Research

Publications

Below you can find a list of our published research.

9618 results

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 58, Issue 7, 1 1 2017, Pages 9N-11N Integrated Residency in Radiology and Nuclear Medicine in The Netherlands. van Schaik JPJ, Bennink RJ

Abstract

Cited 18 times since 2017 (2.2 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 25, Issue 7-8, 1 1 2017, Pages 446-454 Cardiovascular disease risk and secondary prevention of cardiovascular disease among patients with low health literacy. van Schaik TM, Jørstad HT, Twickler TB, Peters RJG, Tijssen JPG, Essink-Bot ML, Fransen MP

Objective: To explore the association between health literacy and the risk of cardiovascular disease (CVD), and to assess the differential effects by health literacy level of a nurse-coordinated secondary prevention program (NCPP) in patients with coronary artery disease (CAD). Methods: Data were collected in two medical centres participating in the RESPONSE trial (Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists). CVD risk profiles were assessed at baseline and 12-m... Abstract

Cited 28 times since 2017 (3.4 per year) source: EuropePMC

Clinical chemistry, Volume 63, Issue 7, 1 1 2017, Pages 1204-1213 Analgesia and Opioids: A Pharmacogenetics Shortlist for Implementation in Clinical Practice. Matic M, de Wildt SN, Tibboel D, van Schaik RHN

Background: The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in dose requirements. Pharmacogenetics (PGx) could possibly be used to tailor pain medication based on an individual's genetic background. Many potential genetic markers have been described, and the importance of genetic predisposition in opioid efficacy and toxicity has been demonstrated in knockout mouse models and human twin studies. Such predictors are especiall... Abstract

Cited 13 times since 2017 (1.6 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 10, Issue 7, 1 1 2017, Pages e005670 Relationship Between Myocardial Function, Body Mass Index, and Outcome After ST-Segment-Elevation Myocardial Infarction. Joyce E, Hoogslag GE, Kamperidis V, Debonnaire P, Katsanos S, Mertens B, Marsan NA, Bax JJ, Delgado V

Background: Better survival for overweight and obese patients after ST-segment-elevation myocardial infarction (STEMI) has been demonstrated. The association between body mass index (BMI), outcome, and left ventricular (LV) structure and function after STEMI, including LV longitudinal strain (global longitudinal strain), was evaluated. Methods and results: First patients with STEMI undergoing primary percutaneous coronary intervention (n=1604; mean age, 61±12 years; 75% men) had BMI measured on... Abstract

Cited 35 times since 2017 (4.3 per year) source: EuropePMC

Rheumatology (Oxford, England), Volume 56, Issue 7, 1 1 2017, Pages 1081-1088 Predicting cardiopulmonary involvement in patients with systemic sclerosis: complementary value of nailfold videocapillaroscopy patterns and disease-specific autoantibodies. Markusse IM, Meijs J, de Boer B, Bakker JA, Schippers HPC, Schouffoer AA, Ajmone Marsan N, Kroft LJM, Ninaber MK, Huizinga TWJ, de Vries-Bouwstra JK

Objective: To evaluate the prevalence of anti-extractable nuclear antigen (anti-ENA) antibodies in Dutch SSc patients and the predictive power of the combination of specific anti-ENA antibodies and nailfold videocapillaroscopy (NVC) patterns to improve identification of patients with high risk for cardiopulmonary involvement. Methods: A total of 287 patients (79%) from the Leiden SSc-Cohort had data available on NVC-pattern (no SSc-specific, early, active, late) and anti-ENA antibodies. Associat... Abstract

Cited 183 times since 2017 (22.5 per year) source: EuropePMC

Neuroscience letters, Volume 710, 28 4 2017, Pages 132931 Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders? van Horssen J, van Schaik P, Witte M

Experimental evidence supports an intricate association between inflammation and mitochondrial dysfunction as main contributors of neurological diseases. Inflammatory mediators produced by activated microglia and infiltrated immune cells trigger intracellular signalling cascades that can alter cellular mitochondrial metabolism. Cytokines, particularly tumor necrosis factor-alpha, impede mitochondrial oxidative phosphorylation and associated ATP production and instigate mitochondrial reactive oxy... Abstract

Cited 10 times since 2017 (1.2 per year) source: EuropePMC

International journal of cardiology, Volume 244, 27 4 2017, Pages 298-302 Chronic use of low-dose aspirin is not associated with lower bone mineral density in the general population. Bonten TN, de Mutsert R, Rosendaal FR, Jukema JW, van der Bom JG, de Jongh RT, den Heijer M

Background: Low-dose aspirin is the cornerstone of secondary prevention of cardiovascular disease. Previous studies suggested that the use of aspirin is associated with an increased fracture risk. However, there is uncertainty whether this is due to an effect of aspirin on bone mineral density (BMD). Methods: Between 2008 and 2012, information on medication use and dual X-ray absorptiometry measured vertebral and femoral BMD of 916 participants was collected in the Netherland Epidemiology of Obe... Abstract

Cited 15 times since 2017 (1.8 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 33, Issue 11, 24 4 2017, Pages 1809-1819 Automatic identification of coronary tree anatomy in coronary computed tomography angiography. Cao Q, Broersen A, de Graaf MA, Kitslaar PH, Yang G, Scholte AJ, Lelieveldt BPF, Reiber JHC, Dijkstra J

An automatic coronary artery tree labeling algorithm is described to identify the anatomical segments of the extracted centerlines from coronary computed tomography angiography (CCTA) images. This method will facilitate the automatic lesion reporting and risk stratification of cardiovascular disease. Three-dimensional (3D) models for both right dominant (RD) and left dominant (LD) coronary circulations were built. All labels in the model were matched with their possible candidates in the extract... Abstract

Cited 17 times since 2017 (2.1 per year) source: EuropePMC

Psychotherapy and psychosomatics, Volume 86, Issue 4, 24 4 2017, Pages 220-230 Effectiveness of Supported Self-Help in Recurrent Depression: A Randomized Controlled Trial in Primary Care. Biesheuvel-Leliefeld KEM, Dijkstra-Kersten SMA, van Schaik DJF, van Marwijk HWJ, Smit F, van der Horst HE, Bockting CLH

Background: The burden and economic consequences of depression are high, mostly due to its recurrent nature. Due to current budget and time restraints, a preventive, low- cost, accessible minimal intervention is much needed. In this study, we evaluated the effectiveness of a supported self-help preventive cognitive therapy (S-PCT) added to treatment as usual (TAU) in primary care, compared to TAU alone. Methods: We conducted a randomized controlled trial among 248 patients with a history of depr... Abstract

Cited 35 times since 2017 (4.3 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 11, Issue 5, 23 4 2017, Pages 383-388 Interpreting results of coronary computed tomography angiography-derived fractional flow reserve in clinical practice. Rabbat MG, Berman DS, Kern M, Raff G, Chinnaiyan K, Koweek L, Shaw LJ, Blanke P, Scherer M, Jensen JM, Lesser J, Nørgaard BL, Pontone G, De Bruyne B, Bax JJ, Leipsic J

The application of computational fluid dynamics to coronary computed tomography angiography allows Fractional Flow Reserve (FFR) to be calculated non-invasively (FFRCT), enabling computation of FFR from coronary computed tomography angiography acquired at rest both for individual lesions as well as along the entire course of a coronary artery. FFRCT, validated in a number of accuracy studies and a large clinical utility trial, is beginning to penetrate clinical practice. Importantly, while accur... Abstract

Cited 25 times since 2017 (3.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 33, Issue 9, 22 4 2017, Pages 1305-1312 Accuracy and reproducibility of fast fractional flow reserve computation from invasive coronary angiography. van Rosendael AR, Koning G, Dimitriu-Leen AC, Smit JM, Montero-Cabezas JM, van der Kley F, Jukema JW, Reiber JHC, Bax JJ, Scholte AJHA

Fractional flow reserve (FFR) guided percutaneous coronary intervention (PCI) is associated with favourable outcome compared with revascularization based on angiographic stenosis severity alone. The feasibility of the new image-based quantitative flow ratio (QFR) assessed from 3D quantitative coronary angiography (QCA) and thrombolysis in myocardial infarction (TIMI) frame count using three different flow models has been reported recently. The aim of the current study was to assess the accuracy,... Abstract

Cited 46 times since 2017 (5.6 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 34, Issue 1, 22 4 2017, Pages 97-112 Cardiovascular magnetic resonance imaging to assess myocardial fibrosis in valvular heart disease. Podlesnikar T, Delgado V, Bax JJ

The left ventricular (LV) remodeling process associated with significant valvular heart disease (VHD) is characterized by an increase of myocardial interstitial space with deposition of collagen and loss of myofibers. These changes occur before LV systolic function deteriorates or the patient develops symptoms. Cardiovascular magnetic resonance (CMR) permits assessment of reactive fibrosis, with the use of T1 mapping techniques, and replacement fibrosis, with the use of late gadolinium contrast... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

The Cochrane database of systematic reviews, Volume 6, 20 3 2017, Pages CD003456 Drug therapy for chronic idiopathic axonal polyneuropathy. Warendorf J, Vrancken AF, van Schaik IN, Hughes RA, Notermans NC

Background: Chronic idiopathic axonal polyneuropathy (CIAP) is an insidiously progressive sensory or sensorimotor polyneuropathy that affects elderly people. Although severe disability or handicap does not occur, CIAP reduces quality of life. CIAP is diagnosed in 10% to 25% of people referred for evaluation of polyneuropathy. There is a need to gather and review emerging evidence on treatments, as the number of people affected is likely to increase in ageing populations. This is an update of a r... Abstract

Cited 135 times since 2017 (16.5 per year) source: EuropePMC

Journal of biological rhythms, Volume 32, Issue 4, 20 3 2017, Pages 359-368 The Association between Social Jetlag, the Metabolic Syndrome, and Type 2 Diabetes Mellitus in the General Population: The New Hoorn Study. Koopman ADM, Rauh SP, van 't Riet E, Groeneveld L, van der Heijden AA, Elders PJ, Dekker JM, Nijpels G, Beulens JW, Rutters F

Only a few studies have investigated the metabolic consequences of social jetlag. Therefore, we examined the association of social jetlag with the metabolic syndrome and type 2 diabetes mellitus in a population-based cohort. We used cross-sectional data from the New Hoorn Study cohort ( n = 1585, 47% men, age 60.8 ± 6 years). Social jetlag was calculated as the difference in midpoint sleep (in hours) between weekdays and weekend days. Poisson and linear regression models were used to study the a... Abstract

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 5, 15 3 2017, Pages 734-739 Comparison of Left Ventricular Function and Myocardial Infarct Size Determined by 2-Dimensional Speckle Tracking Echocardiography in Patients With and Without Chronic Obstructive Pulmonary Disease After ST-Segment Elevation Myocardial Infarction. Goedemans L, Abou R, Hoogslag GE, Ajmone Marsan N, Taube C, Delgado V, Bax JJ

Patients with chronic obstructive pulmonary disease (COPD) have a high risk of mortality after acute ST-segment elevation myocardial infarction (STEMI). We compared STEMI patients with versus without COPD in terms of infarct size and left ventricular (LV) systolic function using advanced 2-dimensional speckle tracking echocardiography. Of 1,750 patients with STEMI (mean age 61 ± 12 years, 76% male), 133 (7.6%) had COPD. With transthoracic echocardiography, left ventricular ejection fraction (LVE... Abstract

Cited 21 times since 2017 (2.6 per year) source: EuropePMC

Frontiers in zoology, Volume 14, 12 2 2017, Pages 29 Getting fat or getting help? How female mammals cope with energetic constraints on reproduction. Heldstab SA, van Schaik CP, Isler K

Background: Fat deposits enable a female mammal to bear the energy costs of offspring production and thus greatly influence her reproductive success. However, increasing locomotor costs and reduced agility counterbalance the fitness benefits of storing body fat. In species where costs of reproduction are distributed over other individuals such as fathers or non-breeding group members, reproductive females might therefore benefit from storing less energy in the form of body fat. Results: Using a... Abstract

Cited 42 times since 2017 (5.1 per year) source: EuropePMC

Frontiers in pharmacology, Volume 8, 8 2 2017, Pages 358 Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation. Woillard JB, Mourad M, Neely M, Capron A, van Schaik RH, van Gelder T, Lloberas N, Hesselink DA, Marquet P, Haufroid V, Elens L

Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variability is explained by genetic polymorphisms affecting the metabolic pathway. The integration of CYP3A4 and CY3A5 genotype in tacrolimus population-based PK (PopPK) modeling approaches... Abstract

Cited 196 times since 2017 (23.9 per year) source: EuropePMC

European journal of heart failure, Volume 19, Issue 12, 8 2 2017, Pages 1664-1671 Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction. Bosch L, Lam CSP, Gong L, Chan SP, Sim D, Yeo D, Jaufeerally F, Leong KTG, Ong HY, Ng TP, Richards AM, Arslan F, Ling LH

Background: Right ventricular (RV) dysfunction is recognized as a major prognostic factor in left-sided heart failure (HF). However, the relative contribution of RV dysfunction in HF with preserved (HFpEF) vs. reduced ejection fraction (HFrEF) is unclear. Methods and results: Right ventricular longitudinal strain (RVLS), tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) were determined by echocardiography in 657 age- and gender-matched groups of pat... Abstract

Cited 2 times since 2017 (0.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 24, Issue 5, 7 1 2017, Pages 1583-1587 Neuro-cardiac imaging has a proven value in patient management: Con. Liga R, Scholte AJHA

Abstract

Cited 13 times since 2017 (1.6 per year) source: EuropePMC

Journal of human evolution, Volume 109, 7 1 2017, Pages 11-21 The social organization of Homo ergaster: Inferences from anti-predator responses in extant primates. Willems EP, van Schaik CP

Patterns of primate socioecology have been used to suggest that the first truly savanna-dwelling hominin, Homo ergaster, lived in sizeable groups. Here, we revisit these estimates and infer additional features of the social organization of these early hominins based on anti-predator responses observed across the primate taxon. We first show that the effect of habitat on primate group size, composition, and sexual dimorphism is negligible after controlling for substrate use and phylogeny: terrest... Abstract