9543 results
Cited 54 times since 2019 (8.9 per year)
source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology,
Volume 30, Issue 11, 1 1 2019, Pages 1697-1727
EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees†.
Horwich A, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Van Der Kwast T, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis I, Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Compérat E, Crabb S, Culine S, De Bari B, DeBlok W, De Visschere PJL, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne V, Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmüller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez V, Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo V, Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinós E, Løgager V, Lorch A, Loriot Y, Meijer R, Carmen Mir M, Moschini M, Mostafid H, Müller AC, Müller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, Oyen WJG, Pacheco-Figueiredo L, Pappot H, Patel MI, Pieters BR,
Background: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. Objective: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. Design: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Del...
Abstract
Cited 92 times since 2019 (15.2 per year)
source: EuropePMC
Nature communications,
Volume 10, Issue 1, 31 5 2019, Pages 4957
Associations of autozygosity with a broad range of human phenotypes.
Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Fuchsberger C, Gao H, Germain M, Gordon SD, de Haan HG, Harris SE, Hofer E, Huerta-Chagoya A, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Munz M, Nutile T, Palviainen T, Prasad G, Prasad RB, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Aguilar-Salinas CA, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Bo
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p
Abstract
Cited 34 times since 2019 (5.6 per year)
source: EuropePMC
Cardiovascular diabetology,
Volume 18, Issue 1, 31 5 2019, Pages 144
Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina.
Caselli C, Del Turco S, Ragusa R, Lorenzoni V, De Graaf M, Basta G, Scholte A, De Caterina R, Neglia D
Objective: Aim of this study was to evaluate the relationship of plasma PCSK9 with metabolic and inflammatory profile and coronary atherosclerotic burden in patients with suspected CAD enrolled in the EVINCI study. Methods: PCSK9 was measured in 539 patients (60.3 ± 8.6 years, 256 males) with symptoms of CAD characterized by risk factors, bio-humoral profiles, and treatment. N = 412 patients underwent coronary computed tomography angiography (CTA) to assess the presence and characteristics of co...
Abstract
Cited 8 times since 2019 (1.3 per year)
source: EuropePMC
Scientific reports,
Volume 9, Issue 1, 30 5 2019, Pages 15604
Low Power, CMOS-MoS<sub>2</sub> Memtransistor based Neuromorphic Hybrid Architecture for Wake-Up Systems.
Gupta S, Kumar P, Paul T, van Schaik A, Ghosh A, Thakur CS
Neuromorphic architectures have become essential building blocks for next-generation computational systems, where intelligence is embedded directly onto low power, small area, and computationally efficient hardware devices. In such devices, realization of neural algorithms requires storage of weights in digital memories, which is a bottleneck in terms of power and area. We hereby propose a biologically inspired low power, hybrid architectural framework for wake-up systems. This architecture util...
Abstract
Cited 22 times since 2019 (3.6 per year)
source: EuropePMC
Biomaterials,
Volume 229, 29 5 2019, Pages 119577
A novel method for engineering autologous non-thrombogenic in situ tissue-engineered blood vessels for arteriovenous grafting.
Geelhoed WJ, van der Bogt KEA, Rothuizen TC, Damanik FFR, Hamming JF, Mota CD, van Agen MS, de Boer HC, Restrepo MT, Hinz B, Kislaya A, Poelma C, van Zonneveld AJ, Rabelink TJ, Moroni L, Rotmans JI
The durability of prosthetic arteriovenous (AV) grafts for hemodialysis access is low, predominantly due to stenotic lesions in the venous outflow tract and infectious complications. Tissue engineered blood vessels (TEBVs) might offer a tailor-made autologous alternative for prosthetic grafts. We have designed a method in which TEBVs are grown in vivo, by utilizing the foreign body response to subcutaneously implanted polymeric rods in goats, resulting in the formation of an autologous fibrocell...
Abstract
Circulation,
Volume 140, Issue 18, 28 4 2019, Pages e744-e745
Response by Timal and Jukema to Letter Regarding Article, "Random Controlled Trials of Sudden Cardiac Death: Use of Autopsy to Refine Sudden Cardiac Death Outcomes".
Timal RJ, Jukema JW
Abstract
Cited 2243 times since 2019 (368 per year)
source: EuropePMC
Nature,
Volume 575, Issue 7784, 21 3 2019, Pages 693-698
FSP1 is a glutathione-independent ferroptosis suppressor.
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids1,2. To date, ferroptosis has been thought to be controlled only by the phospholipid hydroperoxide-reducing enzyme glutathione peroxidase 4 (GPX4)3,4 and radical-trapping antioxidants5,6. However, elucidation of the factors that underlie the sensitivity of a given cell type to ferroptosis7 is crucial to understand the pathophysiological role of ferroptosis and how it may be exploited for the t...
Abstract
Cited 63 times since 2019 (10.3 per year)
source: EuropePMC
Nature communications,
Volume 10, Issue 1, 18 3 2019, Pages 4755
Identification of atrial fibrillation associated genes and functional non-coding variants.
van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Hill MC, Montefiori LE, Scholman KT, Liu J, de Vries AAF, Boukens BJ, Ellinor PT, Goumans MJTH, Efimov IR, Nobrega MA, Barnett P, Martin JF, Christoffels VM
Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized....
Abstract
Cited 25 times since 2019 (4.1 per year)
source: EuropePMC
Frontiers in microbiology,
Volume 10, 17 3 2019, Pages 2394
Metavirome Sequencing to Evaluate Norovirus Diversity in Sewage and Related Bioaccumulated Oysters.
Strubbia S, Schaeffer J, Oude Munnink BB, Besnard A, Phan MVT, Nieuwenhuijse DF, de Graaf M, Schapendonk CME, Wacrenier C, Cotten M, Koopmans MPG, Le Guyader FS
Metagenomic sequencing is a promising method to determine the virus diversity in environmental samples such as sewage or shellfish. However, to identify the short RNA genomes of human enteric viruses among the large diversity of nucleic acids present in such complex matrices, method optimization is still needed. This work presents methodological developments focused on norovirus, a small ssRNA non-enveloped virus known as the major cause of human gastroenteritis worldwide and frequently present...
Abstract
Cited 7 times since 2019 (1.1 per year)
source: EuropePMC
Nanomedicine (London, England),
Volume 14, Issue 21, 16 3 2019, Pages 2783-2798
Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies.
Khan A, Al-Harrasi A, Rehman NU, Sarwar R, Ahmad T, Ghaffar R, Khan H, Al-Amri I, Csuk R, Al-Rawahi A
Aim: Acetyl-11-keto-β-boswellic acid (AKBA) is a potent anti-inflammatory compound limited by its low water solubility and bioavailability. To load AKBA on silver nanoparticles (AgNPs) to improve bioavailability and water solubility of the compound. Materials & methods: AKBA-AgNPs were chemically synthesized and characterized by UV-Vis spectrophotometry, Fourier transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. AKBA and AKBA-Ag were studied f...
Abstract
Cited 6 times since 2019 (1 per year)
source: EuropePMC
Cardiology and therapy,
Volume 8, Issue 2, 16 3 2019, Pages 345-356
Electrocardiographic Detection of Left Ventricular Hypertrophy; Adding Body Mass Index and Spatial QRS-T Angle: A Cross-Sectional Study.
Elffers TW, Trompet S, de Mutsert R, Maan AC, Lamb HJ, Macfarlane PW, Rosendaal FR, Jukema JW
Introduction: We investigated improvement of electrocardiographic LVH detection by adding measures of adiposity and/or novel electrocardiographic measures. Left ventricular hypertrophy (LVH) is an important risk factor for adverse cardiovascular outcomes. Improvement of electrocardiographic criteria for LVH is desirable, since electrocardiography is widely used. Methods: We included 1091 participants of the Netherlands Epidemiology of Obesity Study (NEO) who underwent cardiac magnetic resonance...
Abstract
Cited 15 times since 2019 (2.5 per year)
source: EuropePMC
Brain research,
Volume 1726, 16 3 2019, Pages 146510
Artificial Intelligence and the detection of pediatric concussion using epigenomic analysis.
Bahado-Singh RO, Vishweswaraiah S, Er A, Aydas B, Turkoglu O, Taskin BD, Duman M, Yilmaz D, Radhakrishna U
Concussion, also referred to as mild traumatic brain injury (mTBI) is the most common type of traumatic brain injury. Currently concussion is an area ofintensescientific interest to better understand the biological mechanisms and for biomarker development. We evaluated whole genome-wide blood DNA cytosine ('CpG') methylation in 17 pediatric concussion isolated cases and 18 unaffected controls using Illumina Infinium MethylationEPIC assay. Pathway analysis was performed using Ingenuity...
Abstract
Cited 15 times since 2019 (2.5 per year)
source: EuropePMC
BMC cardiovascular disorders,
Volume 19, Issue 1, 15 3 2019, Pages 217
Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs.
Abawi D, Faragli A, Schwarzl M, Manninger M, Zweiker D, Kresoja KP, Verderber J, Zirngast B, Maechler H, Steendijk P, Pieske B, Post H, Alogna A
Background: Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min- 1 is obtained sharing the same unit as CPO (W). We aimed to validate CPO as a marker of LV SW min- 1 und...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 163, 11 2 2019, Pages D3963
[Suspected traumatic posterior shoulder luxation].
Keulen MHF, de Joode SGCJ, Klemann-Harings SEJM, Samijo SK
BACKGROUND An obstetric brachial plexus lesion arises during childbirth as a consequence of excessive lateral traction of the neonate's head during shoulder dystocia. A small number of patients do not experience spontaneous recovery and secondary glenohumeral deformities can arise due to rotator cuff imbalance. CASE DESCRIPTION A 34-year-old man of Syrian descent with a history of a conservatively treated right-sided obstetric brachial plexus lesion went to the accident and emergency depart...
Abstract
Cited 50 times since 2019 (8.2 per year)
source: EuropePMC
Journal of pineal research,
Volume 68, Issue 1, 10 2 2019, Pages e12614
Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice.
Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dollé MET, Smits NAM, Guichelaar T, van Baarle D, Koemans L, Berbée JFP, Deboer T, Meijer JH, de Vries MR, Vreeken D, van Gils JM, Willems van Dijk K, van Kerkhof LWM, Lutgens E, Biermasz NR, Rensen PCN, Kooijman S
Disruption of circadian rhythm by means of shift work has been associated with cardiovascular disease in humans. However, causality and underlying mechanisms have not yet been established. In this study, we exposed hyperlipidemic APOE*3-Leiden.CETP mice to either regular light-dark cycles, weekly 6 hours phase advances or delays, or weekly alternating light-dark cycles (12 hours shifts), as a well-established model for shift work. We found that mice exposed to 15 weeks of alternating light-dark...
Abstract
Cited 37 times since 2019 (6 per year)
source: EuropePMC
The British journal of surgery,
Volume 107, Issue 2, 9 2 2019, Pages e161-e169
Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery.
EuroSurg Collaborative
Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary ou...
Abstract
Cited 10 times since 2019 (1.6 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 51, Issue 4, 7 1 2019, Pages 1105-1116
Altered Ascending Aorta Hemodynamics in Patients After Arterial Switch Operation for Transposition of the Great Arteries.
van der Palen RLF, Deurvorst QS, Kroft LJM, van den Boogaard PJ, Hazekamp MG, Blom NA, Lamb HJ, Westenberg JJM, Roest AAW
Background: Patients with transposition of the great arteries (TGA) have an altered aortic geometry after an arterial switch operation (ASO), with neo-aortic root dilatation as an important complication. Geometry-related aortic hemodynamics have been assumed to contribute to pathology of the ascending aorta (AAo). Purpose: To evaluate aortic flow displacement (FD) and regional wall shear stress (WSS) in relation to ascending neo-aortic geometry in children after ASO. Study type: Prospective. Pop...
Abstract
Cited 57 times since 2019 (9.3 per year)
source: EuropePMC
Molecular therapy : the journal of the American Society of Gene Therapy,
Volume 28, Issue 1, 7 1 2019, Pages 157-170
MicroRNA-411 and Its 5'-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia.
van der Kwast RVCT, Woudenberg T, Quax PHA, Nossent AY
MicroRNAs are posttranscriptional regulators of gene expression. As microRNAs can target many genes simultaneously, microRNAs can regulate complex multifactorial processes, including post-ischemic neovascularization, a major recovery pathway in cardiovascular disease. MicroRNAs select their target mRNAs via full complementary binding with their seed sequence, i.e., nucleotides 2-8 from the 5' end of a microRNA. The exact sequence of a mature microRNA, and thus of its 5' and 3' end...
Abstract
Cited 32 times since 2019 (5.2 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 109, Issue 6, 5 1 2019, Pages 1858-1863
Total Endovascular Repair of the Aortic Arch: Initial Experience in the Netherlands.
van der Weijde E, Heijmen RH, van Schaik PM, Hazenberg CEVB, van Herwaarden JA
Background: We report procedural and early results in the Netherlands of the Relay Branch device (Terumo Aortic, Sunrise, FL) for total endovascular repair of the aortic arch. Methods: Between 2014 and 2018, all consecutive patients who received the Aortic Relay double-branched stent graft in the Netherlands were included in a multicenter, retrospective registry. Results: The Relay Branch device was used in 11 patients to treat saccular (n = 4), fusiform (n = 5), or false aneurysms (n = 2) in th...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 155, 4 1 2019, Pages 108926
Mean atomic number analysis by the coherent to backscattering intensity ratios at 59.54 and 661.62 photon energies.
Akkuş T, Yılmaz D
In this work, the qualitative analysis has been performed by using ratio of coherent to backscattering intensity ratios. The samples in the mean atomic number range 4.268≤Z‾≤5.786 and 9.743≤Z‾≤83.00 were prepared by using dilution technique. 59.54 and 661.62 keV photon energies are obtained from the radioactive point sources of 241Am and 137Cs an activity of 0.43-0.20 MBq, respectively. The scattered gamma rays were counted by a HPGe detector with a resolution of 182 eV at 5.9 keV. The obtained...
Abstract
