Research

Publications

Below you can find a list of our published research.

8414 results

Cited 1168 times since 2014 (111.2 per year) source: EuropePMC

European heart journal, Volume 35, Issue 43, 29 5 2014, Pages 3033-69, 3069a-3069k 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Konstantinides SV, Torbicki A, Agnelli G, Danchin N, Fitzmaurice D, Galiè N, Gibbs JS, Huisman MV, Humbert M, Kucher N, Lang I, Lankeit M, Lekakis J, Maack C, Mayer E, Meneveau N, Perrier A, Pruszczyk P, Rasmussen LH, Schindler TH, Svitil P, Vonk Noordegraaf A, Zamorano JL, Zompatori M, Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)

Abstract

Cited 16 times since 2014 (1.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 31, Issue 1, 27 4 2014, Pages 151-161 Automatic detection and quantification of the Agatston coronary artery calcium score on contrast computed tomography angiography. Ahmed W, de Graaf MA, Broersen A, Kitslaar PH, Oost E, Dijkstra J, Bax JJ, Reiber JH, Scholte AJ

Potentially, Agatston coronary artery calcium (CAC) score could be calculated on contrast computed tomography coronary angiography (CTA). This will make a separate non-contrast CT scan superfluous. This study aims to assess the performance of a novel fully automatic algorithm to detect and quantify the Agatston CAC score in contrast CTA images. From a clinical registry, 20 patients were randomly selected for each CAC category (i.e. 0, 1-99, 100-399, 400-999, ≥1,000). The Agatston CAC score on no... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Cardiology in the young, Volume 24 Suppl 2, 27 4 2014, Pages 3-12 Imaging the first trimester heart: ultrasound correlation with morphology. Jansen FA, Calkoen EE, Jongbloed MR, Bartelings MM, Haak MC

First trimester sonography is a widely used technique to examine the foetus early in pregnancy. The desire to recognise complex anatomy already in early developmental stages stresses the need for a thorough knowledge of basic developmental processes as well as recognition of cardiac compartments based on their morphology. In this paper, we describe the possibilities and limitations of sonographic assessment of the foetal heart between 10 and 14 weeks of gestation and correlate this to morphology... Abstract

Cited 5 times since 2014 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 114, Issue 10, 27 4 2014, Pages 1490-1496 Determinants of right ventricular remodeling following ST-segment elevation myocardial infarction. Hoogslag GE, Haeck ML, Velders MA, Joyce E, Boden H, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

Right ventricular (RV) function after ST-segment elevation myocardial infarction (STEMI) has important prognostic implications. However, the changes in RV function over time after STEMI and the incidence of RV remodeling remain unknown. The present study evaluated changes in RV dimensions and function in contemporary patients with first STEMI and assessed the independent determinants of RV dysfunction at follow-up. Patients with first STEMI (n = 940, 60 ± 11 years, 77% men) treated with primary... Abstract

Cited 14 times since 2014 (1.3 per year) source: EuropePMC

The American journal of cardiology, Volume 114, Issue 10, 27 4 2014, Pages 1556-1561 Insights into new-onset rhythm conduction disorders detected by multi-detector row computed tomography after transcatheter aortic valve implantation. Katsanos S, van Rosendael P, Kamperidis V, van der Kley F, Joyce E, Debonnaire P, Karalis I, Bax JJ, Marsan NA, Delgado V

New-onset rhythm conduction disorders are frequent after transcatheter aortic valve implantation (TAVI). Multidetector row computed tomography may shed light on the pathophysiology of rhythm conduction disorders in patients who undergo TAVI with the Edwards SAPIEN valve. A total of 94 patients (mean age 81 ± 7 years, 48% men) treated with TAVI with the Edwards SAPIEN valve who underwent pre- and post-TAVI multidetector row computed tomography were included. Patients with preexisting right bundle... Abstract

Cited 110 times since 2014 (10.5 per year) source: EuropePMC

Nature communications, Volume 5, 27 4 2014, Pages 4747 The evolutionary origin of human hyper-cooperation. Burkart JM, Allon O, Amici F, Fichtel C, Finkenwirth C, Heschl A, Huber J, Isler K, Kosonen ZK, Martins E, Meulman EJ, Richiger R, Rueth K, Spillmann B, Wiesendanger S, van Schaik CP

Proactive, that is, unsolicited, prosociality is a key component of our hyper-cooperation, which in turn has enabled the emergence of various uniquely human traits, including complex cognition, morality and cumulative culture and technology. However, the evolutionary foundation of the human prosocial sentiment remains poorly understood, largely because primate data from numerous, often incommensurable testing paradigms do not provide an adequate basis for formal tests of the various functional h... Abstract

Cited 19 times since 2014 (1.8 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 46, Issue 5, 26 4 2014, Pages 831-839 Bicuspid aortic valve: phosphorylation of c-Kit and downstream targets are prognostic for future aortopathy. Grewal N, Gittenberger-de Groot AC, DeRuiter MC, Klautz RJ, Poelmann RE, Duim S, Lindeman JH, Koenraadt WM, Jongbloed MR, Mohamed SA, Sievers HH, Bogers AJ, Goumans MJ

Objectives: The clinical course of many patients with a bicuspid aortic valve (BAV) is complicated by ascending aortic dilatation. Currently, the indication for aortic surgery is solely based on the aortic diameter and subsequently only a small proportion of BAV patients undergoing valve surgery require concomitant ascending aortic replacement based on these recommendations. Unfortunately, a substantial number of BAV patients still develop aortic dilatation in the future and would potentially be... Abstract

Cited 54 times since 2014 (5.1 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 28, Issue 12, 25 4 2014, Pages 5361-5375 Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity. Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbée JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombès M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC

The endocannabinoid system is an important player in energy metabolism by regulating appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (CB1R) leads to long-term maintenance of weight loss and reduction of dyslipidemia in experimental and human obesity. The molecular mechanism by which CB1R blockade reverses dyslipidemia in obesity has not yet been clarified. In this study, we showed that CB1R blockade with the systemic CB1R blocker rimonabant enhanced wh... Abstract

Cited 24 times since 2014 (2.3 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 7, Issue 5, 23 4 2014, Pages 889-897 Left-sided ablation of ventricular tachycardia in adults with repaired tetralogy of Fallot: a case series. Kapel GF, Reichlin T, Wijnmaalen AP, Tedrow UB, Piers SR, Schalij MJ, Hazekamp MG, Jongbloed MR, Stevenson WG, Zeppenfeld K

Background: Radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in repaired Tetralogy of Fallot focuses on isthmuses in the right ventricle but may be hampered by hypertrophied myocardium or prosthetic material. These patients may benefit from ablation at the left side of the ventricular septum. Methods and results: Records from 28 consecutive repaired Tetralogy of Fallot patients from 2 centers who underwent VT ablation were reviewed. Ablation targeted anatomic isthmuses con... Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

Cardiovascular and interventional radiology, Volume 38, Issue 3, 22 4 2014, Pages 600-605 Thromboembolic complications after Zenith® Low Profile Endovascular Graft for infrarenal abdominal aneurysms. Urlings TA, de Vries AC, de Mol van Otterloo JC, Eefting D, van der Linden E

Purpose: The purpose of this study was to objectify and evaluate risk factors for thromboembolic complications after treatment with a Zenith(®) Low Profile Endovascular Graft (Zenith LP). Results were compared with those in the recent literature on endovascular aortic repair (EVAR) and with the thromboembolic complications in the patient group treated with a Zenith Flex Endovascular Graft in our institute in the period before the use of the Zenith LP. Materials and methods: All consecutive patie... Abstract

Cited 23 times since 2014 (2.2 per year) source: EuropePMC

Transplant international : official journal of the European Society for Organ Transplantation, Volume 27, Issue 10, 22 4 2014, Pages 994-1004 Do Asian renal transplant patients need another mycophenolate mofetil dose compared with Caucasian or African American patients? Li P, Shuker N, Hesselink DA, van Schaik RH, Zhang X, van Gelder T

Mycophenolate mofetil (MMF) is used to prevent acute rejection following solid organ transplantation in transplant centers all over the world. Patients from different ethnic backgrounds are treated with this drug, for which therapeutic drug monitoring (TDM) has not become the standard of practice in most centers. Whether or not some ethnic groups require a different MMF dose has been a topic of debate in recent years. In this review, it is shown that Asian patients, compared with Caucasian patie... Abstract

Cited 18 times since 2014 (1.7 per year) source: EuropePMC

British journal of anaesthesia, Volume 114, Issue 2, 21 3 2014, Pages 319-326 Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats. Lirk P, Verhamme C, Boeckh R, Stevens MF, ten Hoope W, Gerner P, Blumenthal S, de Girolami U, van Schaik IN, Hollmann MW, Picardi S

Background: The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine-induced sciatic nerve block when compared with control animals. Methods: Experiments were carried out in Zucker diabetic fatty rats aged 10 weeks (early diabetic) or 18 weeks (late diabetic, with or without insulin 3 units per day), and age-match... Abstract

Cited 24 times since 2014 (2.3 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 41, Issue 6, 20 3 2014, Pages 1512-1520 Characterization and improved quantification of left ventricular inflow using streamline visualization with 4DFlow MRI in healthy controls and patients after atrioventricular septal defect correction. Calkoen EE, Roest AA, Kroft LJ, van der Geest RJ, Jongbloed MR, van den Boogaard PJ, Blom NA, Hazekamp MG, de Roos A, Westenberg JJ

Purpose: To evaluate trans-left atrioventricular valve (LAVV) blood flow and optimize left ventricular inflow quantification in healthy controls and patients after atrioventricular septal defect (AVSD) correction. Materials and methods: Twenty-five patients after AVSD correction and 25 controls underwent 4DFlow MRI. Using streamline visualization in four- and two-chamber views, inflow direction at early and late filling was defined at the annulus level and at the peak inflow velocity (PIV) level... Abstract

Cited 49 times since 2014 (4.7 per year) source: EuropePMC

European heart journal, Volume 36, Issue 1, 20 3 2014, Pages 39-48 Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin. Kühnast S, van der Tuin SJ, van der Hoorn JW, van Klinken JB, Simic B, Pieterman E, Havekes LM, Landmesser U, Lüscher TF, Willems van Dijk K, Rensen PC, Jukema JW, Princen HM

Background: The residual risk that remains after statin treatment supports the addition of other LDL-C-lowering agents and has stimulated the search for secondary treatment targets. Epidemiological studies propose HDL-C as a possible candidate. Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from atheroprotective HDL to atherogenic (V)LDL. The CETP inhibitor anacetrapib decreases (V)LDL-C by ∼15-40% and increases HDL-C by ∼40-140% in clinical trials. We evaluated the effec... Abstract

Cited 124 times since 2014 (11.8 per year) source: EuropePMC

Journal of lipid research, Volume 55, Issue 10, 19 3 2014, Pages 2103-2112 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin. Kühnast S, van der Hoorn JW, Pieterman EJ, van den Hoek AM, Sasiela WJ, Gusarova V, Peyman A, Schäfer HL, Schwahn U, Jukema JW, Princen HM

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a potential novel strategy for treatment of CVD. Alirocumab is a fully human PCSK9 monoclonal antibody in phase 3 clinical development. We evaluated the antiatherogenic potential of alirocumab in APOE*3Leiden.CETP mice. Mice received a Western-type diet and were treated with alirocumab (3 or 10 mg/kg, weekly subcutaneous dosing) alone and in combination with atorvastatin (3.6 mg/kg/d) for 18 weeks. Alirocumab alone dose-dependen... Abstract

European heart journal. Cardiovascular Imaging, Volume 15, Issue 12, 19 3 2014, Pages 1428 Three-dimensional transoesophageal echocardiographic visualization of malignant anomalous left main coronary origin and course causing sudden cardiac death. Kamperidis V, Katsanos S, Bertels RA, Schalij MJ, Delgado V

Abstract

Cited 20 times since 2014 (1.9 per year) source: EuropePMC

European journal of heart failure, Volume 16, Issue 10, 19 3 2014, Pages 1104-1111 Super-responders to cardiac resynchronization therapy remain at risk for ventricular arrhythmias and benefit from defibrillator treatment. van der Heijden AC, Höke U, Thijssen J, Borleffs CJ, van Rees JB, van der Velde ET, Schalij MJ, van Erven L

Aims: Mortality and ventricular arrhythmias are reduced in patients responding to cardiac resynchronization therapy (CRT). This response is accompanied by improvement in LVEF, and some patients even outgrow original eligibility criteria for implantable cardioverter-defibrillator (ICD) implantation. It is however unclear if these patients still benefit from ICD treatment. The current study aimed to evaluate if the incidence of ICD therapy is related to the extent of CRT response. Methods and resu... Abstract

Cited 16 times since 2014 (1.5 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 98, Issue 5, 19 3 2014, Pages 1680-1686 More than 25 years of experience in managing pulmonary atresia with intact ventricular septum. Schneider AW, Blom NA, Bruggemans EF, Hazekamp MG

Background: Management of pulmonary atresia with intact ventricular septum (PAIVS) is challenging and depends on the individual patient's morphologic characteristics. We evaluated outcomes of 25 years of experience in morphologically driven management of PAIVS. Methods: Between January 1985 and December 2011, 60 patients were treated for PAIVS. Patients were retrospectively categorized into mild (n=27), moderate (n=18), and severe (n=15) right ventricular (RV) hypoplasia subgroups based on... Abstract

Cited 17 times since 2014 (1.6 per year) source: EuropePMC

International journal of cardiology, Volume 176, Issue 3, 17 3 2014, Pages 776-781 Increased carotid intima-media thickness predicts cardiovascular events in aortic coarctation. Luijendijk P, Lu H, Heynneman FB, Huijgen R, de Groot EE, Vriend JW, Vliegen HW, Groenink M, Bouma BJ, Mulder BJ

Background: Adult post-coarctectomy patients (CoA) demonstrate increased cardiovascular morbidity and mortality. The carotid intima-media thickness (CIMT), a marker for atherosclerosis, is increased in CoA. The aim was to evaluate the predictive value of CIMT for cardiovascular events. Methods and results: Consecutive CoA patients were prospectively studied during 10.1±0.7 years follow-up. At baseline and follow-up echocardiography, MRI imaging and CIMT imaging were performed, while cardiovascul... Abstract

Cited 4 times since 2014 (0.4 per year) source: Scopus

The international journal of cardiovascular imaging, Volume 31, Issue 1, 17 3 2014, Pages 37-43 Pericardial effusion following transcatheter aortic valve implantation: echocardiography and multi-detector row computed tomography evaluation. Katsanos S, van Rosendael P, Kamperidis V, van der Kley F, Regeer M, Al-Amri I, Karalis I, Palmen M, de Weger A, Marsan NA, Bax JJ, Delgado V

Although pericardial effusion (PE) early after transcatheter aortic valve implantation (TAVI) has been reported in few registries, late PE at follow-up remains unexplored. Particularly, after transapical TAVI, diagnosis of PE with transthoracic echocardiography (TTE) may be challenging. The present evaluation assessed the incidence of PE early after TAVI and at 1 month follow-up using TTE and multi-detector computed tomography (MDCT). The agreement between TTE and MDCT to diagnose the presence a... Abstract