Research

Publications

Below you can find a list of our published research.

7365 results

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Cardiovascular research, Volume 118, Issue 15, 1 1 2022, Pages e105-e107 Conditional immortalization of human cardiomyocytes for translational in vitro modelling of cardiovascular disease. Harlaar N, Pijnappels DA, de Vries AAF

Abstract

Cited 5 times since 2022 (1.7 per year) source: EuropePMC

Medical education online, Volume 27, Issue 1, 1 1 2022, Pages 2016561 Publishing your scholarship: a survey of pearls from top reviewers. Jauregui J, Artino AR, Ilgen JS, Sullivan G, van Schaik SM

Experts have described ways to improve peer review quality. Perspectives from expert reviewers are largely absent in the health professions education literature. To gather guidance from expert reviewers, to aid authors striving to publish and reviewers aiming to perform their task effectively. This study surveyed the Journal of Graduate Medical Education (JGME) 'Top Reviewers' from 2017, 2018, and 2019. 'Top Reviewers' perform four or more reviews per year, with high average... Abstract

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Journal of clinical medicine, Volume 11, Issue 23, 1 1 2022, Pages 7147 The Predictive Power of the 14-51 Ng/L High Sensitive Troponin T (hsTnT) Values for Predicting Cardiac Revascularization in a Clinical Setting. De Jongh FW, Pouwels S, De Jongh MC, Dubois EA, van Schaik RHN

Background: high sensitive Troponin T (hsTnT) values between 14−50 ng/L represent a challenge in diagnosing acute coronary syndrome (ACS) at the Emergency Department (ED). The European Society for Cardiology (ESC) recommends a second hsTnT measurement 3 h later to distinguish between ACS and other causes depending on the Δ hsTnT. Our study aims to evaluate the predictive power this approach in a clinical setting by following patients presenting at the ED with hsTnT values 14−51 ng/L. Materials a... Abstract

Cited 18 times since 2022 (6.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 24, Issue 1, 1 1 2022, Pages 142-151 Prognostic value of left atrial reservoir function in patients with severe primary mitral regurgitation undergoing mitral valve repair. Stassen J, van Wijngaarden AL, Butcher SC, Palmen M, Herbots L, Bax JJ, Delgado V, Ajmone Marsan N

Aims: Mitral regurgitation (MR) has a significant haemodynamic impact on the left atrium. Assessment of left atrial reservoir strain (LARS) may have important prognostic implications, incremental to left atrial (LA) volume, and conventional parameters of left ventricular (LV) structure and function. This study investigated whether preoperative assessment of LARS by speckle tracking echocardiography is associated with long-term outcomes in patients undergoing mitral valve repair for severe primar... Abstract

Cited 16 times since 2022 (5.4 per year) source: EuropePMC

Omega, Volume 91, Issue 2, 1 1 2022, Pages 851-884 The Effect of the COVID-19 Pandemic on Grief Experiences of Bereaved Relatives: An Overview Review. van Schaik T, Brouwer MA, Knibbe NE, Knibbe HJJ, Teunissen SCCM

The COVID-19 pandemic has disrupted grief experiences of bereaved relatives and altered accustomed ways of coping with loss. To understand how bereaved relatives experienced grief during COVID-19, a review, using the overview method, was conducted. An overview of empirical data about this subject has been lacking and therefore, PubMed and CINAHL databases were searched for empirical studies published from January 1, 2020 until December 31, 2021. 28 articles were included in the review. Thematic... Abstract

Cited 13 times since 2022 (4.4 per year) source: EuropePMC

Rheumatology (Oxford, England), Volume 62, Issue 1, 1 1 2022, Pages 300-309 Ultrasound and MR muscle imaging in new onset idiopathic inflammatory myopathies at diagnosis and after treatment: a comparative pilot study. Walter AW, Lim J, Raaphorst J, Smithuis FF, den Harder JM, Eftimov F, Potters W, Saris CGJ, de Visser M, van Schaik IN, de Haan RJ, van der Kooi AJ, Verhamme C

Objectives: To prospectively compare ultrasound (US) and whole-body MRI for detection of muscle abnormalities compatible with idiopathic inflammatory myopathies (IIM). Methods: Newly diagnosed IIM patients underwent US (14 muscles) and MRI (36 muscles) at diagnosis and after nine weeks monotherapy with intravenous immunoglobulin. Muscles were compatible with IIM when quantitative US echo-intensity (EI) z scores was ≥1.5, semi-quantitative US Heckmatt score was ≥2, qualitative US was abnormal, or... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

Vascular biology (Bristol, England), Volume 4, Issue 1, 30 5 2022, Pages 40-49 No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice. Hibender S, Li S, Postma AV, Hoogeland ME, Klaver D, Pouw RB, Niessen HW, Driessen AH, Koolbergen DR, de Vries CJ, Baars MJ, Houweling AC, Krijnen PA, de Waard V

Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture. Upon whole genome sequencing of a Marfan family, we identified a complement gene C1R variant (p.Ser152Leu), which is associated with severe aortic patients. Therefore, we assessed the role of complement activation in MFS aortic tissue. Expression of various complement genes and pr... Abstract

Cited 8 times since 2022 (2.7 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 9, Issue 3, 30 5 2022, Pages 345-355 Importance of Systematic Diagnostic Testing in Idiopathic Ventricular Fibrillation: Results From the Dutch iVF Registry. Groeneveld SA, Verheul LM, van der Ree MH, Mulder BA, Scholten MF, Alings M, van der Voort P, Bootsma M, Evertz R, Balt JC, Yap SC, Doevendans PAFM, Postema PG, Wilde AAM, Volders PGA, Hassink RJ

Background: Idiopathic ventricular fibrillation (iVF) is a diagnosis of exclusion. Systematic diagnostic testing is important to exclude alternative causes for VF. The early use of "high yield" testing, including cardiac magnetic resonance (CMR), exercise testing, and sodium channel blocker provocation, has been increasingly recognized. Objectives: The purpose of this study was to investigate the importance and consistency of systematic diagnostic testing in iVF. Methods: This study in... Abstract

Cited 8 times since 2022 (2.7 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 65, Issue 3, 29 5 2022, Pages 348-357 Excess Mortality for Abdominal Aortic Aneurysms and the Potential of Strict Implementation of Cardiovascular Risk Management: A Multifaceted Study Integrating Meta-Analysis, National Registry, and PHAST and TEDY Trial Data. Tomee SM, Bulder RMA, Meijer CA, van Berkum I, Hinnen JW, Schoones JW, Golledge J, Bastiaannet E, Matsumura JS, Hamming JF, Hultgren R, Lindeman JH

Objective: Previous studies imply a profound residual mortality risk following successful abdominal aorta aneurysm (AAA) repair. This excess mortality is generally attributed to increased cardiovascular risk. The aim of this study was (1) to quantify the excess residual mortality for patients with AAA, (2) to evaluate the cross sectional level of cardiovascular risk management, and (3) to estimate the potential of optimised cardiovascular risk management to reduce the excess mortality in these p... Abstract

Cited 4 times since 2022 (1.3 per year) source: EuropePMC

Animals : an open access journal from MDPI, Volume 12, Issue 23, 29 5 2022, Pages 3344 Coverage and Representativeness of Passive Surveillance Components for Cattle and Swine in The Netherlands. Vredenberg I, van Schaik G, van der Poel WHM, Stegeman A

Common aims of animal health surveillance systems are the timely detection of emerging diseases and health status monitoring. This study aimed to evaluate the coverage and representativeness of passive surveillance components for cattle and swine in the Netherlands from 2015-2019. The passive surveillance components consisted of a telephone helpdesk for veterinary advice and diagnostic and postmortem facilities. Spatial analysis showed heterogeneity (range in RR = 0.26-5.37) of participation acr... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 31, Issue 5, 28 4 2022, Pages 177-180 Career perspectives for young cardiologists in the Netherlands: a steady increase in temporary positions. Vorselaars VMM, Minneboo M, Meijers WC, van der Heijden AC, Haroun D, Baggen VJM, Berger WR, van Hout GPJ

In the Netherlands, concerns have been raised regarding the high unemployment rates and the lack of permanent positions for young medical specialists. In the current study, we present data on contemporary early career perspectives in the field of cardiology. We conducted a survey among 304 young cardiologists who completed their training between 2015 and 2020; the response rate was 91%. Our analysis revealed a low unemployment rate (0.3%). One, 3 and 5 years after registration, 81%, 41% and 18%... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 28 4 2022, Pages 1-4 Career perspectives for young cardiologists in the Netherlands: a steady increase in temporary positions. Vorselaars VMM, Minneboo M, Meijers WC, van der Heijden AC, Haroun D, Baggen VJM, Berger WR, van Hout GPJ

Cited 1 times since 2022 (0.3 per year) source: EuropePMC

Herz, Volume 48, Issue 1, 28 4 2022, Pages 3-14 [The new ESC guidelines on the management of ventricular tachyarrhythmias : Implications for daily practice]. Könemann H, Frommeyer G, Zeppenfeld K, Eckardt L

The recently published guidelines of the European Society of Cardiology (ESC) on the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death is an update of the 2015 guideline. For the first time a new section is dedicated to public basic life support. In the acute treatment of ventricular arrhythmias electrical cardioversion is upgraded, and there is a new focus on the management of electrical storm. Recommendations for the comprehensive diagnostic evaluat... Abstract

Cited 36 times since 2022 (12.1 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 31, Issue 9, 28 4 2022, Pages 982-987 Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan. Hulshof EC, Deenen MJ, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Touw DJ, van der Weide J, van Westrhenen R, Deneer VHM, Guchelaar HJ, Swen JJ

The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize pharmacotherapy. This guideline describes the starting dose optimization of the anti-cancer drug irinotecan to decrease the risk of severe toxicity, such as (febrile) neutropenia or diarrhoea. Uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1 encoded by the UGT1A1 gene) enzyme deficiency increases risk of irinotecan-induced toxicity. Ge... Abstract

Cited 5 times since 2022 (1.7 per year) source: EuropePMC

Biomedicines, Volume 10, Issue 12, 28 4 2022, Pages 3056 NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction. Silvis MJM, Demkes EJ, Timmers L, Arslan F, de Jager SCA, Sluijter JPG, Mosterd A, de Kleijn DPV, Bosch L, van Hout GPJ

NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent of myocardial damage after myocardial infarction (MI). The purpose of this study was to investigate the effects of the NLRP3-inflammasome inhibitor IZD334 on cardiac damage in a pig model of myocardial infarction. Prior to in vivo testing, in vitro, porcine peripheral blood mononuclear cells and whole blood were treated with increasing dosages of IZD334, a novel NLRP3-inflammasome inhibitor, and were stimu... Abstract

Cited 12 times since 2022 (4 per year) source: EuropePMC

Acta dermato-venereologica, Volume 102, 24 4 2022, Pages adv00820 Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry. Boesjes CM, Kamphuis E, Zuithoff NPA, Bakker DS, Loman L, Spekhorst LS, Haeck I, Kamsteeg M, Van Lynden-van Nes AMT, Garritsen FM, Politiek K, Oldhoff M, De Graaf M, Schuttelaar MLA, De Bruin-Weller MS

Clinical trials have shown that baricitinib, an oral selective Janus kinase 1/2 inhibitor, is effective for the treatment of moderate-to-severe atopic dermatitis. However, daily practice data are limited. Therefore, this multicentre prospective study evaluated the effectiveness and safety of 16-weeks' treatment with baricitinib in adult patients with moderate-to-severe atopic dermatitis in daily practice. A total of 51 patients from the BioDay registry treated with baricitinib were included... Abstract

Cited 3 times since 2022 (1 per year) source: EuropePMC

International journal of cardiology, Volume 373, 23 4 2022, Pages 101-106 Incremental value of left ventricular global longitudinal strain in moderate aortic stenosis and reduced left ventricular ejection fraction. Stassen J, Singh GK, Pio SM, Chimed S, Butcher SC, Hirasawa K, Marsan NA, Bax JJ

Background: Moderate aortic stenosis (AS) often coexists with left ventricular (LV) systolic dysfunction and may affect survival through afterload mismatch. Because outcomes are ultimately driven by the condition of the LV, accurate assessment of LV performance is crucial to improve risk stratification. This study investigated the prognostic value of LV global longitudinal strain (GLS) in patients with moderate AS and reduced LV systolic dysfunction. Methods: Patients with moderate AS (aortic va... Abstract

Cited 13 times since 2022 (4.4 per year) source: EuropePMC

European journal of heart failure, Volume 25, Issue 2, 23 4 2022, Pages 213-222 Sequencing and titrating approach of therapy in heart failure with reduced ejection fraction following the 2021 European Society of Cardiology guidelines: an international cardiology survey. Fauvel C, Bonnet G, Mullens W, Giraldo CIS, Mežnar AZ, Barasa A, Tokmakova M, Shchendrygina A, Costa FM, Mapelli M, Zemrak F, Tops LF, Jakus N, Sultan A, Bahouth F, Hadjseyd CE, Salvat M, Anselmino M, Messroghli D, Weberndörfer V, Giverts I, Bochaton T, Courand PY, Berthelot E, Legallois D, Beauvais F, Bauer F, Lamblin N, Damy T, Girerd N, Sebbag L, Pezel T, Cohen-Solal A, Rosano G, Roubille F, Mewton N

Aims: In symptomatic patients with heart failure and reduced ejection fraction (HFrEF), recent international guidelines recommend initiating four major therapeutic classes rather than sequential initiation. It remains unclear how this change in guidelines is perceived by practicing cardiologists versus heart failure (HF) specialists. Methods and results: An independent academic web-based survey was designed by a group of HF specialists and posted by email and through various social networks to a... Abstract

Cited 39 times since 2022 (13.1 per year) source: EuropePMC

Nature cancer, Volume 3, Issue 11, 22 4 2022, Pages 1284-1299 cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis. Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R

Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in different senescent cancer cell models, we identify loss of the death receptor inhibitor cFLIP as a common vulnerability of senescent cancer cells. Senescent cells are primed for apoptotic death by NF-κB-mediated upregulation of death receptor 5 (DR5... Abstract

Cited 4 times since 2022 (1.3 per year) source: EuropePMC

European journal of trauma and emergency surgery : official publication of the European Trauma Society, Volume 49, Issue 2, 22 4 2022, Pages 825-835 The effect of age on resilience of health-related quality of life among polytrauma patients: a cross-sectional multicenter study. de Vries R, Reininga I, de Graaf M, Banierink H, Bosma E, Munzebrock A, Heineman E, Moumni ME, Wendt K

Purpose: The aim of this study was to determine the impact of age on patient-reported health-related quality of life (HRQoL) and the capacity to show resilience-i.e., the ability to adapt to stressful adverse events-after sustaining a polytrauma. Methods: A cross-sectional multicenter cohort was conducted between 2013 and 2016 that included surviving polytrauma patients (ISS ≥ 16). HRQoL was obtained by the Short Musculoskeletal Function assessment and EuroQol (SMFA and EQ-5D-5L). The effect of... Abstract