Research

Publications

Below you can find a list of our published research.

9543 results

Cited 14 times since 2020 (2.5 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 162, Issue 6, 12 2 2020, Pages 1684-1695 Comparison of microstructural alterations in the proximal aorta between aortic stenosis and regurgitation. Sequeira Gross TM, Lindner D, Ojeda FM, Neumann J, Grewal N, Kuntze T, Blankenberg S, Reichenspurner H, Westermann D, Girdauskas E

Objective: We aimed to analyze the association among flow patterns, gene expression, and histologic alterations of the proximal aorta in patients with aortic valve disease. Methods: A total of 131 patients referred for aortic valve replacement were grouped by valve dysfunction (aortic stenosis vs aortic regurgitation) and valve morphology (bicuspid vs tricuspid). On the basis of magnetic resonance imaging, aortic tissue from outer and inner curvature was collected for gene expression and histolo... Abstract

Cited 53 times since 2020 (9.3 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 13, Issue 3, 12 2 2020, Pages e009750 Impact of Clinical Characteristics and Statins on Coronary Plaque Progression by Serial Computed Tomography Angiography. Smit JM, van Rosendael AR, El Mahdiui M, Neglia D, Knuuti J, Saraste A, Buechel RR, Teresinska A, Pizzi MN, Roque A, Poddighe R, Mertens BJ, Caselli C, Rocchiccioli S, Parodi O, Pelosi G, Scholte AJ

Background Progression of coronary artery disease using serial coronary computed tomography angiography (CTA) is of clinical interest. Our primary aim was to prospectively assess the impact of clinical characteristics and statin use on quantitatively assessed coronary plaque progression in a low-risk study population during long-term follow-up. Methods Patients who previously underwent coronary CTA for suspected coronary artery disease were prospectively included to undergo follow-up coronary CT... Abstract

Cited 20 times since 2020 (3.5 per year) source: EuropePMC

Cells, Volume 9, Issue 3, 12 2 2020, Pages E701 Local Mast Cell Activation Promotes Neovascularization. Bot I, Velden DV, Bouwman M, Kröner MJ, Kuiper J, Quax PHA, de Vries MR

Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells promote angiogenesis during ischemia. In human ischemic muscle tissue from patients with end-stage peripheral artery disease, we observed activated mast cells, predominantly located aro... Abstract

Cited 24 times since 2020 (4.2 per year) source: EuropePMC

mSphere, Volume 5, Issue 2, 11 2 2020, Pages e00143-20 Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates. Janssen AB, Bartholomew TL, Marciszewska NP, Bonten MJM, Willems RJL, Bengoechea JA, van Schaik W

Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of lipopolysaccharides, leading to membrane destabilization and cell death. Here, we aimed to uncover the mechanisms of colistin resistance in nine colistin-resistant Escherichia coli strains and one Escherichia albertii strain. These were the only colistin-res... Abstract

Cited 12 times since 2020 (2.1 per year) source: EuropePMC

mSystems, Volume 5, Issue 2, 10 2 2020, Pages e00607-19 Carbon Assimilation Strategies in Ultrabasic Groundwater: Clues from the Integrated Study of a Serpentinization-Influenced Aquifer. Seyler LM, Brazelton WJ, McLean C, Putman LI, Hyer A, Kubo MDY, Hoehler T, Cardace D, Schrenk MO

Serpentinization is a low-temperature metamorphic process by which ultramafic rock chemically reacts with water. Such reactions provide energy and materials that may be harnessed by chemosynthetic microbial communities at hydrothermal springs and in the subsurface. However, the biogeochemistry mediated by microbial populations that inhabit these environments is understudied and complicated by overlapping biotic and abiotic processes. We applied metagenomics, metatranscriptomics, and untargeted m... Abstract

Cited 15 times since 2020 (2.6 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 47, Issue 6, 9 2 2020, Pages 1518-1526 Prevalence of hyperfunctioning thyroid nodules among those in need of fine needle aspiration cytology according to ATA 2015, EU-TIRADS, and ACR-TIRADS. Noto B, Eveslage M, Pixberg M, Gonzalez Carvalho JM, Schäfers M, Riemann B, Kies P

Purpose: Given the large number of patients with thyroid nodules, improvement of the specificity of current ultrasound-based thyroid nodule classification systems (ATA, EU-TIRADS, and ACR-TIRADS) is warranted to reduce the number of diagnostic thyroidectomies. Thyroid scintigraphy has been shown to demonstrate hyperfunctional nodules, associated with a low malignancy risk, in euthyroid patients. However, it is not known if thyroid scintigraphy could improve specificity of current classification... Abstract

Frontiers in veterinary science, Volume 7, 6 1 2020, Pages 67 The Comparison of Three Statistical Models for Syndromic Surveillance in Cattle Using Milk Production Data. Veldhuis AMB, Swart WAJM, Brouwer-Middelesch H, Stegeman JA, Mars MH, van Schaik G

Two vector-borne infections have emerged and spread throughout the north-western part of Europe in the last decade: Bluetongue virus serotype-8 (BTV-8) and the Schmallenberg virus (SBV). The objective of the current study was to compare three statistical methods when applied in a syndromic surveillance context for the early detection of emerging diseases in cattle in the Netherlands. Since BTV-8 and SBV both have a negative effect on milk production in dairy cattle, routinely collected bulk milk... Abstract

Cited 5 times since 2020 (0.9 per year) source: EuropePMC

European journal of obstetrics, gynecology, and reproductive biology, Volume 248, 6 1 2020, Pages 150-155 Evaluation of mode of birth in pregnant women with heart disease. Petrus AHJ, Jongert BL, Kiès P, Sueters M, Jongbloed MRM, Vliegen HW, Schalij MJ, van Lith J, van den Akker T

Objective: Maternal heart disease (HD) complicates 1-4 % of pregnancies and is associated with adverse maternal and fetal outcomes. Although vaginal birth is generally recommended in the guidelines, cesarean section (CS) rates in women with HD are often high. Aim of the present study was to evaluate mode of birth and pregnancy outcomes in women with HD in a tertiary care hospital in the Netherlands. Study design: The study population consisted of 128 consecutive pregnancies in 99 women with HD,... Abstract

Cited 15 times since 2020 (2.6 per year) source: EuropePMC

BMC nephrology, Volume 21, Issue 1, 5 1 2020, Pages 81 The association of kidney function and cognitive decline in older patients at risk of cardiovascular disease: a longitudinal data analysis. Zijlstra LE, Trompet S, Mooijaart SP, van Buren M, Sattar N, Stott DJ, Jukema JW

Background: Chronic kidney disease (CKD) has been identified as a significant direct marker for cognitive decline, but controversy exists regarding the magnitude of the association of kidney function with cognitive decline across the different CKD stages. Therefore, the aim of this study was to investigate the association of kidney function with cognitive decline in older patients at high risk of cardiovascular disease, using data from the PROspective Study of Pravastatin in the Elderly at Risk... Abstract

Cited 13 times since 2020 (2.3 per year) source: EuropePMC

Journal of dairy science, Volume 103, Issue 5, 5 1 2020, Pages 4654-4671 A description and qualitative comparison of the elements of heterogeneous bovine viral diarrhea control programs that influence confidence of freedom. van Roon AM, Santman-Berends IMGA, Graham D, More SJ, Nielen M, van Duijn L, Mercat M, Fourichon C, Madouasse A, Gethmann J, Sauter-Louis C, Frössling J, Lindberg A, Correia-Gomes C, Gunn GJ, Henry MK, van Schaik G

For endemic infections in cattle that are not regulated at the European Union level, such as bovine viral diarrhea virus (BVDV), European Member States have implemented control or eradication programs (CEP) tailored to their specific situations. Different methods are used to assign infection-free status in CEP; therefore, the confidence of freedom associated with the "free" status generated by different CEP are difficult to compare, creating problems for the safe trade of cattle betwee... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

Journal of critical care, Volume 57, 4 1 2020, Pages 203-207 Pharmacogenomic response of low dose haloperidol in critically ill adults with delirium. Trogrlić Z, van der Jagt M, Osse RJ, Devlin JW, Nieboer D, Koch BCP, van Schaik RHN, Hunfeld NGM

Purpose: To characterize the pharmacogenomic response of low-dose haloperidol for delirium treatment in critically ill adults. Materials and methods: Single-center, pilot study of a convenience sample of ICU adults with delirium treated with low-dose IV haloperidol. Patients were evaluated for delirium with the ICDSC every 8 h. Serum haloperidol concentrations were collected on ICU days 2-6, CYP2D6 and CYP3A4 genotypes were characterized and patients were categorized as extensive (EM), intermedi... Abstract

Cited 41 times since 2020 (7.2 per year) source: EuropePMC

The journal of allergy and clinical immunology. In practice, Volume 8, Issue 6, 3 1 2020, Pages 1972-1979.e8 Effectiveness of myAirCoach: A mHealth Self-Management System in Asthma. Khusial RJ, Honkoop PJ, Usmani O, Soares M, Simpson A, Biddiscombe M, Meah S, Bonini M, Lalas A, Polychronidou E, Koopmans JG, Moustakas K, Snoeck-Stroband JB, Ortmann S, Votis K, Tzovaras D, Chung KF, Fowler S, Sont JK, myAirCoach study group

Background: Self-management programs have beneficial effects on asthma control, but their implementation in clinical practice is poor. Mobile health (mHealth) could play an important role in enhancing self-management. Objective: To assess the clinical effectiveness and technology acceptance of myAirCoach-supported self-management on top of usual care in patients with asthma using inhalation medication. Methods: Patients were recruited in 2 separate studies. The myAirCoach system consisted of an... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 21, Issue 3, 1 1 2020, Pages 299-306 Exercise haemodynamics after restrictive mitral annuloplasty for functional mitral regurgitation. Petrus AHJ, Tops LF, Holman ER, Marsan NA, Bax JJ, Schalij MJ, Steendijk P, Klautz RJM, Braun J

Aims: Restrictive mitral annuloplasty (RMA) can provide a durable solution for functional mitral regurgitation (MR), but might result in obstruction to antegrade mitral flow. Aim of this study was to assess the magnitude of change in mitral valve area (MVA) during exercise after RMA, to relate the change in MVA to left ventricular (LV) geometry and function, and to assess its haemodynamic and clinical impact. Methods and results: Bicycle exercise echocardiography was performed in 32 patients aft... Abstract

Cited 20 times since 2020 (3.5 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 30, Issue 3, 1 1 2020, Pages 417-423 An in vitro comparison of internally versus externally mounted leaflets in surgical aortic bioprostheses. Vriesendorp MD, de Lind van Wijngaarden RAF, Rao V, Moront MG, Patel HJ, Sarnowski E, Vatanpour S, Klautz RJM

Objectives: To improve haemodynamic performance, design modifications of prosthetic valves have been proposed with each new generation of valves. These different designs also impact the amount of mechanical wear, because mechanical stresses are distributed differently. Because long-term evidence for new prosthetic valves is lacking, this in vitro study compared hydrodynamic performance and durability among 3 currently available bioprosthetic valves with internally (IMLV) or externally mounted le... Abstract

Cited 6 times since 2020 (1 per year) source: EuropePMC

International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, Volume 43, Issue 1, 1 1 2020, Pages 82-89 The most important activities of daily functioning: the opinion of persons with lower limb amputation and healthcare professionals differ considerably. van Schaik L, Hoeksema S, Huvers LF, Geertzen JHB, Dijkstra PU, Dekker R

The aim of this study is to determine the 15 most important daily activities according to persons with lower limb amputation (LLA) and healthcare professionals. Persons with LLA (n = 125) and healthcare professionals (n = 44) filled in a questionnaire. Participants had to select 10 items out of a list of 40 items on the domains activity and/or participation. Selection criterion was what they considered to be most important to perform independently and order the selected 10 items from most to lea... Abstract

Cited 3 times since 2020 (0.5 per year) source: EuropePMC

New directions for child and adolescent development, Volume 2020, Issue 170, 1 1 2020, Pages 13-41 Getting the Baby on a Schedule: Dutch and American Mothers' Ethnotheories and the Establishment of Diurnal Rhythms in Early Infancy. van Schaik SDM, Mavridis C, Harkness S, De Looze M, Blom MJM, Super CM

One of the earliest challenges for infants and their parents is developing a diurnal sleep-wake cycle. Although the human biological rhythm is circadian by nature, its development varies across cultures, based in part on "zeitgebers" (German: literally "time-givers") or environmental cues. This study uses the developmental niche framework by Super and Harkness to address two different approaches to getting the baby on a schedule. 33 Dutch and 41 U.S. mothers were interviewed... Abstract

Cited 111 times since 2020 (19.4 per year) source: EuropePMC

JAMA cardiology, Volume 5, Issue 3, 1 1 2020, Pages 282-290 Association of High-Density Calcified 1K Plaque With Risk of Acute Coronary Syndrome. van Rosendael AR, Narula J, Lin FY, van den Hoogen IJ, Gianni U, Al Hussein Alawamlh O, Dunham PC, Peña JM, Lee SE, Andreini D, Cademartiri F, Chinnaiyan K, Chow BJW, Conte E, Cury RC, Feuchtner G, Hadamitzky M, Kim YJ, Leipsic J, Maffei E, Marques H, de Araújo Gonçalves P, Plank F, Pontone G, Raff GL, Villines TC, Weirich HG, Al'Aref SJ, Baskaran L, Cho I, Danad I, Han D, Heo R, Lee JH, Rivzi A, Stuijfzand WJ, Gransar H, Lu Y, Sung JM, Park HB, Samady H, Stone PH, Virmani R, Budoff MJ, Berman DS, Chang HJ, Bax JJ, Min JK, Shaw LJ

Importance: Plaque morphologic measures on coronary computed tomography angiography (CCTA) have been associated with future acute coronary syndrome (ACS). However, the evolution of calcified coronary plaques by noninvasive imaging is not known. Objective: To ascertain whether the increasing density in calcified coronary plaque is associated with risk for ACS. Design, setting, and participants: This multicenter case-control cohort study included individuals enrolled in ICONIC (Incident Coronary S... Abstract

New directions for child and adolescent development, Volume 2020, Issue 170, 1 1 2020, Pages 113-141 Parents, Preschools, and the Developmental Niches of Young Children: A Study in Four Western Cultures. Harkness S, Super CM, Bonichini S, Bermudez MR, Mavridis C, van Schaik SDM, Tomkunas A, Palacios J

Recent years have witnessed increasing attention to early childhood education and care as a foundation for children's successful development in school and beyond. The great majority of children in postindustrial societies now attend preschools or daycare, making this setting a major part of their culturally constructed developmental niches. Although an extensive literature demonstrates the importance of parental involvement or engagement in their children's schools, relationships betwe... Abstract

Cited 22 times since 2020 (3.8 per year) source: EuropePMC

Journal for immunotherapy of cancer, Volume 8, Issue 1, 1 1 2020, Pages e000251 T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma. Vroman H, Balzaretti G, Belderbos RA, Klarenbeek PL, van Nimwegen M, Bezemer K, Cornelissen R, Niewold ITG, van Schaik BD, van Kampen AH, Aerts JGJV, de Vries N, Hendriks RW

Background: Malignant pleural mesothelioma (MPM) is a highly lethal malignancy in need for new treatment options. Although immunotherapies have been shown to boost a tumor-specific immune response, not all patients respond and prognostic biomarkers are scarce. In this study, we determined the peripheral blood T cell receptor β (TCRβ) chain repertoire of nine MPM patients before and 5 weeks after the start of dendritic cell (DC)-based immunotherapy. Materials and methods: We separately profiled P... Abstract

Cited 31 times since 2020 (5.4 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 22, Issue 3, 1 1 2020, Pages 450-495 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: executive summary. Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N, Aguinaga L, Leite LR, Al-Khatib SM, Anter E, Berruezo A, Callans DJ, Chung MK, Cuculich P, d'Avila A, Deal BJ, Della Bella P, Deneke T, Dickfeld TM, Hadid C, Haqqani HM, Kay GN, Latchamsetty R, Marchlinski F, Miller JM, Nogami A, Patel AR, Pathak RK, Saenz Morales LC, Santangeli P, Sapp JL, Sarkozy A, Soejima K, Stevenson WG, Tedrow UB, Tzou WS, Varma N, Zeppenfeld K

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. There... Abstract