6190 results
Cited 5 times since 2002 (0.2 per year)
source: EuropePMC
Methods in molecular biology (Clifton, N.J.),
Volume 178, 1 1 2002, Pages 379-387
Expression of scFvs and scFv fusion proteins in eukaryotic cells.
de Graaf M, van der Meulen-Muileman IH, Pinedo HM, Haisma HJ
Abstract
Cited 74 times since 2002 (3.2 per year)
source: EuropePMC
Current pharmaceutical design,
Volume 8, Issue 15, 1 1 2002, Pages 1391-1403
Beta-glucuronidase-mediated drug release.
de Graaf M, Boven E, Scheeren HW, Haisma HJ, Pinedo HM
The selective activation of a relatively non-toxic prodrug by an enzyme present only in the tumour should enhance the drug concentration at the tumour site and result in a better anti-tumour effect and a reduction in systemic toxicity as compared to conventional chemotherapy. beta-Glucuronidase is such an enzyme. It is normally expressed in the lysosomes of cells. In larger tumours, however, high levels of the enzyme are present in necrotic areas. Several glucuronide prodrugs have been synthesis...
Abstract
Cited 5 times since 2002 (0.2 per year)
source: EuropePMC
Journal of cardiovascular pharmacology,
Volume 39, Issue 1, 1 1 2002, Pages 61-72
Calcium sensitizer EMD 57033, but not the beta1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium.
Trines SA, Smits CA, van der Moer J, Slager CJ, Verdouw PD, Krams R
External work, efficiency of energy transfer (EET), and mechanical efficiency (defined as the ratio of external work over myocardial oxygen consumption (MVO2) are reduced in stunned myocardium. We therefore evaluated how inotropic stimulation by dobutamine and the calcium sensitizer EMD 57033 affected the regional stress-strain relationship as, from which contractility (E(es)), external work at the working point (EWwp), maximal external work (EWmax), EETwp (%), and EETmax are determined. Thirty...
Abstract
Cited 11 times since 2002 (0.5 per year)
source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance,
Volume 4, Issue 3, 1 1 2002, Pages 353-357
Noninvasive and invasive evaluation of noncompaction cardiomyopathy.
Bax JJ, Atsma DE, Lamb HJ, Rebergen SA, Bootsma M, Voogd PJ, Somer S, Schalij MJ, de Roos A, van der Wall EE
Noncompaction cardiomyopathy is a recently described rare congenital cardiomyopathy; patients can be asymptomatic or develop diastolic and/or systolic left ventricular dysfunction with heart failure, systemic emboli or ventricular arrhythmias. Long-term prognosis is poor. Currently, diagnosis is based on findings on 2D echocardiography; in the current case report we demonstrate the use of MRI to diagnose noncompaction cardiomyopathy.
Abstract
Cited 12 times since 2002 (0.5 per year)
source: EuropePMC
Journal of pediatric surgery,
Volume 37, Issue 1, 1 1 2002, Pages 80-82
Evaluation of the location of the anus by a modified technique in the neonate.
Genç A, Taneli C, Tansuğ N, Kasirga E, Yilmaz D, Küçükoğlu T, Onağ A
Purpose: The aim of the current study was to bring to notice the anterior displacement of the anus and to recommend the measurement of anal position index in the neonate by a modified method. Methods: Sixty newborns (34 girls and 26 boys) were taken into study, and the anal position index (API), which is the ratio of anus-fourchette (scrotum) distance to coccyx fourchette (scrotum) distance, was measured. To obtain the measurement, a transparent adhesive tape was placed along the midline on the...
Abstract
Cited 50 times since 2001 (2.1 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 281, Issue 6, 1 1 2001, Pages H2697-704
Biventricular systolic function in young lambs subject to chronic systemic right ventricular pressure overload.
Leeuwenburgh BP, Helbing WA, Steendijk P, Schoof PH, Baan J
In various clinical situations of congenital heart disease, the right ventricle (RV) is subject to a chronic systemic pressure overload which affects biventricular function and may progress to the development of RV failure. Young lambs (2-3 wk old) underwent adjustable pulmonary artery banding (PAB) at systemic (aortic) level for 8 wk. Biventricular function was determined by using load-independent indexes of global ventricular contractile performance by the end-systolic pressure-volume relation...
Abstract
Cited 3 times since 2001 (0.1 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 86, Issue 5, 1 1 2001, Pages 533-539
Pravastatin and endothelium dependent vasomotion after coronary angioplasty: the PREFACE trial.
Mulder HJ, Schalij MJ, Kauer B, Visser RF, van Dijkman PR, Jukema JW, Zwinderman AH, Bruschke AV
Objective: To test the hypothesis that the 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor pravastatin ameliorates endothelium mediated responses of dilated coronary segments: the PREFACE (pravastatin related effects following angioplasty on coronary endothelium) trial. Design: A double blind, randomised, placebo controlled, multicentre study. Setting: Four hospitals in the Netherlands. Patients: 63 non-smoking, non-hypercholesterolaemic patients scheduled for elective balloon angiopla...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 9, Issue 8, 1 1 2001, Pages 343-345
Safety of statins in the new millennium.
Jukema JW, Lansberg PJ
Looking at the world today and six months ago in retrospect, it becomes clear that things have changed dramatically. Not only are global economic forecasts in turmoil, other certainties have also been proven to be not as steadfast as we had hoped and expected. Safety in the world has gained a different perspective since the assault on the twin towers of the World Trade Centre in New York and the Pentagon. The safety of medicine and especially statins has also become an issue since the withdrawal...
Abstract
Cited 11 times since 2001 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 88, Issue 9, 1 1 2001, Pages 1011-1017
Prolonged cardiac recovery from exercise in asymptomatic adults late after atrial correction of transposition of the great arteries: evaluation with magnetic resonance flow mapping.
Roest AA, Kunz P, Helbing WA, Lamb HJ, Vliegen HW, van den Aardweg JG, Ruitenberg Q, de Roos A, van der Wall EE
After atrial correction of transposition of the great arteries (TGA), dysfunction of the systemic right ventricle at rest and during exercise has been reported. Information on changes in systemic right ventricular function during recovery from exercise is lacking. This study evaluates cardiac recovery from supine exercise using magnetic resonance (MR) imaging in patients with asymptomatic TGA after atrial correction. Flow in the ascending aorta, representing stroke volume of the systemic ventric...
Abstract
Cited 9 times since 2001 (0.4 per year)
source: Scopus
The International journal of artificial organs,
Volume 24, Issue 11, 1 1 2001, Pages 821-831
Enhancing filtration rates by the use of blood flow around the capillaries of plasmafilters: an in vitro study.
Unger JK, Janssen VR, Kashefi A, Haltern C, Klosterhalfen B, Fischer Y, Gressner AM, Rossaint R
As the low clearance rate of plasmaseparation limits its use in the treatment of patients suffering from liver failure, sepsis or MOF, we intend to develop strategies for a plasmaseparation unit which increases plasmafiltration rates. Our first question focused on whether commercially available plasmaseparation filters, and in particular their membranes, are suitable for the inversion of blood and plasma compartments. This experimental study was performed using in vitro systems. Commercially ava...
Abstract
Cited 52 times since 2001 (2.2 per year)
source: EuropePMC
Human gene therapy,
Volume 12, Issue 16, 1 1 2001, Pages 1989-2005
Highly efficient targeted transduction of undifferentiated human hematopoietic cells by adenoviral vectors displaying fiber knobs of subgroup B.
Knaän-Shanzer S, Van Der Velde I, Havenga MJ, Lemckert AA, De Vries AA, Valerio D
Human hematopoietic stem cells (HSCs) are poorly transduced by vectors based on adenovirus serotype 5 (Ad5). This is primarily due to the paucity of the coxsackievirus-Ad receptor on these cells. In an attempt to change the tropism of Ad5, we constructed a series of chimeric E1-deleted Ad5 vectors in which the shaft and knob of the capsid fibers were exchanged with those of other Ad serotypes. In all these vectors, the Ad E1 region was replaced by an expression cassette containing the cytomegalo...
Abstract
Cited 14 times since 2001 (0.6 per year)
source: EuropePMC
Molecular biology of the cell,
Volume 12, Issue 11, 1 1 2001, Pages 3680-3689
Basic domains target protein subunits of the RNase MRP complex to the nucleolus independently of complex association.
van Eenennaam H, van der Heijden A, Janssen RJ, van Venrooij WJ, Pruijn GJ
The RNase MRP and RNase P ribonucleoprotein particles both function as endoribonucleases, have a similar RNA component, and share several protein subunits. RNase MRP has been implicated in pre-rRNA processing and mitochondrial DNA replication, whereas RNase P functions in pre-tRNA processing. Both RNase MRP and RNase P accumulate in the nucleolus of eukaryotic cells. In this report we show that for three protein subunits of the RNase MRP complex (hPop1, hPop4, and Rpp38) basic domains are respon...
Abstract
Cited 23 times since 2001 (1 per year)
source: EuropePMC
European heart journal,
Volume 22, Issue 22, 1 1 2001, Pages 2058-2074
Genetic aspects of restenosis after percutaneous coronary interventions: towards more tailored therapy.
Agema WR, Jukema JW, Pimstone SN, Kastelein JJ
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 9, Issue 7, 1 1 2001, Pages 267-268
Pulmonary valve insertion late after repair of Fallot's tetralogy.
Vliegen HW, Hazekamp MG
Abstract
Cited 61 times since 2001 (2.6 per year)
source: EuropePMC
Circulation,
Volume 104, Issue 17, 1 1 2001, Pages 2029-2033
Stent placement to prevent restenosis after angioplasty in small coronary arteries.
Doucet S, Schalij MJ, Vrolix MC, Hilton D, Chenu P, de Bruyne B, Udayachalerm W, Seth A, Bilodeau L, Reiber JH, Harel F, Lespérance J, Stent In Small Arteries(SISA) Trial Investigators
Background: Lesions in small-diameter vessels (
Abstract
Cited 23 times since 2001 (1 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 86, Issue 10, 1 1 2001, Pages 4638-4643
Six months of recombinant human GH therapy in patients with ischemic cardiac failure does not influence left ventricular function and mass.
Smit JW, Janssen YJ, Lamb HJ, van der Wall EE, Stokkel MP, Viergever E, Biermasz NR, Bax JJ, Vliegen HW, de Roos A, Romijn JA, Roelfsema F
Beneficial effects of recombinant human GH on cardiac function have been reported in humans with GH deficiency and in patients with idiopathic dilated cardiomyopathy. No randomized controlled trial has been performed on the effects of recombinant human GH on cardiac function in patients with ischemic cardiac failure. We therefore randomly assigned 22 patients with ischemic cardiac failure (left ventricular ejection fraction,
Abstract
Cited 11 times since 2001 (0.5 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 122, Issue 4, 1 1 2001, Pages 767-774
Influence of clenbuterol treatment during six weeks of chronic right ventricular pressure overload as studied with pressure-volume analysis.
Hon JK, Steendijk P, Petrou M, Wong K, Yacoub MH
Objectives: Chronic pressure overload cardiac hypertrophy produces ventricular dysfunction. There is evidence that clenbuterol, a beta(2)-adrenoceptor agonist, produces cardiac hypertrophy with preserved function in rodents. We sought to determine the cardiac hypertrophic effects of clenbuterol on the thin-walled ventricles of large animals undergoing chronic pressure overload by means of pulmonary artery banding. Methods: Right ventricular pressure-volume loops were obtained in open-chest sheep...
Abstract
Cited 11 times since 2001 (0.5 per year)
source: EuropePMC
Respiratory medicine,
Volume 95, Issue 10, 1 1 2001, Pages 802-805
Delays in the diagnosis and treatment of hospitalized patients with smear-positive pulmonary tuberculosis.
Yilmaz A, Boğa S, Sulu E, Durucu M, Yilmaz D, Baran A, Poluman A
The aim of present study was to investigate whether there was any delay in the diagnosis and treatment of inpatients with smear-positive pulmonary tuberculosis followed-up in our centre. We reviewed clinical records in February 1999 and identified 134 hospitalized patients with smear-positive pulmonary tuberculosis. Clinical files of the patients were analysed and a questionnaire was completed. Several intervals and delays were calculated. Median application interval was 17.5 days [95% confidenc...
Abstract
Cited 34 times since 2001 (1.4 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 21, Issue 10, 1 1 2001, Pages 1630-1635
Raman spectroscopic evaluation of the effects of diet and lipid-lowering therapy on atherosclerotic plaque development in mice.
van De Poll SW, Römer TJ, Volger OL, Delsing DJ, Bakker Schut TC, Princen HM, Havekes LM, Jukema JW, van Der Laarse A, Puppels GJ
Quantitative characterization of atherosclerotic plaque composition with standard histopathological methods remains limited to sectioned plaques. Raman spectroscopy enables nondestructive quantification of atherosclerotic plaque composition. We used Raman spectroscopy to study the effects of diet and lipid-lowering therapy on plaque development in apolipoprotein (APO) E*3-Leiden transgenic mice. Raman spectra were obtained over the full width and entire length of the ascending aorta and aortic a...
Abstract
Cited 8 times since 2001 (0.3 per year)
source: EuropePMC
Cardiovascular research,
Volume 51, Issue 4, 1 1 2001, Pages 729-735
The volume-dependency of parallel conductance throughout the cardiac cycle and its consequence for volume estimation of the left ventricle in patients.
Kornet L, Schreuder JJ, van der Velde ET, Jansen JR
Objective: To study the hypothesis that the electrical conductance of tissues and fluids (parallel conductance (G(p))) around the ventricle depends on left ventricular volume throughout the cardiac cycle. Methods: We extended a recently developed method to determine G(p) throughout the cardiac cycle. First, we compared the estimates of parallel conductances obtained with the new method (G(a)(p)) with those of the conventional one (G(1)(p)), both averaged over the cardiac cycles. Secondly, G(a)(p...
Abstract
