Research

Publications

Below you can find a list of our published research.

6239 results

Circulation. Arrhythmia and electrophysiology, 25 4 2025, Pages e013670 Race Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium. Trongtorsak A, De La Rosa Martinez J, Crawford TC, Bogun FM, Gu X, Purroll E, Ellenbogen KA, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Soejima K, Bhan AK, Vedantham V, Dickfeld TL, De Lurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Torosoff M, Judson MA, Martin K, Madias C, Hermel M, Nour K, Torbey E, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium

Background: Differences in cardiac sarcoidosis between racial groups remain understudied. Therefore, this study aims to explore race differences in patients with cardiac sarcoidosis. Methods: We analyzed data from the Cardiac Sarcoidosis Consortium, an international registry including over 25 centers. The primary clinical outcome was a composite end point of all-cause mortality, left ventricular assist device implantation, heart transplantation, or implantable cardioverter defibrillator therapy.... Abstract

PloS one, Volume 20, Issue 6, 25 4 2025, Pages e0327044 Exploring the potential of blood and urine protein electrophoresis in predicting 1-year mortality in acute kidney injury. Yilmaz D, Sahin E, Batar G, Caglayan K, Gulturk E, Aydin Yoldemir S

This retrospective cohort study aimed to assess the predictive value of protein fractions obtained from blood and urine protein electrophoresis, along with various clinical and laboratory parameters, for 1-year all-cause mortality in acute kidney injury (AKI) patients. Data were collected from hospitalized patients who had been diagnosed with AKI. Demographics, smoking status, blood and urine electrophoresis results, serum gamma globulin levels, monoclonal gammopathy status, immunofixation resul... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 23 4 2025 Intravascular Lithotripsy for Calcific Coronary Bifurcations: Procedural Success and 1-Year Clinical Outcomes. Oliveri F, D'Acunto G, Oort MJHV, Phagu A, Amri IA, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) has emerged as a promising treatment for heavily calcified coronary lesions. However, evidence regarding its effectiveness in calcific bifurcation lesions remains limited. Objective: We aimed to evaluate the technical success and 1-year clinical outcomes of IVL in calcified coronary bifurcation lesions. Methods: Patients undergoing PCI with the use of IVL from the ongoing prospective BENELUX-IVL registry were included. Participants were stratified into... Abstract

Acta biomaterialia, 21 3 2025, Pages S1742-7061(25)00454-4 Multilayered Trabecular Meshwork for Dynamic In Vitro Studies in Glaucoma Research. Gładysz MZ, Fernandes MGG, Li X, Koch M, Marchena F, Hofman A, de Graaf M, Wolters JC, Kamperman M, Nagelkerke A, Włodarczyk-Biegun MK

Glaucoma, an eye disease causing incremental vision loss, currently has no cure. Its primary cause is the malfunction of the trabecular meshwork (TM), a multilayered tissue in the eye responsible for draining aqueous humor (AH) from the anterior chamber. TM clogging increases outflow resistance, elevates intraocular pressure (IOP), and damages optic nerves, leading to irreversible blindness. Existing in vitro TM models are suboptimal, as they lack the hierarchical structure of the TM. This artic... Abstract

Physics in medicine and biology, 20 3 2025 Analysis and generation of the fibrosis textures based on histology data of the human hearts with non-ischemic cardiomyopathy. Okenov A, Nezlobinsky T, Glashan CA, Zeppenfeld K, Vandersickel N, Panfilov A

Objective: Cardiac arrhythmias, marked by irregular and/or fast heartbeats, can severely compromise heart function and pose serious health risks. Fibrosis alters the propagation of electrical signals in the heart and plays a critical role in arrhythmogenesis. The impact of fibrosis depends not only on its amount, but also on its geometric features and spatial distribution. Therefore, understanding and replicating the structural characteristics of fibrotic tissue is essential for accurat... Abstract

International journal of cardiology, 19 3 2025, Pages 133526 Sex-specific response to cardiac resynchronization therapy: the BIO|WOMEN trial. Zamorano JL, Vörös G, Calvi V, Osca J, Quesada A, Vernooy K, Martinez JG, Maass AH, Nof E, Tolosana JM, Pardo M, Barr C, Fernández I, Merino JL, Ellery S, Ricoy-Martínez E, Belotti G, Seidlmayer L, Garcia S, Tönnis T, Campbell NG, Foley P, Brockmeier J, Nürnberg M, Ruiz-Granell R, Prinzen FW, Lorente-Ros Á, Moreno A, Pinart M, Ver Heyen M, Van Erven L

Background: Variable evidence exists about the efficacy of Cardiac resynchronization therapy (CRT) in women vs. men with reduced left ventricular ejection fraction (LVEF) and wide QRS complex. Current guidelines, hindered by underrepresentation of women in clinical trials, lack definitive recommendations. The present study was designed to achieve an equal distribution of women and men to prospectively evaluate sex-specific response to CRT. Methods: The primary endpoint was the absolute increase... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 16 3 2025, Pages euaf122 Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrythmia radioablation (STAR) using a commercial software. Rademaker R, Cirkel S, Omara S, Dankers F, Sramko M, Solana Munoz J, Kaya YS, Ter Bekke R, Schiappacasse L, Teres C, Verhoeven K, Pruvot E, Rasch C, Zeppenfeld K

Background and aims: Stereotactic arrhythmia radioablation (STAR) has emerged as bail-out treatment for ventricular tachycardia (VT). Accurate, reproducible, and easy-to-use data transfer from electroanatomical mapping (EAM) systems to radiotherapy planning CT is desirable. We aim to evaluate interobserver variability, ease of use, and learning curve for EAM based target volume (CardTV-EPinv) creation and transfer using available software packages. Methods: In patients considered for STAR, CardT... Abstract

Therapeutic advances in chronic disease, Volume 16, 12 2 2025, Pages 20406223251333570 Systematic review: the use of tacrolimus in steroid-refractory ulcerative colitis. Jangra V, Yilmaz D, Soares D, Taylor F, Andreani S, Hotouras A

Background: Steroid-refractory ulcerative colitis (SR-UC) is a severe form of ulcerative colitis (UC) that persists despite high-dose corticosteroid therapy. Management is challenging and often requires biologics, immunosuppressants or colectomy. Tacrolimus, a calcineurin inhibitor with immunomodulatory effects, has emerged as a potential alternative, though its efficacy, safety and long-term outcomes remain uncertain. Objectives: This systematic review evaluates the efficacy and safety of tacro... Abstract

Human vaccines & immunotherapeutics, Volume 21, Issue 1, 10 2 2025, Pages 2516949 A new quadrivalent meningococcal tetanus toxoid conjugate vaccine: Menquadfi® (MENACWY-TT). Dinleyici EC, Ciftci E, Somer A, Yilmaz D, Tezer H

Neisseria meningitidis (Nm) remains a major global health concern, causing invasive meningococcal disease (IMD) with significant morbidity and mortality. Despite vaccination efforts, Nm serogroup prevalence and antibiotic resistance continue to evolve, necessitating ongoing surveillance and novel immunization strategies. This review aims to assess the role of MenACWY-TT, a quadrivalent meningococcal conjugate vaccine, in IMD prevention by evaluating its immunogenicity, safety, and real-world eff... Abstract

International journal of cardiology, Volume 437, 8 2 2025, Pages 133493 Prognostic utility of hybrid coronary computed tomography angiography and myocardial perfusion imaging in elderly patients with suspected coronary artery disease. Nammas W, Ajosenpää I, Maaniitty T, Stenström I, Bax JJ, Knuuti J, Saraste A

Background: The prognostic utility of sequential hybrid imaging strategy (coronary computed tomography angiography (CCTA) followed by positron emission tomography (PET) myocardial perfusion imaging in those with obstruction) in the elderly remains unclear. We explored the predictors of adverse outcome in patients ≥65, versus those Abstract

European heart journal. Cardiovascular Imaging, 5 1 2025, Pages jeaf165 Left Ventricular Dilatation in Patients with Significant Aortic Regurgitation: Association with Outcome. Lopez Santi P, Bernard J, Fortuni F, Butcher SC, Meucci MC, Sarrazyn C, Chua AP, Nabeta T, Zhang J, Popescu BA, Tay ELW, Yiu KH, Clavel MA, Pibarot P, Bax JJ, Ajmone Marsan N

Aims: Left ventricular (LV) dilatation is an important prognostic factor in patients with aortic regurgitation (AR). Although current guidelines recommend the use of LV end-systolic diameter index (LVESDi) to indicate the need for intervention, recent studies suggested that LV end-systolic volume index (LVESVi) may more accurately characterize LV remodeling.The present study aims to evaluate, in a multi-center setting, whether combining LV-linear and volumetric measures could improve risk strati... Abstract

Expert review of respiratory medicine, 4 1 2025, Pages 1-11 The relation between visceral fat and lung function in the general population is in part mediated by CRP and leptin. Oosterom-Eijmael MJP, le Cessie S, Slats AM, Hiemstra PS, Thijs W, Lamb HJ, Willems van Dijk K, Rosendaal FR, de Mutsert R

Background: Abdominal obesity is associated with reduced lung function. It remains unclear whether this results from mechanical pressure or whether visceral fat also plays a role via inflammation. Our aim was to examine the association between visceral fat and lung function, and the role of inflammation. Methods: In this cross-sectional analysis, visceral fat was measured by magnetic resonance imaging and lung function by spirometry. We examined the association between visceral fat and lung func... Abstract

Neurology, Volume 104, Issue 12, 3 1 2025, Pages e213673 Epigenetic Aging in Pediatric-Onset Multiple Sclerosis. Goyne C, Fair AE, Yilmaz D, Race J, Schuette A, Caillier SJ, Aaen GS, Abrams AW, Benson LA, Casper TC, Chitnis T, Gorman MP, Lotze TE, Krupp LB, Mar SS, Ness JM, Rensel M, Rodriguez M, Rose JW, Schreiner TL, Tillema JM, Waldman AT, Wheeler YS, Barcellos LF, Waubant E, Graves JS, as the US Network of Pediatric MS Centers

Background and objectives: Older chronological age is associated with decreased multiple sclerosis (MS) relapse rates and increased risk of progressive disease. Measurement of biological age may be more precise than birthdate in understanding these aging effects. In addition to normal aging, MS-related accelerated aging may contribute. Measurement of biological age in adults may be confounded by the effects of natural aging and age-related comorbidities. Examining age extremes can be informative... Abstract

American heart journal plus : cardiology research and practice, Volume 56, 3 1 2025, Pages 100562 Impact of aortic valve calcification volume on left ventricular systolic function in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation. Anwar HS, Algowhary M, Abdelmegid MAF, Helmy HA, Montero-Cabezas JM, Van Der Kley F

Background: Aortic valve calcification (AVC) has been linked to negative cardiac outcomes in patients with aortic stenosis (AS). Given the limited understanding of its specific contributions, we aimed to investigate the interaction between AVC and the left ventricular (LV) systolic function in patients with severe AS and LV systolic dysfunction who underwent transcatheter aortic valve implantation (TAVI). Materials and methods: An observational study of 75 patients with severe AS and LV ejection... Abstract

Journal of applied physiology (Bethesda, Md. : 1985), Volume 138, Issue 6, 2 1 2025, Pages 1560-1570 Intraoperative evaluation of right ventricular mechanics in a pressure-overload swine model. Lo Muzio FP, Zirngast B, Karner B, Manninger M, Fontana M, Steendijk P, Mächler H, Rozzi G, Alogna A

Assessment of right ventricular (RV) mechanical performance during open chest surgery is typically based on invasive methods and subjective evaluations. This study developed a porcine model of acute progressive RV pressure overload to evaluate hemodynamic changes and validate the three- dimensional (3-D) video kinematic assessment of the videocardiograph (VCG). Seven healthy Landrace pigs were instrumented under fluoroscopic guidance with Swan-Ganz and RV conductance catheters. Following a media... Abstract

JACC. Cardiovascular imaging, Volume 18, Issue 6, 1 1 2025, Pages 745-746 Reply: Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in the Setting of Mitral Annular Disjunction. van der Bijl P, Stassen J, Ajmone Marsan N, Bax JJ

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Cited 2 times since 2025 (24.1 per year) source: EuropePMC

European heart journal, Volume 46, Issue 22, 1 1 2025, Pages 2079-2088 Transcatheter vs. surgical aortic valve replacement in women: the RHEIA trial. Tchetche D, Pibarot P, Bax JJ, Bonaros N, Windecker S, Dumonteil N, Nietlispach F, Messika-Zeitoun D, Pocock SJ, Berthoumieu P, Swaans MJ, Timmers L, Rudolph TK, Bleiziffer S, Leroux L, Modine T, van der Kley F, Auffret V, Tomasi J, Stastny L, Hengstenberg C, Andreas M, Leclercq F, Gandet T, Mascherbauer J, Trescher K, Prendergast B, Vasa-Nicotera M, Chieffo A, Mares J, Wesselink W, Rakova R, Kurucova J, Bramlage P, Eltchaninoff H

Background and aims: Although women with severe symptomatic aortic stenosis have more complications than men when undergoing surgical valve replacement, they are under-represented in clinical trials. The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial investigates the balance of benefits and risks of transcatheter aortic valve implantation (TAVI) vs. surgery in women. Methods: Women were randomized 1:1 to transfemoral TAVI with a balloon-expandable valve or surgery. Th... Abstract

JACC. Cardiovascular interventions, Volume 18, Issue 12, 1 1 2025, Pages 1540-1553 Aortic Valve Replacement in Women: A Pooled Analysis of the RHEIA and PARTNER 3 Trials. Eltchaninoff H, Windecker S, Mack MJ, Pibarot P, Thourani VH, Bax JJ, Cohen DJ, Bonaros N, Makkar R, Bleiziffer S, Szeto WY, Berthoumieu P, Hahn RT, Hovorka T, Mareš J, Taylor J, Tchetche D, Leon MB

Background: In women with severe aortic stenosis, there are limited data regarding outcome differences following transcatheter (TAVR) vs surgical aortic valve replacement (SAVR). Objectives: The authors sought to examine outcomes of TAVR vs SAVR in a patient-level pooled analysis of women in the RHEIA and PARTNER 3 trials. Methods: Patients in both trials were randomly allocated to a balloon-expandable SAPIEN 3/Ultra valve or to surgical bioprostheses. Individual patient data of female participa... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 67, Issue 6, 1 1 2025, Pages ezaf161 Sex difference in aortic root replacement with a stentless bioprosthesis†. Dagnegård H, Schneider AW, Timmermans PT, Glaser N, Kolseth SM, Vanky F, Gudbjartsson T, Haaverstad R, Cotovanu A, Sartipy U, Klautz RJM, Smerup M, Hjortnaes J, North Atlantic Freestyle Collaboration

Objectives: To investigate and quantify differences in survival and reinterventions between sexes after aortic root replacement with a stentless bioprosthesis, stratified for preoperative valve lesion. Methods: Elective adults undergoing aortic root replacement with the Freestyle bioprosthesis at six North-Atlantic centres were included. Survival analyses were performed using the Kaplan-Meier method or Aalen-Johansen with death as competing risk as relevant. Results were quantified using uni- an... Abstract

Radiology. Cardiothoracic imaging, Volume 7, Issue 3, 1 1 2025, Pages e240200 Pericoronary Adipose Tissue Attenuation in Patients with Future Acute Coronary Syndromes: The ICONIC Study. Kwan AC, Tzolos E, Klein E, Han D, Lin A, Kuronuma K, Chen B, Flores Tomasino G, Gransar H, Slomka PJ, Cheng S, Gebhard C, Kaufmann P, Bax JJ, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic JA, Maffei E, Marques H, Plank F, Pontone G, Villines TC, Al-Mallah MH, Gonçalves PA, Danad I, Lu Y, Lee JH, Lee SE, Baskaran L, Al'Aref SJ, Budoff MJ, Samady H, Stone PH, Virmani R, Achenbach S, Narula J, Chang HJ, Shaw LJ, Berman DS, Lin F, Dey D

Purpose Pericoronary adipose tissue attenuation (PCATa) measured at coronary CT angiography (CCTA) is an imaging biomarker of coronary inflammation associated with long-term adverse cardiac events. The authors hypothesized that PCATa may independently identify patients at risk for acute coronary syndromes (ACS). Materials and Methods The authors performed a retrospective substudy of the Incident Coronary Syndromes Identified by Computed Tomography (ICONIC) study, a propensity-matched case-contro... Abstract