8900 results
Nursing in critical care,
Volume 30, Issue 6, 1 1 2025, Pages e70191
Intensive Care and Operating Room Nurses' Knowledge Regarding Skin Tears.
Yeşilyurt M, Yılmaz D
Background: Skin tears are a prevalent but often under-recognised type of injury in clinical settings, particularly affecting vulnerable patients in intensive care and surgical environments. Aim: The aim of this study was to determine the knowledge levels of nurses working in operating rooms and intensive care units regarding skin tears. Study design: This descriptive study was conducted between December 2024 and April 2025 with 81 intensive care and 76 operating room nurses at a training and re...
Abstract
European heart journal,
17 3 2025, Pages ehaf791
Outcomes of moderate mixed aortic valve stenosis and regurgitation.
Lopez Santi P, Bernard J, Chua A, Laenens D, Powers A, Abdoun K, Velders BJJ, Sarrazyn C, Springhetti P, Zhang J, Amanullah MR, Ewe SH, Yiu KH, Palmen M, Hjortnaes J, Pibarot P, Clavel MA, Bax JJ, Ajmone Marsan N
Background and aims: There are limited data on mortality in patients with moderate mixed aortic valve disease (MAVD), defined as the combination of moderate aortic stenosis (AS) and moderate aortic regurgitation (AR). Consequently, current guidelines lack specific recommendations for aortic valve replacement (AVR) in this population. This study aims to compare survival between moderate MAVD and isolated severe AS or severe AR, and to evaluate the impact of symptoms or left ventricular ejection f...
Abstract
Intensive & critical care nursing,
Volume 92, 15 3 2025, Pages 104253
Important and feasible patient- and family-centered intensive care interventions: A Delphi study with stakeholders.
Tilburgs B, Bakker-Crommentuijn C, de Graaf M, van den Boogaard M
Background: Intensive care unit (ICU) admissions can be stressful for patients and family members. Patients may face discomfort, pain, delirium, immobility, and uncertainty about recovery, while family members often experience emotional strain, uncertainty and fatigue. Patient- and family-centered care (PFCC) is a guideline recommended approach to reduce ICU-burden for both patient and family members. However, which interventions are important and feasible for PFCC in the ICU is unknown. Objecti...
Abstract
Nature communications,
Volume 16, Issue 1, 14 2 2025, Pages 9122
Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels.
Helzer KT, Sharifi MN, Sperger JM, Chrostek MR, Bootsma ML, Reese SR, Taylor A, Kaufmann KR, Krause H, Schehr J, Sethakorn N, Kosoff D, Kyriakopoulos CE, Bassetti M, Blitzer G, Floberg J, Sjöström M, Armstrong AJ, Beltran H, McKay RR, Feng FY, O'Regan R, Wisinski KB, Emamekhoo H, Wyatt AW, Lang JM, Zhao SG
Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which is not readily available clinically. Targeted exon panels are used for clinical cfDNA variant calling. In this report, we conduct an investigation of multiple published fragmentomics methods for WGS, but on cancer exon panels. We find that strategies utilizing normalized depth metrics, as well as all...
Abstract
European journal of preventive cardiology,
14 2 2025, Pages zwaf661
Future myocardial infarction after an acute coronary syndrome and pharmacogenetic response to dalcetrapib.
Tardif JC, Pfeffer MA, Kouz S, Koenig W, Maggioni AP, McMurray JJV, Waters DD, Jukema JW, White HD, Heinonen T, Kallend D, Laghrissi-Thode F, Muroke V, Fortier A, Guertin MC, Dubé MP
Background: Acute coronary syndrome (ACS) survivors have heightened risk for subsequent cardiovascular events. Methods: All baseline characteristics collected in both the Dal-Outcomes and Dal-GenE trials were considered as potential risk markers. A prediction index for subsequent fatal and non-fatal myocardial infarction (MI) following ACS was developed using Cox proportional hazards modeling on data from Dal-Outcomes placebo patients (n=7086). This prediction index was then applied in all Dal-G...
Abstract
European journal of heart failure,
14 2 2025
Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 1: Multimodality imaging for the evaluation of patients with advanced heart failure.
Aimo A, Tops LF, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Gal TB, Moura B
Heart failure (HF) represents a significant global health burden, with approximately 10% of patients progressing to advanced stages characterized by severe symptoms and recurrent hospitalizations despite conventional treatments such as guideline-directed medical therapy, devices, and surgery. This clinical consensus statement from the Heart Failure Association of the European Society of Cardiology discusses the applications of imaging modalities in patients with advanced HF. Transthoracic echoca...
Abstract
European journal of heart failure,
14 2 2025
Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 2: Mechanical circulatory support and heart transplantation.
Tops LF, Aimo A, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Moura B, Ben Gal T
This clinical consensus statement outlines the vital role of multimodality imaging in managing patients with advanced heart failure (HF), particularly those receiving mechanical circulatory support (MCS) and heart transplantation (HT). For both temporary and durable MCS, multimodality imaging, primarily echocardiography, is crucial for selecting candidates, ensuring proper device placement, and monitoring in the post-implantation period. Preoperatively, it helps to identify HF phenotypes, assess...
Abstract
Irish journal of medical science,
14 2 2025
Enhancing educator preparedness for type 1 diabetes: a theory-based intervention targeting knowledge and Self-efficacy in low-resource schools.
Yılmaz DA, Dege G, Atasoy M
Background: Type 1 diabetes mellitus (T1DM) is an increasing concern among school-aged children, with more than 1.2 million affected globally. In low- and middle-income countries (LMICs), teachers often act as first responders to diabetes-related emergencies despite limited preparation. Structured education programs informed by behavioral theory may help strengthen both knowledge and applied competence among school staff. Aim: This study examined the short-term effects of a Bandura-based diabete...
Abstract
Trends in cardiovascular medicine,
13 2 2025, Pages S1050-1738(25)00135-5
Controversies in valvular heart disease: insights from cardiac imaging.
van der Bijl P, Marsan NA, Bax JJ
Numerous controversies still exist in the diagnosis and management of valvular heart disease, for example, the benefit of treating moderate aortic stenosis (AS) or asymptomatic, severe AS and the appropriate selection criteria for transcatheter edge-to-edge mitral valve repair. While numerous imaging parameters have been linked to the risk of sudden cardiac death in mitral valve prolapse, their relative merits are unknown and this is a challenging population to risk-stratify. No large, randomize...
Abstract
Environmental pollution (Barking, Essex : 1987),
13 2 2025, Pages 127266
Assessment of microplastic transport and distribution in the urban environment of Coimbra municipality.
Leitão IA, van Schaik L, Ferreira AJD, Geissen V
Microplastics (MPs) largely originate from terrestrial environments, especially urban areas, where controlling their spread is difficult. This is concerning due to MPs' impacts on ecosystems and human health. To develop mitigation strategies, understanding how MPs move and spread is essential. This study examined MP transport and distribution in Coimbra municipality, Portugal, at a small watershed scale. Samples were collected from dry and wet atmospheric deposition, runoff, and streams, bo...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
12 2 2025
Modification Procedures for Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry.
Kladou E, Strepkos D, Alexandrou M, Mutlu D, Carvalho PEP, Sara JDS, Ser OS, Alaswad K, Basir MB, Khelimskii D, Jaffer FA, Rafeh NA, Chandwaney R, Cevik C, Ahmad Y, Mastrodemos O, Rangan BV, Jalli S, Voudris K, Sandoval Y, Nicholas Burke M, Brilakis ES, PROGRESS‐CTO Investigators
Background: CTO-ARC (Chronic Total Occlusion Academic Research Consortium) defines CTO modification procedures (previously called investment procedures) as intentional balloon dilatation (diameter ≥ 2.0 mm) of the entire CTO, including the proximal and distal caps and the CTO body. Aims: The aim of this study is to compare the outcomes of repeat CTO PCI between patients who underwent lesion modification during the initial failed procedure and those who did not. Methods: We analyzed the associati...
Abstract
JMIR medical informatics,
Volume 13, 10 2 2025, Pages e71994
Evaluation of Machine Learning Model Performance in Diabetic Foot Ulcer: Retrospective Cohort Study.
van Velze VY, Burger HL, van der Steenhoven TJ, Al-Ers H, Goncalves LN, Eefting D, de Jong WJ, Smeets HJ, Welleweerd JCS, van der Vorst JR, Uchtmann S, Rissmann R, Hamming JF, Stergioulas L, van der Bogt KE
Background: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and severe outcomes, providing an ideal example for a comprehensive framework that encompasses all essential steps for implementing ML in a clinically relevant fashion. Objective: This paper aims to provide a framework for the proper use of ML algorithms t...
Abstract
American journal of physiology. Heart and circulatory physiology,
10 2 2025
Bone Morphogenetic Protein 10: Clinical Correlates and Risk of Incident Atrial Fibrillation.
Suthahar N, Yap SC, de Vries AAF, Damman K, Fabritz L, Bakker SJL, Gansevoort RT, Kirchhof P, Rienstra M, de Boer RA
Background: Bone morphogenetic protein-10 (BMP10), a protein predominantly secreted by atrial cardiomyocytes, has emerged as a promising biomarker in patients with atrial fibrillation (AF) and as a marker of atrial stress in patients with heart failure. Its clinical correlates in community-dwelling adults and its association with incident AF remain unexplored. Methods and Results: BMP10 was measured in 5883 participants from the PREVEND community-based cohort (mean age 53.6 years; 51.5% females)...
Abstract
Journal of clinical microbiology,
9 2 2025, Pages e0027225
<i>In vitro</i> activity of antibiotic monotherapy and combination therapy with bacteriophages against <i>Staphylococcus aureus</i> LVAD-driveline infections.
Molendijk MM, Verkaik NJ, de Vogel CP, Lemmens-den Toom N, Knight GM, Caliskan K, Bode LGM, Verbon A, Koopmans MPG, de Graaf M, van Wamel WJB
Left-ventricular assist devices (LVADs) are increasingly used as a bridge to heart transplantation and destination therapy. These devices, especially the driveline, are susceptible to difficult-to-treat infections, associated with high morbidity and mortality rates. Staphylococcus aureus (S. aureus) is a major causative pathogen of LVAD infections. Antibiotic resistance and biofilm formation can complicate the treatment of these infections. A novel in vitro assay was developed to study the antib...
Abstract
Biological research for nursing,
8 2 2025, Pages 10998004251385121
Effect of Infant Massage in Neonates With Hyperbilirubinemia Receiving Phototherapy: A Systematic Review and Meta-Analysis.
Erçelik ZE, Yilmaz DA
Most infants are diagnosed with hyperbilirubinemia in the first day of life. Although phototherapy is the most common treatment used in hyperbilirubinemia, different alternative therapies such as massage are also used. This systematic review and meta-analysis was designed to evaluate the effect of massage on serum bilirubin levels, defecation frequency, and length of hospital stay in neonates with hyperbilirubinemia receiving phototherapy. A review of randomized controlled trials published in En...
Abstract
Journal of cardiovascular computed tomography,
8 2 2025, Pages S1934-5925(25)00442-3
Incremental value of a CCTA-derived AI-based ischemia algorithm over standard CCTA interpretation of predicting myocardial ischemia in patients with suspected coronary artery disease.
Nabeta T, Bär S, Maaniitty T, Kärpijoki H, Bax JJ, Saraste A, Knuuti J
Background: A novel artificial intelligence-guided quantitative computed tomography ischemia algorithm (AI-QCTischemia) comprises a machine-learned method using atherosclerosis and vascular morphology features from coronary computed tomography angiography (CCTA) images to predict myocardial ischemia. This study evaluates the diagnostic performance of AI-QCTischemia compared to standard CCTA interpretation in detecting myocardial ischemia. Methods and results: Patients with suspected coronary art...
Abstract
Endocrine connections,
Volume 14, Issue 10, 6 1 2025, Pages e250400
Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism.
Zhang JLH, Schepers A, Hamming JF, Osman L, Webb SM, Welling L, Winter EM, Snel M, Appelman-Dijkstra NM
Background: Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challenging to quantify. While parathyroidectomy (PTx) recently has been recommended for asymptomatic patients, its benefit remains unclear as existing evidence relies on generic health-related quality of life (HRQoL) tools. In contrast, the disease-specific PHPQoL questionnaire offers more sensitive and clinically relevant symptom assessment. This study aims to t...
Abstract
Annals of vascular surgery,
6 1 2025, Pages S0890-5096(25)00655-7
Prediction of wound healing following amputation surgery based on near-infrared fluorescence with indocyanine green.
Kruiswijk MW, Peul RC, Tange FP, Koning S, van der Aa LE, Eefting D, van der Bogt KEA, van den Hoven P, van der Vorst JR, Vascular Fluorescence group
Objectives: The objective of this study was to evaluate the predictive value of near-infrared (NIR) fluorescence imaging with indocyanine on wound-healing complications within six weeks after lower-extremity amputation. Methods: In this dual-centre cohort study, patients undergoing minor (below-ankle) or major (above-ankle) amputations due to PAD or diabetes mellitus, with perfusion assessment performed using ICG NIR fluorescence imaging, were included. Fluorescence videos were recorded using st...
Abstract
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery,
2 1 2025
Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy.
van Dijk SPJ, Maas CCHM, Alshangi A, van Driel MHE, Feitsma EA, van Kinschot CMJ, Lončar I, van Noord C, Koppert LB, Kruijff S, van Klaveren D, Verhoef C, Peeters RP, van Ginhoven TM, Hypoparathyroidism Study Group of the Thyroid Network
Background: The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy. Methods: This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals. Results: Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after...
Abstract
Frontiers in digital health,
Volume 7, 1 1 2025, Pages 1528860
Content evaluation of the inclusive eHealth guide: how to develop interventions for people with a lower socioeconomic position?
Al-Dhahir I, Breeman LD, Faber JS, Wentzel J, van den Berg-Emons RJG, Kraal JJ, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM
Objectives: eHealth interventions favor those with higher socio-economic positions (SEPs). This can widen disparities, as people with lower SEPs may lack resources and face digital or financial barriers, making tailored solutions necessary. This study evaluates professionals' perceptions of the Inclusive eHealth Guide (IeG) regarding its content. The aim was to ensure it meets the needs of professionals and the targeted lower SEP demographic, thereby enhancing the effectiveness of eHealth i...
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