9026 results
Brain pathology (Zurich, Switzerland),
Volume 26, Issue 5, 1 1 2016, Pages 672
Letter in response to Maderna E et al, Measles Inclusion-Body Encephalitis: Neuronal Phosphorylated Tau Protein Is Present in the Biopsy but Not in the Autoptic Specimens of the Same Patient, Brain Pathology, doi: 10.1111/bpa.12332.
Yuksel D, Yılmaz D, Yurttutan Uyar N, Senbil N, Gürer Y, Anlar B
Abstract
Cited 111 times since 2016 (12.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 68, Issue 13, 1 1 2016, Pages 1435-1448
52 Genetic Loci Influencing Myocardial Mass.
van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Mateo Leach I, Eijgelsheim M, Sotoodehnia N, Hayward C, Sorice R, Meirelles O, Lyytikäinen LP, Polašek O, Tanaka T, Arking DE, Ulivi S, Trompet S, Müller-Nurasyid M, Smith AV, Dörr M, Kerr KF, Magnani JW, Del Greco M F, Zhang W, Nolte IM, Silva CT, Padmanabhan S, Tragante V, Esko T, Abecasis GR, Adriaens ME, Andersen K, Barnett P, Bis JC, Bodmer R, Buckley BM, Campbell H, Cannon MV, Chakravarti A, Chen LY, Delitala A, Devereux RB, Doevendans PA, Dominiczak AF, Ferrucci L, Ford I, Gieger C, Harris TB, Haugen E, Heinig M, Hernandez DG, Hillege HL, Hirschhorn JN, Hofman A, Hubner N, Hwang SJ, Iorio A, Kähönen M, Kellis M, Kolcic I, Kooner IK, Kooner JS, Kors JA, Lakatta EG, Lage K, Launer LJ, Levy D, Lundby A, Macfarlane PW, May D, Meitinger T, Metspalu A, Nappo S, Naitza S, Neph S, Nord AS, Nutile T, Okin PM, Olsen JV, Oostra BA, Penninger JM, Pennacchio LA, Pers TH, Perz S, Peters A, Pinto YM, Pfeufer A, Pilia MG, Pramstaller PP,
Background: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. Objectives: This meta-analysis sought to gain insights into the genetic determinants of myocardi...
Abstract
Cited 27 times since 2016 (2.9 per year)
source: EuropePMC
Journal of medical genetics,
Volume 53, Issue 12, 1 1 2016, Pages 835-845
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ, Cummings SR, Denny JC, Dubé MP, Durrington PN, Eiriksdottir G, Ford I, Guo X, Harris TB, Heckbert SR, Hofman A, Hovingh GK, Kastelein JJ, Launer LJ, Liu CT, Liu Y, Lumley T, McKeigue PM, Munroe PB, Neil A, Nickerson DA, Nyberg F, O'Brien E, O'Donnell CJ, Post W, Poulter N, Vasan RS, Rice K, Rich SS, Rivadeneira F, Sattar N, Sever P, Shaw-Hawkins S, Shields DC, Slagboom PE, Smith NL, Smith JD, Sotoodehnia N, Stanton A, Stott DJ, Stricker BH, Stürmer T, Uitterlinden AG, Wei WQ, Westendorp RG, Whitsel EA, Wiggins KL, Wilke RA, Ballantyne CM, Colhoun HM, Cupples LA, Franco OH, Gudnason V, Hitman G, Palmer CN, Psaty BM, Ridker PM, Stafford JM, Stein CM, Tardif JC, Caulfield MJ, Jukema JW, Rotter JI, Krauss RM
Background: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. Methods and results: We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals wit...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Current opinion in cardiology,
Volume 31, Issue 5, 1 1 2016, Pages 523-530
Mechanical dyssynchrony in patients with heart failure and reduced ejection fraction: how to measure?
Khidir MJ, Delgado V, Ajmone Marsan N, Bax JJ
Purpose of review: This article summarizes the most recent imaging techniques to assess left ventricular mechanical dyssynchrony and discusses their value to predict response to cardiac resynchronization therapy (CRT) together with assessment of myocardial scar and cardiac venous anatomy. Recent findings: Left ventricular mechanical dyssynchrony has been associated with prognosis of heart failure patients and has been shown to influence the efficacy of CRT. Although current guidelines do not rec...
Abstract
Cited 34 times since 2016 (3.7 per year)
source: EuropePMC
Open forum infectious diseases,
Volume 3, Issue 4, 30 5 2016, Pages ofw178
Duration of Colonization With <i>Klebsiella pneumoniae</i> Carbapenemase-Producing Bacteria at Long-Term Acute Care Hospitals in Chicago, Illinois.
Haverkate MR, Weiner S, Lolans K, Moore NM, Weinstein RA, Bonten MJ, Hayden MK, Bootsma MC
Background. High prevalence of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae has been reported in long-term acute care hospitals (LTACHs), in part because of frequent readmissions of colonized patients. Knowledge of the duration of colonization with KPC is essential to identify patients at risk of KPC colonization upon readmission and to make predictions on the effects of transmission control measures. Methods. We analyzed data on surveillance isolates that were collec...
Abstract
Cited 26 times since 2016 (2.8 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 152, Issue 6, 28 4 2016, Pages 1572-1579.e3
Allografts in aortic position: Insights from a 27-year, single-center prospective study.
Arabkhani B, Bekkers JA, Andrinopoulou ER, Roos-Hesselink JW, Takkenberg JJ, Bogers AJ
Objective: Over the past decades, the indication for allograft implantation in aortic position has evolved. The purpose of this study is to report long-term survival, allograft durability, and potential risk factors. Methods: Between 1987 and 2010, 353 patients underwent aortic valve replacements via allograft (92 subcoronary, 261 root replacement; 98% aortic allografts). Patient characteristics, survival, valve durability, and valve-related events were analyzed. Patients also were followed with...
Abstract
Cited 256 times since 2016 (27.8 per year)
source: EuropePMC
European journal of heart failure,
Volume 19, Issue 1, 27 4 2016, Pages 9-42
2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC).
Zamorano JL, Lancellotti P, Rodriguez Muñoz D, Aboyans V, Asteggiano R, Galderisi M, Habib G, Lenihan DJ, Lip GY, Lyon AR, Lopez Fernandez T, Mohty D, Piepoli MF, Tamargo J, Torbicki A, Suter TM, Zamorano JL, Aboyans V, Achenbach S, Agewall S, Badimon L, Barón-Esquivias G, Baumgartner H, Bax JJ, Bueno H, Carerj S, Dean V, Erol Ç, Fitzsimons D, Gaemperli O, Kirchhof P, Kolh P, Lancellotti P, Lip GY, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Roffi M, Torbicki A, Vaz Carneiro A, Windecker S, Authors/Task Force Members, ESC Committee for Practice Guidelines (CPG), Document Reviewers
Abstract
Cited 3 times since 2016 (0.3 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 90, Issue 1, 27 4 2016, Pages E1-E10
Anatomical and functional assessment of Tryton bifurcation stent before and after final kissing balloon dilatation: Evaluations by three-dimensional coronary angiography, optical coherence tomography imaging and fractional flow reserve.
Pyxaras SA, Toth GG, Di Gioia G, Ughi GJ, Tu S, Rusinaru D, Adriaenssens T, Reiber JHC, Leon MB, Bax JJ, Wijns W
Objectives: To assess the anatomical and functional impact of final kissing balloon inflation (FKBI) after implantation of a dedicated bifurcation stent system. Background: Current evidence suggests clinical benefit of FKBI in patients undergoing bifurcation dilatation using the Tryton side branch stent (Tryton-SBS). We hypothesized that FKBI improves anatomical reconstruction and functional results of bifurcation treated by Tryton-SBS. Methods: An unselected group of patients with complex bifur...
Abstract
Cited 1661 times since 2016 (180.4 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 39, 27 4 2016, Pages 2999-3058
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias.
Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, Hoes AW, Jennings CS, Landmesser U, Pedersen TR, Reiner Ž, Riccardi G, Taskinen MR, Tokgozoglu L, Verschuren WMM, Vlachopoulos C, Wood DA, Zamorano JL, Cooney MT, ESC Scientific Document Group
Abstract
Cited 1152 times since 2016 (125.1 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 18, Issue 11, 27 4 2016, Pages 1609-1678
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K
Abstract
Cited 4006 times since 2016 (435 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 38, 27 4 2016, Pages 2893-2962
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, ESC Scientific Document Group
Abstract
Cited 1677 times since 2016 (182.1 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 36, 26 4 2016, Pages 2768-2801
2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC).
Zamorano JL, Lancellotti P, Rodriguez Muñoz D, Aboyans V, Asteggiano R, Galderisi M, Habib G, Lenihan DJ, Lip GYH, Lyon AR, Lopez Fernandez T, Mohty D, Piepoli MF, Tamargo J, Torbicki A, Suter TM, ESC Scientific Document Group
Abstract
Cited 8 times since 2016 (0.9 per year)
source: EuropePMC
Congenital heart disease,
Volume 12, Issue 1, 25 4 2016, Pages 32-39
Surgical outcome in pediatric patients with Ebstein's anomaly: A multicenter, long-term study.
Geerdink LM, du Marchie Sarvaas GJ, Kuipers IM, Helbing WA, Delhaas T, Ter Heide H, Rozendaal L, de Korte CL, Singh SK, Ebels T, Hazekamp MG, Haas F, Bogers AJ, Kapusta L
Objective: Surgical outcomes of pediatric patients with Ebstein's anomaly are often described as part of all-age-inclusive series. Our objective is to focus on patients treated surgically in childhood (0-18 y). We study the intended treatment (biventricular or 1.5 ventricle repair or univentricular palliation), freedom from unplanned reoperation and survival of this specific age group, in a nationwide study. Design: Records of all Ebstein's anomaly patients born between 1980 and 2013 w...
Abstract
Cited 125 times since 2016 (13.6 per year)
source: EuropePMC
Angewandte Chemie (International ed. in English),
Volume 55, Issue 40, 24 4 2016, Pages 12440-12444
Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.
Jain PK, Ramanan V, Schepers AG, Dalvie NS, Panda A, Fleming HE, Bhatia SN
The ability to remotely trigger CRISPR/Cas9 activity would enable new strategies to study cellular events with greater precision and complexity. In this work, we have developed a method to photocage the activity of the guide RNA called "CRISPR-plus" (CRISPR-precise light-mediated unveiling of sgRNAs). The photoactivation capability of our CRISPR-plus method is compatible with the simultaneous targeting of multiple DNA sequences and supports numerous modifications that can enable guide...
Abstract
Angiology,
Volume 68, Issue 6, 23 4 2016, Pages 519-527
Very Long-Term Follow-Up After Coronary Rotational Atherectomy: A Single-Center Experience.
Tohamy A, Klomp M, Putter H, Youssef A, Shams-Eddin H, Abdelsabour M, Schalij MJ, Jukema JW
We assessed the very long-term follow-up of a large cohort of unselected patients treated with coronary rotational atherectomy (RA). All 143 patients who underwent RA at our institution from 2000 to 2013 and with complete baseline and follow-up information were analyzed in a retrospective manner. Major adverse cardiac events (MACE) were defined as the composite of target vessel revascularization (TVR), acute myocardial infarction, and all-cause mortality. The mean follow-up was 8.2 years. The 10...
Abstract
Cited 29 times since 2016 (3.1 per year)
source: EuropePMC
Journal of clinical pharmacology,
Volume 57, Issue 2, 23 4 2016, Pages 235-246
CYP2C19 Genotype-Dependent Pharmacokinetic Drug Interaction Between Voriconazole and Ritonavir-Boosted Atazanavir in Healthy Subjects.
Zhu L, Brüggemann RJ, Uy J, Colbers A, Hruska MW, Chung E, Sims K, Vakkalagadda B, Xu X, van Schaik RH, Burger DM, Bertz RJ
Voriconazole, a broad-spectrum triazole antifungal agent, is metabolized by cytochrome P450 (CYP) 2C19 and, to a lesser extent, by CYP3A. Genetic polymorphism of CYP2C19 not only plays a prominent role in its disposition but may also influence potential drug interactions with CYP450 modulators such as ritonavir. This study assessed 2-way drug interactions of voriconazole added on to ritonavir-boosted atazanavir in both CYP2C19 extensive-metabolizer (EM) and poor-metabolizer (PM) healthy subjects...
Abstract
Cited 24 times since 2016 (2.6 per year)
source: EuropePMC
BMC sports science, medicine & rehabilitation,
Volume 8, Issue 1, 23 4 2016, Pages 25
Exergaming (XBOX Kinect™) versus traditional gym-based exercise for postural control, flow and technology acceptance in healthy adults: a randomised controlled trial.
Barry G, van Schaik P, MacSween A, Dixon J, Martin D
Background: The use of exergaming is a potential alternative to traditional methods of balance training, which can be repetitive and somewhat monotonous. The purpose of this study was to assess the effects of exergaming using XBOX Kinect™ versus traditional gym-based exercise with no virtual stimuli (TGB) on postural control, technology acceptance, flow experience and exercise intensity, in young healthy adults. Methods: Fifty healthy active adults (age: 33.8 ± 12.7 years, height: 172.9 ± 11.9 c...
Abstract
Cited 23 times since 2016 (2.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 118, Issue 10, 23 4 2016, Pages 1533-1538
Comparison of Quantity of Calcific Deposits by Multidetector Computed Tomography in the Aortic Valve and Coronary Arteries.
van Rosendael PJ, Kamperidis V, Kong WK, van Rosendael AR, Marsan NA, Bax JJ, Delgado V
The aim of this study was to compare the calcium burden of the aortic valve and coronary arteries with multidetector computed tomography (MDCT) in a propensity score-matched population of patients with a bicuspid versus a tricuspid aortic valve. From an ongoing clinical registry of patients who underwent MDCT, 70 patients with bicuspid aortic valve and 210 patients with tricuspid aortic valve were matched based on age, gender, cardiovascular risk factors, chest pain symptoms, and MDCT indication...
Abstract
Cited 3 times since 2016 (0.3 per year)
source: EuropePMC
Pharmacogenomics,
Volume 17, Issue 14, 22 4 2016, Pages 1533-1545
Minimum information required for a DMET experiment reporting.
Kumuthini J, Mbiyavanga M, Chimusa ER, Pathak J, Somervuo P, Van Schaik RH, Dolzan V, Mizzi C, Kalideen K, Ramesar RS, Macek M, Patrinos GP, Squassina A
Aim: To provide pharmacogenomics reporting guidelines, the information and tools required for reporting to public omic databases. Material & methods: For effective DMET data interpretation, sharing, interoperability, reproducibility and reporting, we propose the Minimum Information required for a DMET Experiment (MIDE) reporting. Results: MIDE provides reporting guidelines and describes the information required for reporting, data storage and data sharing in the form of XML. Conclusion: The...
Abstract
Cited 23 times since 2016 (2.5 per year)
source: EuropePMC
Infection and immunity,
Volume 84, Issue 9, 19 3 2016, Pages 2524-2533
The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection.
Weber MM, Faris R, van Schaik EJ, McLachlan JT, Wright WU, Tellez A, Roman VA, Rowin K, Case ED, Luo ZQ, Samuel JE
Coxiella burnetii, the etiological agent of Q fever in humans, is an intracellular pathogen that replicates in an acidified parasitophorous vacuole derived from host lysosomes. Generation of this replicative compartment requires effectors delivered into the host cell by the Dot/Icm type IVb secretion system. Several effectors crucial for C. burnetii intracellular replication have been identified, but the host pathways coopted by these essential effectors are poorly defined, and very little is kn...
Abstract
