Research

Publications

Below you can find a list of our published research.

9618 results

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume 62, Issue 11, 5 1 2016, Pages 1470 Reply to Leenders. Hetem DJ, Bootsma MC, Bonten MJ

Abstract

Cited 16 times since 2016 (1.7 per year) source: EuropePMC

The British journal of surgery, Volume 103, Issue 8, 5 1 2016, Pages 995-1002 Quality of life from a randomized trial of open and endovascular repair for abdominal aortic aneurysm. de Bruin JL, Groenwold RH, Baas AF, Brownrigg JR, Prinssen M, Grobbee DE, Blankensteijn JD, DREAM Study Group

Background: Long-term survival is similar after open or endovascular repair of abdominal aortic aneurysm. Few data exist on the effect of either procedure on long-term health-related quality of life (HRQoL) and health status. Methods: Patients enrolled in a multicentre randomized clinical trial (DREAM trial; 2000-2003) in Europe of open repair versus endovascular repair (EVAR) of abdominal aortic aneurysm were asked to complete questionnaires on health status and HRQoL. HRQoL scores were assesse... Abstract

Cited 19 times since 2016 (2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 102, Issue 16, 5 1 2016, Pages 1302-1308 Cardiac adaption during pregnancy in women with congenital heart disease and healthy women. Kampman MA, Valente MA, van Melle JP, Balci A, Roos-Hesselink JW, Mulder BJ, van Dijk AP, Oudijk MA, Jongbloed MR, van Veldhuisen DJ, Pieper PG, ZAHARA II investigators

Objective: Pregnancy in women with congenital heart disease (CHD) is associated with deterioration in cardiac function. However, longitudinal data are scarce. This study describes serial changes in cardiac dimensions and function during pregnancy in women with CHD and compares these with healthy pregnant women (controls). Methods: Eight tertiary centres prospectively enrolled 125 pregnant women with CHD (pregnancy duration 0.1). Left ventricular ejection fraction (LVEF) Abstract

Cited 147 times since 2016 (15.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 67, Issue 19, 2 1 2016, Pages 2263-2288 Natural History, Diagnostic Approaches, and Therapeutic Strategies for Patients With Asymptomatic Severe Aortic Stenosis. Généreux P, Stone GW, O'Gara PT, Marquis-Gravel G, Redfors B, Giustino G, Pibarot P, Bax JJ, Bonow RO, Leon MB

Aortic stenosis (AS) is one of the most common valvular diseases encountered in clinical practice. Current guidelines recommend aortic valve replacement (AVR) when the aortic valve is severely stenotic and the patient is symptomatic; however, a substantial proportion of patients with severe AS are asymptomatic at the time of first diagnosis. Although specific morphological valve features, exercise testing, stress imaging, and biomarkers can help to identify patients with asymptomatic severe AS w... Abstract

Cited 32 times since 2016 (3.4 per year) source: EuropePMC

Circulation research, Volume 118, Issue 8, 1 1 2016, Pages 1254-1263 Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies. Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ, ACCRUE Investigators

In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfa... Abstract

Cited 5 times since 2016 (0.5 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 11, Issue 13, 1 1 2016, Pages 1554-1561 Acute effect of MitraClip implantation on mitral valve geometry in patients with functional mitral regurgitation: insights from three-dimensional transoesophageal echocardiography. Al Amri I, Debonnaire P, van der Kley F, Schalij MJ, Bax JJ, Marsan NA, Delgado V

Aims: Our aim was to evaluate the acute effects of transcatheter edge-to-edge mitral valve repair using the MitraClip device on mitral valve geometry in patients with functional mitral regurgitation (FMR). Methods and results: Forty-two patients (age 73 years [IQ range 66.1-78.0], 55% men, 62% ischaemic FMR) with moderate-to-severe and severe FMR treated with the MitraClip were included. Three-dimensional transoesophageal echocardiography was performed prior to and immediately after MitraClip im... Abstract

Cited 9 times since 2016 (1 per year) source: EuropePMC

Cited 1 times since 2016 (0.1 per year) source: EuropePMC

Pancreas, Volume 45, Issue 4, 1 1 2016, Pages 541-545 A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort. Balázs A, Németh BC, Ördög B, Hegyi E, Hritz I, Czakó L, Czimmer J, Gódi S, Csiszkó A, Rakonczay Z, Párniczky A, Izbéki F, Halász A, Kahán Z, Hegyi P, Sahin-Tóth M, Hungarian Pancreatic Study Group

Objectives: Variant c.811+32C>A in intron 4 of the cholecystokinin-B receptor gene (CCKBR) was reported to correlate with higher pancreatic cancer risk and poorer survival. The variant was suggested to induce retention of intron 4, resulting in a new splice form with enhanced receptor activity. Our objective was to validate the c.811+32C>A variant as an emerging biomarker for pancreatic cancer risk and prognosis. Methods: We genotyped variant c.811+32C>A in 122 pancreatic adenocarcinoma... Abstract

Cited 18 times since 2016 (1.9 per year) source: EuropePMC

Teaching and learning in medicine, Volume 28, Issue 2, 1 1 2016, Pages 125-134 Useful but Different: Resident Physician Perceptions of Interprofessional Feedback. Vesel TP, O'Brien BC, Henry DM, van Schaik SM

Unlabelled: Phenomenon: Based on recently formulated interprofessional core competencies, physicians are expected to incorporate feedback from other healthcare professionals. Based on social identity theory, physicians likely differentiate between feedback from members of their own profession and others. The current study examined residents' experiences with, and perceptions of, interprofessional feedback. Approach: In 2013, Anesthesia, Obstetrics-Gynecology, Pediatrics, and Psychiatry resi... Abstract

Cited 5 times since 2016 (0.5 per year) source: EuropePMC

Medical education, Volume 50, Issue 4, 1 1 2016, Pages 387-389 Context matters: groupthink and outcomes of health care teams. Madigosky W, van Schaik S

Abstract

Cited 30 times since 2016 (3.2 per year) source: EuropePMC

Journal of medical genetics, Volume 53, Issue 7, 1 1 2016, Pages 441-449 Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Marten J, van Klinken JB, Surakka I, Nolte IM, Zhang W, Mbarek H, Li-Gao R, Trompet S, Verweij N, Evangelou E, Lyytikäinen LP, Tayo BO, Deelen J, van der Most PJ, van der Laan SW, Arking DE, Morrison A, Dehghan A, Franco OH, Hofman A, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Mychaleckyj JC, Campbell A, Hocking LJ, Padmanabhan S, Brody JA, Rice KM, White CC, Harris T, Isaacs A, Campbell H, Lange LA, Rudan I, Kolcic I, Navarro P, Zemunik T, Salomaa V, LifeLines Cohort Study, Kooner AS, Kooner JS, Lehne B, Scott WR, Tan ST, de Geus EJ, Milaneschi Y, Penninx BW, Willemsen G, de Mutsert R, Ford I, Gansevoort RT, Segura-Lepe MP, Raitakari OT, Viikari JS, Nikus K, Forrester T, McKenzie CA, de Craen AJ, de Ruijter HM, CHARGE Lipids Working Group, Pasterkamp G, Snieder H, Oldehinkel AJ, Slagboom PE, Cooper RS, Kähönen M, Lehtimäki T, Elliott P, van der Harst P, Jukema JW, Mook-Kanamori DO, Boomsma DI, Ch

Background: So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods: We used the 1000 Genomes Project as a reference panel for the imputation... Abstract

Cited 17 times since 2016 (1.8 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 9, Issue 4, 1 1 2016, Pages e003439 Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias. Yu Z, Liu J, van Veldhoven JP, IJzerman AP, Schalij MJ, Pijnappels DA, Heitman LH, de Vries AA

Background: Ventricular arrhythmias as a result of unintentional blockade of the Kv11.1 (hERG [human ether-à-go-go-related gene]) channel are a major safety concern in drug development. In past years, several highly prescribed drugs have been withdrawn for their ability to cause such proarrhythmia. Here, we investigated whether the proarrhythmic risk of existing drugs could be reduced by Kv11.1 allosteric modulators. Methods and results: Using [(3)H]dofetilide-binding assays with membranes of hu... Abstract

Cited 1 times since 2016 (0.1 per year) source: EuropePMC

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, Volume 20, Issue 4, 31 5 2016, Pages 611-615 Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients. Yılmaz D, Yüksel D, Gökkurt D, Oguz H, Anlar B

Purpose: Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal disease. Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). Because the, phosphorylation of tau is inhibited by insulin and insulin-like growth factor-1 (IGF-1), we investigated cerebrospinal fluid (CSF) insulin and IGF-1 levels in SSPE patients. Methods and results: In this study CSF IGF-1 and insulin levels o... Abstract

Cited 83 times since 2016 (8.8 per year) source: EuropePMC

Nature communications, Volume 7, 31 5 2016, Pages 10846 Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression. de Bruin RG, Shiue L, Prins J, de Boer HC, Singh A, Fagg WS, van Gils JM, Duijs JM, Katzman S, Kraaijeveld AO, Böhringer S, Leung WY, Kielbasa SM, Donahue JP, van der Zande PH, Sijbom R, van Alem CM, Bot I, van Kooten C, Jukema JW, Van Esch H, Rabelink TJ, Kazan H, Biessen EA, Ares M, van Zonneveld AJ, van der Veer EP

A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce transcriptional changes associated with macrophage phenotype, but posttranscriptional control of human macrophage differentiation is less well understood. Here we show that expression levels of the RNA-binding protein Quaking (QKI) are low in monocytes and early human atherosclerotic lesions, bu... Abstract

Revista espanola de cardiologia (English ed.), Volume 69, Issue 5, 30 5 2016, Pages 533 Evidence From Pacing in Obstructive Hypertrophic Cardiomyopathy. Response. Jurado Román A, Montero Cabezas JM, Tascón Pérez JC

Abstract

Cited 18 times since 2016 (1.9 per year) source: EuropePMC

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, Volume 21, Issue 5, 28 4 2016, Pages 526-528 De Winter Electrocardiographic Pattern Related with a Non-Left Anterior Descending Coronary Artery Occlusion. Montero Cabezas JM, Karalis I, Schalij MJ

The electrocardiographic pattern consisting of ST-segment depression and hyperacute T waves in patients with acute chest pain, known as "De Winter pattern," has been related with the occlusion of the proximal left anterior descending artery (LAD). The association of these findings with the involvement of a different coronary artery has not been described. We present a 53-year-old patient with an occlusion of the first diagonal branch and an electrocardiogram showing a "De Winter p... Abstract

Cited 8 times since 2016 (0.8 per year) source: EuropePMC

Diabetic medicine : a journal of the British Diabetic Association, Volume 33, Issue 6, 25 4 2016, Pages 794-802 Effectiveness of insulin therapy in people with Type 2 diabetes in the Hoorn Diabetes Care System. Mast MR, Walraven I, Hoekstra T, Jansen AP, van der Heijden AA, Elders PJ, Heine RJ, Dekker JM, Nijpels G, Hugtenburg JG

Aims: To identify HbA1c trajectories after the start of insulin treatment and to identify clinically applicable predictors of the response to insulin therapy. Methods: The study population comprised 1203 people with Type 2 diabetes included in the Hoorn Diabetes Care System (n = 9849). Inclusion criteria were: age ≥ 40 years; initiation of insulin during follow-up after failure to reach HbA1c levels ≤ 53 mmol/mol (7%) with oral glucose-lowering agents; and a follow up ≥ 2 years after initiating... Abstract

Cited 13 times since 2016 (1.4 per year) source: EuropePMC

Langenbeck's archives of surgery, Volume 401, Issue 3, 24 4 2016, Pages 365-373 Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm. Lodewijk L, Kluijfhout WP, Kist JW, Stegeman I, Plukker JT, Nieveen van Dijkum EJ, Bonjer HJ, Bouvy ND, Schepers A, de Wilt JH, Netea-Maier RT, van der Hage JA, Burger JW, Ho G, Lee WS, Shen WT, Aronova A, Zarnegar R, Benay C, Mitmaker EJ, Sywak MS, Aniss AM, Kruijff S, James B, Grogan RH, Brunaud L, Hoch G, Pandolfi C, Ruan DT, Jones MD, Guerrero MA, Valk GD, Borel Rinkes IH, Vriens MR

Purpose: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm. Methods... Abstract

Cited 6 times since 2016 (0.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 18, Issue 2, 24 4 2016, Pages 203-211 The influence of clinical and acquisition parameters on the interpretability of adenosine stress myocardial computed tomography perfusion. van Rosendael AR, de Graaf MA, Dimitriu-Leen AC, van Zwet EW, van den Hoogen IJ, Kharbanda RK, Bax JJ, Kroft LJ, Scholte AJ

Aims: The interpretation of adenosine stress myocardial computed tomography perfusion (CTP) is often hampered by image artefacts caused by cardiac motion, beam hardening, and cone beam. The aim of the present analysis was to assess the influence of the heart-rate response during adenosine infusion, patient characteristics, and medication use on the interpretability of stress myocardial CTP examinations. Methods and results: Interpretability of stress myocardial CTP examinations was evaluated in... Abstract

Cited 6 times since 2016 (0.6 per year) source: EuropePMC

Journal of vascular surgery, Volume 63, Issue 6, 19 3 2016, Pages 1428-1433.e1 Predicting reinterventions after open and endovascular aneurysm repair using the St George's Vascular Institute score. de Bruin JL, Karthikesalingam A, Holt PJ, Prinssen M, Thompson MM, Blankensteijn JD, Dutch Randomised Endovascular Aneurysm Management (DREAM) Study Group

Background: Identifying patients at risk for aneurysm rupture and sac expansion after open and endovascular abdominal aortic aneurysm (AAA) repair (EVAR) may help to attenuate this risk by intensifying follow-up and early detection of problems. The goal of this study was to validate the St George's Vascular Institute (SGVI) score to identify patients at risk for a secondary intervention after elective aneurysm repair. Methods: A post hoc on-treatment analysis of a randomized trial comparing... Abstract