-Piñeiro L, Babjuk MM, Türkeri LN, Palou J, Patel A, Bjartell AS, Caris C, Schipper RG, Witjes WPJ, EAU Research Foundation NIMBUS Study Group
Background: Intravesical instillation of bacillus Calmette-Guérin (BCG) is an accepted strategy to prevent recurrence of non-muscle-invasive bladder cancer (NMIBC) but associated with significant toxicity. Objective: NIMBUS assessed whether a reduced number of standard-dose BCG instillations are noninferior to the standard number and dose in patients with high-grade NMIBC. Design, setting, and participants: A total of 345 patients from 51 sites were randomised between December 2013 and July 2019...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 14, 19 3 2020, Pages 420
Event-Based Computation for Touch Localization Based on Precise Spike Timing.
Haessig G, Milde MB, Aceituno PV, Oubari O, Knight JC, van Schaik A, Benosman RB, Indiveri G
Precise spike timing and temporal coding are used extensively within the nervous system of insects and in the sensory periphery of higher order animals. However, conventional Artificial Neural Networks (ANNs) and machine learning algorithms cannot take advantage of this coding strategy, due to their rate-based representation of signals. Even in the case of artificial Spiking Neural Networks (SNNs), identifying applications where temporal coding outperforms the rate coding strategies of ANNs is s...
Abstract
