9618 results
Cited 11 times since 2021 (3 per year)
source: EuropePMC
Annals of surgery,
Volume 276, Issue 1, 28 4 2022, Pages 38-45
Pelvic Floor Rehabilitation After Rectal Cancer Surgery: A Multicenter Randomized Clinical Trial (FORCE Trial).
van der Heijden JAG, Kalkdijk-Dijkstra AJ, Pierie JPEN, van Westreenen HL, Broens PMA, Klarenbeek BR, FORCE trial group
Objective: To investigate the effects of PFR after LAR compared to usual care without PFR. Summary of background data: Functional complaints, including fecal incontinence, often occur after LAR for rectal cancer. Controversy exists about the effectiveness of PFR in improving such postoperative functional outcomes. Methods: This was a multicenter, randomized controlled trial involving 17 Dutch centers. Patients after LAR for rectal cancer were randomly assigned (1:1) to usual care or PFR and stra...
Abstract
Cited 12 times since 2021 (3.3 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 35, Issue 5, 23 4 2021, Pages 486-494.e2
Left Atrial Deformation Imaging and Atrial Fibrillation in Patients with Rheumatic Mitral Stenosis.
Stassen J, Butcher SC, Namazi F, Ajmone Marsan N, Bax JJ, Delgado V
Background: Atrial fibrillation (AF) is a frequent complication of rheumatic mitral stenosis (MS) and is associated with worse outcomes. Prediction of new-onset AF by assessing left atrial (LA) mechanics with speckle-tracking echocardiography might be useful for risk stratification and guiding therapeutic strategies. Therefore, the aim of this study was to assess the association of LA reservoir strain (LASr) and strain rate (LASRr) with AF at follow-up in patients with rheumatic MS. Methods: Lef...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 15, Issue 1, 23 4 2021, Pages e009886
Ultrasound-Guided Optogenetic Gene Delivery for Shock-Free Ventricular Rhythm Restoration.
Nyns ECA, Jin T, Bart CI, Bax WH, Zhang G, Poelma RH, de Vries AAF, Pijnappels DA
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Acta chirurgica Belgica,
Volume 122, Issue 2, 22 4 2021, Pages 77-84
Peri-operative nutrition in cardiovascular surgery: current pitfalls and future directions.
Vinck EE, van Ierland KM, Rendón JC, Escobar JJ, Quintero Gómez A, Saldarriaga CI, van Brakel T, Klautz RJM, Cárdenas D
In the field of cardiovascular surgery, many areas are frequently evaluated to improve patient outcomes. Even though cardiac surgery has advanced significantly, peri-operative nutrition remains an area needing special attention and is under-considered in patient results. The three portions of cardiac surgical nutrition optimization are pre-operative, intra-operative and post-operative. All these, merit important clinical intervention which when done properly can significantly improve patient rec...
Abstract
Cited 53 times since 2021 (14.5 per year)
source: EuropePMC
Journal of advanced research,
Volume 40, 22 4 2021, Pages 1-15
The microbiota of the grapevine holobiont: A key component of plant health.
Bettenfeld P, Cadena I Canals J, Jacquens L, Fernandez O, Fontaine F, van Schaik E, Courty PE, Trouvelot S
Background: Grapevine is a woody, perennial plant of high economic importance worldwide. Like other plants, it lives in close association with large numbers of microorganisms. Bacteria, fungi and viruses are structured in communities, and each individual can be beneficial, neutral or harmful to the plant. In this sense, microorganisms can interact with each other and regulate plant functions (including immunity) and even provide new ones. Thus, the grapevine associated with its microbial communi...
Abstract
Cited 8 times since 2021 (2.2 per year)
source: EuropePMC
Seminars in musculoskeletal radiology,
Volume 25, Issue 6, 22 4 2021, Pages 735-744
Orthobiologics: Diagnosis and Treatment of Common Tendinopathies.
Van Schaik KD, Lee KS
Orthobiologics, including platelet-rich plasma, prolotherapy, and mesenchymal stem cells, are seeing increasing use in the treatment of osteoarthritis (OA), muscle injury, and tendinopathy. This article reviews the biology and applications of orthobiologics in tendons, muscles, and joints, and focuses on platelet-rich plasma (PRP). Clinical evidence-based literature related to the use of PRP in the treatment of rotator cuff injury, lateral epicondylosis, Achilles tendinopathy, plantar fasciitis,...
Abstract
Cited 92 times since 2021 (25.1 per year)
source: EuropePMC
Nature immunology,
Volume 23, Issue 1, 22 4 2021, Pages 23-32
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8<sup>+</sup> T cell responses following COVID-19.
Roukens AHE, Pothast CR, König M, Huisman W, Dalebout T, Tak T, Azimi S, Kruize Y, Hagedoorn RS, Zlei M, Staal FJT, de Bie FJ, van Dongen JJM, Arbous SM, Zhang JLH, Verheij M, Prins C, van der Does AM, Hiemstra PS, de Vries JJC, Janse JJ, Roestenberg M, Myeni SK, Kikkert M, Yazdanbakhsh M, Heemskerk MHM, Smits HH, Jochems SP, in collaboration with BEAT-COVID group, in collaboration with COVID-19 LUMC group
Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates1-6. Here, we characterized nasal and systemic immune cells in individuals with COVID-19 who were hospitalized or convalescent and compared the immune cells to those seen in healthy donors. We observed increased nasal granulocytes, monocytes, CD11c+ natura...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Journal of orthopaedic surgery and research,
Volume 16, Issue 1, 20 3 2021, Pages 722
Does circumferential casting prevent fracture redisplacement in reduced distal radius fractures? A retrospective multicentre study.
Berger AC, Barvelink B, Reijman M, Gosens T, Kraan GA, De Vries MR, Verhofstad MHJ, Lansink KWW, Hannemann PFW, Colaris JW
Background: This study evaluates whether a circumferential cast compared to a plaster splint leads to less fracture redisplacement in reduced extra-articular distal radius fractures (DRFs). Methods: This retrospective multicentre study was performed in four hospitals (two teaching hospitals and two academic hospitals). Adult patients with a displaced extra-articular DRF, treated with closed reduction, were included. Patients were included from a 5-year period (January 2012-January 2017). Accordi...
Abstract
Cited 7 times since 2021 (1.9 per year)
source: EuropePMC
American heart journal,
Volume 245, 20 3 2021, Pages 117-125
Harmonization of the definition of sudden cardiac death in longitudinal cohorts of the European Sudden Cardiac Arrest network - towards Prevention, Education, and New Effective Treatments (ESCAPE-NET) consortium.
Warming PE, Ågesen FN, Lynge TH, Jabbari R, Smits RLA, van Valkengoed IGM, Welten SJGC, van der Heijden AA, Elders PJ, Blom MT, Jouven X, Schwartz PJ, Albert CM, Beulens JW, Rutters F, Tan HL, Empana JP, Tfelt-Hansen J, ESCAPE-NET Investigators
Background: The burden of sudden cardiac death (SCD) in the general population is substantial and SCD frequently occurs among people with few or no known risk factors for cardiac disease. Reported incidences of SCD vary due to differences in definitions and methodology between cohorts. This study aimed to develop a method for adjudicating SCD cases in research settings and to describe uniform case definitions of SCD in an international consortium harmonizing multiple longitudinal study cohorts....
Abstract
Cited 8 times since 2021 (2.2 per year)
source: EuropePMC
Insights into imaging,
Volume 12, Issue 1, 18 3 2021, Pages 186
The impact and challenges of implementing CTCA according to the 2019 ESC guidelines on chronic coronary syndromes: a survey and projection of CTCA services in the Netherlands.
van den Boogert TPW, Claessen BEPM, Boekholdt SM, Leiner T, Vliegenthart R, Schuiling SF, Timmer JR, Bekkers SCAM, Voskuil M, Siebelink HJ, van Es W, Lamb HJ, Prokop M, Damman P, Stoker J, Willems HC, Henriques JP, Planken RN
Background: The 2019 ESC-guidelines on chronic coronary syndromes (ESC-CCS) recommend computed tomographic coronary angiography (CTCA) or non-invasive functional imaging instead of exercise ECG as initial test to diagnose obstructive coronary artery disease. Since impact and challenges of these guidelines are unknown, we studied the current utilisation of CTCA-services, status of CTCA-protocols and modeled the expected impact of these guidelines in the Netherlands. Methods and results: A survey...
Abstract
Surgical infections,
Volume 23, Issue 2, 17 3 2021, Pages 135-141
Re-Assessment in Patients with Suspected Acute Appendicitis.
Bom WJ, Scheijmans JCG, van Geloven AAW, Gans SL, Boermeester MA, Bemelman WA, van Rossem CC, SNAPSHOT Collaborators
Background: The effect of diagnosing appendicitis at re-assessment on post-operative outcomes is not clear. This study aims to compare patients diagnosed with appendicitis at initial presentation versus patients who were diagnosed at re-assessment. Patients and Methods: Data from the Dutch SNAPSHOT appendicitis collaborative was used. Patients with appendicitis who underwent appendectomy were included. Effects of diagnosis at re-assessment were compared with diagnosis at initial presentation. Pr...
Abstract
International journal of cardiology,
Volume 351, 17 3 2021, Pages 61-64
Actual management costs of patients with non-valvular atrial fibrillation treated with percutaneous left atrial appendage closure or oral anticoagulation.
D'Ancona G, Arslan F, Safak E, Weber D, Al Ammareen R, Ince H
Aims: Comparing actual management costs in patients with non-valvular atrial fibrillation (AF) treated with percutaneous left atrial appendage closure (LAAC) or OAC only. Methods and results: Patients undergoing percutaneous LAAC and AF patients treated with OAC only were matched for gender, age, and diagnosis related groups (DRG) clinical complexity level (CCL). Costs for cardiovascular outpatient clinic visits and hospitalizations were derived from the actual reimbursement records. Between 1/2...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Journal of patient safety,
Volume 18, Issue 4, 17 3 2021, Pages e760-e768
Measuring What Matters at Morbidity and Mortality Conferences: A Scoping Review of Effectiveness Measures.
Verhagen MJ, de Vos MS, Smaggus A, Hamming JF
Objective: Efforts to study morbidity and mortality conferences (M&MC) are hampered by the lack of rigorous instruments to assess the effectiveness of the conferences for the purpose of quality improvement and medical education. This might limit further advancement of the practice. The aim of this scoping review was to determine commonly used effectiveness measures of M&MC in the literature. Method: A scoping review was performed of quantitative, qualitative, and mixed methods studies of...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
BMJ open,
Volume 11, Issue 12, 16 3 2021, Pages e052128
Topical or oral antibiotics for children with acute otitis media presenting with ear discharge: study protocol of a randomised controlled non-inferiority trial.
Hullegie S, Venekamp RP, van Dongen TMA, Mulder S, van Schaik W, de Wit GA, Hay AD, Little P, Moore MV, Sanders EAM, Bonten MJM, Bogaert D, Schilder AG, Damoiseaux RAMJ
Background: Around 15%-20% of children with acute otitis media present with ear discharge due to a spontaneous tear or perforation of the eardrum (AOMd). Current guidance recommends clinicians to consider oral antibiotics as first-line treatment in this condition. The opening in the eardrum however should allow topical antibiotics to enter the middle ear directly. Local administration of antibiotics does not expose children to systemic side effects and may put less selective resistance pressure...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 165, 16 3 2021, Pages D6492
[Appreciative calamity investigation].
Hamming JF, den Dijker L, Steneker I
Calamity investigations often lead to recommendations that are difficult to implement and that are of little relevance, because the analysis is carried out according to a cause and effect system. The complexity of care provision requires a different method that respects the complexity of day-to-day care and is able to assess it correctly. Research according to the Safety-II philosophy clearly shows the variable interactions and dependencies present in daily work. These investigations require mor...
Abstract
Cited 4 times since 2021 (1.1 per year)
source: EuropePMC
JMIR cardio,
Volume 5, Issue 2, 16 3 2021, Pages e26072
Real-World Experience of mHealth Implementation in Clinical Practice (the Box): Design and Usability Study.
Biersteker T, Hilt A, van der Velde E, Schalij MJ, Treskes RW
Background: Mobile health (mHealth) is an emerging field of scientific interest worldwide. Potential benefits include increased patient engagement, improved clinical outcomes, and reduced health care costs. However, mHealth is often studied in projects or trials, and structural implantation in clinical practice is less common. Objective: The purpose of this paper is to outline the design of the Box and its implementation and use in an outpatient clinic setting. The impact on logistical outcomes...
Abstract
Cited 12 times since 2021 (3.3 per year)
source: EuropePMC
Nanoscale,
Volume 13, Issue 48, 16 3 2021, Pages 20451-20461
Controlled delivery of gold nanoparticle-coupled miRNA therapeutics <i>via</i> an injectable self-healing hydrogel.
van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS
Differential expression of microRNAs (miRNAs) plays a role in many diseases, including cancer and cardiovascular diseases. Potentially, miRNAs could be targeted with miRNA-therapeutics. Sustained delivery of these therapeutics remains challenging. This study couples miR-mimics to PEG-peptide gold nanoparticles (AuNP) and loads these AuNP-miRNAs in an injectable, shear thinning, self-assembling polymer nanoparticle (PNP) hydrogel drug delivery platform to improve delivery. Spherical AuNPs coated...
Abstract
Cited 4 times since 2021 (1.1 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 10, Issue 24, 16 3 2021, Pages e023300
Cardiovascular Effects of Autologous Bone Marrow-Derived Mesenchymal Stromal Cell Therapy With Early Tacrolimus Withdrawal in Renal Transplant Recipients: An Analysis of the Randomized TRITON Study.
Meucci MC, Reinders MEJ, Groeneweg KE, Bezstarosti S, Ajmone Marsan N, Bax JJ, De Fijter JW, Delgado V
Background After renal transplantation, there is a need of immunosuppressive regimens that effectively prevent allograft rejection while minimizing cardiovascular complications. This substudy of the TRITON trial evaluated the cardiovascular effects of autologous bone marrow-derived mesenchymal stromal cells (MSCs) in renal transplant recipients. Methods and Results Renal transplant recipients were randomized to MSC therapy, infused at weeks 6 and 7 after transplantation, with withdrawal at week...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Antioxidants (Basel, Switzerland),
Volume 10, Issue 12, 15 3 2021, Pages 2002
Association of Circulating Heme Oxygenase-1, Lipid Profile and Coronary Disease Phenotype in Patients with Chronic Coronary Syndrome.
Caselli C, De Caterina R, Ragusa R, Liga R, Gimelli A, Scholte AJHA, Clerico A, Knuuti J, Neglia D
Background: The NF-E2-related factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1) pathway has an emerging role in atherosclerosis. Activated by oxidative stress, it is deemed to exert athero-protective effects. We aimed at evaluating the relationships between plasma HO-1, clinical/molecular profiles and coronary disease patterns in patients with chronic coronary syndromes (CCS). Methods: HO-1 was measured in 526 patients (60 ± 9 years, 318 males) with CCS. Coronary computed tomography angiography (CTA) and...
Abstract
Cited 9 times since 2021 (2.4 per year)
source: EuropePMC
Clinical and translational science,
Volume 15, Issue 4, 15 3 2021, Pages 930-941
A randomized crossover study comparing different tacrolimus formulations to reduce intrapatient variability in tacrolimus exposure in kidney transplant recipients.
Bunthof KLW, Al-Hassany L, Nakshbandi G, Hesselink DA, van Schaik RHN, Ten Dam MAGJ, Baas MC, Hilbrands LB, van Gelder T
A high intrapatient variability (IPV) in tacrolimus exposure is a risk factor for poor long-term outcomes after kidney transplantation. The main objective of this trial was to investigate whether tacrolimus IPV decreases after switching patients from immediate-release (IR)-tacrolimus to either extended-release (ER)-tacrolimus or LifeCyclePharma (LCP)-tacrolimus. In this randomized, prospective, open-label, cross-over trial, adult kidney transplant recipients on a stable immunosuppressive regimen...
Abstract
