Research

Publications

Below you can find a list of our published research.

6337 results

European heart journal, 17 3 2025, Pages ehaf791 Outcomes of moderate mixed aortic valve stenosis and regurgitation. Lopez Santi P, Bernard J, Chua A, Laenens D, Powers A, Abdoun K, Velders BJJ, Sarrazyn C, Springhetti P, Zhang J, Amanullah MR, Ewe SH, Yiu KH, Palmen M, Hjortnaes J, Pibarot P, Clavel MA, Bax JJ, Ajmone Marsan N

Background and aims: There are limited data on mortality in patients with moderate mixed aortic valve disease (MAVD), defined as the combination of moderate aortic stenosis (AS) and moderate aortic regurgitation (AR). Consequently, current guidelines lack specific recommendations for aortic valve replacement (AVR) in this population. This study aims to compare survival between moderate MAVD and isolated severe AS or severe AR, and to evaluate the impact of symptoms or left ventricular ejection f... Abstract

Intensive & critical care nursing, Volume 92, 15 3 2025, Pages 104253 Important and feasible patient- and family-centered intensive care interventions: A Delphi study with stakeholders. Tilburgs B, Bakker-Crommentuijn C, de Graaf M, van den Boogaard M

Background: Intensive care unit (ICU) admissions can be stressful for patients and family members. Patients may face discomfort, pain, delirium, immobility, and uncertainty about recovery, while family members often experience emotional strain, uncertainty and fatigue. Patient- and family-centered care (PFCC) is a guideline recommended approach to reduce ICU-burden for both patient and family members. However, which interventions are important and feasible for PFCC in the ICU is unknown. Objecti... Abstract

European journal of preventive cardiology, 14 2 2025, Pages zwaf661 Future myocardial infarction after an acute coronary syndrome and pharmacogenetic response to dalcetrapib. Tardif JC, Pfeffer MA, Kouz S, Koenig W, Maggioni AP, McMurray JJV, Waters DD, Jukema JW, White HD, Heinonen T, Kallend D, Laghrissi-Thode F, Muroke V, Fortier A, Guertin MC, Dubé MP

Background: Acute coronary syndrome (ACS) survivors have heightened risk for subsequent cardiovascular events. Methods: All baseline characteristics collected in both the Dal-Outcomes and Dal-GenE trials were considered as potential risk markers. A prediction index for subsequent fatal and non-fatal myocardial infarction (MI) following ACS was developed using Cox proportional hazards modeling on data from Dal-Outcomes placebo patients (n=7086). This prediction index was then applied in all Dal-G... Abstract

European journal of heart failure, 14 2 2025 Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 1: Multimodality imaging for the evaluation of patients with advanced heart failure. Aimo A, Tops LF, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Gal TB, Moura B

Heart failure (HF) represents a significant global health burden, with approximately 10% of patients progressing to advanced stages characterized by severe symptoms and recurrent hospitalizations despite conventional treatments such as guideline-directed medical therapy, devices, and surgery. This clinical consensus statement from the Heart Failure Association of the European Society of Cardiology discusses the applications of imaging modalities in patients with advanced HF. Transthoracic echoca... Abstract

European journal of heart failure, 14 2 2025 Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 2: Mechanical circulatory support and heart transplantation. Tops LF, Aimo A, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Moura B, Ben Gal T

This clinical consensus statement outlines the vital role of multimodality imaging in managing patients with advanced heart failure (HF), particularly those receiving mechanical circulatory support (MCS) and heart transplantation (HT). For both temporary and durable MCS, multimodality imaging, primarily echocardiography, is crucial for selecting candidates, ensuring proper device placement, and monitoring in the post-implantation period. Preoperatively, it helps to identify HF phenotypes, assess... Abstract

Trends in cardiovascular medicine, 13 2 2025, Pages S1050-1738(25)00135-5 Controversies in valvular heart disease: insights from cardiac imaging. van der Bijl P, Marsan NA, Bax JJ

Numerous controversies still exist in the diagnosis and management of valvular heart disease, for example, the benefit of treating moderate aortic stenosis (AS) or asymptomatic, severe AS and the appropriate selection criteria for transcatheter edge-to-edge mitral valve repair. While numerous imaging parameters have been linked to the risk of sudden cardiac death in mitral valve prolapse, their relative merits are unknown and this is a challenging population to risk-stratify. No large, randomize... Abstract

JMIR medical informatics, Volume 13, 10 2 2025, Pages e71994 Evaluation of Machine Learning Model Performance in Diabetic Foot Ulcer: Retrospective Cohort Study. van Velze VY, Burger HL, van der Steenhoven TJ, Al-Ers H, Goncalves LN, Eefting D, de Jong WJ, Smeets HJ, Welleweerd JCS, van der Vorst JR, Uchtmann S, Rissmann R, Hamming JF, Stergioulas L, van der Bogt KE

Background: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and severe outcomes, providing an ideal example for a comprehensive framework that encompasses all essential steps for implementing ML in a clinically relevant fashion. Objective: This paper aims to provide a framework for the proper use of ML algorithms t... Abstract

Journal of clinical microbiology, 9 2 2025, Pages e0027225 In vitro activity of antibiotic monotherapy and combination therapy with bacteriophages against Staphylococcus aureus LVAD-driveline infections. Molendijk MM, Verkaik NJ, de Vogel CP, Lemmens-den Toom N, Knight GM, Caliskan K, Bode LGM, Verbon A, Koopmans MPG, de Graaf M, van Wamel WJB

Left-ventricular assist devices (LVADs) are increasingly used as a bridge to heart transplantation and destination therapy. These devices, especially the driveline, are susceptible to difficult-to-treat infections, associated with high morbidity and mortality rates. Staphylococcus aureus (S. aureus) is a major causative pathogen of LVAD infections. Antibiotic resistance and biofilm formation can complicate the treatment of these infections. A novel in vitro assay was developed to study the antib... Abstract

Journal of cardiovascular computed tomography, 8 2 2025, Pages S1934-5925(25)00442-3 Incremental value of a CCTA-derived AI-based ischemia algorithm over standard CCTA interpretation of predicting myocardial ischemia in patients with suspected coronary artery disease. Nabeta T, Bär S, Maaniitty T, Kärpijoki H, Bax JJ, Saraste A, Knuuti J

Background: A novel artificial intelligence-guided quantitative computed tomography ischemia algorithm (AI-QCTischemia) comprises a machine-learned method using atherosclerosis and vascular morphology features from coronary computed tomography angiography (CCTA) images to predict myocardial ischemia. This study evaluates the diagnostic performance of AI-QCTischemia compared to standard CCTA interpretation in detecting myocardial ischemia. Methods and results: Patients with suspected coronary art... Abstract

Endocrine connections, Volume 14, Issue 10, 6 1 2025, Pages e250400 Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism. Zhang JLH, Schepers A, Hamming JF, Osman L, Webb SM, Welling L, Winter EM, Snel M, Appelman-Dijkstra NM

Background: Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challenging to quantify. While parathyroidectomy (PTx) recently has been recommended for asymptomatic patients, its benefit remains unclear as existing evidence relies on generic health-related quality of life (HRQoL) tools. In contrast, the disease-specific PHPQoL questionnaire offers more sensitive and clinically relevant symptom assessment. This study aims to t... Abstract

Annals of vascular surgery, 6 1 2025, Pages S0890-5096(25)00655-7 Prediction of wound healing following amputation surgery based on near-infrared fluorescence with indocyanine green. Kruiswijk MW, Peul RC, Tange FP, Koning S, van der Aa LE, Eefting D, van der Bogt KEA, van den Hoven P, van der Vorst JR, Vascular Fluorescence group

Objectives: The objective of this study was to evaluate the predictive value of near-infrared (NIR) fluorescence imaging with indocyanine on wound-healing complications within six weeks after lower-extremity amputation. Methods: In this dual-centre cohort study, patients undergoing minor (below-ankle) or major (above-ankle) amputations due to PAD or diabetes mellitus, with perfusion assessment performed using ICG NIR fluorescence imaging, were included. Fluorescence videos were recorded using st... Abstract

Frontiers in digital health, Volume 7, 1 1 2025, Pages 1528860 Content evaluation of the inclusive eHealth guide: how to develop interventions for people with a lower socioeconomic position? Al-Dhahir I, Breeman LD, Faber JS, Wentzel J, van den Berg-Emons RJG, Kraal JJ, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM

Objectives: eHealth interventions favor those with higher socio-economic positions (SEPs). This can widen disparities, as people with lower SEPs may lack resources and face digital or financial barriers, making tailored solutions necessary. This study evaluates professionals' perceptions of the Inclusive eHealth Guide (IeG) regarding its content. The aim was to ensure it meets the needs of professionals and the targeted lower SEP demographic, thereby enhancing the effectiveness of eHealth i... Abstract

Therapeutic advances in medical oncology, Volume 17, 1 1 2025, Pages 17588359251379665 Predicting response and survival to first-line treatment with baseline [18F]FDG-PET-CT in patients with small-cell lung cancer: an integrated diagnostic approach. Ventura D, Schindler P, Kies P, Bleckmann A, Mohr M, Lenz G, Schäfers M, Roll W, Evers G

Background: Small-cell lung cancer (SCLC) is a highly malignant disease with a propensity for early progression and high mortality. The prognostic value of treatment response and survival has been verified for solely established imaging, clinical, and biochemical markers. There is a lack of evidence for the combination of those parameters with machine learning and integrated models, particularly in the context of molecular imaging. Objectives: The aim of this study was to predict early disease p... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 10, 1 1 2025, Pages euaf240 Evolution of implantable cardioverter-defibrillator shock therapy in children in the era of optimized ICD programming and remote monitoring. Bertels RA, Boersma E, Zeggelaar MD, van Dongen SAF, Ten Harkel ADJ, van Erven L, Smeding C, Bartelds B, van den Berg G, Boesaard EP, Bhagwandien RE, Yap SC, Knops RE, Blom NA, Kammeraad JAE

Aims: Implantable cardioverter defibrillator (ICD) therapy is effective in preventing sudden cardiac death in children. Unnecessary shocks should be avoided. ICD programming strategies and remote monitoring have been proven to be effective in preventing ICD shock therapy in adults; the present study evaluates the effectiveness in children. Methods and results: Retrospective multi-centre study, including children with transvenous or epicardial ICD implantation. During follow-up data on ICD shocks... Abstract

Interdisciplinary cardiovascular and thoracic surgery, 30 5 2025, Pages ivaf231 A European survey on non-technical skills in robotic thoracic surgery for lung resections. Shahin GMM, Verhagen MJ, Hutteman M, Wink J, Stamenkovic SA, Durand M, Baste JM, Melfi F, Braun J

Objectives: In robotic surgery, interaction between team-members differs from that in open surgery, which impacts the team-members' tasks and responsibilities. Training for robot-assisted thoracic surgery (RATS) is primarily focused on technical skills. However, non-technical skills (NOTECHS) are equally important for safe and high-quality surgery. There is debate whether NOTECHS require adjustments to meet specific needs of RATS. The aim of this study is to evaluate how NOTECHS-domains are... Abstract

Arteriosclerosis, thrombosis, and vascular biology, 25 4 2025 Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Reijnders E, Bossuyt P, Jukema JW, Ruhaak LR, Romijn F, Szarek M, Trompet S, Bhatt D, Bittner V, Diaz R, Fazio S, Stevanovic I, Goodman S, Harrington R, White H, Steg PG, Schwartz G, Cobbaert C

Background: Residual cardiovascular risk remains, despite achieving low-density lipoprotein cholesterol targets with high-intensity statins. Traditional risk scores are suboptimal. This study evaluated the prognostic utility of a 9-plex apolipoprotein panel in recent patients with acute coronary syndrome on statins and its role in predicting treatment benefit by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, enabling precision medicine. Methods: Baseline serum sam... Abstract

Allergy, 24 4 2025 Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions. de Bruin-Weller MS, Boesjes CM, Achten RA, Beck LA, Irvine AD, Vestergaard C, de Graaf M, van Wijk F, Bakker DS, Weidinger S

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment. Before 2017, systemic treatment options were limited to broad immunosuppressants, which often had significant toxicity and limited effectiveness. Advances in... Abstract

BMJ open, Volume 15, Issue 9, 23 4 2025, Pages e097306 Comparison of cardiovascular risk profiles of patients with type A aortic dissection and thoracic aortic aneurysm: a retrospective multicentre study. Tirpan AU, Dolmaci OB, Jansen EK, Twisk JWR, Klautz RJM, Grewal N

Objective: A thoracic aortic aneurysm (TAA) is often considered a precursor to an acute type A aortic dissection (ATAAD), a life-threatening condition requiring immediate surgical intervention. While both conditions share histopathological similarities, less is known about their overlap in clinical cardiovascular risk factors. This study aimed to map the cardiovascular disease burden in patients with ATAAD and compare it with patients with TAA. Design: A multicentre retrospective study. Setting:... Abstract

Scientific reports, Volume 15, Issue 1, 19 3 2025, Pages 32618 (Cardiac) complexity needs interaction. De Coster T

The heart exemplifies a complex system where electrical, mechanical, and biochemical processes interact dynamically. Understanding cardiac complexity requires exploring these interactions across multiple levels, from cellular dynamics to organ-wide behavior. This collection examines key interactions in cardiology, including excitation-contraction coupling, arrhythmia quantification, electromechanical modeling, and imaging advances. By integrating mathematical, computational, and clinical perspec... Abstract

NeuroImage. Clinical, Volume 48, 19 3 2025, Pages 103881 Brain age gap reduction following exercise mirrors clinical improvements in schizophrenia spectrum disorders. Yilmaz D, Papiol S, Keeser D, Cole JH, Malchow B, Walter H, Meyer-Lindenberg A, Hirjak D, Schmitt A, Falkai P, Maurus I, Roell L

Schizophrenia spectrum disorders (SSD) are associated with accelerated brain aging, reflected in an increased brain age gap. This gap serves as a biomarker, indicating poorer brain health, cognitive deficits, and greater severity in specific symptom domains. Exercise holds promise as an adjunct therapy to mitigate these deficits by potentially promoting brain recovery. However, the extent of overall improvements in brain health following exercise, along with their predictors and relationships to... Abstract