Research

Publications

Below you can find a list of our published research.

9618 results

Leukemia & lymphoma, Volume 63, Issue 11, 14 2 2022, Pages 2663-2670 Solving coagulation conundrums: comparing prophylaxis strategies in adult patients receiving PEG-asparaginase. Chen Y, Buhlinger K, Perissinotti AJ, Schepers AJ, Benitez L, Auten J, Chen SL, Bixby DL, Burke PW, Pettit KM, Marini BL

PEG-asparaginase is a key component in treatment regimens for acute lymphoblastic leukemia (ALL). Major side effects include thrombosis and bleeding; however, there is currently no consensus on methods to prevent these complications. In this multi-center retrospective cohort study of 101 adults, we compared two prophylaxis strategies: cryoprecipitate and fresh frozen plasma (Cryo/FFP) versus cryoprecipitate and antithrombin (ATIII). The overall incidence of venous thromboembolism (VTE) was not s... Abstract

Cited 6 times since 2022 (1.9 per year) source: EuropePMC

Journal of vascular surgery, Volume 76, Issue 5, 13 2 2022, Pages 1261-1269 Identifying high risk for proximal endograft failure after endovascular aneurysm repair in patients suitable for both open and endovascular elective aneurysm repair. van Schaik TG, Meekel JP, de Bruin JL, Yeung KK, Blankensteijn JD, DREAM-trial collaborators

Objective: Proximal endograft failure (type Ia endoleak or migration) after endovascular aneurysm repair (EVAR) is associated with hostile aneurysm neck morphology. Neck scoring systems were developed to predict proximal endograft failure but were studied in retrospective studies, which, due to selection bias, may have led to an overestimation of bad outcomes after EVAR. To predict patients who benefit from open repair, preoperative neck morphology and occurrence of long-term proximal endograft... Abstract

Cited 8 times since 2022 (2.5 per year) source: EuropePMC

Journal of biotechnology, Volume 354, 11 2 2022, Pages 10-20 SELEX against whole-cell bacteria resulted in lipopolysaccharide binding aptamers. Yılmaz D, Muslu T, Parlar A, Kurt H, Yüce M

Nucleic acid aptamers are target-specific oligonucleotides selected from combinatorial libraries through an iterative in vitro screening process known as Systemic Evolution of Ligands by Exponential Enrichment (SELEX). In this report, the selection of bacteria differentiating ssDNA aptamer candidates from a combinatorial library through the whole-cell SELEX method was performed. The enriched SELEX pool was sequenced using Illumina Next-Generation Sequencing (NGS) technology and analyzed for the... Abstract

Cited 5 times since 2022 (1.6 per year) source: EuropePMC

The American journal of emergency medicine, Volume 59, 9 2 2022, Pages 133-140 COVID-19 Disease in Presenting to the Pediatric Emergency Department: A Multicenter Study of 8886 Cases. Duman M, Şık N, Tekşam Ö, Akça H, Kurt F, Çağlar AA, Yıldız LA, Taşar MA, Fidancı İ, Yayla BCC, Yılmaz D, Güngör E, Demir Ş, Çokuğraş H, Cebeci SO, Önal P, Saz EU, Yurtseven A, Uysalol M, Yıldız R, Gümüş S, Bal A, Bayturan SŞ, Zengin N, Atik S, Çiftdoğan DY, Berksoy E, Çiçek A, Şahin S, Kızıl MC, Kara Y, Apa H, Ulusoy E, Kara AA, Yesil E, Erdem M, Turan C, Arslanoglu S, Duyu M, Besli GE, Arslan G, Oflu AT, Çeleğen M, Buldu E, Pişkin İE, Kardeş H, Yılmaz HL, Yıldızdaş D, Gökulu G, Çay P, Özer U, Güleryüz OD, Çolak Ö, Güneysu ST

Background: The aim was to evaluate the epidemiological, clinical, laboratory, and radiologic data of children with SARS-CoV-2 positivity by polymerase chain reaction (PCR) together with treatment strategies and clinical outcomes and to evaluate cases of multisystem inflammatory syndrome in children (MIS-C) in this population. Methods: This was a multicenter retrospective observational cohort study performed in the pediatric emergency departments of 19 tertiary hospitals. From March 11, 2020, to... Abstract

Cited 4 times since 2022 (1.3 per year) source: EuropePMC

The American journal of cardiology, Volume 177, 9 2 2022, Pages 90-99 Prognostic Implications of Change in Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation. Kuneman JH, Butcher SC, Singh GK, Wang X, Hirasawa K, van der Kley F, Leon MB, Knuuti J, Pibarot P, Ajmone Marsan N, Delgado V, Bax JJ

Reduced left ventricular (LV) systolic function is associated with worse prognosis in patients with severe aortic stenosis (AS) treated with transcatheter aortic valve implantation (TAVI). We aimed to examine the changes in left ventricular ejection fraction (LVEF) after TAVI among patients with varying baseline LVEF. Moreover, variables associated with lack of LVEF improvement were identified and the association with long-term outcomes was investigated. A total of 560 patients (age 80 ± 7 years... Abstract

Cited 32 times since 2022 (10 per year) source: EuropePMC

The American journal of cardiology, Volume 177, 9 2 2022, Pages 151-161 Right Ventricular Myocardial Work Characterization in Patients With Pulmonary Hypertension and Relation to Invasive Hemodynamic Parameters and Outcomes. Butcher SC, Feloukidis C, Kamperidis V, Yedidya I, Stassen J, Fortuni F, Vrana E, Mouratoglou SA, Boutou A, Giannakoulas G, Playford D, Ajmone Marsan N, Bax JJ, Delgado V

Noninvasive evaluation of indexes of right ventricular (RV) myocardial work (RVMW) derived from RV pressure-strain loops may provide novel insights into RV function in precapillary pulmonary hypertension. This study was designed to evaluate the association between the indexes of RVMW and invasive parameters of right heart catheterization and all-cause mortality. Noninvasive analysis of RVMW was completed in 51 patients (mean age 58.1 ± 12.7 years, 31% men) with group I or group IV pulmonary hype... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

Clinical cardiology, Volume 45, Issue 8, 8 2 2022, Pages 873-881 Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease. Won KB, Park HB, Heo R, Lee BK, Lin FY, Hadamitzky M, Kim YJ, Sung JM, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, Gonçalves PA, Leipsic JA, Lee SE, Shin S, Choi JH, Virmani R, Samady H, Chinnaiyan K, Berman DS, Narula J, Bax JJ, Min JK, Chang HJ

Background: Atherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain ) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease. Hypothesis: Normal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease. Methods: We analyzed 95 adults (56... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

Structural heart : the journal of the Heart Team, Volume 6, Issue 3, 8 2 2022, Pages 100042 Sex-Related Differences in Medically Treated Moderate Aortic Stenosis. Stassen J, Pio SM, Ewe SH, Amanullah MR, Hirasawa K, Butcher SC, Singh GK, Sin KYK, Ding ZP, Chew NWS, Sia CH, Kong WKF, Poh KK, Cohen DJ, Généreux P, Leon MB, Marsan NA, Delgado V, Bax JJ

Background: Recent data showed poor long-term survival in patients with moderate AS. Although sex differences in left ventricular (LV) remodeling and outcome are well described in severe AS, it has not been evaluated in moderate AS. Methods: In this retrospective, multicenter study, patients with a first diagnosis of moderate AS diagnosed between 2001 and 2019 were identified. Clinical and echocardiographic parameters were recorded at baseline and compared between men and women. Patients were fo... Abstract

Cited 35 times since 2022 (10.9 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 7, 1 1 2022, Pages 885-897 The dysfunctional right ventricle: the importance of multi-modality imaging. Surkova E, Cosyns B, Gerber B, Gimelli A, La Gerche A, Ajmone Marsan N

Assessment of right ventricular (RV) function is crucial for the evaluation of the dyspnoeic patient and/or with systemic venous congestion and provides powerful prognostic insights. It can be performed using different imaging modalities including standard and advanced echocardiographic techniques, cardiac magnetic resonance imaging, computed tomography, and radionuclide techniques, which should be used in a complementary fashion. Each modality has strengths and weaknesses based on which the cho... Abstract

Cited 218 times since 2022 (67.7 per year) source: EuropePMC

JAMA, Volume 327, Issue 23, 1 1 2022, Pages 2296-2305 Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The DECAAF II Randomized Clinical Trial. Marrouche NF, Wazni O, McGann C, Greene T, Dean JM, Dagher L, Kholmovski E, Mansour M, Marchlinski F, Wilber D, Hindricks G, Mahnkopf C, Wells D, Jais P, Sanders P, Brachmann J, Bax JJ, Morrison-de Boer L, Deneke T, Calkins H, Sohns C, Akoum N, DECAAF II Investigators

Importance: Ablation of persistent atrial fibrillation (AF) remains a challenge. Left atrial fibrosis plays an important role in the pathophysiology of AF and has been associated with poor procedural outcomes. Objective: To investigate the efficacy and adverse events of targeting atrial fibrosis detected on magnetic resonance imaging (MRI) in reducing atrial arrhythmia recurrence in persistent AF. Design, setting, and participants: The Efficacy of Delayed Enhancement-MRI-Guided Fibrosis Ablation... Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 6, 1 1 2022, Pages 765-766 Optimization of guideline-directed medical treatment to reduce secondary mitral regurgitation: treat the ventricle, not only the valve. Stassen J, van der Bijl P, Bax JJ

Abstract

Cited 2 times since 2022 (0.6 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 34, Issue 6, 1 1 2022, Pages 990-998 Long-term follow-up of thoracoscopic ablation in long-standing persistent atrial fibrillation. Harlaar N, Oudeman MA, Trines SA, de Ruiter GS, Mertens BJ, Khan M, Klautz RJM, Zeppenfeld K, Zeppenfeld K, Tjon A, Braun J, van Brakel TJ

Objectives: Catheter ablation of long-standing persistent atrial fibrillation (LSPAF) remains challenging, with suboptimal success rates obtained following multiple procedures. Thoracoscopic ablation has shown effective at creating transmural lesions around the pulmonary veins and box; however, long-term rhythm follow-up data are lacking. This study aims, for the first time, to assess the long-term outcomes of thoracoscopic pulmonary vein and box ablation in LSPAF. Methods: Rhythm follow-up cons... Abstract

Asian Pacific journal of cancer prevention : APJCP, Volume 23, Issue 6, 1 1 2022, Pages 1913-1920 Microscopic Evaluation of Ovarian Surface Epithelium Following Treatment with Conjugated Estrogens in a Mouse Model. Al-Amri IS, Kadim IT, Al-Kindi AA, Khalaf SK, Al-Harrasi AS, Al-Hashmi SA, Al-Shibli AA, Al-Hadi WM, Al-Mahimuli MK, Jamshidi-Adegani F, Vakilian S, Al-Amri AI, Al-Yaqoobi SS, Al-Riyami KO

Background: This study was designed to evaluate the effect of different concentrations of conjugated equine estrogens (CEE) on the ovarian epithelium of female CD1 mice. Methods: Twenty-four female mice at 7 months with irregular estrus cycles were randomly divided into four groups of 6 mice each. Group one was considered as a control group and received a daily dose of 0.5ml of propylene glycol, for three weeks, while those in the treatment groups received a daily dose of 14μg/kg, 28μg/kg and 56... Abstract

Cited 10 times since 2022 (3.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 6, 1 1 2022, Pages 730-740 Clinical implications of left atrial reverse remodelling after cardiac resynchronization therapy. Stassen J, Galloo X, Chimed S, Hirasawa K, Marsan NA, Delgado V, van der Bijl P, Bax JJ

Aims: Left atrial (LA) function is a marker of prognosis in patients with heart failure. The prognostic implications of an improvement in LA function in addition to an improvement in left ventricular (LV) function after cardiac resynchronization therapy (CRT) implantation are unknown. This study aimed to evaluate the prognostic value of a significant change in LA reservoir strain (RS) and/or LV global longitudinal strain (GLS) after initiation of CRT. Methods and results: LARS and LVGLS were mea... Abstract

Cited 9 times since 2022 (2.8 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 6, 1 1 2022, Pages 781-789 Sex differences in left ventricular remodelling in patients with severe aortic valve stenosis. Kuneman JH, Singh GK, Milhorini Pio S, Hirasawa K, Hautemann D, van der Kley F, Ajmone Marsan N, Knuuti J, Delgado V, Bax JJ

Aims: Women with severe aortic stenosis (AS) have better long-term outcome after transcatheter aortic valve implantation (TAVI) but worse survival after surgical aortic valve replacement compared with men. Whether this is related to sex differences in left ventricular (LV) remodelling is unknown. The aim of this study was to examine the sex differences in LV remodelling with multidetector row computed tomography (MDCT) and outcome in patients with severe AS undergoing TAVI between 2007 and 2018.... Abstract

Studies in health technology and informatics, Volume 290, 1 1 2022, Pages 804-808 Expanding Access to CNS-TAP: Design, Development, and Initial Use of a Complex Precision Health Specialty Web App for Neuro-Oncology. Ravi K, Meng G, Roberts HJ, Schepers A, Franson A, Koschmann C, Marini BL, Flynn A

This paper offers a case study to demonstrate how a complex scoring model tool called CNS-TAP, originally created by a neuro-oncology team at one institution, was upgraded and made accessible to a wider audience. In the Results and Discussion, many issues of web app design, development, and sustainability are covered. Overall, we chart a path to expand access to many unique software tools created and needed by today's medical specialists. Abstract

Cited 10 times since 2022 (3.1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 1, 1 1 2022, Pages ezab478 Extracardiac conduit adequacy along the respiratory cycle in adolescent Fontan patients. Rijnberg FM, van der Woude SFS, Hazekamp MG, van den Boogaard PJ, Lamb HJ, Terol Espinosa de Los Monteros C, Kroft LJM, Kenjeres S, Karim T, Jongbloed MRM, Westenberg JJM, Wentzel JJ, Roest AAW

Objectives: Adequacy of 16-20mm extracardiac conduits for adolescent Fontan patients remains unknown. This study aims to evaluate conduit adequacy using the inferior vena cava (IVC)-conduit velocity mismatch factor along the respiratory cycle. Methods: Real-time 2D flow MRI was prospectively acquired in 50 extracardiac (16-20mm conduits) Fontan patients (mean age 16.9 ± 4.5 years) at the subhepatic IVC, conduit and superior vena cava. Hepatic venous flow was determined by subtracting IVC flow fr... Abstract

Chest, Volume 161, Issue 6, 1 1 2022, Pages e355-e358 A 79-Year-Old Woman With Advanced Lung Carcinoma and Bilateral Infiltrates. Jager EC, de Boer WS, van Schaik ML, Tomlow B

Case presentation: A 79-year-old woman was admitted to the hospital for progressive dyspnea and severe hypoxemia, requiring oxygen supplementation. The dyspnea started approximately 3 to 4 weeks before presentation and was slowly progressive throughout the following weeks. Her medical history mentioned an adenocarcinoma with an epidermal growth factor receptor (EGFR) exon 19 deletion of the lung with metastases to the bones and brain for which treatment with osimertinib was started 14 months ear... Abstract

Cited 38 times since 2022 (11.8 per year) source: EuropePMC

Current biology : CB, Volume 32, Issue 12, 1 1 2022, Pages R697-R708 The economics of brain size evolution in vertebrates. Heldstab SA, Isler K, Graber SM, Schuppli C, van Schaik CP

Across the animal kingdom, we see remarkable variation in brain size. This variation has even increased over evolutionary time. Traditionally, studies aiming to explain brain size evolution have looked at the fitness benefits of increased brain size in relation to its increased cognitive performance in the social and/or ecological domain. However, brains are among the most energetically expensive tissues in the body and also require an uninterrupted energy supply. If not compensated, these energ... Abstract

Cited 16 times since 2022 (5 per year) source: EuropePMC

Brain : a journal of neurology, Volume 145, Issue 5, 1 1 2022, Pages 1641-1652 Withdrawal of intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy. Adrichem ME, Lucke IM, Vrancken AFJE, Goedee HS, Wieske L, Dijkgraaf MGW, Voermans NC, Notermans NC, Faber CG, Visser LH, Kuitwaard K, van Doorn PA, Merkies ISJ, de Haan RJ, van Schaik IN, Eftimov F

Intravenous immunoglobulins are an efficacious treatment for chronic inflammatory demyelinating polyradiculoneuropathy. Biomarkers for disease activity are lacking, making the need for ongoing treatment difficult to assess, leading to potential overtreatment and high health-care costs. Our objective was to determine whether intravenous immunoglobulin withdrawal is non-inferior to continuing intravenous immunoglobulin treatment and to determine how often patients are overtreated. We performed a r... Abstract