Research

Publications

Below you can find a list of our published research.

7503 results

Cited 224 times since 2023 (96.4 per year) source: EuropePMC

The New England journal of medicine, Volume 389, Issue 13, 25 4 2023, Pages 1167-1179 Anticoagulation with Edoxaban in Patients with Atrial High-Rate Episodes. Kirchhof P, Toennis T, Goette A, Camm AJ, Diener HC, Becher N, Bertaglia E, Blomstrom Lundqvist C, Borlich M, Brandes A, Cabanelas N, Calvert M, Chlouverakis G, Dan GA, de Groot JR, Dichtl W, Kravchuk B, Lubiński A, Marijon E, Merkely B, Mont L, Ozga AK, Rajappan K, Sarkozy A, Scherr D, Sznajder R, Velchev V, Wichterle D, Sehner S, Simantirakis E, Lip GYH, Vardas P, Schotten U, Zapf A, NOAH-AFNET 6 Investigators, NOAH-AFNET6 sites and investigators

Background: Device-detected atrial high-rate episodes (AHREs) are atrial arrhythmias detected by implanted cardiac devices. AHREs resemble atrial fibrillation but are rare and brief. Whether the occurrence of AHREs in patients without atrial fibrillation (as documented on a conventional electrocardiogram [ECG]) justifies the initiation of anticoagulants is not known. Methods: We conducted an event-driven, double-blind, double-dummy, randomized trial involving patients 65 years of age or older wh... Abstract

Cited 1 times since 2023 (0.4 per year) source: EuropePMC

PloS one, Volume 18, Issue 8, 23 4 2023, Pages e0289412 Closed-Loop ventilation using sidestream versus mainstream capnography for automated adjustments of minute ventilation-A randomized clinical trial in cardiac surgery patients. Nijbroek SGLH, Roozeman JP, Ettayeby S, Rosenberg NM, van Meenen DMP, Cherpanath TGV, Lagrand WK, Tepaske R, Klautz RJM, Serpa Neto A, Schultz MJ

Background: INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop ventilation mode that uses capnography to adjust tidal volume (VT) and respiratory rate according to a user-set end-tidal CO2 (etCO2) target range. We compared sidestream versus mainstream capnography with this ventilation mode with respect to the quality of breathing in patients after cardiac surgery. Methods: Single-center, single-blinded, non-inferiority, randomized clinical trial in adult patients scheduled for elect... Abstract

Urologie (Heidelberg, Germany), Volume 62, Issue 9, 22 4 2023, Pages 903-912 [Models for collaboration]. Köhrmann KU, Schneider AW

In the future, a need-base health care system should be ensured by cooperation between the service providers. To promote this, the current legal framework is being adjusted to include the introduction of "day treatment at hospitals", distribution of "service groups" to individual clinics, and the establishment of integrated control centers and emergency centers. Healthcare providers are to be motivated to collaborate via financial support, and also the utilization of synergis... Abstract

European heart journal. Case reports, Volume 7, Issue 10, 19 3 2023, Pages ytad418 A case report of an intracardiac paraganglioma attached to the left main coronary artery in a patient with a succinate dehydrogenase complex subunit D mutation. Feijen M, Palmen M, Lamb HJ, Corssmit EPM, Antoni ML

Background: Cardiac paragangliomas are extremely rare neuroendocrine tumours derived from neural crest cells that represent Abstract

Cited 18 times since 2023 (7.7 per year) source: EuropePMC

Diagnostics (Basel, Switzerland), Volume 13, Issue 16, 18 3 2023, Pages 2700 A Comprehensive Review of Artificial Intelligence Based Algorithms Regarding Temporomandibular Joint Related Diseases. Ozsari S, Güzel MS, Yılmaz D, Kamburoğlu K

Today, with rapid advances in technology, computer-based studies and Artificial Intelligence (AI) approaches are finding their place in every field, especially in the medical sector, where they attract great attention. The Temporomandibular Joint (TMJ) stands as the most intricate joint within the human body, and diseases related to this joint are quite common. In this paper, we reviewed studies that utilize AI-based algorithms and computer-aided programs for investigating TMJ and TMJ-related di... Abstract

Cited 7 times since 2023 (3 per year) source: EuropePMC

Frontiers in psychiatry, Volume 14, 17 3 2023, Pages 1213011 Lipids in major depressive disorder: new kids on the block or old friends revisited? van der Heijden AR, Houben T

Major depressive disorder (MDD) is a psychiatric mood disorder that results in substantial functional impairment and is characterized by symptoms such as depressed mood, diminished interest, impaired cognitive function, and vegetative symptoms such as disturbed sleep. Although the exact etiology of MDD is unclear, several underlying mechanisms (disturbances in immune response and/or stress response) have been associated with its development, with no single mechanism able to account for all aspec... Abstract

Cited 3 times since 2023 (1.3 per year) source: EuropePMC

Journal of vascular surgery cases and innovative techniques, Volume 9, Issue 4, 15 3 2023, Pages 101297 Therapeutic management of in-stent thrombosis after thoracic endovascular aortic repair for blunt thoracic aortic injury in a coronavirus disease 2019 patient. van Rijn K, Schepers A, van der Meer RW, van Rijswijk CSP, van Schaik J, van der Vorst JR

A 27-year-old man underwent thoracic endovascular aortic repair for blunt thoracic aortic injury. Fourteen months later, he presented with intermittent paraplegia, congestive heart failure, and a decline of kidney function as a result of high-grade aortic stenosis caused by in-stent thrombosis. He had a concurrent infection with coronavirus disease 2019. The patient was successfully treated using axillofemoral bypass, followed by stent relining 2 weeks later. The possible risk factors and the op... Abstract

Cited 6 times since 2023 (2.5 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 21, Issue 1, 10 2 2023, Pages 37-50 Valvular heart disease and cardiomyopathy: reappraisal of their interplay. Ajmone Marsan N, Graziani F, Meucci MC, Wu HW, Lillo R, Bax JJ, Burzotta F, Massetti M, Jukema JW, Crea F

Cardiomyopathies and valvular heart diseases are typically considered distinct diagnostic categories with dedicated guidelines for their management. However, the interplay between these conditions is increasingly being recognized and they frequently coexist, as in the paradigmatic examples of dilated cardiomyopathy and hypertrophic cardiomyopathy, which are often complicated by the occurrence of mitral regurgitation. Moreover, cardiomyopathies and valvular heart diseases can have a shared aetiol... Abstract

Cited 5 times since 2023 (2.1 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 51, Issue 10, 8 2 2023, Pages 2970-2979 Intraoperative molecular imaging of colorectal lung metastases with SGM-101: a feasibility study. Meijer RPJ, Galema HA, Faber RA, Bijlstra OD, Maat APWM, Cailler F, Braun J, Keereweer S, Hilling DE, Burggraaf J, Vahrmeijer AL, Hutteman M, SGM-CLM study group

Purpose: Metastasectomy is a common treatment option for patients with colorectal lung metastases (CLM). Challenges exist with margin assessment and identification of small nodules, especially during minimally invasive surgery. Intraoperative fluorescence imaging has the potential to overcome these challenges. The aim of this study was to assess feasibility of targeting CLM with the carcinoembryonic antigen (CEA) specific fluorescent tracer SGM-101. Methods: This was a prospective, open-label fe... Abstract

The American journal of cardiology, Volume 204, 8 2 2023, Pages 276-283 Relation of Gender to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity. Jonas R, Patel T, Crabtree TR, Jennings RS, Heo R, Park HB, Marques H, Chang HJ, Stuijfzand WJ, van Rosendael AR, Choi JH, Doh JH, Her AY, Koo BK, Nam CW, Shin SH, Cole J, Gimelli A, Khan MA, Lu B, Gao Y, Nabi F, Al-Mallah MH, Nakazato R, Schoepf UJ, Driessen RS, Bom MJ, Thompson RC, Jang JJ, Ridner M, Rowan C, Avelar E, Généreux P, Knaapen P, de Waard GA, Pontone G, Andreini D, Bax JJ, Choi AD, Earls JP, Hoffmann U, Min JK, Villines TC

It is unknown whether gender influences the atherosclerotic plaque characteristics (APCs) of lesions of varying angiographic stenosis severity. This study evaluated the imaging data of 303 symptomatic patients from the derivation arm of the CREDENCE (Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia) trial, all of whom underwent coronary computed tomographic angiography and clinically indicated nonemergent invasive coronary angiography upon study enrollment.... Abstract

Cited 2 times since 2023 (0.8 per year) source: EuropePMC

Journal of neuroimmunology, Volume 382, 4 1 2023, Pages 578169 Serum B-cell activating factor is not a potential biomarker for disease activity in chronic inflammatory demyelinating polyneuropathy. Michael MR, Wieske L, Koel-Simmelink MJ, van Schaik IN, Teunissen CE, Eftimov F

B-cell activating factor (BAFF) is a crucial cytokine for differentiation and survival of B-cells and correlates to disease activity in some auto-immune diseases. To evaluate BAFF as a biomarker for disease activity in chronic inflammatory demyelinating polyneuropathy (CIDP), serum BAFF levels were measured at varying disease stages: patients starting treatment, patients starting treatment withdrawal, patients in remission and healthy controls. Serum BAFF levels were elevated in patients compare... Abstract

Cited 3 times since 2023 (1.3 per year) source: EuropePMC

Scientific reports, Volume 13, Issue 1, 3 1 2023, Pages 12618 Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing. van der Lans SPA, Janet-Maitre M, Masson FM, Walker KA, Doorduijn DJ, Janssen AB, van Schaik W, Attrée I, Rooijakkers SHM, Bardoel BW

Due to multi-drug resistance, physicians increasingly use the last-resort antibiotic colistin to treat infections with the Gram-negative bacterium Klebsiella pneumoniae. Unfortunately, K. pneumoniae can also develop colistin resistance. Interestingly, colistin resistance has dual effects on bacterial clearance by the immune system. While it increases resistance to antimicrobial peptides, colistin resistance has been reported to sensitize certain bacteria for killing by human serum. Here we inves... Abstract

Cited 7 times since 2023 (2.9 per year) source: EuropePMC

Endocrine-related cancer, Volume 30, Issue 9, 3 1 2023, Pages e230047 A clinically applicable molecular classification of oncocytic cell thyroid nodules. de Koster EJ, Corver WE, de Geus-Oei LF, Oyen WJG, Ruano D, Schepers A, Snel M, van Wezel T, Vriens D, Morreau H

Whole chromosome instability with near-whole genome haploidization (GH) and subsequent endoreduplication is considered a main genomic driver in the tumorigenesis of oncocytic cell thyroid neoplasms (OCN). These copy number alterations (CNA) occur less frequently in oncocytic thyroid adenoma (OA) than in oncocytic carcinoma (OCA), suggesting a continuous process. The current study described the CNA patterns in a cohort of 30 benign and malignant OCN, observed using a next-generation sequencing (N... Abstract

Cited 2 times since 2023 (0.8 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 32, Issue 3, 3 1 2023, Pages 545-547 Chronic Limb-Threatening Ischemia: When is Enough Enough? Brouwers J, van Rijswijk C, Van Den Hoven P, Hamming J, van der Vorst JR

Abstract

Cited 18 times since 2023 (7.5 per year) source: EuropePMC

Nature communications, Volume 14, Issue 1, 2 1 2023, Pages 4646 Genetic insights into resting heart rate and its role in cardiovascular disease. van de Vegte YJ, Eppinga RN, van der Ende MY, Hagemeijer YP, Mahendran Y, Salfati E, Smith AV, Tan VY, Arking DE, Ntalla I, Appel EV, Schurmann C, Brody JA, Rueedi R, Polasek O, Sveinbjornsson G, Lecoeur C, Ladenvall C, Zhao JH, Isaacs A, Wang L, Luan J, Hwang SJ, Mononen N, Auro K, Jackson AU, Bielak LF, Zeng L, Shah N, Nethander M, Campbell A, Rankinen T, Pechlivanis S, Qi L, Zhao W, Rizzi F, Tanaka T, Robino A, Cocca M, Lange L, Müller-Nurasyid M, Roselli C, Zhang W, Kleber ME, Guo X, Lin HJ, Pavani F, Galesloot TE, Noordam R, Milaneschi Y, Schraut KE, den Hoed M, Degenhardt F, Trompet S, van den Berg ME, Pistis G, Tham YC, Weiss S, Sim XS, Li HL, van der Most PJ, Nolte IM, Lyytikäinen LP, Said MA, Witte DR, Iribarren C, Launer L, Ring SM, de Vries PS, Sever P, Linneberg A, Bottinger EP, Padmanabhan S, Psaty BM, Sotoodehnia N, Kolcic I, DCCT/EDIC Research Group, Arnar DO, Gudbjartsson DF, Holm H, Balkau B, Silva CT, Newton-Cheh CH, Nikus K, Salo P, Mohlke KL, Peyser PA, Schunkert H, Lorentzon M, Lahti J, R

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously ident... Abstract

Cited 27 times since 2023 (11.3 per year) source: EuropePMC

The British journal of dermatology, Volume 189, Issue 3, 1 1 2023, Pages 327-335 Successful tapering of dupilumab in patients with atopic dermatitis with low disease activity: a large pragmatic daily practice study from the BioDay registry. Spekhorst LS, Boesjes CM, Loman L, Zuithoff NPA, Bakker DS, Kamphuis E, Kamsteeg M, Haeck IM, Oosting AJ, van Lumig PPM, van Lynden-van Nes AMT, Tupker RA, Flinterman A, Garritsen FM, Touwslager WRH, de Bruin-Weller MS, Schuttelaar MA, de Graaf M

Background: Limited data are available regarding patient-centred dosing of dupilumab for atopic dermatitis (AD) in daily practice. Objectives: To evaluate our patient-centred dupilumab dosing regimen in daily practice, to assess prognostic factors for successful tapering and to estimate medication-related cost savings. Methods: This prospective multicentre study included adult patients with AD, participating in the BioDay registry, treated with dupilumab for ≥ 1.3 years. Interval prolongation wa... Abstract

Cited 4 times since 2023 (1.7 per year) source: EuropePMC

Interdisciplinary cardiovascular and thoracic surgery, Volume 37, Issue 2, 1 1 2023, Pages ivad072 Optimized preoperative planning of double outlet right ventricle patients by 3D printing and virtual reality: a pilot study. Peek JJ, Bakhuis W, Sadeghi AH, Veen KM, Roest AAW, Bruining N, van Walsum T, Hazekamp MG, Bogers AJJC

Objectives: In complex double outlet right ventricle (DORV) patients, the optimal surgical approach may be difficult to assess based on conventional 2-dimensional (2D) ultrasound (US) and computed tomography (CT) imaging. The aim of this study is to assess the added value of 3-dimensional (3D) printed and 3D virtual reality (3D-VR) models of the heart used for surgical planning in DORV patients, supplementary to the gold standard 2D imaging modalities. Methods: Five patients with different DORV... Abstract

Cited 3 times since 2023 (1.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 24, Issue 9, 1 1 2023, Pages 1201-1209 Prognostic value of combined coronary CT angiography and myocardial perfusion imaging in women and men. Kujala I, Nammas W, Maaniitty T, Stenström I, Klén R, Bax JJ, Knuuti J, Saraste A

Aims: Combined anatomical and functional imaging enables detection of non-obstructive and obstructive coronary artery disease (CAD) as well as myocardial ischaemia. We evaluated sex differences in disease profile and outcomes after combined computed tomography angiography (CTA) and positron emission tomography (PET) perfusion imaging in patients with suspected obstructive CAD. Methods and results: We retrospectively evaluated 1948 patients (59% women) referred for coronary CTA due to suspected C... Abstract

Cited 9 times since 2023 (3.8 per year) source: EuropePMC

The American journal of cardiology, Volume 204, 1 1 2023, Pages 14-21 Rationale and Design of the Multicenter Catheter Ablation of Ventricular Tachycardia Before Transcatheter Pulmonary Valve Replacement in Repaired Tetralogy of Fallot Study. Moore JP, Aboulhosn JA, Zeppenfeld K, Waldmann V, Bessière F, Blom NA, Combes N, Fish FA, McLeod CJ, Kanter RJ, Tan W, Patel N, von Alvensleben JC, Kamp A, Lloyd MS, Anderson CC, Tan RB, Mariucci E, Levi DS, Salem M, Shivkumar K, Khairy P

Patients with repaired tetralogy of Fallot are at elevated risk for ventricular arrhythmia and sudden cardiac death. Over the past decade, the pathogenesis and natural history of ventricular tachycardia has become increasingly understood, and catheter ablation has emerged as an effective treatment modality. Concurrently, there has been great progress in the development of a versatile array of transcatheter valves that can be placed in the native right ventricular outflow tract for the treatment... Abstract

Medicine, Volume 102, Issue 31, 1 1 2023, Pages e34462 Contribution of lowered hemoglobin threshold value in the diagnosis of polycythemia vera: Comparison of 2016 and 2008 WHO criteria. Gulturk E, Yilmaz D, Sonmezoz GB, Yildirim ES

Polycythemia vera (PV) diagnosis remains a difficult task despite various updates in the 2016 World Health Organization (WHO) diagnostic criteria compared to 2008 criteria. This study aimed to examine the biochemical and clinical features of patients diagnosed with PV using the WHO 2016 criteria but would have been missed by the WHO 2008 criteria, and to ascertain the impact of the lowered thresholds on PV diagnosis. A total of 229 patients with suspected myeloproliferative neoplasms were includ... Abstract