8309 results
Frontiers in neuroscience,
Volume 17, 18 3 2023, Pages 1125210
Event-driven spectrotemporal feature extraction and classification using a silicon cochlea model.
Xu Y, Perera S, Bethi Y, Afshar S, van Schaik A
This paper presents a reconfigurable digital implementation of an event-based binaural cochlear system on a Field Programmable Gate Array (FPGA). It consists of a pair of the Cascade of Asymmetric Resonators with Fast Acting Compression (CAR-FAC) cochlea models and leaky integrate-and-fire (LIF) neurons. Additionally, we propose an event-driven SpectroTemporal Receptive Field (STRF) Feature Extraction using Adaptive Selection Thresholds (FEAST). It is tested on the TIDIGTIS benchmark and compare...
Abstract
The American journal of medicine,
Volume 136, Issue 7, 15 3 2023, Pages 720-721
Corrigendum to 'Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making' The American Journal of Medicine 136:03 (2023); 260-269.e7.
Freeman AM, Raman SV, Aggarwal M, Maron DJ, Bhatt DL, Parwani P, Osborne J, Earls JP, Min JK, Bax JJ, Shapiro MD
Abstract
Cited 4 times since 2023 (2.1 per year)
source: EuropePMC
Cancers,
Volume 15, Issue 8, 14 2 2023, Pages 2297
Radiomics of Tumor Heterogeneity in <sup>18</sup>F-FDG-PET-CT for Predicting Response to Immune Checkpoint Inhibition in Therapy-Naïve Patients with Advanced Non-Small-Cell Lung Cancer.
Ventura D, Schindler P, Masthoff M, Görlich D, Dittmann M, Heindel W, Schäfers M, Lenz G, Wardelmann E, Mohr M, Kies P, Bleckmann A, Roll W, Evers G
We aimed to evaluate the predictive and prognostic value of baseline 18F-FDG-PET-CT (PET-CT) radiomic features (RFs) for immune checkpoint-inhibitor (CKI)-based first-line therapy in advanced non-small-cell lung cancer (NSCLC) patients. In this retrospective study 44 patients were included. Patients were treated with either CKI-monotherapy or combined CKI-based immunotherapy-chemotherapy as first-line treatment. Treatment response was assessed by the Response Evaluation Criteria in Solid Tumors...
Abstract
Cited 2 times since 2023 (1.1 per year)
source: EuropePMC
Atherosclerosis,
Volume 384, 14 2 2023, Pages 117123
Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients.
Lu C, Donners MMPC, Karel J, de Boer H, van Zonneveld AJ, den Ruijter H, Jukema JW, Kraaijeveld A, Kuiper J, Pasterkamp G, Cavill R, Perales-Patón J, Ferrannini E, Goossens P, Biessen EAL
Background and aims: This study aims to identify sex-specific transcriptional differences and signaling pathways in circulating monocytes contributing to cardiovascular disease. Methods and results: We generated sex-biased gene expression signatures by comparing male versus female monocytes of coronary artery disease (CAD) patients (n = 450) from the Center for Translational Molecular Medicine-Circulating Cells Cohort. Gene set enrichment analysis demonstrated that monocytes from female CAD pati...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
Volume 162, 14 2 2023, Pages 114665
Engineered cell-based therapies in ex vivo ready-made CellDex capsules have therapeutic efficacy in solid tumors.
van Schaik TA, Moreno-Lama L, Aligholipour Farzani T, Wang M, Chen KS, Li W, Cai L, Zhang YS, Shah K
Encapsulated cell-based therapies for solid tumors have shown promising results in pre-clinical settings. However, the inability to culture encapsulated therapeutic cells prior to their transplantation has limited their translation into clinical settings. In this study, we created a wide variety of engineered therapeutic cells (ThC) loaded in micropore-forming gelatin methacryloyl (GelMA) hydrogel (CellDex) capsules that can be cultured in vitro prior to their transplantation in surgically debul...
Abstract
Cited 2 times since 2023 (1.1 per year)
source: EuropePMC
Musculoskeletal science & practice,
Volume 65, 14 2 2023, Pages 102764
Comparison between two patient-reported outcome measures for patients with cervical radiculopathy: A think-aloud study.
Thoomes E, de Graaf M, Gallina A, Falla D, Stathi A
Background: The Cervical Radiculopathy Impact Scale (CRIS) and Patient Specific Functional Scale 2.0 (PSFS 2.0) are patient-reported outcome measures (PROMs) used to assess activity limitations in patients with cervical radiculopathy (CR). This study a) compared the CRIS subscale 3 and the PSFS 2.0 in patients with CR with respect to completeness and patient preference, b) established the correlation between both PROMs in assessing the individual patient's level of functional limitations an...
Abstract
Cited 2 times since 2023 (1.1 per year)
source: EuropePMC
EClinicalMedicine,
Volume 59, 13 2 2023, Pages 101955
Influence of germline variations in drug transporters ABCB1 and ABCG2 on intracerebral osimertinib efficacy in patients with non-small cell lung cancer.
Veerman GDM, Boosman RJ, Jebbink M, Oomen-de Hoop E, van der Wekken AJ, Bahce I, Hendriks LEL, Croes S, Steendam CMJ, de Jonge E, Koolen SLW, Steeghs N, van Schaik RHN, Smit EF, Dingemans AC, Huitema ADR, Mathijssen RHJ
Background: Central nervous system (CNS) metastases are present in approximately 40% of patients with metastatic epidermal growth factor receptor-mutated (EGFRm+) non-small cell lung cancer (NSCLC). The EGFR-tyrosine kinase inhibitor osimertinib is a substrate of transporters ABCB1 and ABCG2 and metabolized by CYP3A4. We investigated relationships between single nucleotide polymorphisms (SNPs) ABCB1 3435C>T, ABCG2 421C>A and 34G>A, and CYP3A4∗22 and CNS treatment efficacy of osimertinib...
Abstract
Scientific reports,
Volume 13, Issue 1, 13 2 2023, Pages 6021
Neural network based integration of assays to assess pathogenic potential.
Eslami M, Chen YP, Nicholson AC, Weston M, Bell M, McQuiston JR, Samuel J, van Schaik EJ, de Figueiredo P
Limited data significantly hinders our capability of biothreat assessment of novel bacterial strains. Integration of data from additional sources that can provide context about the strain can address this challenge. Datasets from different sources, however, are generated with a specific objective and which makes integration challenging. Here, we developed a deep learning-based approach called the neural network embedding model (NNEM) that integrates data from conventional assays designed to clas...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
PloS one,
Volume 18, Issue 4, 13 2 2023, Pages e0284329
Patients with infective endocarditis undergoing cardiac surgery have distinct ROTEM profiles and more bleeding complications compared to patients without infective endocarditis.
Breel JS, Wensing AGCL, Eberl S, Preckel B, Schober P, Müller MCA, Klautz RJM, Hollmann MW, Hermanns H
Background: The coagulation system is crucial in the pathogenesis of infective endocarditis and undergoes significant changes during course of the disease. However, little is known about the implications of those changes in the perioperative period. Aim of the present study was to delineate the specific coagulation patterns and their clinical consequence in patients undergoing cardiac surgery due to infective endocarditis. Methods: In this single-centre, exploratory, prospective observational st...
Abstract
Eye (London, England),
Volume 37, Issue 16, 12 2 2023, Pages 3442-3445
A prospective long-term evaluation of the ocular findings of children followed with the diagnosis of multisystem inflammatory syndrome (long-term evaluation of ocular findings following MIS-C).
Kaya-Guner E, Sahin A, Ekemen-Keles Y, Karadag-Oncel E, Kara-Aksay A, Yilmaz D
Background/objectives: The most frequently reported ocular finding in the acute phase of the multisystem inflammatory syndrome in children (MIS-C), is conjunctivitis. More rarely, punctuate epitheliopathy, anterior uveitis and optic disc oedema can be seen. We aimed to investigate the acute and long-term ocular effects of MIS-C. Subjects/methods: Cases aged 1 month to 18 years who were diagnosed with MIS-C between January 2022 and June 2022 in the Department of Pediatric Infectious Diseases in o...
Abstract
The Pediatric infectious disease journal,
Volume 42, Issue 8, 11 2 2023, Pages e316-e318
Isolated Subcutaneous Abscess: A Rare Presentation of Extrapulmonary Tuberculosis.
Sahin A, Kara-Aksay A, Bicmen C, Belkaya S, Kaya A, Yilmaz D
Abstract
Cited 12 times since 2023 (6.4 per year)
source: EuropePMC
BMC biology,
Volume 21, Issue 1, 11 2 2023, Pages 76
Genome-wide association reveals host-specific genomic traits in Escherichia coli.
Tiwari SK, van der Putten BCL, Fuchs TM, Vinh TN, Bootsma M, Oldenkamp R, La Ragione R, Matamoros S, Hoa NT, Berens C, Leng J, Álvarez J, Ferrandis-Vila M, Ritchie JM, Fruth A, Schwarz S, Domínguez L, Ugarte-Ruiz M, Bethe A, Huber C, Johanns V, Stamm I, Wieler LH, Ewers C, Fivian-Hughes A, Schmidt H, Menge C, Semmler T, Schultsz C
Background: Escherichia coli is an opportunistic pathogen which colonizes various host species. However, to what extent genetic lineages of E. coli are adapted or restricted to specific hosts and the genomic determinants of such adaptation or restriction is poorly understood. Results: We randomly sampled E. coli isolates from four countries (Germany, UK, Spain, and Vietnam), obtained from five host species (human, pig, cattle, chicken, and wild boar) over 16 years, from both healthy and diseased...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Clinical oral implants research,
Volume 34, Issue 6, 10 2 2023, Pages 582-590
Anti-Apoptotic and Pro-Apoptotic Bcl-2 Family Proteins in Peri-Implant Diseases.
Yilmaz D, Gürsoy M, Gürsoy UK
Objectives: Intrinsic apoptosis, which is regulated by Bcl-2 family proteins, has an important role in chronic inflammatory diseases. The aim of the study was to identify the tissue levels and ratios of anti- and pro-apoptotic Bcl-2 family proteins in peri-implant diseases. Materials and methods: Twenty-three individuals with peri-implant mucositis, 25 individuals with peri-implantitis, and 24 controls were included. The following clinical parameters were recorded: keratinized mucosa width, modi...
Abstract
Cited 2 times since 2023 (1.1 per year)
source: EuropePMC
Sensors (Basel, Switzerland),
Volume 23, Issue 8, 7 1 2023, Pages 3804
Rapid and On-Scene Chemical Identification of Intact Explosives with Portable Near-Infrared Spectroscopy and Multivariate Data Analysis.
van Damme IM, Mestres-Fitó P, Ramaker HJ, Hulsbergen AWC, van der Heijden AEDM, Kranenburg RF, van Asten AC
There is an ongoing forensic and security need for rapid, on-scene, easy-to-use, non-invasive chemical identification of intact energetic materials at pre-explosion crime scenes. Recent technological advances in instrument miniaturization, wireless transfer and cloud storage of digital data, and multivariate data analysis have created new and very promising options for the use of near-infrared (NIR) spectroscopy in forensic science. This study shows that in addition to drugs of abuse, portable N...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
European heart journal. Case reports,
Volume 7, Issue 4, 6 1 2023, Pages ytad176
Genetic variant in the <i>BRAF</i> gene compatible with Noonan spectrum disorders in an adult Fontan patient with refractory protein losing enteropathy: a follow-up report.
Nederend M, Stoger JL, Egorova AD, Barge-Schaapveld DQCM, Jongbloed MRM
Background: Patients with a univentricular heart form a morphological heterogenous group of patients at the most severe end of the congenital heart disease (CHD) spectrum. Over the past decades, more awareness and knowledge has been raised on the genetic contributions to CHD. To date, only a limited number of genes have been identified in the hypoplastic heart, mainly in left-sided hypoplasia. There is still much more to be elucidated in this field. Case summary: Here, we present a follow-up rep...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Journal of dairy science,
Volume 106, Issue 6, 5 1 2023, Pages 4257-4265
Prevalence of extended-spectrum and AmpC β-lactamase-producing Escherichia coli in young calves on Dutch dairy farms.
Gonggrijp MA, Velthuis AGJ, Heuvelink AE, van den Heuvel KWH, Ter Bogt-Kappert CC, Buter GJ, van Schaik G, Lam TJGM
In young calves on dairy farms the animal prevalence of extended-spectrum and AmpC β-lactamase-producing Escherichia coli (ESBL/AmpC-EC) is significantly higher compared with the animal prevalence in young stock and dairy cows. Hitherto it was unknown at what age antimicrobial resistant bacteria appear for the first time in the gut of calves on dairy farms, and how long these infections persist. The aim of this study was to examine the prevalence of ESBL/AmpC-EC, the number of excreted ESBL/AmpC...
Abstract
Cited 4 times since 2023 (2.1 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 94, 5 1 2023, Pages 178-185
Nutcracker Syndrome: Challenges in Diagnosis and Surgical Treatment.
Dieleman F, Hamming JF, Erben Y, van der Vorst JR
Background: Nutcracker syndrome (NCS) is an uncommon syndrome that presents with signs and symptoms caused by compression of the left renal vein (LRV), whereas 'nutcracker phenomenon' is solely used to refer to the anatomical configuration without clinical symptoms. Treatment for NCS may include nonoperative management, open surgical intervention, and in some instances endovascular stenting. We present a single-center retrospective case series of patients who presented with NCS managed...
Abstract
Cited 14 times since 2023 (7.4 per year)
source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Volume 41, Issue 22, 5 1 2023, Pages 3805-3815
Endosonography With or Without Confirmatory Mediastinoscopy for Resectable Lung Cancer: A Randomized Clinical Trial.
Bousema JE, Dijkgraaf MGW, van der Heijden EHFM, Verhagen AFTM, Annema JT, van den Broek FJC, MEDIASTrial study group
Purpose: Resectable non-small-cell lung cancer (NSCLC) with a high probability of mediastinal nodal involvement requires mediastinal staging by endosonography and, in the absence of nodal metastases, confirmatory mediastinoscopy according to current guidelines. However, randomized data regarding immediate lung tumor resection after systematic endosonography versus additional confirmatory mediastinoscopy before resection are lacking. Methods: Patients with (suspected) resectable NSCLC and an indi...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 10, Issue 4, 5 1 2023, Pages 156
Fluid Overload in Pediatric Univentricular Patients Undergoing Fontan Completion.
Luppes VAC, Willems A, Hazekamp MG, Blom NA, Ten Harkel ADJ
Background: Fluid overload (FO) is known to occur frequently after pediatric cardiac surgery and is associated with morbidity and mortality. Fontan patients are at risk to develop FO due to their critical fluid balance. Furthermore, they need an adequate preload in order to maintain adequate cardiac output. This study aimed to identify FO in patients undergoing Fontan completion and the impact of FO on pediatric intensive care unit (PICU) length of stay (LOS) and cardiac events, defined as death...
Abstract
Medical education,
Volume 57, Issue 6, 5 1 2023, Pages 516-522
Challenges facing standardised patients representing equity-deserving groups: Insights from health care educators.
Sibbald M, Last N, Keuhl A, Azim A, Sheth U, Khalid F, Banji F, Geekie-Sousa A, Yilmaz DU, Monteiro S
Introduction: Health professions training programmes increasingly rely on standardised patient (SP) programmes to integrate equity-deserving groups into learning and assessment opportunities. However, little is known about the optimal approach, and many SP programmes struggle to meet these growing needs. This study explored insights from health care educators working with SP programmes to deliver curricular content around equity-deserving groups. Methods: We interviewed 14 key informants in 2021...
Abstract
