8251 results
Cited 5 times since 2018 (0.7 per year)
source: EuropePMC
Pharmacogenomics,
Volume 19, Issue 4, 22 4 2018, Pages 305-310
Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype.
Lloberas N, Hesselink DA, van Schaik RH, Grinyò JM, Colom H, Gelder TV, Elens L
A validated CYP3A genotype classification system allows clustering patients into poor, intermediate and extensive metabolizer phenotypes. However, substantial overlap exists between the clusters. A rare CYP3A4 allele, named CYP3A4*20 (rs67666821), has been specifically described in the Spanish population. The authors investigated the relevance of CYP3A4*20 testing to see if the above-mentioned metabolic CYP3A classification system can be improved. In a cohort of 204 kidney transplant recipients,...
Abstract
Cited 26 times since 2018 (3.6 per year)
source: EuropePMC
The New phytologist,
Volume 218, Issue 2, 22 4 2018, Pages 724-737
Genome-wide association mapping of the architecture of susceptibility to the root-knot nematode Meloidogyne incognita in Arabidopsis thaliana.
Warmerdam S, Sterken MG, van Schaik C, Oortwijn MEP, Sukarta OCA, Lozano-Torres JL, Dicke M, Helder J, Kammenga JE, Goverse A, Bakker J, Smant G
Susceptibility to the root-knot nematode Meloidogyne incognita in plants is thought to be a complex trait based on multiple genes involved in cell differentiation, growth and defence. Previous genetic analyses of susceptibility to M. incognita have mainly focused on segregating dominant resistance genes in crops. It is not known if plants harbour significant genetic variation in susceptibility to M. incognita independent of dominant resistance. To study the genetic architecture of susceptibility...
Abstract
Cited 8 times since 2018 (1.1 per year)
source: EuropePMC
Frontiers in microbiology,
Volume 9, 21 3 2018, Pages 293
High Prevalence of Intra-Familial Co-colonization by Extended-Spectrum Cephalosporin Resistant <i>Enterobacteriaceae</i> in Preschool Children and Their Parents in Dutch Households.
Liakopoulos A, van den Bunt G, Geurts Y, Bootsma MCJ, Toleman M, Ceccarelli D, van Pelt W, Mevius DJ
Extended-spectrum cephalosporin-resistant (ESCR) Enterobacteriaceae pose a serious infection control challenge for public health. The emergence of the ESCR phenotype is mostly facilitated by plasmid-mediated horizontal extended-spectrum β-lactamases (ESBLs) and AmpC gene transfer within Enterobacteriaceae. Current data regarding the plasmid contribution to this emergence within the Dutch human population is limited. Hence, the aim of this study was to gain insight into the role of plasmids in th...
Abstract
Cited 1 times since 2018 (0.1 per year)
source: EuropePMC
PloS one,
Volume 13, Issue 2, 21 3 2018, Pages e0192257
A pneumatic Bionic Voice prosthesis-Pre-clinical trials of controlling the voice onset and offset.
Ahmadi F, Noorian F, Novakovic D, van Schaik A
Despite emergent progress in many fields of bionics, a functional Bionic Voice prosthesis for laryngectomy patients (larynx amputees) has not yet been achieved, leading to a lifetime of vocal disability for these patients. This study introduces a novel framework of Pneumatic Bionic Voice Prostheses as an electronic adaptation of the Pneumatic Artificial Larynx (PAL) device. The PAL is a non-invasive mechanical voice source, driven exclusively by respiration with an exceptionally high voice quali...
Abstract
Cited 99 times since 2018 (13.7 per year)
source: EuropePMC
Cell stem cell,
Volume 22, Issue 4, 15 3 2018, Pages 501-513.e7
Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo.
Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yi H, Dey D, Nelakanti R, Brouwer TP, Paik DT, Sagiv-Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC
Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated antigens, and we show here a proof of principle for using irradiated iPSCs in autologous anti-tumor vaccines. In a prophylactic setting, iPSC vaccines prevent tumor growth in syngeneic murine breast cancer, mesot...
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 29, Issue 5, 14 2 2018, Pages 780-787
Assessment of left ventricular dyssynchrony by three-dimensional echocardiography: Prognostic value in patients undergoing cardiac resynchronization therapy.
Höke U, Bax JJ, Delgado V, Ajmone Marsan N
Background: Systolic dyssynchrony index (SDI) using three-dimensional echocardiography (3DE) was shown to be a reliable measure of left ventricular (LV) dyssynchrony. However, the prognostic value of SDI on long-term outcomes after cardiac resynchronization therapy (CRT) remains unknown. Methods and results: A total of 414 patients (mean age 67 ± 10 years, 60% ischemic etiology) with 3DE evaluation before CRT implantation were included. SDI was evaluated as continuous value and in quartiles. The...
Abstract
Cited 5 times since 2018 (0.7 per year)
source: EuropePMC
PloS one,
Volume 13, Issue 2, 14 2 2018, Pages e0192282
Latent tuberculosis infection in foreign-born communities: Import vs. transmission in The Netherlands derived through mathematical modelling.
Korthals Altes H, Kloet S, Cobelens F, Bootsma M
While tuberculosis (TB) represents a significant disease burden worldwide, low-incidence countries strive to reach the WHO target of pre-elimination by 2035. Screening for TB in immigrants is an important component of the strategy to reduce the TB burden in low-incidence settings. An important option is the screening and preventive treatment of latent TB infection (LTBI). Whether this policy is worthwhile depends on the extent of transmission within the country, and introduction of new cases thr...
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
PloS one,
Volume 13, Issue 2, 8 2 2018, Pages e0189372
Randomized trial of one-hour sodium bicarbonate vs standard periprocedural saline hydration in chronic kidney disease patients undergoing cardiovascular contrast procedures.
Kooiman J, de Vries JPM, Van der Heyden J, Sijpkens YWJ, van Dijkman PRM, Wever JJ, van Overhagen H, Vahl AC, Aarts N, Verberk-Jonkers IJAM, Brulez HFH, Hamming JF, van der Molen AJ, Cannegieter SC, Putter H, van den Hout WB, Kilicsoy I, Rabelink TJ, Huisman MV
Background: Guidelines advise periprocedural saline hydration for prevention of contrast induced-acute kidney injury (CI-AKI). We analysed whether 1-hour sodium bicarbonate hydration administered solely prior to intra-arterial contrast exposure is non-inferior to standard periprocedural saline hydration in chronic kidney disease (CKD) patients undergoing elective cardiovascular diagnostic or interventional contrast procedures. Methods: We performed an open-label multicentre non-inferiority trial...
Abstract
Cited 1 times since 2018 (0.1 per year)
source: EuropePMC
Frontiers in zoology,
Volume 15, 8 2 2018, Pages 2
Correction to: development of foraging skills in two orangutan populations: needing to learn or needing to grow?
Schuppli C, Forss SIF, Meulman EJM, Zweifel N, Lee KC, Rukmana E, Vogel ER, van Noordwijk MA, van Schaik CP
[This corrects the article DOI: 10.1186/s12983-016-0178-5.].
Abstract
Frontiers in zoology,
Volume 15, 8 2 2018, Pages 3
Correction to: getting fat or getting help? how female mammals cope with energetic constraints on reproduction.
Heldstab SA, van Schaik CP, Isler K
[This corrects the article DOI: 10.1186/s12983-017-0214-0.].
Abstract
Cited 6 times since 2018 (0.8 per year)
source: EuropePMC
Clinical genetics,
Volume 93, Issue 3, 7 1 2018, Pages 498-507
A critical appraisal of pharmacogenetic inference.
Smit RAJ, Noordam R, le Cessie S, Trompet S, Jukema JW
In essence, pharmacogenetic research is aimed at discovering variants of importance to gene-treatment interaction. However, epidemiological studies are rarely set up with this goal in mind. It is therefore of great importance that researchers clearly communicate which assumptions they have had to make, and which inherent limitations apply to the interpretation of their results. This review discusses considerations of, and the underlying assumptions for, utilizing different response phenotypes an...
Abstract
Cited 8 times since 2018 (1.1 per year)
source: EuropePMC
Journal of the peripheral nervous system : JPNS,
Volume 23, Issue 1, 6 1 2018, Pages 49-54
Elevated leukocyte count in cerebrospinal fluid of patients with chronic inflammatory demyelinating polyneuropathy.
Lucke IM, Peric S, van Lieverloo GGA, Wieske L, Verhamme C, van Schaik IN, Basta I, Eftimov F
Cerebrospinal fluid (CSF) examination is often part of the diagnostic work-up of a patient suspected of having chronic inflammatory demyelinating polyneuropathy (CIDP). According to the European Federation of Neurological Societies and the Peripheral Nerve Society (EFNS/PNS) criteria, an elevated protein level without pleocytosis (leukocytes
Abstract
Cited 12 times since 2018 (1.7 per year)
source: EuropePMC
Nutrients,
Volume 10, Issue 2, 3 1 2018, Pages E172
The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice.
Hoving LR, de Vries MR, de Jong RCM, Katiraei S, Pronk A, Quax PHA, van Harmelen V, Willems van Dijk K
The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden (E3L) mice. Male E3L mice were fed a high-cholesterol (1%) diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce ac...
Abstract
Cited 11 times since 2018 (1.5 per year)
source: EuropePMC
JAAD case reports,
Volume 4, Issue 2, 2 1 2018, Pages 192-195
Juvenile interleukin-36 receptor antagonist deficiency (DITRA) with c.80T>C (p.Leu27Pro) mutation successfully treated with etanercept and acitretin.
Cuperus E, Koevoets R, van der Smagt JJ, Toonstra J, de Graaf M, Frenkel J, Pasmans SGMA
Abstract
Cited 22 times since 2018 (3 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 12, Issue 2, 2 1 2018, Pages 95-100
Incidence and predictors of lesion-specific ischemia by FFR<sub>CT</sub>: Learnings from the international ADVANCE registry.
Kitabata H, Leipsic J, Patel MR, Nieman K, De Bruyne B, Rogers C, Pontone G, Nørgaard BL, Bax JJ, Raff G, Chinnaiyan KM, Rabbat M, Rønnow Sand NP, Blanke P, Fairbairn TA, Matsuo H, Amano T, Kawasaki T, Morino Y, Akasaka T
Background: To date, the clinical utility of coronary computed tomography angiography (CTA)-derived fractional flow reserve (FFRCT) has been limited to trials and single center experiences. We herein report the incidence of abnormal FFRCT (≤0.80) and the relationship of lesion-specific ischemia to subject demographics, symptoms, and degree of stenosis in the multicenter, prospective ADVANCE registry. Methods: One thousand patients with suspected angina having documented coronary artery disease o...
Abstract
Cited 35 times since 2018 (4.8 per year)
source: EuropePMC
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
Volume 33, 2 1 2018, Pages 62-69
Pathogenesis of aortic wall complications in Marfan syndrome.
Grewal N, Gittenberger-de Groot AC
Background: Patients with Marfan (MFS) syndrome and patients with a bicuspid aortic valve (BAV) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common as well as distinct pathways of clinical relevance, we compared the histopathological substrates of aortic pathology. Patient and methods: Ascending aortic wall specimen were divided in five groups: BAV (n=36) and TAV (n=23) without and with dilation and non-d...
Abstract
Cited 8 times since 2018 (1.1 per year)
source: EuropePMC
BMC psychiatry,
Volume 18, Issue 1, 2 1 2018, Pages 29
Prevention of violent revictimization in depressed patients with an add-on internet-based emotion regulation training (iERT): study protocol for a multicenter randomized controlled trial.
Christ C, de Waal MM, van Schaik DJF, Kikkert MJ, Blankers M, Bockting CLH, Beekman ATF, Dekker JJM
Background: Psychiatric patients are at high risk of becoming victim of a violent crime compared to the general population. Although most research has focused on patients with severe mental illness, depressed patients have been demonstrated to be prone to victimization as well. Victimization is associated with more severe symptomatology, decreased quality of life, and high risk of revictimization. Hence, there is a strong need for interventions that focus on preventing violent revictimization. S...
Abstract
Cited 11 times since 2018 (1.5 per year)
source: EuropePMC
Current opinion in lipidology,
Volume 29, Issue 1, 1 1 2018, Pages 51-52
Plasma apolipoprotein-B is an important risk factor for cardiovascular disease, and its assessment should be routine clinical practice.
Trompet S, Packard CJ, Jukema JW
Abstract
Cited 24 times since 2018 (3.3 per year)
source: EuropePMC
Scientific reports,
Volume 8, Issue 1, 1 1 2018, Pages 2050
Arrhythmogenicity of fibro-fatty infiltrations.
De Coster T, Claus P, Kazbanov IV, Haemers P, Willems R, Sipido KR, Panfilov AV
The onset of cardiac arrhythmias depends on electrophysiological and structural properties of cardiac tissue. One of the most important changes leading to arrhythmias is characterised by the presence of a large number of non-excitable cells in the heart, of which the most well-known example is fibrosis. Recently, adipose tissue was put forward as another similar factor contributing to cardiac arrhythmias. Adipocytes infiltrate into cardiac tissue and produce in-excitable obstacles that interfere...
Abstract
Cited 23 times since 2018 (3.2 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 20, Issue 2, 1 1 2018, Pages 315-322
Cardiac resynchronization therapy in adults with congenital heart disease.
Koyak Z, de Groot JR, Krimly A, Mackay TM, Bouma BJ, Silversides CK, Oechslin EN, Hoke U, van Erven L, Budts W, Van Gelder IC, Mulder BJM, Harris L
Aims: In adults with congenital heart disease (CHD) heart failure is one of the leading causes of morbidity and mortality but experience with and reported outcome of cardiac resynchronization therapy (CRT) is limited. We investigated the efficacy of CRT in adults with CHD. Methods and results: This was a retrospective study including 48 adults with CHD who received CRT since 2003 in four tertiary referral centres. Responders were defined as patients who showed improvement in NYHA functional clas...
Abstract
