Research

Publications

Below you can find a list of our published research.

8684 results

Journal of the peripheral nervous system : JPNS, Volume 30, Issue 2, 1 1 2025, Pages e70031 Validity and Responsiveness of Balance Measurements Using Posturography in Patients With Immune-Mediated Neuropathies. Michael MR, van Veen R, Wieske L, Merkies ISJ, van Schaik IN, Eftimov F

Background and aims: Validated objective measures for balance in immune mediated neuropathies are lacking. In this study, we investigated the clinimetric properties of posturography using a force platform, a quantitative assessment of postural control. Methods: We assessed patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and IgM-related polyneuropathy (IgM-PNP) using sway parameters (path, area and amplitude) measured at multiple time points. Validity was investigated by as... Abstract

The clinical teacher, Volume 22, Issue 3, 1 1 2025, Pages e70073 Faculty Development for the People: Workplace-Based Solutions for Busy Clinicians. Brode EC, Bernal JM, Cornes SB, Santhosh L, Rivera JA, Kulkarni SA, Mandal JR, Henry DM, Bartz KS, Van Schaik SM

Background: Across clinical learning environments (CLEs), learners often encounter supervising clinicians who do not self-identify as educators and, therefore, may not seek out faculty development to augment their teaching skills. To reach those faculty, we conducted a proof-of-concept project framed by Billet's theory on workplace learning, bringing tailored faculty development to the clinical workplace. Approach: We recruited 22 faculty champions from 8 clinical departments at our institu... Abstract

Substance abuse treatment, prevention, and policy, Volume 20, Issue 1, 28 4 2025, Pages 23 Effect and acceptability of an mHealth smoking cessation intervention 'Stopcoach' combined with smoking cessation counseling for people from multiple levels of socioeconomic position: a multi-methods study. de Frel DL, Zijp A, van den Putte B, Troelstra S, Hermsen S, Heemskerk E, Janssen VR, Atsma DE, Chavannes NH, Meijer E

Introduction: Smoking cessation interventions tend to be less effective for people of lower socioeconomic position (SEP) compared to those of higher SEP. Mobile phone-based interventions have been shown to increase abstinence from smoking. Stopcoach is an mHealth smoking cessation intervention that specifically targets people with a lower SEP. A pilot study showed the potential and feasibility of Stopcoach but as yet no research exists that assesses the effectiveness of Stopcoach. Objective: Thi... Abstract

Open heart, Volume 12, Issue 1, 27 4 2025, Pages e003355 Clinical course and outcomes of supravalvular aortic stenosis in adults. de Keijzer AR, Keuning ZA, Meccanici F, van Kimmenade RRL, van Melle JP, Bouma BJ, Kluin J, Jongbloed MRM, Voskuil M, Roos-Hesselink JW, van den Bosch AE

Background: Supravalvular aortic stenosis (SVAS) is a rare condition with limited data on patients beyond childhood. This study aims to investigate the clinical course and outcomes of SVAS in adults. Methods: All adult (≥18 years) patients with SVAS, prospectively registered in the Dutch Congenital Cor Vitia database between 2001 and 2019, were included. Survival and event-free survival were assessed. Evolution of peak velocity was analysed using linear mixed models. Differences in previous oper... Abstract

Chemistry & biodiversity, 27 4 2025, Pages e00911 Formation of Colchicine-incorporated Hybrid Nanoflower With an Intrinsic Peroxidase-Mimic and Enhanced Antimicrobial Activities. Yilmaz E, Koca FD, Saticioglu IB, Ozen B, Yilmaz DD, Nisari M, Ocsoy I

We report the formation of colchicine-Cu3(PO4)2 hybrid nanoflowers (Colc-NFs) with intrinsic catalytic and antimicrobial activities with and without hydrogen peroxide (H2O2). While the colchicine molecule, known as a secondary metabolite with anti-inflammatory properties, was used as an organic part of Colc-NFs, the Cu2+ ion acted as an inorganic part of Colc-NFs. The acetamide group in the colchicine structure may react with Cu2+ ions in phosphate-buffered saline to form Colc-NFs. The Colc-NFs... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 27 4 2025 Comparison of Procedural and Clinical Outcomes of Angiography- Versus Imaging-Guided Percutaneous Coronary Intervention With Intravascular Lithotripsy. Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Mincione G, Paradies V, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Al Amri I, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) is an innovative treatment for coronary artery calcification (CAC). Aims: This study aimed to compare procedural and clinical outcomes of intracoronary imaging (ICI)-guided percutaneous coronary intervention (PCI) versus angiography-guided PCI with IVL in patients with CAC. Methods: A total of 509 patients were analyzed from the BENELUX-IVL registry (May 2019 to September 2024). Angiography-guided PCI with IVL was defined as therapy under solely fluoro... Abstract

The Journal of dermatological treatment, Volume 36, Issue 1, 27 4 2025, Pages 2503273 Treatment goals and preferences of pediatric atopic dermatitis patients, young adults, and caregivers. van der Rijst LP, de Bruin-Weller MS, Zuithoff NPA, Spillekom-van Koulil S, Seyger MMB, de Graaf M

Purpose: Understanding the treatment goals and preferences of young atopic dermatitis (AD) patients and their caregivers is crucial for enhancing patient-centered care. This study aims to identify these goals and preferences and explore heterogeneity among subgroups. Materials and methods: A web-based survey was conducted among children (6-11 years), adolescents (12-17 years), and young adults (18-30 years) with AD and caregivers of AD patients. Survey questions included multiple-choice, four-po... Abstract

Journal of cardiac failure, 23 4 2025, Pages S1071-9164(25)00236-2 The Association between Serially Measured Circulating Biomarker Patterns and Pulmonary Artery Pressures measured by Invasive Hemodynamic Monitoring. de Jong MBL, Allach Y, Kamar SA, Clephas PRD, Brunner-La Rocca HP, Handoko ML, van de Halm VP, Kok WEM, Asselbergs FW, van Kimmenade R, Beeres SLMA, Rienstra M, Szymanski MK, de Boer RA, Kardys I, Brugts JJ

Aims: Invasive hemodynamic monitoring devices provide relevant insights into the remote hemodynamic status of heart failure (HF) patients. Additionally, circulating biomarkers have been advocated as additive in HF management by offering prognostic information and therapeutic targets. However, limited data exist correlating serially measured biomarkers to hemodynamic pressures provided by invasive sensors. This study aims to investigate the association between serial biomarker patterns and pulmon... Abstract

Bone research, Volume 13, Issue 1, 23 4 2025, Pages 55 Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging. Yılmaz D, Marques FC, Gregorio L, Schlatter J, Gehre C, Pararajasingam T, Qiu W, Mathavan N, Qin XH, Wehrle E, Kuhn GA, Müller R

Age-related osteoporosis poses a significant challenge in musculoskeletal health; a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms. Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss. Our study uses the prematurely aged PolgD257A/D257A (PolgA) mouse... Abstract

The international journal of cardiovascular imaging, 22 4 2025 Evolution and prognostic implications of cardiac damage in women after transcatheter aortic valve implantation. Myagmardorj R, Fortuni F, Galloo X, Nabeta T, Meucci MC, Butcher SC, van der Kley F, Ajmone Marsan N, Bax JJ

Recently, a cardiac damage staging system has been proposed in patients with severe AS to improve risk stratification, but there is still paucity of data in women. Accordingly, we aimed to characterize the change in cardiac damage after transcatheter aortic valve implantation (TAVI), and to assess the prognostic value of cardiac damage staging in women. A total of 334 women (mean age 81 ± 7 years) with severe AS undergoing TAVI were included and retrospectively analyzed. Echocardiography was per... Abstract

BMC medical education, Volume 25, Issue 1, 22 4 2025, Pages 757 The effect of three different techniques used to improve vein prominence on the first peripheral venous catheterization experience in nursing students: a randomized controlled study. Yılmaz H, Yılmaz D, Çinar HG

Background: Peripheral venous catheterization (PVC) insertion is a complex sensory-motor skill that can be difficult for nursing students to acquire. Objectives: The authors aimed to examine the effect of three techniques used to improve vein prominence on achievement, knowledge, and psychomotor skills in the first PVC experience in nursing students. Methods: A single-center, parallel-group, randomized control study. Near-infrared light visualization (n = 49) and isometric exercise (n = 50) tech... Abstract

European urology oncology, 20 3 2025, Pages S2588-9311(25)00104-X Towards Defining Follow-up Strategies for Patients with Primary Intermediate-risk Non-muscle-invasive Bladder Cancer. Contieri R, Martini A, Beijert IJ, Mertens LS, Hentschel AE, Bründl J, Compérat EM, Plass K, Rodríguez O, Subiela Henríquez JD, Hernández V, de la Peña E, Alemany I, Turturica D, Pisano F, Soria F, Čapoun O, Bauerová L, Pešl M, Maxim Bruins H, Runneboom W, Herdegen S, Breyer J, Brisuda A, Calatrava A, Rubio-Briones J, Seles M, Mannweiler S, Bosschieter J, Kusuma VRM, Ashabere D, Huebner N, Seisen T, Claps F, Masson-Lecomte A, Liedberg F, Cohen D, Lunelli L, Cussenot O, Sheikh SE, Volanis D, Côté JF, Rouprêt M, Haitel A, Shariat SF, Mostafid AH, Nieuwenhuijzen JA, Zigeuner R, Dominguez-Escrig JL, Hacek J, Zlotta AR, Burger M, Evert M, de Kaa CAH, van der Heijden AG, Kiemeney LALM, Soukup V, Molinaro L, Hurle R, Paciotti M, Moschini M, Pradere B, Perdonà S, Gontero P, Llorente C, Algaba F, Palou J, N'Dow J, Ribal MJ, van der Kwast TH, Babjuk M, Sylvester RJ, van Rhijn BWG

Background and objective: The current European Association of Urology (EAU) guidelines on non-muscle-invasive bladder cancer (NMIBC) categorize patients into four risk groups. In 2024, a specific follow-up schedule was introduced for intermediate-risk (IR) disease. However, recommendations are based on expert opinion and restricted to patients with IR-NMIBC who have primary low-grade or high-grade/grade 2 disease. Our aim was to identify a subgroup of patients with IR-NMIBC who may require more... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 19 3 2025 Efficacy and Safety of Intravascular Lithotripsy in the Management of Underexpanded Stents: A Systematic Review and Meta-Analysis. Sagris M, Soulaidopoulos S, Papanikolaou A, Ktenopoulos N, van Oort MJH, Montero-Cabezas JM, Patsourakos N, Honton B, Tousoulis D, Tsioufis K

Background: Stent underexpansion significantly heightens the risk of major adverse cardiac events (MACE), and available treatment options for this condition remain limited. Intravascular Lithotripsy (IVL) technology disrupts superficial and deep calcium by using localized pulsative sonic pressure waves, emerges as a promising tool for underexpanded stents. Aims: This study examines the overall efficacy and safety of IVL, an until-now off-label modality, in the management of underexpanded stents.... Abstract

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 15 3 2025 Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum. van der Rijst LP, Knol EF, Zuithoff NPA, den Hartog Jager CF, van Wijk F, de Bruin-Weller MS, de Graaf M

Objective: This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity. Methods: Twenty paediatric AD patients ( Abstract

Journal of clinical medicine, Volume 14, Issue 10, 13 2 2025, Pages 3393 Pseudoaneurysmectomy After Left Ventricular Free Wall Rupture Repair: A Case Report. Baldan BU, Klein P, Stöger JL, Klautz RJM, Palmen M

Background/Objectives: Left ventricular (LV) pseudoaneurysm is a rare but life-threatening complication after acute myocardial infarction, often resulting from inadequate excision of damaged myocardium and use of only a xenopericardial patch during primary LV free wall rupture repair. Methods: A 62-year-old female developed a giant LV pseudoaneurysm one year after initial surgical repair of a free wall rupture with a xenopericardial patch. Imaging confirmed a large pseudoaneurysm with a broad ne... Abstract

Arthritis & rheumatology (Hoboken, N.J.), 12 2 2025 Differences in dynamics of specific anti-nuclear antibodies and their susceptibility to B cell targeting treatment in Systemic Lupus Erythematosus. van Dooren HJ, van Schaik M, Dorjée AL, Arends EJ, Mackay M, Laura C, Fox DA, Wofsy D, Smilek D, Aranow C, Dall'Era M, Huizinga TWJ, van Kooten C, Toes REM, Diamond B, Teng YKO, Suurmond J

Objective: The presence of anti-nuclear antibodies (ANAs) is characteristic for systemic lupus erythematosus (SLE). Antibody dynamics over time are thought to reflect the cellular source of ANAs and their therapeutic targetability. Anti-dsDNA is the most prevalent and well-studied of all ANAs, and fluctuations in anti-dsDNA serum levels are associated with disease activity. Antibody dynamics of other ANAs, such as antibodies targeting RNA-binding proteins (RBPs), are often considered more stable... Abstract

Heart & lung : the journal of critical care, Volume 73, 12 2 2025, Pages 108-113 Intravascular lithotripsy and temporary mechanical circulatory support for the treatment of heavily calcified coronary artery disease: insights from the BENELUX-IVL registry. Oliveri F, Merino I, van Oort MJH, Al Amri I, Bingen BO, Arslan F, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Kley F, Jukema JW, Montero-Cabezas J

Background: Intravascular lithotripsy (IVL) is increasingly utilized for the treatment of heavily calcified coronary lesions. However its use in conjunction with temporary mechanical circulatory support (tMCS) remains underexplored. Objective: This study aims to evaluate the current use of tMCS and IVL for the treatment of heavily calcified coronary lesions. Method: From the BENELUX-IVL prospective registry, patients who underwent IVL during PCI and required tMCS during the procedure were select... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 12 2 2025, Pages ezaf161 Sex difference in aortic root replacement with a stentless bioprosthesis. Dagnegård H, Schneider AW, Timmermans PT, Glaser N, Kolseth SM, Vanky F, Gudbjartsson T, Haaverstad R, Cotovanu A, Sartipy U, Klautz RJM, Smerup M, Hjortnaes J

Objectives: To investigate and quantify differences in survival and reinterventions between sexes after aortic root replacement with a stentless bioprosthesis, stratified for preoperative valve lesion. Methods: Elective adults undergoing aortic root replacement with the Freestyle bioprosthesis at six North-Atlantic centers were included. Survival analyses were performed using the Kaplan-Meier method or Aahlen-Johansen with death as competing risk as relevant. Results were quantified using uni- a... Abstract

Annals of surgery, 8 2 2025 Combined Clinical and Histopathological Risk Stratification for Prediction of (severe) Endoscopic Postoperative Recurrence in Patients with Crohn's Disease after Ileocolic Resection: Results from A Prospective Multicenter Cohort Study. Bak MTJ, Oudijk L, Ooms AHAG, Beelen EMJ, van der Bilt JDW, Romberg-Camps M, Dijkstra G, Duijvestein M, van der Marel S, Stassen LPS, Maljaars PWJ, Buskens CJ, Lange JFM, Kats-Ugurlu G, Jansen SV, Jharap BJH, Horjus CS, van Schaik FDM, West RL, de Boer NKH, Janneke van der Woude C, Parikh K, van Ruler O, Doukas M, de Vries AC, RAP-CD study group; on behalf of the Dutch Initiative on Crohn and Colitis (ICC) & Dutch Initiative on Crohn and Colitis – Surgery (ICC-S)

Objective: This study assessed the association of histopathological features in the resection specimen of CD patients with (severe) endoscopic postoperative recurrence (ePOR) in a large prospective, multicenter cohort study. Summary background data: The predictive value of histopathologic features of the intestinal resection specimen for the risk of Crohn's disease (CD) recurrence after ileocolic (re-)resection (ICR) remains a matter of debate. Methods: CD patients (≥16 y) scheduled for ICR... Abstract

Psychological research, Volume 89, Issue 3, 8 2 2025, Pages 98 Moral decision-making 'on the fly'. Kusev P, Martin R, van Schaik P, Teal J

Over a century of research has focused on the consistency and inconsistency of human moral decision preferences. We proposed and found that moral decision preferences are flexible and shift towards newly learned moral rules when their application leads to utilitarian choices. Hence, decision-makers' psychological concept of morality is continually under construction (on the fly); based on learning, informed by changes in moral rules and specific moral contexts. Accordingly, in two experimen... Abstract