6125 results
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Herz,
Volume 48, Issue 1, 28 4 2022, Pages 3-14
[The new ESC guidelines on the management of ventricular tachyarrhythmias : Implications for daily practice].
Könemann H, Frommeyer G, Zeppenfeld K, Eckardt L
The recently published guidelines of the European Society of Cardiology (ESC) on the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death is an update of the 2015 guideline. For the first time a new section is dedicated to public basic life support. In the acute treatment of ventricular arrhythmias electrical cardioversion is upgraded, and there is a new focus on the management of electrical storm. Recommendations for the comprehensive diagnostic evaluat...
Abstract
Cited 2 times since 2022 (0.9 per year)
source: EuropePMC
Biomedicines,
Volume 10, Issue 12, 28 4 2022, Pages 3056
NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction.
Silvis MJM, Demkes EJ, Timmers L, Arslan F, de Jager SCA, Sluijter JPG, Mosterd A, de Kleijn DPV, Bosch L, van Hout GPJ
NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent of myocardial damage after myocardial infarction (MI). The purpose of this study was to investigate the effects of the NLRP3-inflammasome inhibitor IZD334 on cardiac damage in a pig model of myocardial infarction. Prior to in vivo testing, in vitro, porcine peripheral blood mononuclear cells and whole blood were treated with increasing dosages of IZD334, a novel NLRP3-inflammasome inhibitor, and were stimu...
Abstract
Cited 4 times since 2022 (1.8 per year)
source: EuropePMC
Acta dermato-venereologica,
Volume 102, 24 4 2022, Pages adv00820
Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry.
Boesjes CM, Kamphuis E, Zuithoff NPA, Bakker DS, Loman L, Spekhorst LS, Haeck I, Kamsteeg M, Van Lynden-van Nes AMT, Garritsen FM, Politiek K, Oldhoff M, De Graaf M, Schuttelaar MLA, De Bruin-Weller MS
Clinical trials have shown that baricitinib, an oral selective Janus kinase 1/2 inhibitor, is effective for the treatment of moderate-to-severe atopic dermatitis. However, daily practice data are limited. Therefore, this multicentre prospective study evaluated the effectiveness and safety of 16-weeks' treatment with baricitinib in adult patients with moderate-to-severe atopic dermatitis in daily practice. A total of 51 patients from the BioDay registry treated with baricitinib were included...
Abstract
Cited 2 times since 2022 (0.9 per year)
source: EuropePMC
International journal of cardiology,
Volume 373, 23 4 2022, Pages 101-106
Incremental value of left ventricular global longitudinal strain in moderate aortic stenosis and reduced left ventricular ejection fraction.
Stassen J, Singh GK, Pio SM, Chimed S, Butcher SC, Hirasawa K, Marsan NA, Bax JJ
Background: Moderate aortic stenosis (AS) often coexists with left ventricular (LV) systolic dysfunction and may affect survival through afterload mismatch. Because outcomes are ultimately driven by the condition of the LV, accurate assessment of LV performance is crucial to improve risk stratification. This study investigated the prognostic value of LV global longitudinal strain (GLS) in patients with moderate AS and reduced LV systolic dysfunction. Methods: Patients with moderate AS (aortic va...
Abstract
Cited 6 times since 2022 (2.7 per year)
source: EuropePMC
European journal of heart failure,
Volume 25, Issue 2, 23 4 2022, Pages 213-222
Sequencing and titrating approach of therapy in heart failure with reduced ejection fraction following the 2021 European Society of Cardiology guidelines: an international cardiology survey.
Fauvel C, Bonnet G, Mullens W, Giraldo CIS, Mežnar AZ, Barasa A, Tokmakova M, Shchendrygina A, Costa FM, Mapelli M, Zemrak F, Tops LF, Jakus N, Sultan A, Bahouth F, Hadjseyd CE, Salvat M, Anselmino M, Messroghli D, Weberndörfer V, Giverts I, Bochaton T, Courand PY, Berthelot E, Legallois D, Beauvais F, Bauer F, Lamblin N, Damy T, Girerd N, Sebbag L, Pezel T, Cohen-Solal A, Rosano G, Roubille F, Mewton N
Aims: In symptomatic patients with heart failure and reduced ejection fraction (HFrEF), recent international guidelines recommend initiating four major therapeutic classes rather than sequential initiation. It remains unclear how this change in guidelines is perceived by practicing cardiologists versus heart failure (HF) specialists. Methods and results: An independent academic web-based survey was designed by a group of HF specialists and posted by email and through various social networks to a...
Abstract
Cited 19 times since 2022 (8.4 per year)
source: EuropePMC
Nature cancer,
Volume 3, Issue 11, 22 4 2022, Pages 1284-1299
cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis.
Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R
Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in different senescent cancer cell models, we identify loss of the death receptor inhibitor cFLIP as a common vulnerability of senescent cancer cells. Senescent cells are primed for apoptotic death by NF-κB-mediated upregulation of death receptor 5 (DR5...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
European journal of trauma and emergency surgery : official publication of the European Trauma Society,
Volume 49, Issue 2, 22 4 2022, Pages 825-835
The effect of age on resilience of health-related quality of life among polytrauma patients: a cross-sectional multicenter study.
de Vries R, Reininga I, de Graaf M, Banierink H, Bosma E, Munzebrock A, Heineman E, Moumni ME, Wendt K
Purpose: The aim of this study was to determine the impact of age on patient-reported health-related quality of life (HRQoL) and the capacity to show resilience-i.e., the ability to adapt to stressful adverse events-after sustaining a polytrauma. Methods: A cross-sectional multicenter cohort was conducted between 2013 and 2016 that included surviving polytrauma patients (ISS ≥ 16). HRQoL was obtained by the Short Musculoskeletal Function assessment and EuroQol (SMFA and EQ-5D-5L). The effect of...
Abstract
Cited 6 times since 2022 (2.6 per year)
source: EuropePMC
Communications medicine,
Volume 2, Issue 1, 19 3 2022, Pages 146
The importance of sustained compliance with physical distancing during COVID-19 vaccination rollout.
Teslya A, Rozhnova G, Pham TM, van Wees DA, Nunner H, Godijk NG, Bootsma M, Kretzschmar ME
Background: Increasing vaccination coverage against SARS-CoV-2 enabled relaxation of lockdowns in many countries in Europe. As the vaccination rollouts progressed, the public health authorities were seeking recommendations on the continuation of physical distancing measures during ongoing vaccination rollouts. Compliance with these measures was declining while more transmissible virus variants have emerged. Methods: We used a SARS-CoV-2 transmission model to investigate the feedback between comp...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
Volume 63, 18 3 2022, Pages 107498
Can transforming growth factor beta and downstream signalers distinguish bicuspid aortic valve patients susceptible for future aortic complications?
Grewal N, Klautz R, Poelmann RE
Patients with a bicuspid aortic valve have an extreme high risk to develop a thoracic aortic aneurysm and dissection (TAAD). TAADs form a leading cause of death worldwide, with the majority of deaths being preventable if individuals at risk are identified and properly managed. Risk stratification for TAADs in bicuspidy is so far solely based on the aortic diameter. Exclusive use of aortic wall dimension, as in the current guidelines, is however not sufficient in selecting patients vulnerable for...
Abstract
Clinical nutrition (Edinburgh, Scotland),
Volume 42, Issue 1, 17 3 2022, Pages 18-21
An omission in guidelines. Cardiovascular disease prevention should also focus on dietary policies for healthcare facilities.
de Frel DL, Assendelft WJJ, Hondmann S, Janssen VR, Molema JJW, Trines SA, de Vries IAC, Schalij MJ, Atsma DE
Suboptimal diet is a major modifiable risk factor in cardiovascular disease. Governments, individuals, educational institutes, healthcare facilities and the industry all share the responsibility to improve dietary habits. Healthcare facilities in particular present a unique opportunity to convey the importance of healthy nutrition to patients, visitors and staff. Guidelines on cardiovascular disease do include policy suggestions for population-based approaches to diet in a broad list of settings...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 101, Issue 1, 16 3 2022, Pages 97-101
Bail out lithotripsy to treat delayed valve-in-valve TAVR-related coronary obstruction.
Bingen BO, Al Amri I, Montero-Cabezas JM, van der Kley F
Coronary access difficulty and stent compression by the juxtaposed aortic valve leaflet hamper percutaneous management of delayed coronary artery obstruction (CAO) after valve-in-valve (Edwards Sapien 3 in St. Jude Trifecta) transcatheter aortic valve replacement (TAVR). Here, we present a case of delayed post-TAVR CAO treated with intravascular lithotripsy and multistenting to overcome stent compression by the adjacent calcified leaflet.
Abstract
Cited 2 times since 2022 (0.9 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 30, Issue 1, 15 3 2022, Pages 178-188
Incorporating coronary artery calcium scoring in the prediction of obstructive coronary artery disease with myocardial ischemia: a study with sequential use of coronary computed tomography angiography and positron emission tomography imaging.
van den Hoogen IJ, Wang X, Butcher SC, Maaniitty T, Schultz J, van Rosendael AR, Saraste A, Knuuti J, Bax JJ
Background: Additional strategies are needed to refine the referral for diagnostic testing of symptomatic patients with suspected coronary artery disease (CAD). We aimed to compare various models to predict hemodynamically obstructive CAD. Methods and results: Symptomatic patients with suspected CAD who underwent coronary artery calcium scoring (CACS) and sequential coronary computed tomography angiography (CCTA) and [15O]H2O positron emission tomography (PET) myocardial perfusion imaging were a...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Cardio-oncology (London, England),
Volume 8, Issue 1, 15 3 2022, Pages 18
Case report: challenges in monitoring and treatment of anthracycline induced cardiotoxicity in young adults with osteosarcoma.
Heemelaar JC, Janson J, Braun J, Speetjens FM, van de Sande MAJ, Hugo JDV, Barge-Schaapveld DQCM, Beeres SLMA, Tops LF, Gelderblom H, Antoni ML
Neo(adjuvant) systemic treatment regimens containing anthracyclines such as doxorubicin cause a significant risk of heart failure. These regimens are one of the corner stones of osteosarcoma treatment, and therefore several guidelines are in place to steer cardiotoxicity monitoring through baseline risk stratification and cardiac surveillance during and after completion of cancer therapy.Importantly, baseline risk stratification modules are dependent on age, prior cardiovascular disease and card...
Abstract
Cited 3 times since 2022 (1.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 370, 14 2 2022, Pages 442-444
Introduction to hemodynamic forces by echocardiography.
Laenens D, van der Bijl P, Stassen J, Rossi AC, Pedrizzetti G, Reiber JHC, Marsan NA, Bax JJ
Hemodynamic force (HDF) analysis represents a novel approach to quantify intraventricular pressure gradients, responsible for blood flow. A new mathematical model allows the derivation of HDF parameters from routine transthoracic echocardiography, making this tool more accessible for clinical use. HDF analysis is considered the fluid dynamics correlate of deformation imaging and may be even more sensitive to detect mechanical abnormalities. This has the potential to add incremental clinical valu...
Abstract
Cited 4 times since 2022 (1.7 per year)
source: EuropePMC
Cardiovascular diabetology,
Volume 21, Issue 1, 12 2 2022, Pages 239
Glycemic control is independently associated with rapid progression of coronary atherosclerosis in the absence of a baseline coronary plaque burden: a retrospective case-control study from the PARADIGM registry.
Won KB, Lee BK, Lin FY, Hadamitzky M, Kim YJ, Sung JM, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, de Araújo Gonçalves P, Leipsic JA, Lee SE, Shin S, Choi JH, Virmani R, Samady H, Chinnaiyan K, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ
Background: The baseline coronary plaque burden is the most important factor for rapid plaque progression (RPP) in the coronary artery. However, data on the independent predictors of RPP in the absence of a baseline coronary plaque burden are limited. Thus, this study aimed to investigate the predictors for RPP in patients without coronary plaques on baseline coronary computed tomography angiography (CCTA) images. Methods: A total of 402 patients (mean age: 57.6 ± 10.0 years, 49.3% men) without...
Abstract
EJVES vascular forum,
Volume 57, 9 2 2022, Pages 17-27
Identifying Women at High Risk of 90 Day Death after Elective Open Abdominal Aortic Aneurysm Repair: A Multicentre Case Control Study.
Tedjawirja VN, Bulder RMA, Lindeman JHN, Hamming JF, van Dieren S, Balm R, Koelemay MJW, Study Group Collaborators
Objective: The aim of this study was to identify risk factors for 90 day death after elective open surgical repair (OSR) of abdominal aortic aneurysms (AAAs) in women. Methods: This was a multicentre case control study. The nationwide Dutch Surgical Aneurysm Audit registry (2013-2019) was solely used to identify women who underwent elective OSR as eligible patients. Data for this study were subsequently collected from the patients' medical files. Women with AAA were included and those who d...
Abstract
Cited 3 times since 2022 (1.3 per year)
source: EuropePMC
Molecular therapy. Nucleic acids,
Volume 30, 9 2 2022, Pages 522-534
Filamin A pre-mRNA editing modulates vascularization and tumor growth.
Jain M, Manjaly G, Maly K, de Vries MR, Janisiw M, König L, Nossent AY, Jantsch MF
Adenosine to inosine (A to I) editing is mediated by adenosine deaminases acting on RNA (ADAR) enzymes. Inosines are interpreted as guanosines by the translational machinery. Consequently, A to I editing in mRNAs can lead to their recoding and the formation of proteins not encoded in the genome. Filamin A is an actin-crosslinking protein. A to I editing in the filamin pre-mRNA leads to the exchange of a glutamine to an arginine in a highly interactive domain of the protein. However, the conseque...
Abstract
The Annals of thoracic surgery,
Volume 116, Issue 1, 8 2 2022, Pages 200-201
Why and When Is Aortic Root Replacement in Acute Type A Dissection Preferable.
Arabkhani B, Klautz RJM
Abstract
Cited 7 times since 2022 (3 per year)
source: EuropePMC
Journal of interventional cardiology,
Volume 2022, 7 1 2022, Pages 8167011
Prophylactic Impella CP versus VA-ECMO in Patients Undergoing Complex High-Risk Indicated PCI.
van den Buijs DMF, Wilgenhof A, Knaapen P, Zivelonghi C, Meijers T, Vermeersch P, Arslan F, Verouden N, Nap A, Sjauw K, van den Brink FS
Objectives: To compare two different forms of mechanical circulatory support (MCS) in patients with complex high-risk indicated PCI (CHIP): the Impella CP system and veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Background: To prevent hemodynamic instability in CHIP, various MCS systems are available. However, comparable data on different forms of MCS are not at hand. Methods: In this multicenter observational study, we retrospectively evaluated all CHIP procedures with the suppor...
Abstract
Cited 2 times since 2022 (0.9 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 23, Issue 21, 7 1 2022, Pages 13662
Phosphorylcholine Monoclonal Antibody Therapy Decreases Intraplaque Angiogenesis and Intraplaque Hemorrhage in Murine Vein Grafts.
Baganha F, Sluiter TJ, de Jong RCM, van Alst LA, Peters HAB, Jukema JW, Delibegovic M, Pettersson K, Quax PHA, de Vries MR
Phosphorylcholine (PC) is one of the main oxLDL epitopes playing a central role in atherosclerosis, due to its atherogenic and proinflammatory effects. PC can be cleared by natural IgM antibodies and low levels of these antibodies have been associated with human vein graft (VG) failure. Although PC antibodies are recognized for their anti-inflammatory properties, their effect on intraplaque angiogenesis (IPA) and intraplaque hemorrhage (IPH)-interdependent processes contributing to plaque ruptur...
Abstract
