8684 results
Cited 7 times since 2024 (6.1 per year)
source: EuropePMC
Journal of clinical lipidology,
Volume 18, Issue 4, 10 2 2024, Pages e548-e561
Alirocumab and cardiovascular outcomes according to sex and lipoprotein(a) after acute coronary syndrome: a report from the ODYSSEY OUTCOMES study.
Bittner VA, Schwartz GG, Bhatt DL, Chua T, De Silva HA, Diaz R, Goodman SG, Harrington RA, Jukema JW, McGinniss J, Pordy R, Garon G, Scemama M, White HD, Steg PG, Szarek M, ODYSSEY OUTCOMES Investigators
Background: The ODYSSEY OUTCOMES trial (NCT01663402) compared the effects of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo on major adverse cardiovascular events (MACE) in patients with recent acute coronary syndrome (ACS). Objective: We assessed efficacy and safety of alirocumab versus placebo according to sex and lipoprotein(a) level. Methods: This prespecified analysis compared the effects of alirocumab versus placebo on lipoproteins, MACE (coronary heart...
Abstract
Journal of the American Heart Association,
Volume 13, Issue 8, 9 2 2024, Pages e032033
Impact of a Chronic Total Coronary Occlusion on the Incidence of Appropriate Implantable Cardioverter-Defibrillator Shocks and Mortality: A Substudy of the Dutch Outcome in ICD Therapy (DO-IT)) Registry.
van Veelen A, Verstraelen TE, Somsen YBO, Elias J, van Dongen IM, Delnoy PPHM, Scholten MF, Boersma LVA, Maass AH, Strikwerda S, Firouzi M, Allaart CP, Vernooy K, Grauss RW, Tukkie R, Knaapen P, Zwinderman AH, Dijkgraaf MGW, Claessen BEPM, van Barreveld M, Wilde AAM, Henriques JPS, DO‐IT investigators *
Background: Chronic total coronary occlusions (CTO) substantially increase the risk for sudden cardiac death. Among patients with chronic ischemic heart disease at risk for sudden cardiac death, an implantable cardioverter defibrillator (ICD) is the favored therapy for primary prevention of sudden cardiac death. This study sought to investigate the impact of CTOs on the risk for appropriate ICD shocks and mortality within a nationwide prospective cohort. Methods and results: This is a subanalysi...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
International journal of cardiology,
Volume 407, 5 1 2024, Pages 132027
Decreased clinical performance in TGA-ASO patients after RVOT interventions; a multicenter European collaboration.
Engele LJ, González-Fernández V, Mulder BJM, Ruperti-Repilado FJ, Abia RL, van der Vlist K, Buendía F, Rueda J, Gabriel H, Schrutka L, Bouchardy J, Schwerzmann M, Possner M, Greutmann M, Gallego P, Ladouceur M, Jongbloed MRM, Tobler D, Dos L, Bouma BJ
Background: In patients with transposition of the great arteries and an arterial switch operation (TGA-ASO) right ventricular outflow tract (RVOT) obstruction is a common complication requiring one or more RVOT interventions. Objectives: We aimed to assess cardiopulmonary exercise capacity and right ventricular function in patients stratified for type of RVOT intervention. Methods: TGA-ASO patients (≥16 years) were stratified by type of RVOT intervention. The following outcome parameters were in...
Abstract
Journal of clinical medicine,
Volume 13, Issue 7, 5 1 2024, Pages 2118
Comparative Analysis of Therapeutic Strategies in Post-Cardiotomy Cardiogenic Shock: Insight into a High-Volume Cardiac Surgery Center.
Baldan BU, Hegeman RRMJJ, Bos NMJP, Smeenk HG, Klautz RJM, Klein P
Background: Post-cardiotomy cardiogenic shock (PCCS), which is defined as severe low cardiac output syndrome after cardiac surgery, has a mortality rate of up to 90%. No study has yet been performed to compare patients with PCCS treated by conservative means to patients receiving additional mechanical circulatory support with veno-arterial extracorporeal membrane oxygenation (ECMO). Methods: A single-center retrospective analysis from January 2018 to June 2022 was performed. Results: Out of 7028...
Abstract
Cited 5 times since 2024 (4.3 per year)
source: EuropePMC
The Lancet. Oncology,
Volume 25, Issue 5, 5 1 2024, Pages 603-613
MRI-guided optimisation of neoadjuvant chemotherapy duration in stage II-III HER2-positive breast cancer (TRAIN-3): a multicentre, single-arm, phase 2 study.
van der Voort A, Louis FM, van Ramshorst MS, Kessels R, Mandjes IA, Kemper I, Agterof MJ, van der Steeg WA, Heijns JB, van Bekkum ML, Siemerink EJ, Kuijer PM, Scholten A, Wesseling J, Vrancken Peeters MTFD, Mann RM, Sonke GS, Dutch Breast Cancer Research Group
Background: Patients with stage II-III HER2-positive breast cancer have good outcomes with the combination of neoadjuvant chemotherapy and HER2-targeted agents. Although increasing the number of chemotherapy cycles improves pathological complete response rates, early complete responses are common. We investigated whether the duration of chemotherapy could be tailored on the basis of radiological response. Methods: TRAIN-3 is a single-arm, phase 2 study in 43 hospitals in the Netherlands. Patient...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Journal of cardiothoracic surgery,
Volume 19, Issue 1, 4 1 2024, Pages 174
Continuous or interrupted pledgeted suture technique in stented bioprosthetic aortic valve replacement: a comparison of in-hospital outcomes.
Arabkhani B, Gonthier S, Lorenz V, Deschamps S, Jahanyar J, Boute M, Vancraeynest D, Mastrobuoni S, Khoury GE, de Kerchove L
Background: There is ambiguity in the literature regarding the continuous suture technique (CST) for aortic valve replacement (AVR). At our center, there has been a gradual shift towards CST over the interrupted pledgeted technique (IPT). This study aims at comparing outcomes for both techniques. Methods: We performed a retrospective analysis of a single-center study of patients undergoing AVR between January 2011 and July 2020. Patients were divided into two groups: Continuous suture technique...
Abstract
Frontiers in molecular biosciences,
Volume 11, 3 1 2024, Pages 1288677
TGF-β mRNA levels in circulating extracellular vesicles are associated with response to anti-PD1 treatment in metastatic melanoma.
Crucitta S, Cucchiara F, Marconcini R, Bulleri A, Manacorda S, Capuano A, Cioni D, Nuzzo A, de Jonge E, Mathjissen RHJ, Neri E, van Schaik RHN, Fogli S, Danesi R, Del Re M
Introduction: Immune checkpoint inhibitors (ICIs) represent the standard therapy for metastatic melanoma. However, a few patients do not respond to ICIs and reliable predictive biomarkers are needed. Methods: This pilot study investigates the association between mRNA levels of programmed cell death-1 (PD-1) ligand 1 (PD-L1), interferon-gamma (IFN-γ), and transforming growth factor-β (TGF-β) in circulating extracellular vesicles (EVs) and survival in 30 patients with metastatic melanoma treated w...
Abstract
Cited 5 times since 2024 (4.3 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 32, Issue 8, 3 1 2024, Pages 903-911
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction of CYP2C9, HLA-A and HLA-B with anti-epileptic drugs.
Manson LEN, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Swen JJ, Touw DJ, van Westrhenen R, Deneer VHM, Guchelaar HJ
By developing evidence-based pharmacogenetics guidelines to optimize pharmacotherapy, the Dutch Pharmacogenetics Working Group (DPWG) aims to advance the implementation of pharmacogenetics (PGx). This guideline outlines the gene-drug interaction of CYP2C9 and HLA-B with phenytoin, HLA-A and HLA-B with carbamazepine and HLA-B with oxcarbazepine and lamotrigine. A systematic review was performed and pharmacotherapeutic recommendations were developed. For CYP2C9 intermediate and poor metabolisers,...
Abstract
European journal of clinical investigation,
Volume 54, Issue 8, 1 1 2024, Pages e14200
Prognostic significance of echocardiographic deformation imaging in adult congenital heart disease.
van Rosendael PJ, Taha K, Guglielmo M, Teske AJ, van der Harst P, Sieswerda G, Cramer MJ, van der Zwaan HB
Background: Due to medical and surgical advancements, the population of adult patients with congenital heart disease (ACHD) is growing. Despite successful therapy, ACHD patients face structural sequalae, placing them at increased risk for heart failure and arrhythmias. Left and right ventricular function are important predictors for adverse clinical outcomes. In acquired heart disease it has been shown that echocardiographic deformation imaging is of superior prognostic value as compared to conv...
Abstract
Cited 3 times since 2024 (2.6 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 25, Issue 5, 1 1 2024, Pages 657-667
Prognostic value of a novel artificial intelligence-based coronary computed tomography angiography-derived ischaemia algorithm for patients with suspected coronary artery disease.
Bär S, Nabeta T, Maaniitty T, Saraste A, Bax JJ, Earls JP, Min JK, Knuuti J
Aims: Coronary computed tomography angiography (CTA) imaging is used to diagnose patients with suspected coronary artery disease (CAD). A novel artificial intelligence-guided quantitative computed tomography ischaemia algorithm (AI-QCTischaemia) aims to identify myocardial ischaemia directly from CTA images and may be helpful to improve risk stratification. The aims were to investigate (i) the prognostic value of AI-QCTischaemia amongst symptomatic patients with suspected CAD entering diagnostic...
Abstract
The lancet. Gastroenterology & hepatology,
Volume 9, Issue 4, 1 1 2024, Pages 293-294
Gluten and non-coeliac gluten sensitivity: the nocebo effect and future avenues - Authors' reply.
de Graaf MCG, Keszthelyi D, Brouns FJPH, Dye L, Jonkers DMAE, all authors
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Volume 38, Issue 7, 1 1 2024, Pages e23579
Effects of repeated weight cycling on non-alcoholic steatohepatitis in diet-induced obese mice.
Inia JA, de Jong JCBC, Keijzer N, Menke AL, Princen HMG, Jukema JW, van den Hoek AM
Lifestyle interventions remain the treatment of choice for patients with obesity and metabolic complications, yet are difficult to maintain and often lead to cycles of weight loss and regain (weight cycling). Literature on weight cycling remains controversial and we therefore investigated the association between weight cycling and metabolic complications using preexistent obese mice. Ldlr-/-.Leiden mice received a high-fat diet (HFD) for 20 weeks to induce obesity. Subsequently, weight-cycled mi...
Abstract
Cited 12 times since 2024 (10.2 per year)
source: EuropePMC
European journal of heart failure,
Volume 26, Issue 4, 1 1 2024, Pages 1078-1089
Interatrial shunt therapy in advanced heart failure: Outcomes from the open-label cohort of the RELIEVE-HF trial.
Rodés-Cabau J, Lindenfeld J, Abraham WT, Zile MR, Kar S, Bayés-Genís A, Eigler N, Holcomb R, Núñez J, Lee E, Perl ML, Moravsky G, Pfeiffer M, Boehmer J, Gorcsan J, Bax JJ, Anker S, Stone GW
Aims: Heart failure (HF) outcomes remain poor despite optimal guideline-directed medical therapy (GDMT). We assessed safety, effectiveness, and transthoracic echocardiographic (TTE) outcomes during the 12 months after Ventura shunt implantation in the RELIEVE-HF open-label roll-in cohort. Methods and results: Eligibility required symptomatic HF despite optimal GDMT with ≥1 HF hospitalization in the prior year or elevated natriuretic peptides. The safety endpoint was device-related major adverse...
Abstract
IEEE transactions on biomedical circuits and systems,
Volume 18, Issue 2, 1 1 2024, Pages 423-437
Tau-Cell-Based Analog Silicon Retina With Spatio- Temporal Filtering and Contrast Gain Control.
Philip P, Jainwal K, van Schaik A, Thakur CS
Developing precise artificial retinas is crucial because they hold the potential to restore vision, improve visual prosthetics, and enhance computer vision systems. Emulating the luminance and contrast adaption features of the retina is essential to improve visual perception and efficiency to provide an environment realistic representation to the user. In this article, we introduce an artificial retina model that leverages its potent adaptation to luminance and contrast to enhance vision sensing...
Abstract
Cited 3 times since 2024 (2.6 per year)
source: EuropePMC
JAMA network open,
Volume 7, Issue 4, 1 1 2024, Pages e246556
Nationwide Association of Surgical Performance of Minimally Invasive Esophagectomy With Patient Outcomes.
Ketel MHM, Klarenbeek BR, Abma I, Belgers EHJ, Coene PLO, Dekker JWT, van Duijvendijk P, Emous M, Gisbertz SS, Haveman JW, Heisterkamp J, Nieuwenhuijzen GAP, Ruurda JP, van Sandick JW, van der Sluis PC, van Det MJ, van Esser S, Law S, de Steur WO, Sosef MN, Wijnhoven B, Hannink G, Rosman C, van Workum F, MIE-CAT Netherlands Collaborative Group
Importance: Suboptimal surgical performance is hypothesized to be associated with less favorable patient outcomes in minimally invasive esophagectomy (MIE). Establishing this association may lead to programs that promote better surgical performance of MIE and improve patient outcomes. Objective: To investigate associations between surgical performance and postoperative outcomes after MIE. Design, setting, and participants: In this nationwide cohort study of 15 Dutch hospitals that perform more t...
Abstract
Cited 2 times since 2024 (1.7 per year)
source: EuropePMC
Radiology. Cardiothoracic imaging,
Volume 6, Issue 2, 1 1 2024, Pages e220197
Impact of Smoking on Coronary Volume-to-Myocardial Mass Ratio: An ADVANCE Registry Substudy.
Holmes KR, Gulsin GS, Fairbairn TA, Hurwitz-Koweek L, Matsuo H, Nørgaard BL, Jensen JM, Sand NR, Nieman K, Bax JJ, Pontone G, Chinnaiyan KM, Rabbat MG, Amano T, Kawasaki T, Akasaka T, Kitabata H, Rogers C, Patel MR, Payne GW, Leipsic JA, Sellers SL
Purpose To examine the relationship between smoking status and coronary volume-to-myocardial mass ratio (V/M) among individuals with coronary artery disease (CAD) undergoing CT fractional flow reserve (CT-FFR) analysis. Materials and Methods In this secondary analysis, participants from the ADVANCE registry evaluated for suspected CAD from July 15, 2015, to October 20, 2017, who were found to have coronary stenosis of 30% or greater at coronary CT angiography (CCTA) were included if they had kno...
Abstract
Cited 1 times since 2024 (0.8 per year)
source: EuropePMC
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Volume 30, Issue 7, 28 4 2024, Pages 930-936
Intradermal delivery of the third dose of the mRNA-1273 SARS-CoV-2 vaccine: safety and immunogenicity of a fractional booster dose.
Roozen GVT, Prins MLM, Prins C, Janse JJ, de Gruyter HLM, Pothast CR, Huisman W, Koopman JPR, Lamers OAC, Kuijer M, Myeni SK, van Binnendijk RS, Hartog GD, Heemskerk MHM, Jochems SP, Feltkamp MCW, Kikkert M, Rosendaal FR, Roestenberg M, Visser LG, Roukens AHE
Objectives: The aim of this study was to assess the safety and immunogenicity of a dose-sparing fractional intradermal (ID) booster strategy with the mRNA-1273 COVID-19 vaccine. Methods: COVID-19 naive adults aged 18-30 years were recruited from a previous study on primary vaccination regimens that compared 20 μg ID vaccinations with 100 μg intramuscular (IM) vaccinations with mRNA-1273 as the primary vaccination series. Participants previously immunized with ID regimens were randomly assigned (...
Abstract
Cited 4 times since 2024 (3.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 221, 28 4 2024, Pages 37-43
Association of Left Atrial Appendage Morphology and Function With Stroke and Transient Ischemic Attack in Atrial Fibrillation Patients.
Simon J, Smit JM, El Mahdiui M, Száraz L, van Rosendael AR, Zsarnóczay E, Nagy AI, Gellér L, van der Geest RJ, Bax JJ, Maurovich-Horvat P, Merkely B
We aimed to correlate left atrial appendage (LAA) structure and function with the history of stroke/transient ischemic attack (TIA) in patients with atrial fibrillation (AF). We analyzed the data of 649 patients with AF who were scheduled for catheter ablation. Patients underwent cardiac computed tomography and transesophageal echocardiography before ablation. The LAA morphologies depicted by cardiac computed tomography were categorized into 4 groups: cauliflower, chicken wing, swan, and windsoc...
Abstract
Cited 1 times since 2024 (0.8 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 18, 28 4 2024, Pages 1335422
Optimizing event-based neural networks on digital neuromorphic architecture: a comprehensive design space exploration.
Xu Y, Shidqi K, van Schaik GJ, Bilgic R, Dobrita A, Wang S, Meijer R, Nembhani P, Arjmand C, Martinello P, Gebregiorgis A, Hamdioui S, Detterer P, Traferro S, Konijnenburg M, Vadivel K, Sifalakis M, Tang G, Yousefzadeh A
Neuromorphic processors promise low-latency and energy-efficient processing by adopting novel brain-inspired design methodologies. Yet, current neuromorphic solutions still struggle to rival conventional deep learning accelerators' performance and area efficiency in practical applications. Event-driven data-flow processing and near/in-memory computing are the two dominant design trends of neuromorphic processors. However, there remain challenges in reducing the overhead of event-driven proc...
Abstract
Cited 39 times since 2024 (32.8 per year)
source: EuropePMC
The lancet. Diabetes & endocrinology,
Volume 12, Issue 5, 27 4 2024, Pages 306-319
Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis.
Cholesterol Treatment Trialists’ (CTT) Collaboration Electronic address: ctt@ndphoxacuk, Cholesterol Treatment Trialists’ (CTT) Collaboration
Background: Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this effect, or who is at greatest risk. We aimed to address these gaps in knowledge through analysis of individual participant data from large, long-term, randomised, double-blind trials of statin therapy. Methods: We conducted a meta-analysis of individual participant data from randomised controlled tri...
Abstract
