6190 results
European journal of heart failure,
25 4 2025
Heart failure in patients with a systemic right ventricle: A multicentre study with long-term follow-up.
Ansari Ramandi MM, Budts W, Roos-Hesselink JW, Helbing WA, Egorova AD, Bouma BJ, Duijnhouwer A, van Kimmenade R, Sieswerda GT, Konings TC, Wagenaar LJ, Ubachs JFA, Berger RMF, Hoendermis ES, Voors AA, van Melle JP
Aims: Adult patients with transposition of the great arteries (TGA) and an systemic right ventricle (sRV) are at risk for heart failure (HF). In this study, we investigated risk factors for HF hospitalization and developed a novel risk stratification tool to optimize risk prediction for clinical practice. Methods and results: In this international multicentre study, 522 patients with TGA and an sRV, without history of HF hospitalization, were followed retrospectively for a median of 17.9 years (...
Abstract
eLife,
Volume 13, 25 4 2025, Pages RP99116
Major nuclear locales define nuclear genome organization and function beyond A and B compartments.
Gholamalamdari O, van Schaik T, Wang Y, Kumar P, Zhang L, Zhang Y, Gonzalez GAH, Vouzas AE, Zhao PA, Gilbert DM, Ma J, van Steensel B, Belmont AS
Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here, we integrated analysis of sequencing and image-based data to compare genome organization in four human cell types relative to three different nuclear locales: the nuclear lamina, nuclear speckles, and nucleoli. Although gene expression correlates mostly with nuclear speckle proximity, DNA replication timing correlates with proximity to multip...
Abstract
Cardiology and therapy,
23 4 2025
Defibrillation Threshold Testing After ICD Implantation in Patients with Chronic Kidney Disease.
Timal RJ, Osman L, Rotmans JI, Bootsma M, Mertens B, Schalij MJ, Rabelink TJ, Jukema JW
Introduction: Routine defibrillation threshold (DFT) testing at the time of implantable cardioverter-defibrillator (ICD) implantation is no longer recommended because testing did not improve shock efficacy or reduce arrhythmic death. However, patients with severe chronic kidney disease (CKD) were not included in these trials and might benefit from DFT testing. International guidelines shed no light on the subject of the effect of kidney function on DFT testing in patients with CKD. Methods: In t...
Abstract
The international journal of cardiovascular imaging,
22 4 2025
Plaque burden improves the detection of ischemic CAD over stenosis from coronary computed tomography angiography.
Kero T, Bär S, Saraste A, Klén R, Bax JJ, Knuuti J, Maaniitty T
In symptomatic patients undergoing coronary CTA for suspected coronary artery disease (CAD), we assessed if quantification of plaque burden, in addition to luminal narrowing and clinical risk factors, offers incremental value for the identification of ischemic CAD on a per patient level. We evaluated 2145 patients who underwent coronary CTA for suspected CAD with sequential selective downstream 15O-water positron emission tomography (PET) myocardial perfusion imaging. Coronary CTA scans were ana...
Abstract
Rheumatology advances in practice,
Volume 9, Issue 2, 18 3 2025, Pages rkae155
Improving efficiency of a rheumatology outpatient clinic through classification of newly referred patients.
Dijkstra S, de Man YA, Braaksma A, de Graaf M, Bernelot Moens HJ, Boucherie RJ
Objectives: Diagnosing a rheumatological disease in patients newly referred by their general practitioner requires assessment by a rheumatologist and often diagnostic tests. Ideally, these tests are performed prior to the patient's first consultation with the rheumatologist, aiming for quick diagnosis and fewer visits. We retrospectively studied whether a pre-first visit digital patient questionnaire can lead to fewer consultations and faster diagnosis. Methods: We applied machine learning-...
Abstract
JACC. Advances,
Volume 4, Issue 5, 18 3 2025, Pages 101728
Investigating the Anrep Effect in Hypertrophic Obstructive Cardiomyopathy With Invasive Pressure-Volume Analysis.
Reil JC, Sequeira V, Reil GH, Scholtz S, Rudolph V, Maack C, Serruys P, Steendijk P
The Anrep effect, an adaptation enhancing left ventricular (LV) contractility in response to raised afterload, is hypothesized to influence hypertrophic cardiomyopathy pathophysiology. This study investigated the activation and reversibility of the Anrep effect in obstructive hypertrophic cardiomyopathy (HOCM) patients undergoing percutaneous transluminal septal myocardial ablation (PTSMA) to relieve LV outflow tract obstruction. Invasive pressure-volume (PV) analysis was performed on 14 HOCM pa...
Abstract
Heart rhythm,
17 3 2025, Pages S1547-5271(25)02342-2
Visualization of Acute Atrial Injury Post-Ablation Using Contrast-Enhanced T1-Weighted Short Inversion Time Cardiac Magnetic Resonance Imaging.
van Pouderoijen N, Hopman LHGA, Escartin T, Sheagren C, van Rosendael PJ, Allaart CP, Hofman MBM, Wright GA, Götte MJW
Abstract
European heart journal. Cardiovascular Imaging,
17 3 2025, Pages jeaf121
Derivation and Validation of an Artificial Intelligence-Based Plaque Burden Safety Cut-Off for Long-Term Acute Coronary Syndrome from Coronary Computed Tomography Angiography.
Bär S, Knuuti J, Saraste A, Klén R, Kero T, Nabeta T, Bax JJ, Danad I, Nurmohamed NS, Jukema RA, Knaapen P, Maaniitty T
Aims: Artificial intelligence (AI) has enabled accurate and fast plaque quantification from coronary computed tomography angiography (CCTA). However, AI detects any coronary plaque in up to 97% of patients. To avoid overdiagnosis, a plaque burden safety cut-off for future coronary events is needed. Methods and results: Percent atheroma volume (PAV) was quantified with artificial intelligence-guided quantitative computed tomography (AI-QCT) in a blinded fashion. Safety cut-off derivation was perf...
Abstract
Cancers,
Volume 17, Issue 8, 17 3 2025, Pages 1352
Molecular-Targeted Fluorescence Lymph Node Imaging Could Play a Clinical Role in the Surgical Setting: A Systematic Review.
Zweedijk BE, Dalmeijer SWR, van Manen L, Galema HA, Lauwerends LJ, Abbasi H, Kremer B, Verhoef C, Robinson DJ, Koppes SA, Vahrmeijer AL, van der Vorst JR, Hilling DE, Keereweer S
The lymphatic system plays a crucial role in the spread of solid tumors and is often the first site of metastasis, as cancer cells typically invade nearby lymph nodes (LN) before potentially spreading to other LNs through the lymphatic system and distant organs through the bloodstream [...].
Abstract
European urology focus,
16 3 2025, Pages S2405-4569(25)00074-4
External Urinary Devices for Stress Urinary Incontinence: Does One Size Fit All?
Cobussen-Boekhorst H, van Benthum-van Ooijen N, Janssen V, Schuurmans C
Both males and females can be effected by stress urinary incontinence (SUI), with symptoms ranging from mild to severe. External urinary devices (EUDs) can help in managing incontinence in daily life and thus improve quality of life. EUDs include absorbent products, female external catheters, male external catheters/sheaths, and penile compression devices/clamps. To address the needs of individual patient, a shared decision-making process is essential, with the involvement of health care profess...
Abstract
Digestive diseases and sciences,
16 3 2025
Obesity Is Associated with Inferior Clinical Treatment Outcomes in Inflammatory Bowel Disease: A Nationwide Dutch Registry Study.
Oomkens D, Mujagic Z, de Vries A, van der Meulen-de Jong A, Straatmijer T, Löwenberg M, van der Marel S, West R, Bodelier A, van Schaik F, Visschedijk M, Duijvestein M, Initiative on Crohn and Colitis (ICC)
Purpose: To examine the impact of obesity on treatment outcomes in inflammatory bowel disease (IBD). Methods: Patients aged ≥ 16 years, with IBD, a documented baseline body mass index (BMI), and starting thiopurines and allopurinol, intravenous (iv) vedolizumab, subcutaneous (sc) vedolizumab, ustekinumab, ozanimod, filgotinib, or tofacitinib were selected from the Dutch Initiative on Crohn and Colitis (ICC) registry. Underweight patients (BMI
Abstract
Cardiovascular drugs and therapy,
14 2 2025
Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY).
S Ramos K, Nassiri S, Wijdeveld LFJ, van der Palen RL, Kuipers MF, Hills MT, Slijkerman P, van Raalte DH, Handoko ML, de Groot NMS, Grewal N, Klautz RJM, Eringa EC, Brundel BJJM
Purpose: Interestingly, 30-50% of patients undergoing elective cardiothoracic surgery develop postoperative AF (PoAF). Unfortunately, preventive PoAF therapy is still suboptimal. In our previous studies, we showed that oral Geranylgeranylacetone (GGA) administration increased cardioprotective heat shock protein (HSP) protecting against AF onset and progression in clinically relevant animal model studies. Methods: The GENIALITY study is a phase II single-center, double-blind, placebo-controlled r...
Abstract
International journal of cardiology,
Volume 432, 11 2 2025, Pages 133269
Early aortic valve replacement versus conservative management in asymptomatic severe aortic stenosis: Meta-analysis of time-to-event data of randomized controlled trials.
Jacquemyn X, Sá MP, Marín-Cuartas M, Bax JJ, Borger MA, Clavel MA, Pibarot P, Généreux P, Sultan I
Background: Current guidelines recommend aortic valve replacement (AVR) for symptomatic patients with severe aortic stenosis (AS), but the optimal timing for intervention in asymptomatic patients is still debated. Recent randomized controlled trials (RCTs) have offered new insights, prompting a reevaluation of the potential benefits of early AVR. Methods: A systematic review and pooled meta-analysis of Kaplan-Meier-derived reconstructed time-to-event data of RCTs published by November 2024 was c...
Abstract
JACC. Cardiovascular imaging,
10 2 2025, Pages S1936-878X(25)00130-5
Prognostic Time Frame of Plaque and Hemodynamic Characteristics and Integrative Risk Prediction for Acute Coronary Syndrome.
Yang S, Jung JW, Park SH, Zhang J, Lee K, Hwang D, Lee KS, Na SH, Doh JH, Nam CW, Kim TH, Shin ES, Chun EJ, Choi SY, Kim HK, Hong YJ, Park HJ, Kim SY, Husic M, Lambrechtsen J, Jensen JM, Nørgaard BL, Andreini D, Maurovich-Horvat P, Merkely B, Penicka M, de Bruyne B, Ihdayhid A, Ko B, Tzimas G, Leipsic J, Sanz J, Rabbat MG, Katchi F, Shah M, Tanaka N, Nakazato R, Asano T, Terashima M, Takashima H, Amano T, Sobue Y, Matsuo H, Otake H, Kubo T, Takahata M, Akasaka T, Kido T, Mochizuki T, Yokoi H, Okonogi T, Kawasaki T, Nakao K, Sakamoto T, Yonetsu T, Kakuta T, Yamauchi Y, Taylor CA, Bax JJ, Shaw LJ, Stone PH, Narula J, Koo BK
Background: The relevant time frame for predicting future acute coronary syndrome (ACS) based on coronary lesion characteristics remains uncertain. Objectives: The aim of this study was to investigate the association of lesion characteristics with test-to-event time and their prognostic impact on ACS. Methods: The EMERALD II (Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II) study analyzed 351 patients who unde...
Abstract
European journal of preventive cardiology,
9 2 2025, Pages zwaf193
Lifestyle behaviour change of patients following cardiac rehabilitation: the BENEFIT intervention study with one-year follow-up.
Breeman LD, Janssen VR, Kraaijenhagen RA, Al-Dhahir I, IJzerman RVH, Wolstencroft K, Kraaij W, Bonten TN, Atsma DE, Chavannes NH, van Gemert-Pijnen L, Kemps HMC, Scholte Op Reimer W, Evers AWM
Background: The majority of people with cardiovascular disease (CVD) do not maintain a healthy lifestyle. To help patients implement behaviour change at home, the BENEFIT programme was developed as an addition to cardiac rehabilitation (CR) care. Methods: Using a cluster non-randomised controlled trial design involving 7 CR centres, we examined whether intervention group patients (n=587) showed increased improvements in health behaviour change compared to control group patients (n=298) who (only...
Abstract
Circulation,
Volume 151, Issue 14, 7 1 2025, Pages 1047-1050
Relation of Low-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Lipoprotein(a) Each to Future Cardiovascular Events and Death After Acute Coronary Syndrome on High-Intensity Statin Therapy: An Analysis of the Placebo Arm of ODYSSEY OUTCOMES.
Steg PG, Szarek M, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators
Abstract
Journal of cardiovascular development and disease,
Volume 12, Issue 4, 7 1 2025, Pages 140
Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms.
Bacour N, Theijsse RT, Grewal S, Klautz RJM, Grewal N
(1) Background: Thoracic aortic aneurysms (TAAs) pose critical health risks and are often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasizing the importance of early detection and intervention. Despite established clinical risk factors for the early detection of TAAs, the influence of racial disparities on TAAs remains underexplored. This study aims to provide a comprehensive summary of existing...
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
3 1 2025
Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results.
van der Gang LF, Atash K, Zuithoff NPA, Haeck I, Boesjes CM, Bacoş-Cosma OI, Loman L, Kamsteeg M, Stadhouders-Keet S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynksi A, Berntsen-Zandbergen L, Christoffers WA, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, de Graaf M, Schuttelaar MA, de Bruin-Weller MS
Background: Limited data exist on the comparative risk of infections during biologic and Janus kinase inhibitor (JAKi) treatment for atopic dermatitis (AD) in daily practice. Objective: To assess the differential infection risk of biologic and JAKi treatment in patients with moderate-to-severe AD in a real-world setting. Methods: This prospective, multicentre study evaluated treatment-emergent infections in patients (age ≥ 12 years) using biologics or JAKi from the BioDay registry from October 2...
Abstract
Atherosclerosis,
Volume 404, 3 1 2025, Pages 119184
Sex related coronary plaque progression patterns among patients with family history as the sole cardiovascular risk factor: A PARADIGM sub-study.
Conte E, Lee SE, Chang HJ, Hadamitzky M, Kim YJ, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Di Lenarda F, Guarnieri G, Leipsic JA, Shin S, Choi JH, Mouaz AM, Chinnaiyan K, Pedro AG, Sung JM, Virmani R, Samady H, Lin FY, Stone PH, Narula J, Shaw L, Bax JJ, Andreini D
Background and aims: How sex may influence the prevalence and progression of coronary atherosclerosis in patients with positive family history for CAD is still unclear. Aim of the present study was to explore the role of family history of CAD in coronary atherosclerosis expression and progression in male and female subjects. Methods: A total of 2252 patients who underwent clinically indicated serial CCTAs at an interscan interval of more than 2 years were enrolled in the PARADIGM Study. For the...
Abstract
European heart journal,
2 1 2025, Pages ehaf133
Transcatheter vs. surgical aortic valve replacement in women: the RHEIA trial.
Tchetche D, Pibarot P, Bax JJ, Bonaros N, Windecker S, Dumonteil N, Nietlispach F, Messika-Zeitoun D, Pocock SJ, Berthoumieu P, Swaans MJ, Timmers L, Rudolph TK, Bleiziffer S, Leroux L, Modine T, van der Kley F, Auffret V, Tomasi J, Stastny L, Hengstenberg C, Andreas M, Leclercq F, Gandet T, Mascherbauer J, Trescher K, Prendergast B, Vasa-Nicotera M, Chieffo A, Mares J, Wesselink W, Rakova R, Kurucova J, Bramlage P, Eltchaninoff H
Background and aims: Although women with severe symptomatic aortic stenosis have more complications than men when undergoing surgical valve replacement, they are under-represented in clinical trials. The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial investigates the balance of benefits and risks of transcatheter aortic valve implantation (TAVI) vs. surgery in women. Methods: Women were randomized 1:1 to transfemoral TAVI with a balloon-expandable valve or surgery. Th...
Abstract
