7971 results
Cited 262 times since 2017 (35.2 per year)
source: EuropePMC
Nature genetics,
Volume 50, Issue 1, 22 4 2017, Pages 26-41
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heij
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in ge...
Abstract
Cited 6 times since 2017 (0.8 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 21 3 2017, Pages 18039
Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice.
Ellenbroek GHJM, de Haan JJ, van Klarenbosch BR, Brans MAD, van de Weg SM, Smeets MB, de Jong S, Arslan F, Timmers L, Goumans MTH, Hoefer IE, Doevendans PA, Pasterkamp G, Meyaard L, de Jager SCA
Heart failure after myocardial infarction (MI) depends on infarct size and adverse left ventricular (LV) remodelling, both influenced by the inflammatory response. Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is an inhibitory receptor of ITAM-dependent cell activation, present on almost all immune cells. We investigated regulation of LAIR-1 leukocyte expression after MI in patients and hypothesized that its absence in a mouse model of MI would increase infarct size and adverse re...
Abstract
Cited 1 times since 2017 (0.1 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 3, Issue 13, 18 3 2017, Pages 1519-1522
Cardiac Resynchronization Therapy With Multipoint Left Ventricular Lead Pacing.
Bax JJ, Delgado V
Abstract
Cited 79 times since 2017 (10.6 per year)
source: EuropePMC
Nurse education in practice,
Volume 29, 15 3 2017, Pages 127-132
Undergraduate nursing students' experience related to their clinical learning environment and factors affecting to their clinical learning process.
Arkan B, Ordin Y, Yılmaz D
Clinical education is an essential part of nursing education. The purpose of this study was to explore nurse students' experiences related to cinical learning environments, factors effecting to clinical learning process. Descriptive qualitative design was used in this study, and data were collected from 2nd class nursing student (n = 14). The study took the form of in-depth interviews between August-October 2015. The qualitative interviews were analyzed by using simple content analysis. Dat...
Abstract
Cited 2 times since 2017 (0.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 121, Issue 5, 11 2 2017, Pages 537-543
Gender-Specific Differences in All-Cause Mortality Between Incomplete and Complete Revascularization in Patients With ST-Elevation Myocardial Infarction and Multi-Vessel Coronary Artery Disease.
Dimitriu-Leen AC, Hermans MPJ, van Rosendael AR, van Zwet EW, van der Hoeven BL, Bax JJ, Scholte AJHA
The best revascularization strategy (complete vs incomplete revascularization) in patients with ST-elevation myocardial infarction (STEMI) is still debated. The interaction between gender and revascularization strategy in patients with STEMI on all-cause mortality is uncertain. The aim of the present study was to evaluate gender-specific difference in all-cause mortality between incomplete and complete revascularization in patients with STEMI and multi-vessel coronary artery disease. The study p...
Abstract
Cited 2 times since 2017 (0.3 per year)
source: EuropePMC
PloS one,
Volume 12, Issue 12, 11 2 2017, Pages e0188970
A model for warfare in stratified small-scale societies: The effect of within-group inequality.
Pandit S, Pradhan G, van Schaik C
In order to predict the features of non-raiding human warfare in small-scale, socially stratified societies, we study a coalitionary model of war that assumes that individuals participate voluntarily because their decisions serve to maximize fitness. Individual males join the coalition if war results in a net economic and thus fitness benefit. Within the model, viable offensive war ensues if the attacking coalition of males can overpower the defending coalition. We assume that the two groups wil...
Abstract
Cited 45 times since 2017 (6 per year)
source: EuropePMC
European journal of heart failure,
Volume 20, Issue 4, 11 2 2017, Pages 663-673
Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997.
Delles C, Rankin NJ, Boachie C, McConnachie A, Ford I, Kangas A, Soininen P, Trompet S, Mooijaart SP, Jukema JW, Zannad F, Ala-Korpela M, Salomaa V, Havulinna AS, Welsh P, Würtz P, Sattar N
Aims: We investigated the association between quantified metabolite, lipid and lipoprotein measures and incident heart failure hospitalisation (HFH) in the elderly, and examined whether circulating metabolic measures improve HFH prediction. Methods and results: Overall, 80 metabolic measures from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial were measured by proton nuclear magnetic resonance spectroscopy (n = 5341; 182 HFH events during 2.7-year follow-up). We repea...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 121, Issue 5, 11 2 2017, Pages 570-578
Relation of Overall and Abdominal Adiposity With Electrocardiogram Parameters of Subclinical Cardiovascular Disease in Individuals Aged 45 to 65 Years (from the Netherlands Epidemiology of Obesity Study).
Elffers TW, de Mutsert R, Lamb HJ, Maan AC, Macfarlane PW, Willems van Dijk K, Rosendaal FR, Jukema JW, Trompet S
Overall and abdominal obesity are well-established risk factors for cardiometabolic disease. However, associations of overall and abdominal adiposity with electrocardiographic (ECG) markers of subclinical cardiovascular disease (CVD) have not yet been fully elucidated. Therefore, we investigated these associations in a population without preexisting CVD. We performed cross-sectional analyses in the Netherlands Epidemiology of Obesity Study. Body mass index (BMI), total body fat, and waist circum...
Abstract
Cited 8 times since 2017 (1.1 per year)
source: EuropePMC
Cardiology in the young,
Volume 28, Issue 3, 10 2 2017, Pages 403-408
The evaluation of arterial stiffness of essential hypertension and white coat hypertension in children: a case-control study.
Tokgöz ST, Yılmaz D, Tokgöz Y, Çelik B, Bulut Y
Background: The aim of this study was to determine and compare cardiovascular risks by assessing arterial stiffness in children with essential hypertension and white coat hypertension. Methods: Paediatric patients followed up with essential hypertension and white coat hypertension diagnoses and with no established end organ damage were involved in the study. Arterial stiffness in children included in the study was evaluated and compared by using the oscillometric device (Mobil-O-Graph) method. R...
Abstract
Bioorganic & medicinal chemistry letters,
Volume 28, Issue 3, 9 2 2017, Pages 459-465
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P<sub>5</sub> receptor agonist chemotype.
Stoit AR, Lange JHM, Coolen HKAC, Rensink A, van den Hoogenband A, den Hartog AP, van Schaik S, Kruse CG
The synthesis and SAR of a novel class of spirobenzofuranpiperidinyl-derived alkanoic acids 6-34 as sphingosine S1P5 receptor agonists are described. The target compounds generally elicit high S1P5 receptor agonistic potencies and in general are selective against both S1P1 and S1P3 receptor subtypes. The key compound 32 shows a high bioavailability of 73% and a CNS/plasma ratio of 0.8 after oral administration in rats.
Abstract
Cited 2 times since 2017 (0.3 per year)
source: EuropePMC
Physiological genomics,
Volume 50, Issue 2, 8 2 2017, Pages 102-103
Association of complement receptor 1 gene polymorphisms with cognitive function.
Zijlstra LE, Jukema JW, Mooijaart SP, de Vries MA, Stott DJ, Castro Cabezas M, Trompet S
Previous evidence suggest involvement of the complement receptor 1 (CR1) in development of Alzheimer's disease. We investigated the association of CR1 gene polymorphisms with cognitive function in older subjects. Single nucleotide polymorphisms (SNPs) within the CR1 region on chromosome 1 ( n = 73) were assessed in 5,244 participants in the PROspective Study of Pravastatin in the Elderly at Risk (51.9% female, mean age 75.3 yr). Linear regression, adjusted for age, sex, country, and use of...
Abstract
Cited 30 times since 2017 (4 per year)
source: EuropePMC
Circulation,
Volume 137, Issue 14, 8 2 2017, Pages 1463-1471
Effect of Losartan on Right Ventricular Dysfunction: Results From the Double-Blind, Randomized REDEFINE Trial (Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-Angiotensin-Aldosterone System) in Adults With Repaired Tetralogy of Fallot.
Bokma JP, Winter MM, van Dijk AP, Vliegen HW, van Melle JP, Meijboom FJ, Post MC, Berbee JK, Boekholdt SM, Groenink M, Zwinderman AH, Mulder BJM, Bouma BJ
Background: The effect of angiotensin II receptor blockers on right ventricular (RV) function is still unknown. Angiotensin II receptor blockers are beneficial in patients with acquired left ventricular dysfunction, and recent findings have suggested a favorable effect in symptomatic patients with systemic RV dysfunction. The current study aimed to determine the effect of losartan, an angiotensin II receptor blocker, on subpulmonary RV dysfunction in adults after repaired tetralogy of Fallot. Me...
Abstract
Cited 10 times since 2017 (1.3 per year)
source: EuropePMC
Infection control and hospital epidemiology,
Volume 39, Issue 1, 7 1 2017, Pages 32-39
Quantifying Hospital-Acquired Carriage of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Among Patients in Dutch Hospitals.
Kluytmans-van den Bergh MFQ, van Mens SP, Haverkate MR, Bootsma MCJ, Kluytmans JAJW, Bonten MJM, SoM Study Group and the R-GNOSIS Study Group
BACKGROUND Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are emerging worldwide. Contact precautions are recommended for known ESBL-E carriers to control the spread of ESBL-E within hospitals. OBJECTIVE This study quantified the acquisition of ESBL-E rectal carriage among patients in Dutch hospitals, given the application of contact precautions. METHODS Data were used from 2 cluster-randomized studies on isolation strategies for ESBL-E: (1) the SoM study, performed in 14 Du...
Abstract
Cited 14 times since 2017 (1.9 per year)
source: EuropePMC
PloS one,
Volume 12, Issue 12, 5 1 2017, Pages e0189139
Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart.
van Eldik W, den Adel B, Monshouwer-Kloots J, Salvatori D, Maas S, van der Made I, Creemers EE, Frank D, Frey N, Boontje N, van der Velden J, Steendijk P, Mummery C, Passier R, Beqqali A
Aims: The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched Actin-associated Protein (CHAP) is essential for cardiac and skeletal muscle development. Furthermore, the CHAP gene has been associated with atrial fibrillation in humans. Here, we studied the misregulated expression of CHAP isoforms in heart disea...
Abstract
Cited 14 times since 2017 (1.9 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 4 1 2017, Pages 16826
Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults.
Keustermans GC, Kofink D, Eikendal A, de Jager W, Meerding J, Nuboer R, Waltenberger J, Kraaijeveld AO, Jukema JW, Sels JW, Garssen J, Prakken BJ, Asselbergs FW, Kalkhoven E, Hoefer IE, Pasterkamp G, Schipper HS
Childhood obesity coincides with increased numbers of circulating classical CD14++CD16- and intermediate CD14++CD16+ monocytes. Monocytes are key players in the development and exacerbation of atherosclerosis, which prompts the question as to whether the monocytosis in childhood obesity contributes to atherogenesis over the years. Here, we dissected the monocyte gene expression profile in childhood obesity using an Illumina microarray platform on sorted monocytes of 35 obese children and 16 lean...
Abstract
Cited 8 times since 2017 (1.1 per year)
source: EuropePMC
Journal of general internal medicine,
Volume 33, Issue 2, 4 1 2017, Pages 182-188
External Validation of a Tool Predicting 7-Year Risk of Developing Cardiovascular Disease, Type 2 Diabetes or Chronic Kidney Disease.
Rauh SP, Rutters F, van der Heijden AAWA, Luimes T, Alssema M, Heymans MW, Magliano DJ, Shaw JE, Beulens JW, Dekker JM
Background: Chronic cardiometabolic diseases, including cardiovascular disease (CVD), type 2 diabetes (T2D) and chronic kidney disease (CKD), share many modifiable risk factors and can be prevented using combined prevention programs. Valid risk prediction tools are needed to accurately identify individuals at risk. Objective: We aimed to validate a previously developed non-invasive risk prediction tool for predicting the combined 7-year-risk for chronic cardiometabolic diseases. Design: The prev...
Abstract
Preventive veterinary medicine,
Volume 150, 2 1 2017, Pages 133-134
SVEPM 2017-Recent developments and contemporary foci in veterinary epidemiology and economics, Society of Veterinary Epidemiology and Preventive Medicine conference Inverness, Scotland 29-31 March 2017.
McIntyre KM, van den Borne BHP, Calvo-Artavia FF, van Schaik G
Abstract
Cited 30 times since 2017 (4 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 25, Issue 4, 1 1 2017, Pages 1204-1236
Radiopharmaceutical tracers for cardiac imaging.
Manabe O, Kikuchi T, Scholte AJHA, El Mahdiui M, Nishii R, Zhang MR, Suzuki E, Yoshinaga K
Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Nuclear myocardial perfusion imaging with either single-photon emission computed tomography or positron emission tomography has been used extensively to perform diagnosis, monitor therapies, and predict cardiovascular events. Several radiopharmaceutical tracers have recently been developed to evaluate CVD by targeting myocardial perfusion, metabolism, innervation, and inflammation. This article reviews old a...
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 52, Issue 6, 1 1 2017, Pages 1155-1160
Fifteen years' experience with the use of artificial chords for valve reconstruction in children.
Kluin J, Sojak V, Koolbergen DR, Boon R, Bökenkamp R, Hazekamp MG
Objectives: To retrospectively review our experience with artificial chords in mitral and tricuspid reconstructive surgery in children. Methods: All consecutive paediatric (
Abstract
Cited 54 times since 2017 (7.2 per year)
source: EuropePMC
European heart journal,
Volume 38, Issue 45, 1 1 2017, Pages 3370-3377
Mechanical aortic valve replacement in non-elderly adults: meta-analysis and microsimulation.
Korteland NM, Etnel JRG, Arabkhani B, Mokhles MM, Mohamad A, Roos-Hesselink JW, Bogers AJJC, Takkenberg JJM
Aims: To support decision-making regarding prosthetic valve selection in non-elderly adults, we aim to provide a detailed overview of outcome after contemporary mechanical aortic valve replacement (AVR). Methods and results: A systematic review was conducted for papers reporting clinical outcome after AVR with bileaflet mechanical valves with a mean patient age ≥18 and ≤55 years, published between 1 January 1995 and 31 December 2015. Through meta-analysis outcomes were pooled and entered into a...
Abstract
