Research

Publications

Below you can find a list of our published research.

6478 results

Cited 5 times since 2023 (2.3 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 9 2 2023, Pages 1032755 Are acute type A aortic dissections atherosclerotic? Grewal N, Dolmaci O, Jansen E, Klautz R, Driessen A, Lindeman J, Poelmann RE

Background: Type A aortic dissections (TAAD) are devastating aortic complications. Patients with Marfan syndrome, a bicuspid aortic valve or a thoracic aortic aneurysm have an increased risk to develop a TAAD. These predisposing conditions are characterized by a histologically thin intimal layer and hardly any atherosclerosis. Little is known about the susceptibility for atherosclerosis in patients with a type A aortic dissection. Objective: We aim to systematically describe atherosclerotic lesi... Abstract

Cited 8 times since 2023 (3.7 per year) source: EuropePMC

Vascular pharmacology, Volume 148, 7 1 2023, Pages 107141 The effect of the 2019 ESC/EAS dyslipidaemia guidelines on low-density lipoprotein cholesterol goal achievement in patients with acute coronary syndromes: The ACS EuroPath IV project. Laufs U, Catapano AL, De Caterina R, Schiele F, Sionis A, Zaman A, Jukema JW

Aims: To evaluate the effect of the ESC/EAS 2019 dyslipidaemia guidelines on patient management of lipid-lowering therapy in patients with acute coronary syndrome (ACS), through a survey designed to compare post-ACS patient management in 2022 with that in 2018. Methods: Online questionnaires focused on lipid profile and medications were used to gather data from 2650 ACS patients in 6 European countries, treated between March-June 2022 (ACS EuroPath IV survey). These data were compared with data... Abstract

Cited 2 times since 2023 (0.9 per year) source: EuropePMC

Cellular signalling, Volume 104, 5 1 2023, Pages 110587 Early adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex. Clemente-Olivo MP, Hernández-Quiles M, Sparrius R, van der Stoel MM, Janssen V, Habibe JJ, van den Burg J, Jongejan A, Alcaraz-Sobrevals P, van Es R, Vos H, Kalkhoven E, de Vries CJM

The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells towards osteoblast and myocyte phenotypes. We hypothesized that FHL2 may simultaneously interfere with the induction of the adipocyte lineage. Therefore, we investigated the role of FHL2 in adipocyte differentiation. For these studies pre-adipocytes isolated from mouse adipose tissue and the 3T3-L1 (pre)adipocyte cell line were applied. We performed FH... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 16, Issue 1, 3 1 2023, Pages e010826 Pleomorphic Ventricular Tachycardia in Dilated Cardiomyopathy Predicts Ventricular Tachycardia Recurrence After Ablation Independent From Cardiac Function: Comparison With Patients With Ischemic Heart Disease. Kimura Y, de Riva M, Ebert M, Glashan C, Wijnmaalen AP, Piers SR, Dekkers OM, Trines SA, Zeppenfeld K

Background: In dilated cardiomyopathy (DCM), outcome after catheter ablation of ventricular tachycardia (VT) is modest, compared with ischemic heart disease (IHD). Pleomorphic VT (PL-VT) has been associated with fibrotic remodeling and end-stage heart failure in IHD. The prognostic role of PL-VT in DCM is unknown. Methods: Consecutive IHD (2009-2016) or DCM (2008-2018) patients undergoing ablation for monomorphic VT were included. PL-VT was defined as ≥1 spontaneous change of the 12-lead VT-morp... Abstract

Journal of the American College of Cardiology, Volume 81, Issue 3, 1 1 2023, Pages e25 Reply: Outcomes in Bicuspid Aortic Valve Disease. Hecht S, Bax JJ, Pibarot P

Abstract

Cited 22 times since 2023 (10.2 per year) source: EuropePMC

European heart journal, Volume 44, Issue 1, 1 1 2023, Pages 28-40 Valvular heart disease: shifting the focus to the myocardium. Ajmone Marsan N, Delgado V, Shah DJ, Pellikka P, Bax JJ, Treibel T, Cavalcante JL

Adverse cardiac remodelling is the main determinant of patient prognosis in degenerative valvular heart disease (VHD). However, to give an indication for valvular intervention, current guidelines include parameters of cardiac chamber dilatation or function which are subject to variability, do not directly reflect myocardial structural changes, and, more importantly, seem to be not sensitive enough in depicting early signs of myocardial dysfunction before irreversible myocardial damage has occurr... Abstract

Cited 116 times since 2023 (53.7 per year) source: EuropePMC

The New England journal of medicine, Volume 388, Issue 4, 1 1 2023, Pages 299-309 Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest. Suverein MM, Delnoij TSR, Lorusso R, Brandon Bravo Bruinsma GJ, Otterspoor L, Elzo Kraemer CV, Vlaar APJ, van der Heijden JJ, Scholten E, den Uil C, Jansen T, van den Bogaard B, Kuijpers M, Lam KY, Montero Cabezas JM, Driessen AHG, Rittersma SZH, Heijnen BG, Dos Reis Miranda D, Bleeker G, de Metz J, Hermanides RS, Lopez Matta J, Eberl S, Donker DW, van Thiel RJ, Akin S, van Meer O, Henriques J, Bokhoven KC, Mandigers L, Bunge JJH, Bol ME, Winkens B, Essers B, Weerwind PW, Maessen JG, van de Poll MCG

Background: Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival with a favorable neurologic outcome in refractory out-of-hospital cardiac arrest is inconclusive. Methods: In this multicenter, randomized, controlled trial conducted in the Netherlands, we assigned patients with an out-of-hospital cardiac arrest to receive extracorporeal... Abstract

Cited 32 times since 2023 (14.8 per year) source: EuropePMC

European heart journal, Volume 44, Issue 3, 1 1 2023, Pages 176-177 The '10 commandments' for the 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Tfelt-Hansen J, Winkel BG, de Riva M, Zeppenfeld K

Abstract

Cited 2 times since 2023 (0.9 per year) source: EuropePMC

Age and ageing, Volume 52, Issue 1, 1 1 2023, Pages afac312 Weight loss, visit-to-visit body weight variability and cognitive function in older individuals. Zonneveld MH, Noordam R, Sabayan B, Stott DJ, Mooijaart SP, Blauw GJ, Jukema JW, Sattar N, Trompet S

Objective: to investigate the association between variability and loss of body weight with subsequent cognitive performance and activities of daily living in older individuals. Design: cross-sectional cohort study. Setting: PROspective Study of Pravastatin in the Elderly at Risk, multicentre trial with participants from Scotland, Ireland and the Netherlands. Subjects: 4,309 participants without severe cognitive dysfunction (mean age 75.1 years, standard deviation (SD) = 3.3), at higher risk for... Abstract

Cited 2 times since 2023 (0.9 per year) source: EuropePMC

European heart journal, Volume 44, Issue 2, 1 1 2023, Pages 159-161 Guideline-based use of cardiac imaging for chronic coronary syndromes. van der Bijl P, Stassen J, Bax JJ

Abstract

Cited 4 times since 2023 (1.9 per year) source: EuropePMC

Clinical and translational allergy, Volume 13, Issue 1, 1 1 2023, Pages e12221 High dupilumab levels in tear fluid of atopic dermatitis patients with moderate-to-severe ocular surface disease. Achten R, Thijs J, van der Wal M, van Luijk C, van Luin M, El Amrani M, Knol E, Delemarre E, Jager CDH, de Graaf M, Bakker D, de Boer J, van Wijk F, de Bruin-Weller M

Background: The patho-mechanism of ocular surface disease (OSD) in dupilumab-treated atopic dermatitis (AD) patients remains unclear. The aim of this study is to measure dupilumab levels in tear fluid and serum, and relate these findings to the severity of OSD during dupilumab treatment in AD patients. Methods: This prospective study included dupilumab-treated moderate-to-severe AD patients who were seen by a dermatologist and an ophthalmologist before the start of dupilumab (baseline), and afte... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Clinical and translational allergy, Volume 13, Issue 1, 1 1 2023, Pages e12219 The positive effect of dupilumab on comorbid asthma in patients with atopic dermatitis. Spekhorst LS, de Graaf M, van der Rijst LP, Zuithoff NPA, Schweizer RC, Kamsteeg M, Haeck I, van Lynden-van Nes AMT, van Lumig P, Romeijn GLE, Schuttelaar ML, de Bruin-Weller MS

Abstract

Cited 8 times since 2022 (3.7 per year) source: EuropePMC

Circulation. Genomic and precision medicine, Volume 16, Issue 1, 29 5 2022, Pages e003672 Variant Location Is a Novel Risk Factor for Individuals With Arrhythmogenic Cardiomyopathy Due to a Desmoplakin (<i>DSP</i>) Truncating Variant. Hoorntje ET, Burns C, Marsili L, Corden B, Parikh VN, Te Meerman GJ, Gray B, Adiyaman A, Bagnall RD, Barge-Schaapveld DQCM, van den Berg MP, Bootsma M, Bosman LP, Correnti G, Duflou J, Eppinga RN, Fatkin D, Fietz M, Haan E, Jongbloed JDH, Hauer AD, Lam L, van Lint FHM, Lota A, Marcelis C, McCarthy HJ, van Mil AM, Oldenburg RA, Pachter N, Planken RN, Reuter C, Semsarian C, van der Smagt JJ, Thompson T, Vohra J, Volders PGA, van Waning JI, Whiffin N, van den Wijngaard A, Amin AS, Wilde AAM, van Woerden G, Yeates L, Zentner D, Ashley EA, Wheeler MT, Ware JS, van Tintelen JP, Ingles J

Background: Truncating variants in desmoplakin (DSPtv) are an important cause of arrhythmogenic cardiomyopathy; however the genetic architecture and genotype-specific risk factors are incompletely understood. We evaluated phenotype, risk factors for ventricular arrhythmias, and underlying genetics of DSPtv cardiomyopathy. Methods: Individuals with DSPtv and any cardiac phenotype, and their gene-positive family members were included from multiple international centers. Clinical data and family hi... Abstract

Cited 4 times since 2022 (1.8 per year) source: EuropePMC

Journal of clinical medicine, Volume 12, Issue 1, 29 5 2022, Pages 272 Are Thoracic Aortic Aneurysm Patients at Increased Risk for Cardiovascular Diseases? Dolmaci OB, El Mathari S, Driessen AHG, Klautz RJM, Poelmann RE, Lindeman JHN, Grewal N

Objectives: Abdominal aortic aneurysms are associated with a sharply increased cardiovascular risk. Cardiovascular risk management is therefore recommended in prevailing guidelines for abdominal aneurysm patients. It has been hypothesized that associated risk relates to loss of aortic compliance. If this hypothesis is correct, observations for abdominal aneurysms would also apply to thoracic aortic aneurysms. The objective of this study is to test whether thoracic aneurysms are also associated w... Abstract

Cited 10 times since 2022 (4.6 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 16, Issue 2, 28 4 2022, Pages 140-151 Staging Heart Failure Patients With Secondary Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair. Stolz L, Doldi PM, Orban M, Karam N, Puscas T, Wild MG, Popescu A, von Bardeleben RS, Iliadis C, Baldus S, Adamo M, Thiele H, Besler C, Unterhuber M, Ruf T, Pfister R, Higuchi S, Koell B, Giannini C, Petronio A, Kassar M, Weckbach LT, Butter C, Stocker TJ, Neuss M, Melica B, Braun D, Windecker S, Massberg S, Praz F, Näbauer M, Kalbacher D, Lurz P, Metra M, Bax JJ, Hausleiter J, EuroSMR Investigators

Background: Secondary mitral regurgitation (SMR) is a progressive disease with characteristic pathophysiological changes that may influence prognosis. Although the staging of SMR patients suffering from heart failure with reduced ejection fraction (HFrEF) according to extramitral cardiac involvement has prognostic value in medically treated patients, such data are so far lacking for edge-to-edge mitral valve repair (M-TEER). Objectives: This study sought to classify M-TEER patients into disease... Abstract

Cited 5 times since 2022 (2.3 per year) source: EuropePMC

International journal of cardiology, Volume 374, 28 4 2022, Pages 79-82 Right ventricular strain in Fabry disease: Prognostic implications. Meucci MC, Lillo R, Mango F, Lombardo A, Lanza GA, Parisi V, Grandinetti M, Massetti M, Ajmone Marsan N, Crea F, Graziani F

Introduction: Left ventricular (LV) hypertrophy is the main feature of cardiac involvement in Anderson-Fabry disease (FD), but the right ventricle (RV) is also frequently affected. Previous studies failed to demonstrate an independent association between conventional parameters of RV performance and outcomes in FD. Nevertheless, if RV free wall strain (RV-FWS), assessed by 2D speckle tracking analysis, may provide a better prognostication is currently unknown. Methods: We retrospectively evaluat... Abstract

Cited 1 times since 2022 (0.5 per year) source: EuropePMC

Circulation, Volume 147, Issue 10, 27 4 2022, Pages 798-811 The MIDA-Q Mortality Risk Score: A Quantitative Prognostic Tool for the Mitral Valve Prolapse Spectrum. Essayagh B, Benfari G, Antoine C, Grigioni F, Le Tourneau T, Roussel JC, Bax JJ, Delgado V, Ajmone Marsan N, van Wijngaarden A, Tribouilloy C, Rusinaru D, Hochstadt A, Topilsky Y, Topilsky Y, Thapa P, Michelena HI, Enriquez-Sarano M

Background: Mitral valve prolapse (MVP) is responsible for a considerable disease burden but is widely heterogeneous. The lack of a comprehensive prognostic instrument covering the entire MVP spectrum, encompassing the quantified consequent degenerative mitral regurgitation (DMR), hinders clinical management and therapeutic trials. Methods: The new Mitral Regurgitation International Database Quantitative (MIDA-Q) registry enrolled 8187 consecutive patients (ages 63±16 years, 47% women, follow-up... Abstract

Cited 3 times since 2022 (1.4 per year) source: EuropePMC

Molecular imaging and biology, Volume 25, Issue 1, 27 4 2022, Pages 228-239 Data-Driven Identification of Targets for Fluorescence-Guided Surgery in Non-Small Cell Lung Cancer. Meijer RPJ, Neijenhuis LKA, Zeilstra AP, Roerink SF, Bhairosingh SS, Hilling DE, Mieog JSD, Kuppen PJK, Sier CFM, Braun J, Burggraaf J, Vahrmeijer AL, Cohen D, Hutteman M

Purpose: Intraoperative identification of lung tumors can be challenging. Tumor-targeted fluorescence-guided surgery can provide surgeons with a tool for real-time intraoperative tumor detection. This study evaluated cell surface biomarkers, partially selected via data-driven selection software, as potential targets for fluorescence-guided surgery in non-small cell lung cancers: adenocarcinomas (ADC), adenocarcinomas in situ (AIS), and squamous cell carcinomas (SCC). Procedures: Formalin-fixed p... Abstract

Cited 27 times since 2022 (12.4 per year) source: EuropePMC

Genome biology, Volume 23, Issue 1, 27 4 2022, Pages 268 Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Yousri NA, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Hwu CM, Hung YJ, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Saba

Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,65... Abstract

Cited 17 times since 2022 (7.8 per year) source: EuropePMC

The Science of the total environment, Volume 865, 26 4 2022, Pages 161196 Normalisation of SARS-CoV-2 concentrations in wastewater: The use of flow, electrical conductivity and crAssphage. Langeveld J, Schilperoort R, Heijnen L, Elsinga G, Schapendonk CEM, Fanoy E, de Schepper EIT, Koopmans MPG, de Graaf M, Medema G

Over the course of the Corona Virus Disease-19 (COVID-19) pandemic in 2020-2022, monitoring of the severe acute respiratory syndrome coronavirus 2 ribonucleic acid (SARS-CoV-2 RNA) in wastewater has rapidly evolved into a supplementary surveillance instrument for public health. Short term trends (2 weeks) are used as a basis for policy and decision making on measures for dealing with the pandemic. Normalisation is required to account for the dilution rate of the domestic wastewater that can stro... Abstract