8086 results
Cited 4 times since 2023 (1.9 per year)
source: EuropePMC
The Canadian journal of cardiology,
Volume 39, Issue 10, 26 4 2023, Pages 1315-1324
Lipoprotein(a) and the Effect of Alirocumab on Revascularization After Acute Coronary Syndrome.
Steg PG, Szarek M, Valgimigli M, Islam S, Zeiher AM, Bhatt DL, Bittner VA, Chiang CE, Diaz R, Goodman SG, Gotcheva N, Harrington RA, Jukema JW, Kim HS, Kim SH, Morais J, Pordy R, Scemama M, White HD, Schwartz GG, ODYSSEY OUTCOMES Investigators
Background: Many patients require revascularization after index acute coronary syndrome (ACS). Lipoprotein(a) is thought to play a pathogenic role in atherothrombosis. In ODYSSEY OUTCOMES, alirocumab reduced major adverse cardiovascular events after ACS, with greater reduction among those with higher lipoprotein(a) levels. We explored whether risk of revascularization after ACS was modified by the level of lipoprotein(a) and treatment with alirocumab or placebo. Methods: In ODYSSEY OUTCOMES alir...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Terapevticheskii arkhiv,
Volume 95, Issue 3, 26 4 2023, Pages 248-254
[Difficult case of differential diagnosis of partial lung atelectasis. Case report].
Gordeeva OM, Egorova AD, Chesalina YO, Gretcov EM, Semenova LA, Karpina NL, Sivokozov IV
In December 2018 the patient over 60 years old sought medical help with complaints of persistent cough. Based on computed tomography data there were identified the sings (symptoms) of right lung lower lobe atelectasis. To run this patient diagnostics there were performed 6 bronchoscopies narrowed down by bronchi checks up only and described the right lung central cancer picture. At the same time the biopsy taken during one of the bronchoscopies appeared non informative. Fine needle biopsy of med...
Abstract
Preventive veterinary medicine,
Volume 215, 25 4 2023, Pages 105927
SVEPM 2022, the annual conference of the Society for Veterinary Epidemiology and Preventive Medicine: A joyful hybrid meeting after two years online.
Dórea FC, Vergne T, Correia-Gomes C, Carmo LP, Fischer EAJ, Brodbelt DC, Robinson PA, van Schaik G
Abstract
Cited 10 times since 2023 (4.7 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 24, Issue 9, 25 4 2023, Pages 7818
Atorvastatin Attenuates Diet-Induced Non-Alcoholic Steatohepatitis in APOE*3-Leiden Mice by Reducing Hepatic Inflammation.
Inia JA, Stokman G, Pieterman EJ, Morrison MC, Menke AL, Verschuren L, Caspers MPM, Giera M, Jukema JW, van den Hoek AM, Princen HMG
Patients with metabolic syndrome are often prescribed statins to prevent the development of cardiovascular disease. Conversely, data on their effects on non-alcoholic steatohepatitis (NASH) are lacking. We evaluated these effects by feeding APOE*3-Leiden mice a Western-type diet (WTD) with or without atorvastatin to induce NASH and hepatic fibrosis. Besides the well-known plasma cholesterol lowering (-30%) and anti-atherogenic effects (severe lesion size -48%), atorvastatin significantly reduced...
Abstract
Cited 5 times since 2023 (2.3 per year)
source: EuropePMC
The Science of the total environment,
Volume 883, 25 4 2023, Pages 163599
Capturing the SARS-CoV-2 infection pyramid within the municipality of Rotterdam using longitudinal sewage surveillance.
de Graaf M, Langeveld J, Post J, Carrizosa C, Franz E, Izquierdo-Lara RW, Elsinga G, Heijnen L, Been F, van Beek J, Schilperoort R, Vriend R, Fanoy E, de Schepper EIT, Koopmans MPG, Medema G
Despite high vaccination rates in the Netherlands, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate. Longitudinal sewage surveillance was implemented along with the notification of cases as two parts of the surveillance pyramid to validate the use of sewage for surveillance, as an early warning tool, and to measure the effect of interventions. Sewage samples were collected from nine neighborhoods between September 2020 and November 2021. Comparative analysis an...
Abstract
Cited 25 times since 2023 (11.6 per year)
source: EuropePMC
Microbiome,
Volume 11, Issue 1, 21 3 2023, Pages 84
Gauge your phage: benchmarking of bacteriophage identification tools in metagenomic sequencing data.
Ho SFS, Wheeler NE, Millard AD, van Schaik W
Background: The prediction of bacteriophage sequences in metagenomic datasets has become a topic of considerable interest, leading to the development of many novel bioinformatic tools. A comparative analysis of ten state-of-the-art phage identification tools was performed to inform their usage in microbiome research. Methods: Artificial contigs generated from complete RefSeq genomes representing phages, plasmids, and chromosomes, and a previously sequenced mock community containing four phage sp...
Abstract
Cited 16 times since 2023 (7.4 per year)
source: EuropePMC
Frontiers in cellular and infection microbiology,
Volume 13, 21 3 2023, Pages 1160198
The emerging roles of long non-coding RNA in host immune response and intracellular bacterial infections.
Arunima A, van Schaik EJ, Samuel JE
The long non-coding RNAs (lncRNAs) are evolutionarily conserved classes of non-coding regulatory transcripts of > 200 nucleotides in length. They modulate several transcriptional and post-transcriptional events in the organism. Depending on their cellular localization and interactions, they regulate chromatin function and assembly; and alter the stability and translation of cytoplasmic mRNAs. Although their proposed range of functionality remains controversial, there is increasing research ev...
Abstract
Cited 4 times since 2023 (1.9 per year)
source: EuropePMC
American heart journal,
Volume 262, 20 3 2023, Pages 55-65
Validation of the ARIC prediction model for sudden cardiac death in the European population: The ESCAPE-NET project.
Welten SJGC, Remmelzwaal S, Blom MT, van der Heijden AA, Nijpels G, Tan HL, van Valkengoed I, Empana JP, Jouven X, Ågesen FN, Warming PE, Tfelt-Hansen J, Prescott E, Jabbari R, Elders PJM, for ESCAPE-NET investigators,
Background: Sudden cardiac death is responsible for 10% to 20% of all deaths in Europe. The current study investigates how well the risk of sudden cardiac death can be predicted. To this end, we validated a previously developed prediction model for sudden cardiac death from the Atherosclerosis Risk in Communities study (USA). Methods: Data from participants of the Copenhagen City Heart Study (CCHS) (n=9988) was used to externally validate the previously developed prediction model for sudden card...
Abstract
Cited 5 times since 2023 (2.3 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 10, Issue 4, 20 3 2023, Pages 180
Cardiac Fibrosis and Innervation State in Uncorrected and Corrected Transposition of the Great Arteries: A Postmortem Histological Analysis and Systematic Review.
Engele LJ, van der Palen RLF, Egorova AD, Bartelings MM, Wisse LJ, Glashan CA, Kiès P, Vliegen HW, Hazekamp MG, Mulder BJM, Ruiter MC, Bouma BJ, Jongbloed MRM
In the transposition of the great arteries (TGA), alterations in hemodynamics and oxygen saturation could result in fibrotic remodeling, but histological studies are scarce. We aimed to investigate fibrosis and innervation state in the full spectrum of TGA and correlate findings to clinical literature. Twenty-two human postmortem TGA hearts, including TGA without surgical correction (n = 8), after Mustard/Senning (n = 6), and arterial switch operation (ASO, n = 8), were studied. In newborn uncor...
Abstract
Cited 4 times since 2023 (1.9 per year)
source: EuropePMC
Journal of tissue viability,
Volume 32, Issue 3, 20 3 2023, Pages 333-338
Analysis of the prevalence and risk factors of pressure injuries in the hospitalized pediatric population: A retrospective study.
Semerci R, Umaç EH, Yılmaz D, Karadağ A
Background: Pressure injury (PI) is an essential indicator of the quality of nursing care and affects hospitalized newborns and children. However, studies on the prevalence of PI and associated risk factors in children are limited. Aims: This study aimed to analyze the prevalence of PI and risk factors affecting the development of PI in the hospitalized pediatric population. Methods: This was a descriptive, retrospective study. Data were obtained via electronic medical records of 6350 pediatric...
Abstract
Frontiers in neuroscience,
Volume 17, 18 3 2023, Pages 1125210
Event-driven spectrotemporal feature extraction and classification using a silicon cochlea model.
Xu Y, Perera S, Bethi Y, Afshar S, van Schaik A
This paper presents a reconfigurable digital implementation of an event-based binaural cochlear system on a Field Programmable Gate Array (FPGA). It consists of a pair of the Cascade of Asymmetric Resonators with Fast Acting Compression (CAR-FAC) cochlea models and leaky integrate-and-fire (LIF) neurons. Additionally, we propose an event-driven SpectroTemporal Receptive Field (STRF) Feature Extraction using Adaptive Selection Thresholds (FEAST). It is tested on the TIDIGTIS benchmark and compare...
Abstract
The American journal of medicine,
Volume 136, Issue 7, 15 3 2023, Pages 720-721
Corrigendum to 'Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making' The American Journal of Medicine 136:03 (2023); 260-269.e7.
Freeman AM, Raman SV, Aggarwal M, Maron DJ, Bhatt DL, Parwani P, Osborne J, Earls JP, Min JK, Bax JJ, Shapiro MD
Abstract
Cited 8 times since 2023 (3.7 per year)
source: EuropePMC
Cancers,
Volume 15, Issue 8, 14 2 2023, Pages 2297
Radiomics of Tumor Heterogeneity in <sup>18</sup>F-FDG-PET-CT for Predicting Response to Immune Checkpoint Inhibition in Therapy-Naïve Patients with Advanced Non-Small-Cell Lung Cancer.
Ventura D, Schindler P, Masthoff M, Görlich D, Dittmann M, Heindel W, Schäfers M, Lenz G, Wardelmann E, Mohr M, Kies P, Bleckmann A, Roll W, Evers G
We aimed to evaluate the predictive and prognostic value of baseline 18F-FDG-PET-CT (PET-CT) radiomic features (RFs) for immune checkpoint-inhibitor (CKI)-based first-line therapy in advanced non-small-cell lung cancer (NSCLC) patients. In this retrospective study 44 patients were included. Patients were treated with either CKI-monotherapy or combined CKI-based immunotherapy-chemotherapy as first-line treatment. Treatment response was assessed by the Response Evaluation Criteria in Solid Tumors...
Abstract
Cited 5 times since 2023 (2.3 per year)
source: EuropePMC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
Volume 162, 14 2 2023, Pages 114665
Engineered cell-based therapies in ex vivo ready-made CellDex capsules have therapeutic efficacy in solid tumors.
van Schaik TA, Moreno-Lama L, Aligholipour Farzani T, Wang M, Chen KS, Li W, Cai L, Zhang YS, Shah K
Encapsulated cell-based therapies for solid tumors have shown promising results in pre-clinical settings. However, the inability to culture encapsulated therapeutic cells prior to their transplantation has limited their translation into clinical settings. In this study, we created a wide variety of engineered therapeutic cells (ThC) loaded in micropore-forming gelatin methacryloyl (GelMA) hydrogel (CellDex) capsules that can be cultured in vitro prior to their transplantation in surgically debul...
Abstract
Cited 5 times since 2023 (2.3 per year)
source: EuropePMC
Atherosclerosis,
Volume 384, 14 2 2023, Pages 117123
Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients.
Lu C, Donners MMPC, Karel J, de Boer H, van Zonneveld AJ, den Ruijter H, Jukema JW, Kraaijeveld A, Kuiper J, Pasterkamp G, Cavill R, Perales-Patón J, Ferrannini E, Goossens P, Biessen EAL
Background and aims: This study aims to identify sex-specific transcriptional differences and signaling pathways in circulating monocytes contributing to cardiovascular disease. Methods and results: We generated sex-biased gene expression signatures by comparing male versus female monocytes of coronary artery disease (CAD) patients (n = 450) from the Center for Translational Molecular Medicine-Circulating Cells Cohort. Gene set enrichment analysis demonstrated that monocytes from female CAD pati...
Abstract
Cited 2 times since 2023 (0.9 per year)
source: EuropePMC
Musculoskeletal science & practice,
Volume 65, 14 2 2023, Pages 102764
Comparison between two patient-reported outcome measures for patients with cervical radiculopathy: A think-aloud study.
Thoomes E, de Graaf M, Gallina A, Falla D, Stathi A
Background: The Cervical Radiculopathy Impact Scale (CRIS) and Patient Specific Functional Scale 2.0 (PSFS 2.0) are patient-reported outcome measures (PROMs) used to assess activity limitations in patients with cervical radiculopathy (CR). This study a) compared the CRIS subscale 3 and the PSFS 2.0 in patients with CR with respect to completeness and patient preference, b) established the correlation between both PROMs in assessing the individual patient's level of functional limitations an...
Abstract
Cited 2 times since 2023 (0.9 per year)
source: EuropePMC
EClinicalMedicine,
Volume 59, 13 2 2023, Pages 101955
Influence of germline variations in drug transporters ABCB1 and ABCG2 on intracerebral osimertinib efficacy in patients with non-small cell lung cancer.
Veerman GDM, Boosman RJ, Jebbink M, Oomen-de Hoop E, van der Wekken AJ, Bahce I, Hendriks LEL, Croes S, Steendam CMJ, de Jonge E, Koolen SLW, Steeghs N, van Schaik RHN, Smit EF, Dingemans AC, Huitema ADR, Mathijssen RHJ
Background: Central nervous system (CNS) metastases are present in approximately 40% of patients with metastatic epidermal growth factor receptor-mutated (EGFRm+) non-small cell lung cancer (NSCLC). The EGFR-tyrosine kinase inhibitor osimertinib is a substrate of transporters ABCB1 and ABCG2 and metabolized by CYP3A4. We investigated relationships between single nucleotide polymorphisms (SNPs) ABCB1 3435C>T, ABCG2 421C>A and 34G>A, and CYP3A4∗22 and CNS treatment efficacy of osimertinib...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Scientific reports,
Volume 13, Issue 1, 13 2 2023, Pages 6021
Neural network based integration of assays to assess pathogenic potential.
Eslami M, Chen YP, Nicholson AC, Weston M, Bell M, McQuiston JR, Samuel J, van Schaik EJ, de Figueiredo P
Limited data significantly hinders our capability of biothreat assessment of novel bacterial strains. Integration of data from additional sources that can provide context about the strain can address this challenge. Datasets from different sources, however, are generated with a specific objective and which makes integration challenging. Here, we developed a deep learning-based approach called the neural network embedding model (NNEM) that integrates data from conventional assays designed to clas...
Abstract
Cited 5 times since 2023 (2.3 per year)
source: EuropePMC
PloS one,
Volume 18, Issue 4, 13 2 2023, Pages e0284329
Patients with infective endocarditis undergoing cardiac surgery have distinct ROTEM profiles and more bleeding complications compared to patients without infective endocarditis.
Breel JS, Wensing AGCL, Eberl S, Preckel B, Schober P, Müller MCA, Klautz RJM, Hollmann MW, Hermanns H
Background: The coagulation system is crucial in the pathogenesis of infective endocarditis and undergoes significant changes during course of the disease. However, little is known about the implications of those changes in the perioperative period. Aim of the present study was to delineate the specific coagulation patterns and their clinical consequence in patients undergoing cardiac surgery due to infective endocarditis. Methods: In this single-centre, exploratory, prospective observational st...
Abstract
Eye (London, England),
Volume 37, Issue 16, 12 2 2023, Pages 3442-3445
A prospective long-term evaluation of the ocular findings of children followed with the diagnosis of multisystem inflammatory syndrome (long-term evaluation of ocular findings following MIS-C).
Kaya-Guner E, Sahin A, Ekemen-Keles Y, Karadag-Oncel E, Kara-Aksay A, Yilmaz D
Background/objectives: The most frequently reported ocular finding in the acute phase of the multisystem inflammatory syndrome in children (MIS-C), is conjunctivitis. More rarely, punctuate epitheliopathy, anterior uveitis and optic disc oedema can be seen. We aimed to investigate the acute and long-term ocular effects of MIS-C. Subjects/methods: Cases aged 1 month to 18 years who were diagnosed with MIS-C between January 2022 and June 2022 in the Department of Pediatric Infectious Diseases in o...
Abstract
