6397 results
Expert opinion on biological therapy,
7 1 2025, Pages 1-22
Current treatment landscape of atopic dermatitis focusing on real-world evidence of dupilumab treatment.
Boesjes CM, van der Gang LF, Achten RE, Bakker DS, van der Rijst LP, Dekkers CC, van Wijk F, Haeck IM, de Bruin-Weller MS, de Graaf M
Introduction: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder and has a considerable impact on patients' quality of life. Dupilumab, the first biologic approved for moderate-to-severe AD, is a human monoclonal antibody targeting the interleukin (IL)-4 receptor α, thereby blocking both IL-4 and IL-13 signaling, key drivers of type 2 inflammation in AD. Its introduction has marked a paradigm shift in the management of AD and paved the way for future therapies. As real...
Abstract
ESMO open,
Volume 10, Issue 12, 5 1 2025, Pages 105923
Pathological complete response and survival after neoadjuvant chemotherapy in patients with stage I TNBC: a registry-based study.
de Graaf M, Gielen RCAM, Balduzzi S, Siesling S, Linn SC, Kok M
Background: Pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) is a strong prognostic factor in patients with early-stage triple-negative breast cancer (TNBC). One-third of all patients with early-stage TNBC have stage I disease. Chemotherapy is recommended for most patients with stage I TNBC with an increasing use in the neoadjuvant setting supported by recent guidelines. However, little is known on the chemotherapy benefit for stage I TNBC, in particular the likelihood...
Abstract
Circulation. Cardiovascular imaging,
4 1 2025, Pages e018862
Global Longitudinal Strain for Prognostic Staging in Wild-Type Transthyretin Cardiac Amyloidosis.
Debonnaire P, L'Hoyes W, Donal E, Verheyen N, Vervloet D, Dujardin K, Pouleur AC, Dulgheru R, Sarli Issa V, Droogmans S, Jurcut R, Regeer M, Dupont M, Bondue A, Timmermans P, Bohyn A, Christiaen E, Wyseure N, Bezard M, Zach D, Schwegel N, Knapen R, Buytaert L, de Marneffe N, Adam R, Ajmone Marsan N, Tavernier R, Buysschaert I, Trenson S
Background: A formal prognostic staging system in wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM), based on echocardiographic imaging, is lacking. We evaluated the prognostic performance of global longitudinal strain (GLS) staging in a large ATTRwt-CM patient cohort, including under tafamidis treatment and relative to National Amyloidosis Center (NAC) biomarker staging. Methods: A multicentric, international ATTRwt-CM patient cohort with baseline GLS (distribution quartiles), evaluate...
Abstract
Journal of the American Heart Association,
3 1 2025, Pages e046283
Anrep Effect in the Right Ventricle: Evidence From Systolic Duration Analysis.
Reil JC, Sequeira V, Wink J, Federspiel JM, Reil GH, Steendijk P
Abstract
Annals of hepatology,
3 1 2025, Pages 102170
Genetic risk factors for MASLD/MASH and cardiovascular disease in elderly individuals.
Theel WB, de Jong VD, Grobbee DE, Jukema JW, Trompet S, Cabezas MC
Introduction and objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, MASH, are closely related to obesity and lifestyle. From previous studies, MASLD is also known for its strong genetic background. This study aimed to investigate the association between previously reported genetic polymorphisms of MASLD/MASH and clinical outcomes in an elderly Western European population. Patients and methods: We performed an analysis of 5,244 participants (mea...
Abstract
Cardiovascular diabetology,
Volume 24, Issue 1, 2 1 2025, Pages 453
Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes.
Mäenpää M, Jukema RA, van Diemen P, Bär S, Raijmakers PG, Sprengers R, Driessen RS, Bax JJ, Knaapen P, Knuuti J, Danad I, Saraste A, Maaniitty T
Background: Coronary artery disease (CAD) is a major contributor to cardiovascular events in individuals with diabetes. Quantification of coronary atherosclerotic burden is now feasible from coronary computed tomography angiography (CTA) whereas positron emission tomography (PET) enables quantitative assessment of myocardial perfusion. We studied the prognostic implications of quantitatively measured coronary plaque burden and myocardial perfusion in diabetic vs. non-diabetic patients with suspe...
Abstract
Annals of vascular surgery,
2 1 2025, Pages S0890-5096(25)00855-6
Considerations with respect to elective Abdominal Aortic Aneurysm repair in older people.
Biemond MJ, Paping JHM, Bulder RMA, Hultgren R, Mooijaart SP, Hamming JF, Lindeman JH
Objectives: The epidemiology of abdominal aortic aneurysm (AAA) is changing, with progressively more older patients receiving repair. Advancing age associates with an increased procedural risk, but also with a decreasing life-time rupture risk. This national study aims to provide background information for decision-making in older people. Methods: National administrative data (Statistics Netherlands) was used to estimate time-varying trends in the age and sex distribution of patients that underw...
Abstract
Circulation. Arrhythmia and electrophysiology,
2 1 2025, Pages e014049
International Survey on Vein of Marshall Retrograde Ethanol Infusion.
De Becker B, Derval N, Amin R, El Haddad M, Pambrun T, Bouyer B, Francois C, De Smet M, Channan EM, Blankoff N, Krahnefeld O, Agdirlioglu T, Minois D, Andorin A, Bessiere F, Gardey K, Sesselberg HW, Leyton-Mange JS, Marchand H, Mariottini C, Miled M, Sebag FA, Lellouche N, Andronache M, Marchese P, Rossi A, Nesti M, Herzet JM, Rodríguez Manero M, Pavlović N, Anselme F, Chaumont C, Wijnmaalen AP, Piers SRD, Waktare JEP, Najm A, Almorad A, Sousa PA, Lepièce C, Badot D, Auquier N, Efremidis M, Lian E, Maslova V, Tavernier R, Duytschaever M, Le Polain de Waroux JB, Valderrabano M, Knecht S
Background: Retrograde ethanolization of the vein of Marshall (VOM) has been identified as an adjunct technique in the treatment of persistent atrial fibrillation (AF) and left atrial tachycardia, as stated in the last consensus statement on ablation of AF. However, there is a lack of high-volume data on the technique. Methods: Through the collection of data from worldwide centers, we performed this international survey that aims to analyze the safety and procedural characteristics of VOM ethano...
Abstract
Giornale italiano di cardiologia (2006),
Volume 26, Issue 12 Suppl. 1, 1 1 2025, Pages e1-e108
[2025 ESC/EACTS Guidelines for the management of valvular heart disease].
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
Volume 39, Issue 12, 1 1 2025, Pages 2028-2029
Reading the palms: Palmar hyperlinearity and type 2 biomarkers as early predictors of atopic dermatitis onset in infancy?
Vroman F, de Graaf M
Abstract
Circulation,
1 1 2025
Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes after Acute Coronary Syndrome.
Tsimikas S, Szarek M, Cobbaert CM, Romijn F, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Yuan C, Gong XM, Goodman SG, White HD, Witztum JL, Steg PG, Schwartz GG, ODYSSEY OUTCOMES investigators
Background: Oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) reflect pro-inflammatory properties of Lp(a) (lipoprotein(a)). The effect of OxPL-apoB on major adverse cardiovascular events (MACE) in patients with acute coronary syndrome in recent the era is not known. Methods: OxPL-apoB levels and Lp(a) were measured in 11 630 participants before and 5185 participants 4 months after randomization to alirocumab or placebo in the ODYSSEY OUTCOMES trial. Proportional hazards models adjusted...
Abstract
Nature communications,
Volume 16, Issue 1, 28 4 2025, Pages 10707
Unveiling the global urban virome through wastewater metagenomics.
Worp N, Nieuwenhuijse DF, Izquierdo-Lara RW, Schapendonk CME, Brinch C, Jensen EEB, Munk P, Hendriksen RS, Global Sewage Surveillance Consortium, Aarestrup F, Oude Munnink BB, Koopmans MPG, de Graaf M
Understanding global viral dynamics is critical for public health. Traditional surveillance focuses on individual pathogens and symptomatic cases, which may miss asymptomatic infections or newly emerging viruses, delaying detection and response. Wastewater-based epidemiology has been used to track pathogens through targeted molecular assays, but its reliance on predefined targets limits detection of the full viral spectrum. Here, we analyse longitudinal wastewater samples from 62 cities across s...
Abstract
The American journal of cardiology,
27 4 2025, Pages S0002-9149(25)00691-5
Intravascular Lithotripsy in Diabetic Patients Undergoing Percutaneous Coronary Intervention: Long-Term Outcomes from the BENELUX Registry.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, Sagris M, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Diabetes mellitus (DM) is associated with increased coronary calcification and adverse outcomes after percutaneous coronary intervention (PCI), yet the performance of intravascular lithotripsy (IVL) in this high-risk population remains insufficiently defined. This study, conducted within the all-comers BENELUX-IVL registry, evaluated the safety and efficacy of IVL-assisted PCI in patients with and without DM. The primary endpoint was major adverse cardiovascular events (MACE) at 1 and 2 years, d...
Abstract
Communications biology,
Volume 8, Issue 1, 26 4 2025, Pages 1684
Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling.
Muntjewerff EM, Epremidze D, Nezhyva M, Kal S, Rohm TV, Tang K, Singh K, Espes D, Jati S, Bootsma M, Mannaa AM, Ikebuchi H, Nilsson AM, Rajasekaran M, Andrén PE, Jansson ET, Mahata SK, Christoffersson G
Chromogranin A (CgA), a neuroendocrine pro-hormone, is proteolytically cleaved into bioactive peptides, most notably catestatin (CST) and pancreastatin (PST), which exert opposing effects on metabolic and inflammatory processes. Using CgA- and CST knockout (KO) mice, we investigated the roles of these peptides in pancreatic endocrine function, morphology, neurotransmitter dynamics, and systemic glucose homeostasis. CST-KO mice displayed impaired insulin secretion in vivo (but not ex vivo), disru...
Abstract
JAMA cardiology,
26 4 2025
Interventions for Tricuspid Regurgitation.
Praz F, Angellotti D, Ajmone Marsan N, Butler J
Abstract
BMC primary care,
25 4 2025
Navigating chest pain online: who uses health information and what actions follow?
van Dijkman ED, de Boer YK, de Hollander EL, Numans ME, Siebelink HJ, Bonten TN
Abstract
JACC. Cardiovascular imaging,
22 4 2025, Pages S1936-878X(25)00579-0
Prognostic Value of AI-Based Quantitative Coronary CTA vs Human Reader-Based Visual Assessment: Results From the CONFIRM2 Registry.
van Rosendael A, Nakanishi R, Bax JJ, Pontone G, Mushtaq S, Buechel RR, Gräni C, Feuchtner G, Lacaita PG, Patel AR, Singulane CC, Choi AD, Al-Mallah M, Andreini D, Karlsberg RP, Cho GW, Rochitte CE, Alasnag M, Hamdan A, Cademartiri F, Maffei E, Marques H, Gonçalves PA, Gupta H, Hadamitzky M, Khalique O, Kalra D, Mills JD, Nurmohamed NS, Knaapen P, Budoff M, Shaikh K, Martin E, German DM, Ferencik M, Oehler AC, Deaño R, Nagpal P, van Assen M, De Cecco CN, Kamperidis V, Foldyna B, Brendel JM, Cheng VY, Branch KR, Bittencourt M, Bhatti S, Polsani V, Wesbey G, Cardoso R, Blankstein R, Delago A, Pursnani A, Alsaid A, Singh V, Aquino M, Park J, Danad I
Background: The severity and extent of whole heart coronary plaque volume and stenosis can be reliably measured by artificial intelligence-guided quantitative coronary computed tomography angiography (AI-QCT). Limited data are available on the potential incremental prognostic value compared with currently recommended qualitative coronary computed tomography angiography (CTA) reads and the coronary artery calcium score (CACS). Objectives: The aim of this study was to evaluate the prognostic value...
Abstract
Consciousness and cognition,
Volume 137, 17 3 2025, Pages 103964
Disentangling perceptual from non-perceptual expectation biases in short-term memory.
Koopmans JG, Thorat S, Quek GL, Peelen MV
There is debate about how many items can be represented in visual consciousness at once. Evidence against the view that visual consciousness consists of many detailed items has come from a study using the partial-report paradigm. De Gardelle et al. (2009) showed that rotated letters shown in non-cued (i.e., unattended) parts of a briefly presented letter array are sometimes illusorily perceived as upright. Presumably, the expectation that letters are generally seen upright modulated a rotated le...
Abstract
Frontiers in cardiovascular medicine,
Volume 12, 17 3 2025, Pages 1708865
Exploring ethnic differences in the perioperative course of thoracic aortopathy.
Bacour N, Tirpan AU, Grewal S, Klautz RJM, Grewal N
Background: In patients with thoracic aortopathy post-operative recovery can be complicated by a lack of consistent, clear communication and guidance. Despite the growing recognition of these challenges, the specific needs of patients undergoing aortic surgery, especially across different ethnic groups, remain insufficiently explored. This study aims to examine the peri-operative course in thoracic aortopathy in order to identify the specific needs of the patients, particularly across ethnic gro...
Abstract
JACC. Clinical electrophysiology,
13 2 2025, Pages S2405-500X(25)00824-2
Characterizing Sustained Arrhythmias in Patients With Arrhythmic Mitral Valve Prolapse: Insights From the SAVE-MVP collaboration.
Sabbag A, Ajmone-Marsan N, Ezzeddine F, Ascione G, Guicciardi NA, Baudinaud P, Beinart R, Ben Kilani M, Bergonti M, Bhardwaj PK, Boveda S, Czimbalmos C, Cristin L, Conte G, Del Carpio F, Delling F, de Riva M, Deharo JC, Escande W, Font J, Foltran D, Guerra F, Guenancia C, Haugaa KH, Haddad C, Hermida A, Huttin O, Jacon P, Krebsová A, Laredo M, Lim HS, López-Santi P, Maury P, Mansourati J, Milman A, Mazor E, Nagy A, Przybylski A, Saba M, Sohns C, Sticherling C, Siontis KC, Ter Bekke RMA, Tixier R, Acha MR, Richard-Vitton R, Winkel BG, Ollitrault P, Aabel EW
Background: Arrhythmic mitral valve prolapse (AMVP) is a cause of sustained ventricular tachyarrhythmias (VAs) and sudden cardiac death (SCD), but the arrhythmias remain only partially understood. Objectives: In this worldwide collaboration, this study aimed to characterize the VAs occurring in AMVP patients, explore factors associated with various types of sustained VA, and describe common triggering mechanisms. Methods: In this multicenter retrospective cohort study, we collected patients with...
Abstract
