Research

Publications

Below you can find a list of our published research.

6205 results

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 5, 1 1 2013, Pages 256-261 Einthoven dissertation prizes 2012. van der Wall EE, van Gilst WH, Schalij MJ, Umans V

Abstract

Cited 14 times since 2013 (1.2 per year) source: EuropePMC

The bone & joint journal, Volume 95-B, Issue 5, 1 1 2013, Pages 689-693 Risk factors for the displacement of fractures of both bones of the forearm in children. Colaris JW, Allema JH, Reijman M, Biter LU, de Vries MR, van de Ven CP, Bloem RM, Verhaar JA

Forearm fractures in children have a tendency to displace in a cast leading to malunion with reduced functional and cosmetic results. In order to identify risk factors for displacement, a total of 247 conservatively treated fractures of the forearm in 246 children with a mean age of 7.3 years (sd 3.2; 0.9 to 14.9) were included in a prospective multicentre study. Multivariate logistic regression analyses were performed to assess risk factors for displacement of reduced or non-reduced fractures i... Abstract

Cited 18 times since 2013 (1.5 per year) source: EuropePMC

Respiratory medicine, Volume 107, Issue 7, 30 5 2013, Pages 959-966 CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma. Ravensberg AJ, Slats AM, van Wetering S, Janssen K, van Wijngaarden S, de Jeu R, Rabe KF, Sterk PJ, Hiemstra PS

Background: Smoking in asthma occurs frequently and is associated with increased symptom severity, an impaired response to corticosteroids, and accelerated lung function decline. Airway pathology in smoking asthmatics is characterized by neutrophilia and epithelial changes such as goblet cell hyperplasia and increased proliferation. Bronchial CD8(+) T cells are implicated in lung function decline in asthma and COPD. We hypothesized that smoking modifies airway inflammation in asthma by increasin... Abstract

Cited 38 times since 2013 (3.1 per year) source: EuropePMC

American heart journal, Volume 166, Issue 1, 30 5 2013, Pages 20-29 Effect of atrioventricular and ventriculoventricular delay optimization on clinical and echocardiographic outcomes of patients treated with cardiac resynchronization therapy: a meta-analysis. Auger D, Hoke U, Bax JJ, Boersma E, Delgado V

Background: Optimization of atrioventricular (AV) and ventriculoventricular (VV) delays of cardiac resynchronization therapy (CRT) devices maximizes left ventricular filling and stroke volume. However, the incremental value of these optimizations over empiric device programming remains unclear. The objective of this analysis was to perform a systematic review and meta-analysis of the effects of AV and VV delay optimization on clinical and echocardiographic end points of patients with heart failu... Abstract

Cited 22 times since 2013 (1.8 per year) source: EuropePMC

Journal of cardiothoracic and vascular anesthesia, Volume 27, Issue 4, 28 4 2013, Pages 723-727 Determinants of clinical right ventricular failure after congenital heart surgery in adults. Schuuring MJ, van Gulik EC, Koolbergen DR, Hazekamp MG, Lagrand WK, Backx AP, Mulder BJ, Bouma BJ

Objectives: Right ventricular (RV) failure after cardiac surgery is a clinical entity with high morbidity and mortality. Patients with congenital heart disease (CHD) often undergo right-sided cardiac surgery. The authors aimed to identify determinants of RV failure after cardiac surgery to differentiate patients with increased risk. Design: A retrospective chart review. Setting: University hospital. Participants: Adults with CHD operated on between January 2001 and January 2011. Interventions: C... Abstract

Cited 7 times since 2013 (0.6 per year) source: EuropePMC

International journal of cardiology, Volume 168, Issue 3, 26 4 2013, Pages 3031-3032 Long term effects of intramyocardial bone marrow cell injection on anginal symptoms and quality of life in patients with chronic myocardial ischemia. van Ramshorst J, Rodrigo SF, Beeres SL, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Atsma DE

Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 44, Issue 4, 26 4 2013, Pages 654-655 Very early repair of tetralogy of Fallot: we can, but should we? Hazekamp MG

Abstract

Cited 45 times since 2013 (3.7 per year) source: EuropePMC

Cyberpsychology, behavior and social networking, Volume 16, Issue 7, 25 4 2013, Pages 497-503 Display of alcohol use on Facebook: a content analysis. Beullens K, Schepers A

The present study has two main objectives. First, to examine how alcohol use is portrayed in the visual and textual references on Facebook, and second, to determine how friends react to these alcohol-related postings. A theoretically based content analysis of 160 Facebook profiles generated 2,575 pictures and 92 status updates referring to alcohol use, which represented about 6.50% of the pictures in the total sample and 2.90% of the status updates. These visual and textual references, as well a... Abstract

Cited 60 times since 2013 (5 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 6, Issue 3, 25 4 2013, Pages 513-521 Outcome of ventricular tachycardia ablation in patients with nonischemic cardiomyopathy: the impact of noninducibility. Piers SR, Leong DP, van Huls van Taxis CF, Tayyebi M, Trines SA, Pijnappels DA, Delgado V, Schalij MJ, Zeppenfeld K

Background: Ablation failure and recurrence rates after ventricular tachycardia (VT) ablation in nonischemic cardiomyopathy are high and the optimal procedural end point is not well defined. This study assessed the outcome after ablation, the impact of noninducibility, and other potential predictors of VT recurrence. Methods and results: Forty-five patients with nonischemic cardiomyopathy (60±16 years; left ventricular ejection fraction, 44±14%) accepted for VT ablation were included. Epicardial... Abstract

Cited 29 times since 2013 (2.4 per year) source: EuropePMC

The American journal of cardiology, Volume 111, Issue 10, 24 4 2013, Pages 1387-1393 Peak and fixed-time high-sensitive troponin for prediction of infarct size, impaired left ventricular function, and adverse outcomes in patients with first ST-segment elevation myocardial infarction receiving percutaneous coronary intervention. Boden H, Ahmed TA, Velders MA, van der Hoeven BL, Hoogslag GE, Bootsma M, le Cessie S, Cobbaert CM, Delgado V, van der Laarse A, Schalij MJ

The clinical use of advanced imaging modalities for early determination of infarct size and prognosis is limited. As a specific indicator of myocardial necrosis, cardiac troponin T (cTnT) can be used as a surrogate measure for this purpose. The present study sought to investigate the use of peak and serial 6-hour fixed-time high-sensitive (hs) cTnT for estimation of infarct size, left ventricular (LV) function, and prognosis in consecutive patients with ST-segment elevation myocardial infarction... Abstract

Cited 67 times since 2013 (5.5 per year) source: EuropePMC

PloS one, Volume 8, Issue 4, 24 4 2013, Pages e62395 Citation analysis may severely underestimate the impact of clinical research as compared to basic research. van Eck NJ, Waltman L, van Raan AF, Klautz RJ, Peul WC

Background: Citation analysis has become an important tool for research performance assessment in the medical sciences. However, different areas of medical research may have considerably different citation practices, even within the same medical field. Because of this, it is unclear to what extent citation-based bibliometric indicators allow for valid comparisons between research units active in different areas of medical research. Methodology: A visualization methodology is introduced that reve... Abstract

Cited 8 times since 2013 (0.7 per year) source: EuropePMC

Forensic science international, Volume 230, Issue 1-3, 23 4 2013, Pages 37-45 Pentaerythritol tetranitrate (PETN) profiling in post-explosion residues to constitute evidence of crime-scene presence. Brust H, van Asten A, Koeberg M, van der Heijden A, Kuijpers CJ, Schoenmakers P

Pentaerythritol tetranitrate (PETN) and its degradation products are analyzed to discriminate between residues originating from PETN explosions and residues obtained under other circumstances, such as natural degradation on textile, or after handling intact PETN. The degradation products observed in post-explosion samples were identified using liquid chromatography-mass spectrometry as the less-nitrated analogues of PETN: pentaerythritol trinitrate (PETriN), pentaerythritol dinitrate (PEDiN) and... Abstract

Cited 4 times since 2013 (0.3 per year) source: EuropePMC

Cardiology in the young, Volume 24, Issue 2, 18 3 2013, Pages 376-378 Ruptured aneurysm of the right coronary sinus of Valsalva in a child with Down syndrome. Lahrouchi N, Rammeloo LA, Koolbergen DR, Hruda J

Aneurysms of one of the aortic sinuses of Valsalva are rare congenital or acquired lesions. Here we present the case of an adolescent with Down syndrome with ruptured aneurysm of the right coronary sinus into the right atrium. All sinuses of Valsalva were normal during cardiological screening owing to Down syndrome at the age of 2 weeks. Paediatricians should have a low threshold for referring patients with Down syndrome for cardiac re-evaluation because of the new onset of cardiac symptoms or c... Abstract

Cited 25 times since 2013 (2.1 per year) source: EuropePMC

Accounts of chemical research, Volume 46, Issue 12, 18 3 2013, Pages 2910-2923 Bright ion channels and lipid bilayers. Szymański W, Yilmaz D, Koçer A, Feringa BL

If we look at a simple organism such as a zebrafish under a microscope, we would see many cells working in harmony. If we zoomed in, we would observe each unit performing its own tasks in a special aqueous environment isolated from the other units by a lipid bilayer approximately 5 nm thick. These confined units are social: they communicate with one another by sensing and responding to the chemical changes in their environment through receptors and ion channels. These channels control the highly... Abstract

Cited 13 times since 2013 (1.1 per year) source: EuropePMC

PloS one, Volume 8, Issue 4, 18 3 2013, Pages e61923 Protease-activated receptor (PAR)2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model. van den Hengel LG, Hellingman AA, Nossent AY, van Oeveren-Rietdijk AM, de Vries MR, Spek CA, van Zonneveld AJ, Reitsma PH, Hamming JF, de Boer HC, Versteeg HH, Quax PH

Aims: In collateral development (i.e. arteriogenesis), mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR)1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in... Abstract

Cited 108 times since 2013 (8.9 per year) source: EuropePMC

International journal of cardiology, Volume 168, Issue 3, 18 3 2013, Pages 2487-2493 Heart failure admissions in adults with congenital heart disease; risk factors and prognosis. Zomer AC, Vaartjes I, van der Velde ET, de Jong HM, Konings TC, Wagenaar LJ, Heesen WF, Eerens F, Baur LH, Grobbee DE, Mulder BJ

Background: Heart failure (HF) is a serious complication and often the cause of death in adults with congenital heart disease (CHD). Therefore, our aims were to determine the frequency of HF-admissions, and to assess risk factors of first HF-admission and of mortality after first HF-admission in adults with CHD. Methods: The Dutch CONCOR registry was linked to the Hospital Discharge Registry and National Mortality Registry to obtain data on HF-admissions and mortality. Risk factors for both HF-a... Abstract

Cited 123 times since 2013 (10.1 per year) source: EuropePMC

European journal of epidemiology, Volume 28, Issue 6, 11 2 2013, Pages 513-523 The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection. de Mutsert R, den Heijer M, Rabelink TJ, Smit JW, Romijn JA, Jukema JW, de Roos A, Cobbaert CM, Kloppenburg M, le Cessie S, Middeldorp S, Rosendaal FR

Obesity is a well-established risk factor for many chronic diseases. Incomplete insight exists in the causal pathways responsible for obesity-related disorders and consequently, in the identification of obese individuals at risk of these disorders. The Netherlands Epidemiology of Obesity (NEO) study is designed for extensive phenotyping to investigate pathways that lead to obesity-related diseases. The NEO study is a population-based, prospective cohort study that includes 6,673 individuals aged... Abstract

Cited 23 times since 2013 (1.9 per year) source: Scopus

European journal of heart failure, Volume 15, Issue 9, 10 2 2013, Pages 1011-1018 Galectin-3 and left ventricular reverse remodelling after surgical mitral valve repair. Kortekaas KA, Hoogslag GE, de Boer RA, Dokter MM, Versteegh MI, Braun J, Marsan NA, Verwey HF, Delgado V, Schalij MJ, Klautz RJ

Aims: Mitral valve repair in patients with functional mitral regurgitation (FMR) has been associated with beneficial left ventricular (LV) reverse remodelling. Recently, galectin-3 emerged as a marker of myocardial inflammation and fibrosis which may influence LV remodelling after surgery. The aim of the current study was to evaluate the association between pre-operative galectin-3 levels and LV reverse remodelling in heart failure patients with significant FMR who underwent mitral valve repair.... Abstract

Cited 48 times since 2013 (4 per year) source: EuropePMC

International journal of cardiology, Volume 168, Issue 3, 10 2 2013, Pages 2441-2446 Circulating transforming growth factor-β as a prognostic biomarker in Marfan syndrome. Franken R, den Hartog AW, de Waard V, Engele L, Radonic T, Lutter R, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Groenink M, Mulder BJ

Background: Patients with Marfan syndrome (MFS) are at risk for cardiovascular disease. Marfan associated mutations in the FBN1 gene lead to increased transforming growth factor-β (TGF-β) activation. The aim of this study was to investigate the role of plasma TGF-β as a biomarker for progressive aortic root dilatation and dissection. Methods: Plasma TGF-β level and aortic root diameter by means of echocardiography were assessed in 99 MFS patients. After 38 months of follow-up measurement of the... Abstract

Cited 10 times since 2013 (0.8 per year) source: EuropePMC

Clinical journal of the American Society of Nephrology : CJASN, Volume 8, Issue 8, 4 1 2013, Pages 1358-1366 Candidate gene analysis of arteriovenous fistula failure in hemodialysis patients. Verschuren JJ, Ocak G, Dekker FW, Rabelink TJ, Jukema JW, Rotmans JI

Background and objectives: Arteriovenous fistula (AVF) failure remains an important cause of morbidity in hemodialysis patients. The exact underlying mechanisms responsible for AVF failure are unknown but processes like proliferation, inflammation, vascular remodeling, and thrombosis are thought to be involved. The current objective was to investigate the association between AVF failure and single nucleotide polymorphisms (SNPs) in genes related to these pathophysiologic processes in a large pop... Abstract