9618 results
Cited 1 times since 2024 (1.4 per year)
source: EuropePMC
Interdisciplinary cardiovascular and thoracic surgery,
Volume 40, Issue 1, 1 1 2024, Pages ivae227
Examining the learning curves in robotic cardiac surgery wet lab simulation training.
Atroshchenko GV, Navarra E, Valdis M, Sandoval E, Hashemi N, Cerny S, Pereda D, Palmen M, Bjerrum F, Bruun NH, Tolsgaard MG
Background: Simulation-based training has gained distinction in cardiothoracic surgery as robotic-assisted cardiac procedures evolve. Despite the increasing use of wet lab simulators, the effectiveness of these training methods and skill acquisition rates remain poorly understood. Objectives: This study aimed to compare learning curves and assess the robotic cardiac surgical skill acquisition rate for cardiac and noncardiac surgeons who had no robotic experience in a wet lab simulation setting....
Abstract
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer,
Volume 20, Issue 4, 29 5 2024, Pages 475-486
Sex and Common Germline Variants Affect the Toxicity Profile and Pharmacokinetics of Alectinib: A Nationwide Cohort Study in Patients With ALK-Positive NSCLC.
Heersche N, Lanser DAC, Muntinghe-Wagenaar MB, Mohmaed Ali MI, Ulas EB, Trooster TMA, de Jonge E, Oomen-de Hoop E, Paats MS, Bahce I, Croes S, Hendriks LEL, van der Wekken AJ, Dingemans AC, Huitema ADR, van Schaik RHN, Mathijssen RHJ, Veerman GDM
Introduction: Alectinib, a small-molecule kinase inhibitor, is used as first-line treatment for ALK-positive (ALK+) NSCLC. Albeit generally well-tolerated, a considerable subset of patients requires dose adjustments due to drug-related toxicity. Single-nucleotide polymorphisms in genes related to the metabolism of alectinib may upfront identify patients at risk for toxicity. Methods: In this multicenter observational cohort study in patients with advanced ALK+ NSCLC receiving alectinib treatment...
Abstract
Cited 1 times since 2024 (1.4 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 66, Issue 1, 29 5 2024, Pages 3-16
Hemodynamic considerations in arteriovenous vascular access modalities for hemodialysis.
White NA, Xiao Z, De Winter EP, Li M, De Vries MR, Van Der Bogt KE, Rotmans JI
Arteriovenous fistulas and arteriovenous grafts are the most commonly used vascular access for hemodialysis in patients with end-stage chronic kidney disease. However, both methods face significant challenges due to the hemodynamic disturbances induced by the arteriovenous anastomosis. This causes changes in vascular structure and blood flow velocity near the anastomosis site after the fistula/graft surgery, and introduces abnormal wall shear stress and cyclic stretch. This leads to endothelial...
Abstract
Cited 2 times since 2024 (2.8 per year)
source: EuropePMC
Talanta,
Volume 285, 29 5 2024, Pages 127293
Flexible 3D nanofiber-based SERS biosensor for detection of miRNA-223-3p in early Laryngeal Cancer diagnosis.
Martino S, Yilmaz D, Tammaro C, Misso G, Esposito A, Falco M, Cossu AM, Lombardi A, Amler E, Divin R, Giannetti A, Scrima M, Dardano P, De Stefano L, Rea I, De Luca AC, Caraglia M
MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nucleotides) that regulate gene expression and are associated with various diseases, including Laryngeal Cancer (LCa), which has a high mortality rate due to late diagnosis. Traditional methods for miRNA detection present several drawbacks (time-consuming steps, high cost and high false positive rate). Early-stage diagnosis and selective detection of miRNAs remain challenging. This study proposes a 3D flexible biosensor that combines nanofibers...
Abstract
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
Volume 44, Issue 2, 29 5 2024, Pages 333-342
Overview of Pediatric Respiratory Syncytial Virus (RSV) infections: has risk perception for RSV changed in children with comorbid conditions?
Yilmaz D, Tasar S, Tuz AE, Eroz NA, Oncel EK, Aksay AK, Yilmaz N
Objective: Respiratory syncytial virus (RSV) is the primary etiology of lower respiratory tract infection in children. The fluctuating incidence of RSV, particularly in light of the COVID-19 pandemic, has shifted the spotlight onto preventive strategies. Our study aims to investigate both the risk factors and clinical symptoms of RSV. Materials and methods: From February 2015 to February 2023, samples were analyzed during all seasons to identify viral respiratory infections. RSV was identified i...
Abstract
Cited 2 times since 2024 (2.7 per year)
source: EuropePMC
Scientific reports,
Volume 14, Issue 1, 26 4 2024, Pages 29256
Severe and post-COVID-19 are associated with high expression of vimentin and reduced expression of N-cadherin.
Yilmaz E, Yilmaz D, Cacan E
SARS-CoV-2 penetrates human cells via its spike protein, which mainly interacts with ACE2 receptors, triggering viral replication and an exacerbated immune response characterized by a cytokine storm. Vimentin III, an intermediate filament protein predominantly found in mesenchymal cells, has garnered considerable attention in recent research due to its multifaceted biological roles and significance in the endothelial-mesenchymal transition (EndMT) during various fibrotic processes. However, the...
Abstract
Cited 4 times since 2024 (5.5 per year)
source: EuropePMC
Genome medicine,
Volume 16, Issue 1, 25 4 2024, Pages 137
Genomic surveillance of multidrug-resistant organisms based on long-read sequencing.
Landman F, Jamin C, de Haan A, Witteveen S, Bos J, van der Heide HGJ, Schouls LM, Hendrickx APA, Dutch CPE/MRSA surveillance study group
Background: Multidrug-resistant organisms (MDRO) pose a significant threat to public health worldwide. The ability to identify antimicrobial resistance determinants, to assess changes in molecular types, and to detect transmission are essential for surveillance and infection prevention of MDRO. Molecular characterization based on long-read sequencing has emerged as a promising alternative to short-read sequencing. The aim of this study was to characterize MDRO for surveillance and transmission s...
Abstract
Cited 1 times since 2024 (1.4 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 105, Issue 2, 24 4 2024, Pages 385-393
Intravascular Lithotripsy in Acute Coronary Syndromes: Procedural and One-Year Clinical Outcomes From the BENELUX-IVL Registry.
Oliveri F, van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Despite the excellent success and safety of intravascular lithotripsy (IVL) in heavily calcified lesions, evidence in acute coronary syndromes (ACS) remains limited. Aims: This study aimed to evaluate the procedural and clinical outcomes of IVL in heavily calcified ACS. Methods: Patients who underwent IVL between 2019 and 2024 from the ongoing prospective BENELUX registry were eligible for inclusion. Patients were therefore classified in ACS and chronic coronary syndrome (CCS) groups...
Abstract
Cited 1 times since 2024 (1.4 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 111, 23 4 2024, Pages 203-211
A Diagnostic Comparison Study between Maximal Systolic Acceleration and Acceleration Time to Detect Peripheral Arterial Disease.
Willems SA, van Bennekom OO, Schepers A, van Schaik J, van der Vorst JR, Hamming JF, Brouwers JJWM
Background: Detecting peripheral arterial disease (PAD) can be particularly challenging in patients with diabetes mellitus (DM) or chronic kidney disease (CKD) due to medial arterial calcification (MAC). Current bedside tests, such as the ankle-brachial index, are less accurate in these patient groups. The primary aim of this study is to evaluate the diagnostic accuracy of point-of-care duplex ultrasound parameters maximal systolic acceleration (ACCmax) and acceleration time (AT) to detect PAD,...
Abstract
BMC cancer,
Volume 24, Issue 1, 22 4 2024, Pages 1441
Relevant factors for policy concerning comprehensive genomic profiling in oncology: stakeholder perspectives.
van Schaik LF, Engelhardt EG, van Harten WH, Retèl VP
Background: Comprehensive genomic profiling (CGP) can identify targets beyond standard of care, potentially revolutionizing personalized cancer management. However, conducting well designed studies in this rapidly evolving field is complex and demands time and investments. Consequently, the total added value of CGP remains uncertain. Clinical benefit and costs often are driving factors in coverage decisions. Recently, five additional factors were identified in the literature that can influence t...
Abstract
Cited 7 times since 2024 (9.4 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 386, Issue 6724, 21 3 2024, Pages 920-925
Population connectivity shapes the distribution and complexity of chimpanzee cumulative culture.
Gunasekaram C, Battiston F, Sadekar O, Padilla-Iglesias C, van Noordwijk MA, Furrer R, Manica A, Bertranpetit J, Whiten A, van Schaik CP, Vinicius L, Migliano AB
Although cumulative culture is a hallmark of hominin evolution, its origins can be traced back to our common ancestor with chimpanzees. Here, we investigated the evolutionary origins of chimpanzee cumulative culture and why it remained incipient. To trace cultural transmission among the four chimpanzee subspecies, we compared population networks based on genetic markers of recent migration and shared cultural traits. We show that limited levels of group connectivity favored the emergence of a fe...
Abstract
The American journal of bioethics : AJOB,
Volume 24, Issue 12, 20 3 2024, Pages 62-64
Navigating Moral Stress and Moral Distress in Moral Case Deliberation: A Joint Endeavor.
van Schaik MV, Metselaar S
Abstract
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
Volume 134, Issue 2, 19 3 2024, Pages 223-230
Behavioral feeding problems and parenting stress in toddlers with food protein-induced allergic proctocolitis.
Celik P, Yilmaz D, Yuksel F, Akpinar F, Karabag K, Uzun AK, Dibek Misirlioglu E
Background: Food protein-induced allergic proctocolitis (FPIAP) typically develops in infancy, a critical period for taste preference and feeding skill development. Eliminating culprit foods, along with limited food options and the child's distressing symptoms, can significantly impact the mothers' parenting roles. However, research on behavioral feeding problems and parenting stress in toddlers with FPIAP is lacking. Objective: To assess feeding behaviors and parenting stress levels i...
Abstract
Cited 1 times since 2024 (1.3 per year)
source: EuropePMC
Molecular imaging and biology,
Volume 26, Issue 6, 19 3 2024, Pages 955-964
Effects of Neoadjuvant Therapy on Tumour Target Expression of Oesophageal Cancer Tissue for NIR Fluorescence Imaging.
Galema HA, Neijenhuis LKA, Lauwerends LJ, Dekker-Ensink NG, Verhoef C, Vahrmeijer AL, Bhairosingh SS, Kuppen PJK, Rogalla S, Burggraaf J, Lagarde SM, Wijnhoven BPL, Hutteman M, Doukas M, Keereweer S, Hilling DE
Purpose: Oesophaegal cancer patients with a clinical complete response (CR) after neoadjuvant chemoradiotherapy (nCRT) are candidates for an active surveillance strategy. Regrowth rates of 40% after initial clinical CR indicate that identification of a true complete response to nCRT remains challenging. Near-infrared tumour-specific fluorescence endoscopic imaging might help to discriminate patients with a true complete response from patients with residual disease. This study aims to find potent...
Abstract
Annals of medicine and surgery (2012),
Volume 87, Issue 3, 18 3 2024, Pages 1351-1359
The safety of indocyanine green in patients with advanced chronic kidney disease or kidney transplantation: a scoping review.
Kruiswijk MW, Nguyen Dinh HL, Tange FP, Koning S, van den Hoven P, Peul RC, Rotmans JI, Huurman VAL, Alwayn IPJ, Hamming JF, Vahrmeijer AL, van der Vorst JR
Near-infrared fluorescence imaging with indocyanine green (ICG) is increasingly being used in the field of image-guided surgery. Although ICG is considered non-nephrotoxic in current literature, caution is advised for the use of ICG in patients with advanced chronic kidney disease (CKD), including kidney transplant recipients. Therefore, a scoping review was performed to assess the safety of ICG in patients with advanced CKD or a renal allograft. This scoping review was guided by the PRISMA-ScR...
Abstract
Preventive veterinary medicine,
Volume 234, 17 3 2024, Pages 106383
A dynamic framework for calculating the biomass of fattening pigs with an application in estimating the burden of porcine reproductive and respiratory syndrome in the Netherlands.
Boeters M, Steeneveld W, Garcia-Morante B, Rushton J, van Schaik G
Gaining insight into the size and composition of national pig populations can support decisions on disease control, welfare, and environmental sustainability. However, if one needs to draw meaningful comparisons between the performance of various production systems or countries, a method for standardization is required. One approach to achieve this is by means of biomass estimation. The objective of this study was to develop a biomass estimation framework that can provide detailed and reliable e...
Abstract
Cited 177 times since 2024 (234.1 per year)
source: EuropePMC
The New England journal of medicine,
Volume 392, Issue 5, 16 3 2024, Pages 427-437
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.
Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, Ge J, Weerakkody GJ, Ou Y, Bunck MC, Hurt KC, Murakami M, Borlaug BA, SUMMIT Trial Study Group
Background: Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, causes considerable weight loss, but data are lacking with respect to its effects on cardiovascular outcomes. Methods: In this international, double-blind, randomized, placebo-controlled trial, we randomly assigned, in a 1:1 ratio, 731 patients with heart failure, an ejection fraction of...
Abstract
Cited 3 times since 2024 (4 per year)
source: EuropePMC
Aging cell,
Volume 24, Issue 3, 15 3 2024, Pages e14401
Age-related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing.
Conway J, De Jong EN, White AJ, Dugan B, Rees NP, Parnell SM, Lamberte LE, Sharma-Oates A, Sullivan J, Mauro C, van Schaik W, Anderson G, Bowdish DME, Duggal NA
The intestinal epithelium serves as a physical and functional barrier against harmful substances, preventing their entry into the circulation and subsequent induction of a systemic immune response. Gut barrier dysfunction has recently emerged as a feature of ageing linked to declining health, and increased intestinal membrane permeability has been shown to promote heightened systemic inflammation in aged hosts. Concurrent with age-related changes in the gut microbiome, the thymic microenvironmen...
Abstract
Cited 1 times since 2024 (1.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 420, 15 3 2024, Pages 132712
Unilateral-access vs. bilateral-access in transfemoral transcatheter aortic valve replacement: A slim fit approach.
Pereira AR, Al Jaff AAM, Montero-Cabezas J, de Weger A, Candura D, Jukema JW, Arslan F, Regeer MV, Ajmone Marsan N, van-der-Kley F
Background: Vascular complications remain prevalent on transfemoral transcatheter aortic valve replacement (TF-TAVR) with a significant proportion related to the secondary arterial access. We hypothesized that placing the second sheath ipsilateral and distal to the delivery sheath could reduce vascular complications with similar safety and efficacy. Objectives: Comparing vascular complications and clinical outcomes when placing the secondary arterial sheath in the ipsilateral (unilateral-access)...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 168, 14 2 2024, Pages D8236
[Transmural collaboration in palliative care: a feasibility study into structured transfer of care for acutely hospitalized patients].
van Schaik T, de Vos FYF, Valkenburg TACH, de Graaf E, Teunissen SCCM
Objective: Care transitions are common in the last months of life and continuity of information and care is at risk when unplanned admissions are necessary. To mitigate the risk of inappropriate care, a transmural care pathway was developed, that includes active involvement of a patient's general practitioner during hospitalization. Design: Multiple-method feasibility study in an academic hospital and affiliated general practices from July to December 2022. Data collection involved a survey...
Abstract
