8892 results
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer,
Volume 10, Issue 2, 1 1 2015, Pages e9
Difference in outcome between types of KRAS mutation may point toward difference in tumor biology.
Mellema WW, Dingemans AM, Jonker M, Smit EF
Abstract
Cited 11 times since 2015 (1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 2, 1 1 2015, Pages 102-108
Left ventricular assist device for end-stage heart failure: results of the first LVAD destination program in the Netherlands.
Haeck ML, Beeres SL, Höke U, Palmen M, Couperus LE, Delgado V, Logeman EA, Maas JJ, Klautz RJ, Schalij MJ, Verwey HF
Purpose: Mechanical circulatory support with a continuous-flow left ventricular assist device (LVAD) may be a valuable treatment in end-stage heart failure patients for an extended period of time. The purpose of this study was to evaluate the safety and efficacy of implantation of a continuous-flow LVAD in end-stage heart failure patients within the first destination program in the Netherlands. Methods: A third-generation LVAD was implanted in 16 heart failure patients (age 61 ± 8; 81 % male; le...
Abstract
Cited 3323 times since 2015 (309.9 per year)
source: EuropePMC
Nature,
Volume 518, Issue 7538, 1 1 2015, Pages 197-206
Genetic studies of body mass index yield new insights for obesity biology.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan J, Mägi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Zhao JH, Zhao W, Chen J, Fehrmann R, Hedman ÅK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Mangino M, Leach IM, Medina-Gomez C, Medland SE, Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Shungin D, Stančáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Isaacs A, Albrecht E, Ärnlöv J, Arscott GM, Attwood AP, Bandinelli S, Barrett A, Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Blüher M, Böhringer S, Bonnycastle LL, Böttcher
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new...
Abstract
Cited 1211 times since 2015 (112.9 per year)
source: EuropePMC
Nature,
Volume 518, Issue 7538, 1 1 2015, Pages 187-196
New genetic loci link adipose and insulin biology to body fat distribution.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JMW, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C, Gustafsson S, Day FR, Esko T, Fall T, Kutalik Z, Luan J, Randall JC, Scherag A, Vedantam S, Wood AR, Chen J, Fehrmann R, Karjalainen J, Kahali B, Liu CT, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bragg-Gresham JL, Buyske S, Demirkan A, Ehret GB, Feitosa MF, Goel A, Jackson AU, Johnson T, Kleber ME, Kristiansson K, Mangino M, Leach IM, Medina-Gomez C, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Stančáková A, Sung YJ, Tanaka T, Teumer A, Van Vliet-Ostaptchouk JV, Yengo L, Zhang W, Albrecht E, Ärnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Böhringer S, Bonnet F, Böttcher Y, Bruinenberg M, Carba DB, Caspersen IH, Clarke R, Daw EW, Deelen J, Deelman E, Delgado G, Doney AS, Eklund N, Erdos MR, Estrada K, Eury E, Friedrich N, Garcia ME, Giedraitis V,
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI)...
Abstract
Cited 16 times since 2015 (1.5 per year)
source: EuropePMC
Cardiovascular drugs and therapy,
Volume 29, Issue 1, 1 1 2015, Pages 59-73
Post-myocardial infarct inflammation and the potential role of cell therapy.
van Zuylen VL, den Haan MC, Geutskens SB, Roelofs H, Fibbe WE, Schalij MJ, Atsma DE
Myocardial infarction triggers reparative inflammatory processes programmed to repair damaged tissue. However, often additional injury to the myocardium occurs through the course of this inflammatory process, which ultimately can lead to heart failure. The potential beneficial effects of cell therapy in treating cardiac ischemic disease, the number one cause of death worldwide, are being studied extensively, both in clinical trials using adult stem cells as well as in fundamental research on car...
Abstract
Cited 16 times since 2015 (1.5 per year)
source: EuropePMC
Critical care medicine,
Volume 43, Issue 2, 1 1 2015, Pages 373-381
Postoperative pro-adrenomedullin levels predict mortality in thoracic surgery patients: comparison with Acute Physiology and Chronic Health Evaluation IV Score*.
Schoe A, Schippers EF, Struck J, Ebmeyer S, Klautz RJ, de Jonge E, van Dissel JT
Objectives: Risk assessment in ICU patients using commonly used prognostic models may be influenced using different data definitions and by errors in data collection. We investigated whether a set of biomarkers (procalcitonin, MR-pro-adrenomedullin, CT-pro-endothelin-1, CT-pro-arginine vasopressin, and MR-pro-atrial natriuretic peptide), alone or as a panel, could be useful in postoperative risk assessment for hospital mortality in comparison with the Acute Physiology and Chronic Health Evaluati...
Abstract
Cited 4 times since 2015 (0.4 per year)
source: EuropePMC
Cardiovascular diagnosis and therapy,
Volume 5, Issue 1, 1 1 2015, Pages 63-66
Myocardial CT perfusion for the prediction of obstructive coronary artery disease, valuable or not?
van Rosendael AR, de Graaf MA, Scholte AJ
Adenosine stress myocardial computed tomography perfusion (CTP) is a relatively new myocardial perfusion imaging technique. Together with coronary CT angiography (CTA) it provides anatomic and functional information of coronary artery disease (CAD). In previous studies, the combination of these techniques demonstrated to be valuable for identifying hemodynamically significant stenoses. George et al., performed a secondary analysis on the CORE320 study and compared the diagnostic performance of C...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 2, 1 1 2015, Pages 130-132
Cardiac arrest during vigorous exercise: coronary plaque rupture or myocardial ischaemia?
van Rosendael AR, de Graaf MA, Scholte AJ
Abstract
Preventive medicine,
Volume 73, 31 5 2015, Pages 117-118
Evolution of prevention: Epidemiological transitions, evolutionary medicine, and clinical practice.
van Schaik K, Rühli F
Abstract
Cited 26 times since 2015 (2.4 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 28, Issue 4, 27 4 2015, Pages 470-477
The relationship between time from myocardial infarction, left ventricular dyssynchrony, and the risk for ventricular arrhythmia: speckle-tracking echocardiographic analysis.
Leong DP, Hoogslag GE, Piers SR, Höke U, Thijssen J, Marsan NA, Schalij MJ, Zeppenfeld K, Bax JJ, Delgado V
Background: Differences in arrhythmogenic substrate may explain the variable efficacy of implantable cardioverter-defibrillators (ICDs) in primary sudden cardiac death prevention over time after myocardial infarction (MI). Speckle-tracking echocardiography allows the assessment left ventricular (LV) dyssynchrony, which may reflect the electromechanical heterogeneity of myocardial tissue. The aim of the present study was to evaluate the relationship among LV dyssynchrony, age of MI, and their ass...
Abstract
Cited 23 times since 2015 (2.1 per year)
source: Scopus
Journal of cardiovascular computed tomography,
Volume 9, Issue 2, 26 4 2015, Pages 129-138
Atherosclerosis burden of the aortic valve and aorta and risk of acute kidney injury after transcatheter aortic valve implantation.
van Rosendael PJ, Kamperidis V, van der Kley F, Katsanos S, Al Amri I, Regeer MV, Schalij MJ, de Weger A, Marsan NA, Bax JJ, Delgado V
Background: Atheroembolic renal disease, due to dislodgement of cholesterol crystals during maneuvering of a large catheter across the aorta and deployment of the transcatheter prosthesis within a calcified aortic valve, may be one of the pathophysiological mechanisms of acute kidney injury (AKI) complicating transcatheter aortic valve implantation (TAVI). Objective: To investigate the association between the atherosclerotic burden and plaque characteristics of the aortic valve and thoracic aort...
Abstract
Cited 282 times since 2015 (26.2 per year)
source: EuropePMC
European heart journal,
Volume 36, Issue 14, 23 4 2015, Pages 847-855
Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated mutation carriers.
Bhonsale A, Groeneweg JA, James CA, Dooijes D, Tichnell C, Jongbloed JD, Murray B, te Riele AS, van den Berg MP, Bikker H, Atsma DE, de Groot NM, Houweling AC, van der Heijden JF, Russell SD, Doevendans PA, van Veen TA, Tandri H, Wilde AA, Judge DP, van Tintelen JP, Calkins H, Hauer RN
Aims: We sought to determine the influence of genotype on clinical course and arrhythmic outcome among arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)-associated mutation carriers. Methods and results: Pathogenic mutations in desmosomal and non-desmosomal genes were identified in 577 patients (241 families) from USA and Dutch ARVD/C cohorts. Patients with sudden cardiac death (SCD)/ventricular fibrillation (VF) at presentation (n = 36) were younger (median 23 vs. 36 years; P &...
Abstract
Cited 10 times since 2015 (0.9 per year)
source: EuropePMC
Cell transplantation,
Volume 24, Issue 12, 23 4 2015, Pages 2463-2478
Human Placenta-Derived Multipotent Cells (hPDMCs) Modulate Cardiac Injury: From Bench to Small and Large Animal Myocardial Ischemia Studies.
Liu YH, Peng KY, Chiu YW, Ho YL, Wang YH, Shun CT, Huang SY, Lin YS, de Vries AA, Pijnappels DA, Lee NT, Yen BL, Yen ML
Cardiovascular disease is the leading cause of death globally, and stem cell therapy remains one of the most promising strategies for regeneration or repair of the damaged heart. We report that human placenta-derived multipotent cells (hPDMCs) can modulate cardiac injury in small and large animal models of myocardial ischemia (MI) and elucidate the mechanisms involved. We found that hPDMCs can undergo in vitro cardiomyogenic differentiation when cocultured with mouse neonatal cardiomyocytes. Mor...
Abstract
Cited 111 times since 2015 (10.3 per year)
source: EuropePMC
Circulation. Cardiovascular genetics,
Volume 8, Issue 2, 22 4 2015, Pages 383-388
Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome.
Franken R, den Hartog AW, Radonic T, Micha D, Maugeri A, van Dijk FS, Meijers-Heijboer HE, Timmermans J, Scholte AJ, van den Berg MP, Groenink M, Mulder BJ, Zwinderman AH, de Waard V, Pals G
Background: It has been shown that losartan reduces aortic dilatation in patients with Marfan syndrome. However, treatment response is highly variable. This study investigates losartan effectiveness in genetically classified subgroups. Methods and results: In this predefined substudy of COMPARE, Marfan patients were randomized to daily receive losartan 100 mg or no losartan. Aortic root dimensions were measured by MRI at baseline and after 3 years. FBN1 mutations were classified based on fibrill...
Abstract
Cited 11 times since 2015 (1 per year)
source: EuropePMC
Physics in medicine and biology,
Volume 60, Issue 4, 22 4 2015, Pages 1477-1496
Influence of vascular normalization on interstitial flow and delivery of liposomes in tumors.
Ozturk D, Yonucu S, Yilmaz D, Unlu MB
Elevated interstitial fluid pressure is one of the barriers of drug delivery in solid tumors. Recent studies have shown that normalization of tumor vasculature by anti-angiogenic factors may improve the delivery of conventional cytotoxic drugs, possibly by increasing blood flow, decreasing interstitial fluid pressure, and enhancing the convective transvascular transport of drug molecules. Delivery of large therapeutic agents such as nanoparticles and liposomes might also benefit from normalizati...
Abstract
Cited 36 times since 2015 (3.3 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 20, Issue 4, 22 4 2015, Pages 520-530
Mortality after cardiac surgery in patients with liver cirrhosis classified by the Child-Pugh score.
Jacob KA, Hjortnaes J, Kranenburg G, de Heer F, Kluin J
Liver cirrhosis is a known risk factor for postoperative mortality in patients undergoing cardiac surgery. Clinical assessment of liver cirrhosis using the widely accepted Child-Pugh (CP) score is thus vital for evaluation of surgical options and perioperative care. However, detailed mortality rates as a consequence of liver cirrhosis are unclear. This review aimed to stratify the risk of short-term (
Abstract
Cited 63 times since 2015 (5.9 per year)
source: EuropePMC
Journal of virology,
Volume 89, Issue 7, 21 3 2015, Pages 3763-3775
Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses.
Koel BF, Mögling R, Chutinimitkul S, Fraaij PL, Burke DF, van der Vliet S, de Wit E, Bestebroer TM, Rimmelzwaan GF, Osterhaus AD, Smith DJ, Fouchier RA, de Graaf M
Unlabelled: The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from neutralizing antibodies, affect viral fitness, and change receptor preference. In this study, we constructed mutants with substitutions in the hemagglutinin of A/Netherlands/602/0...
Abstract
Cited 62 times since 2015 (5.8 per year)
source: EuropePMC
Circulation research,
Volume 116, Issue 5, 21 3 2015, Pages 836-845
Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling.
Qi XY, Huang H, Ordog B, Luo X, Naud P, Sun Y, Wu CT, Dawson K, Tadevosyan A, Chen Y, Harada M, Dobrev D, Nattel S
Rationale: Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis. Fibroblasts display robust ion currents, but their functional importance is poorly understood. Objective: To characterize atrial fibroblast inward-rectifier K(+) current (IK1) remodeling in CHF and its effects on fibroblast properties. Methods and results: Freshly isolated left atrial fibroblasts were obtained from co...
Abstract
Cited 18 times since 2015 (1.7 per year)
source: EuropePMC
European journal of radiology,
Volume 84, Issue 5, 20 3 2015, Pages 856-861
Volumetric CT-images improve testing of radiological image interpretation skills.
Ravesloot CJ, van der Schaaf MF, van Schaik JP, ten Cate OT, van der Gijp A, Mol CP, Vincken KL
Rationale and objectives: Current radiology practice increasingly involves interpretation of volumetric data sets. In contrast, most radiology tests still contain only 2D images. We introduced a new testing tool that allows for stack viewing of volumetric images in our undergraduate radiology program. We hypothesized that tests with volumetric CT-images enhance test quality, in comparison with traditional completely 2D image-based tests, because they might better reflect required skills for clin...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
Renal failure,
Volume 37, Issue 3, 19 3 2015, Pages 387-391
Evaluation of children with steroid-sensitive nephrotic syndrome in terms of allergies.
Yılmaz D, Yenigün A, Sönmez F, Kurt Ömürlü İ
Background: The etiology of minimal-change disease is not fully known, it is believed to be mediated by the immune system. Minimal-change disease also reported as having association with atopy. In this study, atopy history, the levels of serum IgE, and skin prick test in children with steroid-sensitive nephrotic syndrome were investigated. Methods: A group of 30 children (mean age 7.7 ± 2.2 years, 56.6% male) diagnosed with steroid-sensitive nephrotic syndrome were included in the study. Serum i...
Abstract
