Research

Publications

Below you can find a list of our published research.

6263 results

European heart journal, 25 4 2025, Pages ehaf456 Arrhythmia ablation in patients with congenital heart disease: challenges and opportunities in using complex spectrum data to guide individual care. Kimura Y, Zeppenfeld K

Abstract

Circulation. Arrhythmia and electrophysiology, 25 4 2025, Pages e013150 Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging. Jungen C, Chen HS, Wijnmaalen AP, Dibbets-Schneider P, Meretta A, Piers SR, Kimura Y, Androulakis AFA, van der Geest RJ, de Geus-Oei LF, Mertens BJA, Scholte AJHA, Lamb HJ, Jongbloed MRM, Zeppenfeld K

Background: In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown. Methods: Consecutive patients from the Leiden Nonischemic Cardiomyopathy Study who underwent progr... Abstract

The American journal of cardiology, 22 4 2025, Pages S0002-9149(25)00421-7 Procedural and Clinical Outcomes of Coronary Intravascular Lithotripsy in Patients With Impaired Renal Function: A Multicenter Retrospective Study. Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM

Chronic kidney disease (CKD) is a prevalent comorbidity in patients undergoing percutaneous coronary intervention (PCI), yet its impact on outcomes following intravascular lithotripsy (IVL) remains insufficiently studied. This study evaluated procedural and long-term outcomes of IVL-assisted PCI in patients with renal insufficiency compared to those with normal renal function. From the BENELUX-IVL registry (May 2019-September 2024), 558 patients were included in a retrospective multicenter analy... Abstract

Nature medicine, 21 3 2025 Polygenic prediction of body mass index and obesity through the life course and across ancestries. Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina-Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, G

Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry... Abstract

Open heart, Volume 12, Issue 2, 21 3 2025, Pages e003445 Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure. Neijenhuis RM, Regeer MV, Walker NL, Mertens BJ, Hunter A, Kiès P, Swan L, Vliegen HW, MacDonald ST, Zemrak F, Zaidi AN, Cedars AM, Jongbloed MR, Jukema JW, Veldtman GR, Egorova AD

Background: Systemic right ventricle (sRV) patients are at an increased risk of developing heart failure. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) could be a valuable treatment option. This study investigated the changes in ventricular function in sRV failure patients in the first year after starting SGLT2i. Methods: Adult sRV patients from the international, real-world ACHIEVE-SGLT2i registry were included if they had a clinical diagnosis of sRV failure, a transthoracic echocardiogram... Abstract

Journal of the American Heart Association, 17 3 2025, Pages e040868 Disproportionate Left Ventricular Enlargement in Mitral Valve Prolapse: Prevalence, Predictors, and Association With Outcomes. Topilsky Y, Essayagh B, Benfari G, Le Tourneau T, Antoine C, Grigioni F, Roussel JC, Bax JJ, Marsan NA, van Wijngaarden A, Tribouilloy C, Loewenstein I, Hochstadt A, Thapa P, Michelena HI, Enriquez-Sarano M

Background: Left ventricular (LV) end-systolic enlargement in severe degenerative mitral-regurgitation (MR) is a class I surgical trigger. Whether it occurs disproportionately to less-than-severe MR due to mitral valve prolapse and is associated with mortality are unknown. We aimed to analyze prevalence and association with survival of disproportionate LV enlargement in less-than-severe MR. Methods: A multicenter cohort international study enrolled 2848 consecutive patients (52% women, 69±16 yea... Abstract

American heart journal, 15 3 2025, Pages S0002-8703(25)00218-2 Design and rationale of the HARTc 2.0 trial: a multicentre randomized controlled study on the impact of point-of-care hs-cTnI testing in prehospital ACS triage on diagnosis and cost-effectiveness. van der Lande ACMH, Diederiks NM, de Koning ER, Bosch J, Romijn FPHTM, van der Loo WPM, van den Akker-van Marle ME, Dehnavi RA, Tietge WJ, Mertens BJA, Jukema JW, Cobbaert CM, Schalij MJ, Boogers MJ

Introduction: Chest pain accounts for ∼10% of emergency department visits, though most cases are not ACS, underscoring the need for effective prehospital triage. The HARTc 2.0 study evaluates the modified HEART score incorporating point-of-care (POC) high-sensitivity cardiac troponin I (hs-cTnI) capillary fingerprick testing with sex-specific cut-offs to improve ACS risk stratification. The randomized controlled trial (RCT) compares a prehospital triage strategy using this modified HEART score a... Abstract

The Journal of asthma : official journal of the Association for the Care of Asthma, 14 2 2025, Pages 1-10 Inhaled Muscarinic Antagonists during Pregnancy in Women with Asthma: Case Series from a Dutch Prospective Observational Cohort Study. Kathiravetpillai N, van Buul AR, Ezinga M, Koehorst-Ter Huurne K, Van Nederveen-Bendien SA

A large proportion of women with asthma experience worsening of asthma during pregnancy. Well-controlled asthma during pregnancy decreases risk of maternal and foetal complications. Long-acting muscarinic antagonists (LAMA) are part of treatment guidelines for poorly controlled asthma. There are no clinical safety data available on LAMA and short-acting muscarinic antagonists (SAMA) use in pregnancy. The aim was to evaluate asthma control and pregnancy outcomes in pregnant women with asthma usin... Abstract

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 12 2 2025, Pages S1078-5884(25)00678-1 Factors Influencing Vascular Surgeons' Compliance with Elective Repair Guidelines for Abdominal Aortic Aneurysm: A Qualitative Study. Brust M, van Gestel LC, Vriens PWHE, Hamming JF, Adriaanse MA, Lindeman JH

Objective: Despite guideline recommendations to delay elective abdominal aortic aneurysm (AAA) repair until the diameter exceeds the intervention threshold, a notable proportion of repairs occur earlier. This study aimed to explore factors influencing vascular surgeons' compliance with the intervention threshold regarding AAA repair, adopting a behavioural science perspective. Methods: This qualitative study employed semi-structured interviews with vascular surgeons. Twelve vascular surgeon... Abstract

Heart (British Cardiac Society), 8 2 2025, Pages heartjnl-2025-326162 Representativeness of surgical controls in aortic valve replacement trials: comparison with routine surgical cohorts. Tomsic A, Velders BJJ, Kawczynski MJ, Schoones JW, Klautz RJM, Palmen M, Sardari Nia P, Owais T, Girdauskas E, Heuts S

Background: Randomised controlled trials (RCTs) comparing transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) have significantly influenced treatment guidelines for aortic stenosis, expanding the use of TAVI into lower risk populations. However, the patients enrolled in the SAVR arms of these trials may differ from those typically undergoing SAVR in routine clinical practice. This study aims to critically assess the representativeness of SAVR patients in t... Abstract

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 8 2 2025, Pages S1479-666X(25)00123-4 Bridging generational gaps in Surgery: A narrative review on values, well-being, and training preferences. Huizing F, Sier VQ, Sark AD, Snijders HS, van der Vorst JR, Schmitz RF, Schepers A, Blok JJ, Future Surgeon Initiative

Background and purpose: Intergenerational differences in surgery create both challenges and opportunities. While differening perspectives and expectations may deter younger generations from pursuing surgical careers, it is crucial to balance these with the core values that define the surgical profession. This narrative review was conducted to better understand how the profession needs to evolve. Methods: A structured literature search on generational changes in surgery was conducted using PubMed... Abstract

The international journal of cardiovascular imaging, 5 1 2025 Incremental prognostic value of left atrial reservoir strain after ST-segment elevation myocardial infarction for the prediction of new-onset atrial fibrillation. Caunite L, Myagmardorj R, Galloo X, Laenens D, Stassen J, Nabeta T, Yedidya I, Meucci MC, Kuneman JH, van den Hoogen IJ, van Rosendael SE, Wu HW, van den Brand VM, Giuca A, Trusinskis K, Marsan NA, Bax JJ, van der Bijl P

New-onset atrial fibrillation (AF) affects up to 21% of ST-segment elevation myocardial infarction (STEMI) patients. The value of LA reservoir strain to predict new-onset AF in a STEMI population has not been thoroughly investigated. We aimed to explore the incremental value of LA reservoir strain for predicting new-onset AF post-STEMI. Data were analyzed retrospectively from an ongoing STEMI registry. LA reservoir strain Abstract

Waste management (New York, N.Y.), Volume 205, 4 1 2025, Pages 115003 Coupling of chemical deconstruction and pyrolysis to upcycle metallized multilayer plastic films. Kulas D, Aloba S, Noecker A, Putman L, Meinholz C, Garland K, Henry J, Flores H, Chipkar S, Zolghadr A, Techtmann S, Ong R, Shonnard D

Multilayer metallized plastic films are popular packaging materials that are not currently recycled due to their complex multi-material make-up. In this study, a sequential pathway combining chemical, thermal and biological techniques was introduced to recycle military multilayer packaging made up of Polyethylene Terephthalate (PET), Polyethylene (PE), and aluminum. Chemical deconstruction using 10 wt% aqueous ammonia was able to selectively depolymerize the PET layer at a conversion close to 10... Abstract

EClinicalMedicine, Volume 85, 4 1 2025, Pages 103342 Intravascular lithotripsy for the treatment of calcified coronary lesions in individuals of advanced age: a post-hoc analysis of the multicentre, prospective BENELUX-IVL study. Oliveri F, García PV, van Oort MJH, Phagu A, Al Amri I, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Mandurino-Mirizzi A, Van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Patients of advanced age are frequently underrepresented or excluded from major clinical trials, leading to limited evidence in this population and a reliance on data extrapolated from younger populations. The present study aims to compare and evaluate the safety and efficacy of intravascular lithotripsy (IVL) for the treatment of calcified coronary lesions in individuals of advanced age and in younger populations. Methods: In this post-hoc analysis, from the ongoing prospective, mul... Abstract

JAMA cardiology, 2 1 2025 Location of LMNA Variants and Clinical Outcomes in Cardiomyopathy. Bhaskaran A, Ben Yaou R, Helms AS, Fayssoil A, Richard P, Stojkovic T, Anselme F, Labombarda F, Chikhaoui C, De Sandre-Giovannoli A, Jeru I, Leturcq F, Vigouroux C, Dembele M, Elliott P, Savvatis K, Zeppenfeld K, Bouguerra H, Charron P, Kumar S, Bonne G, Wahbi K, Lakdawala NK

Importance: Prior studies have suggested that patients with nonmissense (ie, truncating) variants causing LMNA cardiomyopathy have worse arrhythmic outcomes compared to those with missense variants. However, the effect of the spatial distribution of missense and truncating variants on clinical outcomes remains poorly understood. Objective: To determine the association of the spatial distribution of missense and truncating LMNA variants with cardiac outcomes. Design, setting, and participants: Th... Abstract

Heart rhythm, Volume 22, Issue 7, 1 1 2025, Pages 1877-1879 Top stories on proactive ventricular arrhythmia assessment in repaired tetralogy of Fallot. Zeppenfeld K, Kimura Y

Abstract

Current heart failure reports, Volume 22, Issue 1, 1 1 2025, Pages 21 Impact of Multisensor CIED-based Heart Failure Monitoring on Mortality, Heart Failure Hospitalizations and Outpatient Visits: A Systematic Review. Zwaenepoel BAC, Kluft A, Feijen M, Schoones JW, Heggermont WA, Egorova AD, Beeres SLMA

Purpose of review: Cardiac Implantable Electronic Device (CIED)-based remote monitoring has been proposed to improve heart failure (HF) management by enabling early detection of decompensation. This systematic review evaluates the effectiveness of multisensor CIED-based monitoring in reducing mortality, HF hospitalizations, and unplanned HF outpatient visits. Recent findings: Earlier CIED-based remote monitoring strategies were mainly based on single-sensor impedance-based algorithms, and showed... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 7, 1 1 2025, Pages euaf122 Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrhythmia radioablation using a commercial software. Rademaker R, Cirkel S, Omara S, Dankers FJWM, Sramko M, Solana Munoz J, Kaya YS, Ter Bekke RMA, Schiappacasse L, Teres C, Verhoeven K, Pruvot E, Rasch CRN, Zeppenfeld K

Aims: Stereotactic arrhythmia radioablation (STAR) has emerged as bail-out treatment for ventricular tachycardia (VT). Accurate, reproducible, and easy-to-use data transfer from electroanatomical mapping (EAM) systems to radiotherapy planning CT is desirable. We aim to evaluate interobserver variability, ease of use, and learning curve for EAM based target volume (CardTV-EPinv) creation and transfer using available software packages. Methods and results: In patients considered for STAR, CardTV-E... Abstract

Journal of magnetic resonance imaging : JMRI, 30 5 2025 Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol. Bosshardt D, van Andel MM, Schrauben EM, van Kimmenade RRJ, Scholte AJ, Cox MGJP, Robbers-Visser D, Zwinderman AH, Mulder BJM, Nederveen AJ, de Waard V, Groenink M, van Ooij P

Background: New treatment strategies are required to reduce aortic events in Marfan syndrome (MFS). Resveratrol is a dietary supplement that intervenes in aortic wall cellular metabolism and may benefit MFS patients. Purpose: To evaluate whether treatment with Resveratrol affects aorta hemodynamics derived from 4D flow MRI in MFS. Study type: Prospective single-arm open-label multicenter trial. Population: 46 MFS patients (mean age 36 ± 9 years, 23 female), 20 with and 26 without a history of ao... Abstract

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Volume 210, 27 4 2025, Pages 111004 Transfer of arrhythmia substrate targets from the cardiac electroanatomical and imaging modalities to the planning computed tomography scan for stereotactic arrhythmia radioablation for refractory ventricular tachycardia - a state-of-the-art review on software developments on behalf of the STOPSTORM.eu consortium. Ter Bekke RMA, Hohmann S, Xie J, Grehn M, Verhoeven K, Volders PGA, Mihl C, Kaya YS, Manninger M, Scherr D, Corradini S, Schweikard A, Rademaker R, Hoeksema WF, Schiappacasse L, Knybel L, Pruvot E, Postema PG, Peichl P, Cvek J, Zeppenfeld K, Blanck O, Boda-Heggemann J

Stereotactic arrhythmia radioablation (STAR) for ventricular tachycardia (VT) is a non-invasive treatment modality to reduce the VT burden by delivering a single high radiation dose to the arrhythmogenic substrate. Identification and delineation of the arrhythmogenic substrate, definition of the radiation target, and transfer of this target across different imaging modalities from the invasive electroanatomic map (EAM) to the planning computed tomography (CT) scan are key to the success of thera... Abstract