6173 results
Scientific reports,
Volume 14, Issue 1, 29 5 2024, Pages 26018
Accessible viral metagenomics for public health and clinical domains with Jovian.
Schmitz D, Zwagemaker F, Nooij S, Janssens TKS, Cremer J, Verhagen R, Vennema H, Kroneman A, Koopmans MPG, Laros JFJ, de Graaf M
The integration of next-generation sequencing into clinical diagnostics and surveillance initiatives is impeded by the lack of data analysis pipelines that align with privacy legislation and laboratory certification protocols. To address these challenges, we developed Jovian, an open-source, virus-focused, metagenomic analysis workflow for Illumina data. Jovian generates scaffolds enriched with pertinent annotations, including taxonomic classification, combined with metrics needed for quality as...
Abstract
Cited 7 times since 2024 (14.7 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 85, Issue 9, 28 4 2024, Pages 878-890
Transcatheter Aortic Valve Replacement in Patients With Systolic Heart Failure and Moderate Aortic Stenosis: TAVR UNLOAD.
Van Mieghem NM, Elmariah S, Spitzer E, Pibarot P, Nazif TM, Bax JJ, Hahn RT, Popma A, Ben-Yehuda O, Kallel F, Redfors B, Chuang ML, Alu MC, Lindeboom W, Kolte D, Zahr FE, Kodali SK, Strote JA, Hermanides RS, Cohen DJ, Tijssen JGP, Leon MB
Background: Neurohormonal modulation and afterload reduction are key for treatment of heart failure with reduced ejection fraction (HFrEF). In HFrEF patients with concomitant moderate aortic stenosis (AS), treatment with transcatheter aortic valve replacement (TAVR) may be complementary to guideline-directed medical therapy (GDMT). Objectives: This study sought to determine whether TAVR for moderate AS provides clinical benefit in patients with HFrEF on top of GDMT. Methods: We performed an inve...
Abstract
Translational lung cancer research,
Volume 13, Issue 10, 28 4 2024, Pages 2813-2827
What do we know about the role of neoadjuvant targeted therapy in early-stage <i>EGFR</i>-mutant and <i>ALK</i>-fused non-small cell lung cancer?-a narrative review of the current literature.
Kemper M, Elges S, Kies P, Wiebe K, Lenz G, Bleckmann A, Evers G
Background and objective: The standard first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions is targeted therapy using tyrosine kinase inhibitors (TKIs). However, data are still lacking on the use of TKIs as a neoadjuvant or induction approach. Therefore, this narrative review aims to summarize the current knowledge on resectable EGFR-mutant and ALK-fused NSCLC re...
Abstract
Cited 2 times since 2024 (4.1 per year)
source: EuropePMC
GeroScience,
Volume 47, Issue 2, 22 4 2024, Pages 2035-2045
Increased <sup>1</sup>H-NMR metabolomics-based health score associates with declined cognitive performance and functional independence in older adults at risk of cardiovascular disease.
Zonneveld MH, Al Kuhaili N, Mooijaart SP, Slagboom PE, Jukema JW, Noordam R, Trompet S
The 1-HMR metabolomics-based MetaboHealth score, comprised of 14 serum metabolic markers, associates with disease-specific mortality, but it is unclear whether the score also reflects cognitive changes and functional impairment. We aimed to assess the associations between the MetaboHealth score with cognitive function and functional decline in older adults at increased cardiovascular risk. A total of 5292 older adults free of dementia at baseline with mean age 75.3 years (SD = 3.4) from the Pros...
Abstract
Nature communications,
Volume 15, Issue 1, 17 3 2024, Pages 8953
Author Correction: Time-series sewage metagenomics distinguishes seasonal, human-derived and environmental microbial communities potentially allowing source-attributed surveillance.
Becsei Á, Fuschi A, Otani S, Kant R, Weinstein I, Alba P, Stéger J, Visontai D, Brinch C, de Graaf M, Schapendonk CME, Battisti A, De Cesare A, Oliveri C, Troja F, Sironen T, Vapalahti O, Pasquali F, Bányai K, Makó M, Pollner P, Merlotti A, Koopmans M, Csabai I, Remondini D, Aarestrup FM, Munk P
Abstract
JACC. Advances,
Volume 3, Issue 11, 14 2 2024, Pages 101327
30 Years' Experience in Percutaneous Pulmonary Artery Interventions in Transposition of the Great Arteries.
Joosen RS, van der Palen RLF, Udink Ten Cate FEA, Voskuil M, Krings GJ, Bökenkamp R, Molenschot MC, Hahurij ND, Dickinson MG, Hazekamp MG, Schoof PH, Slieker MG, Straver B, Blom NA, Breur JMPJ
Background: Pulmonary artery (PA) stenosis is common after arterial switch operation (ASO) for transposition of the great arteries (TGA). Differences between balloon angioplasty (BA) and stents on right ventricular (RV) and PA pressures are not well studied. Objectives: The purpose of this study was to analyze percutaneous PA interventions' frequency after ASO, complications, and the effects of BA and stents on RV and PA pressures. Methods: All TGA patients with ASO between 1977 and 2022 in...
Abstract
Cited 1 times since 2024 (1.9 per year)
source: EuropePMC
European journal of clinical investigation,
Volume 54, Issue 12, 13 2 2024, Pages e14317
Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry.
Stähli BE, Schindler M, Schweiger V, Cammann VL, Szawan KA, Niederseer D, Würdinger M, Schönberger A, Schönberger M, Koleva I, Mercier JC, Petkova V, Mayer S, Citro R, Vecchione C, Bossone E, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, D'Ascenzo F, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm
Background: The clinical relevance of cardiac troponin (cTn) elevation in takotsubo syndrome (TTS) remains uncertain. The present study sought to investigate the role of cardiac troponin (cTn) elevations in mortality prediction of patients with Takotsubo syndrome (TTS). Methods: Patients enrolled in the International Takotsubo (InterTAK) Registry from January 2011 to February 2020 with available data on peak cTn levels were included in the analysis. Peak cTn levels during the index hospitalizati...
Abstract
Cited 1 times since 2024 (1.9 per year)
source: EuropePMC
EBioMedicine,
Volume 109, 12 2 2024, Pages 105391
Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatment.
Izquierdo-Lara RW, Villabruna N, Hesselink DA, Schapendonk CME, Ribó Pons S, Nieuwenhuijse D, Meier JIJ, Goodfellow I, Dalm VASH, Fraaij PLA, van Kampen JJA, Koopmans MPG, de Graaf M
Background: Currently, there is no licensed treatment for chronic norovirus infections, but the use of intra-duodenally-delivered immunoglobulins is promising; nevertheless, varying results have limited their wide use. Little is known about the relationship between norovirus genetic diversity and treatment efficacy. Methods: We analyzed the norovirus within-host diversity and evolution in a cohort of 20 immunocompromised individuals using next-generation sequencing (NGS) and clone-based sequenci...
Abstract
Cited 1 times since 2024 (1.9 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 11, Issue 10, 7 1 2024, Pages 310
Association between Left Atrial Function and Survival in Systemic Sclerosis.
Giucă A, Galloo X, Meucci MC, Butcher SC, Popescu BA, Jurcuț R, Săftoiu A, Jurcuț C, Groșeanu L, Mușetescu AE, Ahmed S, De Vries-Bouwstra J, Bax JJ, Ajmone Marsan N
Systemic sclerosis (SSc) is a multisystemic autoimmune disorder in which cardiac involvement is frequent and portends negative prognosis. Left ventricular (LV) diastolic dysfunction is one of the most common cardiac alterations in these patients, and left atrial (LA) reservoir strain (ƐR) measurement using speckle tracking echocardiography has been proposed as a novel parameter for a better assessment of LV diastolic function. Therefore, the aim of this study was to test the prognostic value of...
Abstract
Cited 3 times since 2024 (5.5 per year)
source: EuropePMC
Journal of vascular surgery. Venous and lymphatic disorders,
Volume 13, Issue 1, 2 1 2024, Pages 101970
Nutcracker syndrome (a Delphi consensus).
Heilijgers F, Gloviczki P, O'Sullivan G, Chavent B, Avgerinos ED, Harth K, Black SA, Erben YM, Rotmans JI, Richards T, Chaer RA, Villalba L, Jayaraj A, Malgor RD, Tripathi RK, Dua A, Murphy E, Rinckenbach S, Vedantham S, Hamming JF, van der Vorst JR
Background: Nutcracker syndrome (NCS) describes the symptomatic compression of the left renal vein between the aorta and superior mesenteric artery. Whereas asymptomatic compression is a common radiological finding, patients with NCS can report a range of symptoms. There are no specific diagnostic criteria and interventions include a range of open surgical and endovascular procedures. Therefore, we wished to develop an international consensus document covering aspects of diagnosis, management, a...
Abstract
Cited 2 times since 2024 (3.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 26, Issue 10, 1 1 2024, Pages euae235
Ventricular arrhythmias in acute heart failure: a clinical consensus statement of the Association for Acute CardioVascular Care, the European Heart Rhythm Association, and the Heart Failure Association of the European Society of Cardiology.
Gorenek B, Wijnmaalen AP, Goette A, Mert GO, Porter B, Gustafsson F, Dan GA, Ector J, Stuehlinger M, Spartalis M, Gosau N, Amir O, Chioncel O
Patients presenting with or alerting emergency networks due to acute heart failure (AHF) form a diverse group with a plethora of symptoms, risks, comorbidities, and aetiologies. During AHF, there is an increased risk of destabilizing the functional substrate and modulatory adding to the risk of ventricular arrhythmias (VAs) already created by the structural substrate. New VAs during AHF have previously identified patients with higher intra-hospital and 60-day morbidity and mortality. Risk strati...
Abstract
JACC. Cardiovascular interventions,
Volume 17, Issue 20, 1 1 2024, Pages 2408-2410
The Promise and Challenges of Pressure-Guided Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension.
Montero-Cabezas JM, Delgado V
Abstract
Giornale italiano di cardiologia (2006),
Volume 25, Issue 10, 1 1 2024, Pages 699-710
[Ten questions about infective endocarditis].
Fortuni F, Ciliberti G, Marsan NA, Delgado V, Franchin L, Magnesa M, Spinelli A, Vitale E, Cangemi S, Cornara S, Gabrielli D, Colivicchi F, Grimaldi M, Oliva F
Infective endocarditis (IE) is an infective process involving the endocardium and, more frequently, the native heart valves, valvular prostheses and cardiac implantable electronic devices. IE can manifest with various non-specific symptoms making the diagnosis challenging. This condition is associated with high in-hospital and long-term mortality. Therefore, it is particularly important to prevent it by implementing an adequate antibiotic prophylaxis especially in patients at high risk undergoin...
Abstract
Cited 2 times since 2024 (3.6 per year)
source: EuropePMC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Volume 38, Issue 20, 1 1 2024, Pages e70087
Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice.
Inia JA, Attema J, de Ruiter C, Menke AL, Caspers MPM, Verschuren L, Wilson M, Arlantico A, Brightbill HD, Jukema JW, van den Hoek AM, Princen HMG, Chen MZ, Morrison MC
Fibroblast growth factor 21 (FGF21) is a promising target for treatment of obesity-associated diseases including metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. We evaluated the effects of the bispecific anti-FGF21-β klotho (KLB) agonist antibody bFKB1 in a preclinical model of MASH and atherosclerosis. Low-density lipoprotein receptor knockout (Ldlr-/-).Leiden mice received a high-fat diet for 20 weeks, followed by treatment with an isotype control antibody or bFKB1...
Abstract
Journal of cardiothoracic surgery,
Volume 19, Issue 1, 1 1 2024, Pages 560
Aortic root replacement for bicuspid aortic valve dysfunction does not impair survival rates.
Dolmaci OB, van Maasakker NE, Poelmann RE, Klautz RJ, Grewal N
Background: Patients with a bicuspid aortic valve carry an increased risk for developing an ascending aortic aneurysm due to intrinsic aortic wall alterations. A lower threshold for aortic surgery may therefore be considered in these patients, especially in those who require aortic valve surgery. This study aimed to compare the outcomes of an isolated aortic valve replacement with that of an aortic root replacement in bicuspid aortic valve patients with an indication for aortic valve surgery. Me...
Abstract
Cited 2 times since 2024 (3.6 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 66, Issue 4, 1 1 2024, Pages ezae339
European Association of Cardiothoracic Surgeons future view on robotic cardiac surgery in Europe.
Oosterlinck W, Gianoli M, Palmen M, Folliguet T, Bonatti J, Agnino A, Singh S, Franke U, Modi P, Pereda D, Kempfert J, Navarra E, Suwalski P, Vojacek J, Casselman F, Myers P, Sadaba JR, Melfi F, Hazekamp M, Bavaria J, Beyersdorf F, Milojevic M, Falk V, Cerny S
Abstract
Cited 5 times since 2024 (9.1 per year)
source: EuropePMC
Brain communications,
Volume 6, Issue 5, 1 1 2024, Pages fcae309
Sudden death in epilepsy: the overlap between cardiac and neurological factors.
Shlobin NA, Thijs RD, Benditt DG, Zeppenfeld K, Sander JW
People with epilepsy are at risk of premature death, of which sudden unexpected death in epilepsy (SUDEP), sudden cardiac death (SCD) and sudden arrhythmic death syndrome (SADS) are the primary, partly overlapping, clinical scenarios. We discuss the epidemiologies, risk factors and pathophysiological mechanisms for these sudden death events. We reviewed the existing evidence on sudden death in epilepsy. Classification of sudden death depends on the presence of autopsy and expertise of the clinic...
Abstract
Cited 3 times since 2024 (5.5 per year)
source: EuropePMC
JAMA dermatology,
Volume 160, Issue 10, 1 1 2024, Pages 1044-1055
Long-Term Effectiveness and Reasons for Discontinuation of Dupilumab in Patients With Atopic Dermatitis.
Boesjes CM, Kamphuis E, de Graaf M, Spekhorst LS, Haeck I, van der Gang LF, Loman L, Zuithoff NPA, Dekkers C, van der Rijst LP, Romeijn GLE, Oosting AJ, Gostynksi A, van Lynden-van Nes AMT, Tupker RA, van Tuyll van Serooskerken AM, Flinterman A, Politiek K, Touwslager WRH, Christoffers WA, Stewart SM, Kamsteeg M, Schuttelaar MA, de Bruin-Weller MS
Importance: Limited data are available on the long-term effectiveness and safety of dupilumab for atopic dermatitis (AD) in daily practice. Objective: To evaluate clinical effectiveness and reasons for discontinuation of dupilumab treatment in children, adults, and older adults with AD with up to 5 years of treatment in daily practice. Design, setting, and participants: This prospective multicenter cohort study was conducted using the BioDay registry (4 academic and 10 nonacademic hospitals in t...
Abstract
Cited 2 times since 2024 (3.6 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 31, Issue 14, 1 1 2024, Pages 1690-1699
Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions.
Hageman SHJ, Kaptoge S, de Vries TI, Lu W, Kist JM, van Os HJA, Numans ME, Läll K, Bobak M, Pikhart H, Kubinova R, Malyutina S, Pająk A, Tamosiunas A, Erbel R, Stang A, Schmidt B, Schramm S, Bolton TR, Spackman S, Bakker SJL, Blaha M, Boer JMA, Bonnefond A, Brenner H, Brunner EJ, Cook NR, Davidson K, Dennison E, Donfrancesco C, Dörr M, Floyd JS, Ford I, Fu M, Gansevoort RT, Giampaoli S, Gillum RF, Gómez-de-la-Cámara A, Håheim LL, Hansson PO, Harms P, Humphries SE, Ikram MK, Jukema JW, Kavousi M, Kiechl S, Kucharska-Newton A, Pablos DL, Matsushita K, Meyer HE, Moons KGM, Mortensen MB, Muilwijk M, Nordestgaard BG, Packard C, Pamieri L, Panagiotakos D, Peters A, Potier L, Providencia R, Psaty BM, Ridker PM, Rodriguez B, Rosengren A, Sattar N, Schöttker B, Schwartz JE, Shea S, Shipley MJ, Sofat R, Thorand B, Verschuren WMM, Völzke H, Wareham NJ, Westbury L, Willeit P, Zhou B, Danesh J, Visseren FLJ, Di Angelantonio E, Pennells L, Dorresteijn JAN
Aims: The 2021 European Society of Cardiology prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding initiation of prevention. We aimed to update and systematically recalibrate the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model to four European risk regions for the estimation of lifetime CVD risk for apparently healthy individuals. Methods and results: The updated LIFE-CVD (i.e. LIFE-CVD2) models were derived using individual partici...
Abstract
Echocardiography (Mount Kisco, N.Y.),
Volume 41, Issue 10, 1 1 2024, Pages e70006
Evolution and Prognostic Impact of Left Ventricular Myocardial Work Indices After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis.
Wu HW, Fortuni F, Muzafarova T, Sarrazyn C, Lopez Santi P, Chua APA, Butcher SC, van der Kley F, de Weger A, Jukema JW, Bax JJ, Ajmone Marsan N
Purpose: Left ventricular myocardial work (LVMW) has been shown to better characterize LV function in patients with severe aortic stenosis by correcting LV afterload. The aim of this study was to evaluate the evolution in LVMW indices after transcatheter aortic valve replacement (TAVR) and their prognostic value. Methods: The following LVMW indices were calculated before and immediately after TAVR in 255 patients (median age 82 years, 51% male): global work index (GWI), global constructive work...
Abstract
