6228 results
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
16 3 2025, Pages euaf122
Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrythmia radioablation (STAR) using a commercial software.
Rademaker R, Cirkel S, Omara S, Dankers F, Sramko M, Solana Munoz J, Kaya YS, Ter Bekke R, Schiappacasse L, Teres C, Verhoeven K, Pruvot E, Rasch C, Zeppenfeld K
Background and aims: Stereotactic arrhythmia radioablation (STAR) has emerged as bail-out treatment for ventricular tachycardia (VT). Accurate, reproducible, and easy-to-use data transfer from electroanatomical mapping (EAM) systems to radiotherapy planning CT is desirable. We aim to evaluate interobserver variability, ease of use, and learning curve for EAM based target volume (CardTV-EPinv) creation and transfer using available software packages. Methods: In patients considered for STAR, CardT...
Abstract
Therapeutic advances in chronic disease,
Volume 16, 12 2 2025, Pages 20406223251333570
Systematic review: the use of tacrolimus in steroid-refractory ulcerative colitis.
Jangra V, Yilmaz D, Soares D, Taylor F, Andreani S, Hotouras A
Background: Steroid-refractory ulcerative colitis (SR-UC) is a severe form of ulcerative colitis (UC) that persists despite high-dose corticosteroid therapy. Management is challenging and often requires biologics, immunosuppressants or colectomy. Tacrolimus, a calcineurin inhibitor with immunomodulatory effects, has emerged as a potential alternative, though its efficacy, safety and long-term outcomes remain uncertain. Objectives: This systematic review evaluates the efficacy and safety of tacro...
Abstract
Human vaccines & immunotherapeutics,
Volume 21, Issue 1, 10 2 2025, Pages 2516949
A new quadrivalent meningococcal tetanus toxoid conjugate vaccine: Menquadfi® (MENACWY-TT).
Dinleyici EC, Ciftci E, Somer A, Yilmaz D, Tezer H
Neisseria meningitidis (Nm) remains a major global health concern, causing invasive meningococcal disease (IMD) with significant morbidity and mortality. Despite vaccination efforts, Nm serogroup prevalence and antibiotic resistance continue to evolve, necessitating ongoing surveillance and novel immunization strategies. This review aims to assess the role of MenACWY-TT, a quadrivalent meningococcal conjugate vaccine, in IMD prevention by evaluating its immunogenicity, safety, and real-world eff...
Abstract
International journal of cardiology,
8 2 2025, Pages 133493
Prognostic utility of hybrid coronary computed tomography angiography and myocardial perfusion imaging in elderly patients with suspected coronary artery disease.
Nammas W, Ajosenpää I, Maaniitty T, Stenström I, Bax JJ, Knuuti J, Saraste A
Background: The prognostic utility of sequential hybrid imaging strategy (coronary computed tomography angiography (CCTA) followed by positron emission tomography (PET) myocardial perfusion imaging in those with obstruction) in the elderly remains unclear. We explored the predictors of adverse outcome in patients ≥65, versus those
Abstract
European heart journal. Cardiovascular Imaging,
5 1 2025, Pages jeaf165
Left Ventricular Dilatation in Patients with Significant Aortic Regurgitation: Association with Outcome.
Lopez Santi P, Bernard J, Fortuni F, Butcher SC, Meucci MC, Sarrazyn C, Chua AP, Nabeta T, Zhang J, Popescu BA, Tay ELW, Yiu KH, Clavel MA, Pibarot P, Bax JJ, Ajmone Marsan N
Aims: Left ventricular (LV) dilatation is an important prognostic factor in patients with aortic regurgitation (AR). Although current guidelines recommend the use of LV end-systolic diameter index (LVESDi) to indicate the need for intervention, recent studies suggested that LV end-systolic volume index (LVESVi) may more accurately characterize LV remodeling.The present study aims to evaluate, in a multi-center setting, whether combining LV-linear and volumetric measures could improve risk strati...
Abstract
Expert review of respiratory medicine,
4 1 2025, Pages 1-11
The relation between visceral fat and lung function in the general population is in part mediated by CRP and leptin.
Oosterom-Eijmael MJP, le Cessie S, Slats AM, Hiemstra PS, Thijs W, Lamb HJ, Willems van Dijk K, Rosendaal FR, de Mutsert R
Background: Abdominal obesity is associated with reduced lung function. It remains unclear whether this results from mechanical pressure or whether visceral fat also plays a role via inflammation. Our aim was to examine the association between visceral fat and lung function, and the role of inflammation. Methods: In this cross-sectional analysis, visceral fat was measured by magnetic resonance imaging and lung function by spirometry. We examined the association between visceral fat and lung func...
Abstract
Neurology,
Volume 104, Issue 12, 3 1 2025, Pages e213673
Epigenetic Aging in Pediatric-Onset Multiple Sclerosis.
Goyne C, Fair AE, Yilmaz D, Race J, Schuette A, Caillier SJ, Aaen GS, Abrams AW, Benson LA, Casper TC, Chitnis T, Gorman MP, Lotze TE, Krupp LB, Mar SS, Ness JM, Rensel M, Rodriguez M, Rose JW, Schreiner TL, Tillema JM, Waldman AT, Wheeler YS, Barcellos LF, Waubant E, Graves JS, as the US Network of Pediatric MS Centers
Background and objectives: Older chronological age is associated with decreased multiple sclerosis (MS) relapse rates and increased risk of progressive disease. Measurement of biological age may be more precise than birthdate in understanding these aging effects. In addition to normal aging, MS-related accelerated aging may contribute. Measurement of biological age in adults may be confounded by the effects of natural aging and age-related comorbidities. Examining age extremes can be informative...
Abstract
Journal of applied physiology (Bethesda, Md. : 1985),
2 1 2025
Intraoperative Evaluation of Right Ventricular Mechanics in a Pressure-Overload Swine Model.
Lo Muzio FP, Zirngast B, Karner B, Manninger M, Fontana M, Steendijk P, Mächler H, Rozzi G, Alogna A
Objectives: Assessment of right ventricular (RV) mechanical performance during open chest surgery is typically based on invasive methods and subjective evaluations. This study developed a porcine model of acute progressive RV pressure overload to evaluate hemodynamic changes and validate the 3D-video kinematic assessment of the Videocardiograph (VCG). Methods: Seven healthy Landrace pigs were instrumented under fluoroscopic guidance with Swan-Ganz and RV conductance catheters. Following a median...
Abstract
JACC. Cardiovascular imaging,
Volume 18, Issue 6, 1 1 2025, Pages 745-746
Reply: Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in the Setting of Mitral Annular Disjunction.
van der Bijl P, Stassen J, Ajmone Marsan N, Bax JJ
Abstract
Cited 2 times since 2025 (43.1 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 22, 1 1 2025, Pages 2079-2088
Transcatheter vs. surgical aortic valve replacement in women: the RHEIA trial.
Tchetche D, Pibarot P, Bax JJ, Bonaros N, Windecker S, Dumonteil N, Nietlispach F, Messika-Zeitoun D, Pocock SJ, Berthoumieu P, Swaans MJ, Timmers L, Rudolph TK, Bleiziffer S, Leroux L, Modine T, van der Kley F, Auffret V, Tomasi J, Stastny L, Hengstenberg C, Andreas M, Leclercq F, Gandet T, Mascherbauer J, Trescher K, Prendergast B, Vasa-Nicotera M, Chieffo A, Mares J, Wesselink W, Rakova R, Kurucova J, Bramlage P, Eltchaninoff H
Background and aims: Although women with severe symptomatic aortic stenosis have more complications than men when undergoing surgical valve replacement, they are under-represented in clinical trials. The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial investigates the balance of benefits and risks of transcatheter aortic valve implantation (TAVI) vs. surgery in women. Methods: Women were randomized 1:1 to transfemoral TAVI with a balloon-expandable valve or surgery. Th...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 6, 1 1 2025, Pages ezaf161
Sex difference in aortic root replacement with a stentless bioprosthesis†.
Dagnegård H, Schneider AW, Timmermans PT, Glaser N, Kolseth SM, Vanky F, Gudbjartsson T, Haaverstad R, Cotovanu A, Sartipy U, Klautz RJM, Smerup M, Hjortnaes J, North Atlantic Freestyle Collaboration
Objectives: To investigate and quantify differences in survival and reinterventions between sexes after aortic root replacement with a stentless bioprosthesis, stratified for preoperative valve lesion. Methods: Elective adults undergoing aortic root replacement with the Freestyle bioprosthesis at six North-Atlantic centres were included. Survival analyses were performed using the Kaplan-Meier method or Aalen-Johansen with death as competing risk as relevant. Results were quantified using uni- an...
Abstract
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Volume 39, Issue 12, 1 1 2025, Pages e70735
Fibrogenic Gene Signature as Early Prediction for the Efficacy of Pharmacological Interventions for MASH-Associated Fibrosis.
Inia JA, Morrison MC, van Koppen A, Gart E, Caspers MPM, Menke AL, Worms N, Kleemann R, Verschuren L, Jukema JW, Princen HMG, Hanemaaijer R, van den Hoek AM
The incidence of metabolic dysfunction-associated steatohepatitis (MASH) and associated liver fibrosis is rapidly increasing, while pharmacological treatment options remain limited. Despite great efforts in developing novel MASH therapeutics, many investigative therapeutics that reduced fibrosis in preclinical models ultimately failed in clinical trials. To this end, we explored the possibility of predicting the efficacy of therapeutics by evaluating changes in the expression of a fibrogenic gen...
Abstract
Substance abuse treatment, prevention, and policy,
Volume 20, Issue 1, 28 4 2025, Pages 23
Effect and acceptability of an mHealth smoking cessation intervention 'Stopcoach' combined with smoking cessation counseling for people from multiple levels of socioeconomic position: a multi-methods study.
de Frel DL, Zijp A, van den Putte B, Troelstra S, Hermsen S, Heemskerk E, Janssen VR, Atsma DE, Chavannes NH, Meijer E
Introduction: Smoking cessation interventions tend to be less effective for people of lower socioeconomic position (SEP) compared to those of higher SEP. Mobile phone-based interventions have been shown to increase abstinence from smoking. Stopcoach is an mHealth smoking cessation intervention that specifically targets people with a lower SEP. A pilot study showed the potential and feasibility of Stopcoach but as yet no research exists that assesses the effectiveness of Stopcoach. Objective: Thi...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
27 4 2025
Comparison of Procedural and Clinical Outcomes of Angiography- Versus Imaging-Guided Percutaneous Coronary Intervention With Intravascular Lithotripsy.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Mincione G, Paradies V, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Al Amri I, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) is an innovative treatment for coronary artery calcification (CAC). Aims: This study aimed to compare procedural and clinical outcomes of intracoronary imaging (ICI)-guided percutaneous coronary intervention (PCI) versus angiography-guided PCI with IVL in patients with CAC. Methods: A total of 509 patients were analyzed from the BENELUX-IVL registry (May 2019 to September 2024). Angiography-guided PCI with IVL was defined as therapy under solely fluoro...
Abstract
The Journal of dermatological treatment,
Volume 36, Issue 1, 27 4 2025, Pages 2503273
Treatment goals and preferences of pediatric atopic dermatitis patients, young adults, and caregivers.
van der Rijst LP, de Bruin-Weller MS, Zuithoff NPA, Spillekom-van Koulil S, Seyger MMB, de Graaf M
Purpose: Understanding the treatment goals and preferences of young atopic dermatitis (AD) patients and their caregivers is crucial for enhancing patient-centered care. This study aims to identify these goals and preferences and explore heterogeneity among subgroups. Materials and methods: A web-based survey was conducted among children (6-11 years), adolescents (12-17 years), and young adults (18-30 years) with AD and caregivers of AD patients. Survey questions included multiple-choice, four-po...
Abstract
The international journal of cardiovascular imaging,
22 4 2025
Evolution and prognostic implications of cardiac damage in women after transcatheter aortic valve implantation.
Myagmardorj R, Fortuni F, Galloo X, Nabeta T, Meucci MC, Butcher SC, van der Kley F, Ajmone Marsan N, Bax JJ
Recently, a cardiac damage staging system has been proposed in patients with severe AS to improve risk stratification, but there is still paucity of data in women. Accordingly, we aimed to characterize the change in cardiac damage after transcatheter aortic valve implantation (TAVI), and to assess the prognostic value of cardiac damage staging in women. A total of 334 women (mean age 81 ± 7 years) with severe AS undergoing TAVI were included and retrospectively analyzed. Echocardiography was per...
Abstract
Healthcare (Basel, Switzerland),
Volume 13, Issue 11, 22 4 2025, Pages 1217
Bridging Barriers: Engaging Ethnic Minorities in Cardiovascular Research.
Bacour N, Grewal S, Ploem MC, Suurmond J, Klautz RJM, Grewal N
Background/Objectives: We address the ongoing under-representation of ethnic minority groups in cardiovascular research in this opinion paper-a challenge that limits both scientific validity and equitable healthcare outcomes. We aim to outline the underlying causes of this issue and propose concrete strategies to address it. Methods: To engage ethnic minorities in cardiovascular research, we thoroughly studied the existing literature and gathered expert opinions to identify barriers and formulat...
Abstract
American journal of preventive cardiology,
Volume 22, 22 4 2025, Pages 101008
The interactions of Lipoprotein(a) with common cardiovascular risk factors in cardiovascular disease risk: evidence based on the UK Biobank.
Ao L, Noordam R, Jukema JW, van Heemst D, Willems van Dijk K
Background: : Although Lipoprotein(a) (Lp(a)) is associated with cardiovascular disease, it is unclear whether the associated risk is similar in the presence of other concomitant risk factors. Here, we aimed to investigate the interactions between Lp(a) and common cardiovascular risk factors on coronary artery disease (CAD), calcific aortic valve stenosis (CAVS) and ischemic stroke (IS). Methods: : We included 127,958 unrelated European-ancestry participants from UK Biobank (54.7 % women) with d...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
19 3 2025
Efficacy and Safety of Intravascular Lithotripsy in the Management of Underexpanded Stents: A Systematic Review and Meta-Analysis.
Sagris M, Soulaidopoulos S, Papanikolaou A, Ktenopoulos N, van Oort MJH, Montero-Cabezas JM, Patsourakos N, Honton B, Tousoulis D, Tsioufis K
Background: Stent underexpansion significantly heightens the risk of major adverse cardiac events (MACE), and available treatment options for this condition remain limited. Intravascular Lithotripsy (IVL) technology disrupts superficial and deep calcium by using localized pulsative sonic pressure waves, emerges as a promising tool for underexpanded stents. Aims: This study examines the overall efficacy and safety of IVL, an until-now off-label modality, in the management of underexpanded stents....
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
15 3 2025
Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum.
van der Rijst LP, Knol EF, Zuithoff NPA, den Hartog Jager CF, van Wijk F, de Bruin-Weller MS, de Graaf M
Objective: This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity. Methods: Twenty paediatric AD patients (
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