Research

Publications

Below you can find a list of our published research.

6131 results

Cited 14 times since 2018 (2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 19, Issue 2, 1 1 2018, Pages 176-184 Three-dimensional assessment of mitral valve annulus dynamics and impact on quantification of mitral regurgitation. van Wijngaarden SE, Kamperidis V, Regeer MV, Palmen M, Schalij MJ, Klautz RJ, Bax JJ, Ajmone Marsan N, Delgado V

Aims: To assess mitral annulus dynamics in primary and secondary mitral regurgitation (MR) with 3-dimensional transesophageal echocardiography (3D TEE) and the impact on MR quantification. Methods and results: One hundred and twenty-three patients with moderate and severe MR (63 ± 11 years, 78 males) and 29 controls (59 ± 15 years, 19 males) were evaluated. Functional MR (FMR) was present in 31 patients, fibroelastic deficiency (FED) in 52 and Barlow's disease (BD) in 40. Annular geometry w... Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 19, Issue 2, 1 1 2018, Pages 208-215 Mitral valve repair for secondary mitral regurgitation in non-ischaemic dilated cardiomyopathy is associated with left ventricular reverse remodelling and increase of forward flow. Kamperidis V, van Wijngaarden SE, van Rosendael PJ, Kong WKF, Regeer MV, van der Kley F, Sianos G, Ajmone Marsan N, Bax JJ, Delgado V

Aims: It remains unclear whether surgical or transcatheter mitral valve repair for secondary mitral regurgitation (MR) in patients with non-ischaemic cardiomyopathy reverse the underlying left ventricular (LV) pathophysiology. We hypothesized that mitral valve repair improves LV systolic function and forward flow and induces LV reverse remodelling in this group of patients. Methods and results: Seventy-six patients (65 ± 14 years old, 43% male) with non-ischaemic cardiomyopathy and moderate to s... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 155, Issue 2, 1 1 2018, Pages 600-601 Respect versus resect: Two different repair techniques or two different tools in the toolbox? Tomšič A, Klautz RJM, Palmen M

Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

International journal of cardiology, Volume 252, 1 1 2018, Pages 88-93 Incidence and risk factors of post-operative arrhythmias and sudden cardiac death after atrioventricular septal defect (AVSD) correction: Up to 47years of follow-up. Kharbanda RK, Blom NA, Hazekamp MG, Yildiz P, Mulder BJM, Wolterbeek R, Weijerman ME, Schalij MJ, Jongbloed MRM, Roest AAW

Background: Atrioventricular septal defect (AVSD) has an incidence of 4-5.3 per 10.000 live births and is associated with Down syndrome (DS). Data on arrhythmias and sudden cardiac death (SCD) after AVSD correction is scarce. Aim: To analyse the incidence of post-operative arrhythmias and SCD after AVSD correction and explore risk factors. Methods: This is a retrospective multicenter study including patients after biventricular AVSD correction. Univariate and multivariate analyses were performed... Abstract

Cited 24 times since 2018 (3.4 per year) source: EuropePMC

PloS one, Volume 13, Issue 1, 30 5 2018, Pages e0191442 Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics, histology and matrix content. Paul CPL, Smit TH, de Graaf M, Holewijn RM, Bisschop A, van de Ven PM, Mullender MG, Helder MN, Strijkers GJ

Introduction: Low-back pain (LBP) has been correlated to the presence of intervertebral disc (IVD) degeneration on T2-weighted (T2w) MRI. It remains challenging, however, to accurately stage degenerative disc disease (DDD) based on T2w MRI and measurements of IVD height, particularly for early DDD. Several quantitative MRI techniques have been introduced to detect changes in matrix composition signifying early DDD. In this study, we correlated quantitative T2, T1rho and Apparent Diffusion Coeffi... Abstract

Acta radiologica (Stockholm, Sweden : 1987), Volume 59, Issue 9, 29 5 2018, Pages 1074-1081 Early animal model evaluation of an implantable contrast agent to enhance magnetic resonance imaging of arterial bypass vein grafts. Mitsouras D, Tao M, de Vries MR, Trocha K, Miranda OR, Vemula PK, Ding K, Imanzadeh A, Schoen FJ, Karp JM, Ozaki CK, Rybicki FJ

Background Non-invasive monitoring of autologous vein graft (VG) bypass grafts is largely limited to detecting late luminal narrowing. Although magnetic resonance imaging (MRI) delineates vein graft intima, media, and adventitia, which may detect early failure, the scan time required to achieve sufficient resolution is at present impractical. Purpose To study VG visualization enhancement in vivo and delineate whether a covalently attached MRI contrast agent would enable quicker longitudinal imag... Abstract

Cited 126 times since 2018 (17.7 per year) source: EuropePMC

The Lancet. Infectious diseases, Volume 18, Issue 5, 26 4 2018, Pages 545-553 Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network. van Beek J, de Graaf M, Al-Hello H, Allen DJ, Ambert-Balay K, Botteldoorn N, Brytting M, Buesa J, Cabrerizo M, Chan M, Cloak F, Di Bartolo I, Guix S, Hewitt J, Iritani N, Jin M, Johne R, Lederer I, Mans J, Martella V, Maunula L, McAllister G, Niendorf S, Niesters HG, Podkolzin AT, Poljsak-Prijatelj M, Rasmussen LD, Reuter G, Tuite G, Kroneman A, Vennema H, Koopmans MPG, NoroNet

Background: The development of a vaccine for norovirus requires a detailed understanding of global genetic diversity of noroviruses. We analysed their epidemiology and diversity using surveillance data from the NoroNet network. Methods: We included genetic sequences of norovirus specimens obtained from outbreak investigations and sporadic gastroenteritis cases between 2005 and 2016 in Europe, Asia, Oceania, and Africa. We genotyped norovirus sequences and analysed sequences that overlapped at op... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Multimedia manual of cardiothoracic surgery : MMCTS, Volume 2018, 25 4 2018, Pages http://mmcts.org/tutorial/884 Bileaflet pericardial patch repair for rheumatic mitral valve disease. Bissessar D, Tomšič A, van Brakel T, Klautz R, Palmen M

Surgical repair in rheumatic mitral valve disease is technically challenging as the disease affects both valvular and subvalvular structures. Due to the resultant shortage of pliable valve tissue, pericardial patch techniques are progressively used to restore normal valve function. This makes mitral valve repair possible even in the most severe forms of rheumatic mitral valve disease. In this tutorial, we report a case of mitral valve repair with a bileaflet (decellularized) pericardial patch in... Abstract

Cited 23 times since 2018 (3.2 per year) source: EuropePMC

BMC genomics, Volume 19, Issue 1, 25 4 2018, Pages 90 A SNP panel for identification of DNA and RNA specimens. Yousefi S, Abbassi-Daloii T, Kraaijenbrink T, Vermaat M, Mei H, van 't Hof P, van Iterson M, Zhernakova DV, Claringbould A, Franke L, 't Hart LM, Slieker RC, van der Heijden A, de Knijff P, BIOS consortium, 't Hoen PAC

Background: SNP panels that uniquely identify an individual are useful for genetic and forensic research. Previously recommended SNP panels are based on DNA profiles and mostly contain intragenic SNPs. With the increasing interest in RNA expression profiles, we aimed for establishing a SNP panel for both DNA and RNA-based genotyping. Results: To determine a small set of SNPs with maximally discriminative power, genotype calls were obtained from DNA and blood-derived RNA sequencing data belonging... Abstract

Cited 55 times since 2018 (7.7 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 5, 24 4 2018, Pages 3 Inflammation in Vein Graft Disease. de Vries MR, Quax PHA

Bypass surgery is one of the most frequently used strategies to revascularize tissues downstream occlusive atherosclerotic lesions. For venous bypass surgery the great saphenous vein is the most commonly used vessel. Unfortunately, graft efficacy is low due to the development of vascular inflammation, intimal hyperplasia and accelerated atherosclerosis. Moreover, failure of grafts leads to significant adverse outcomes and even mortality. The last couple of decades not much has changed in the tre... Abstract

Cited 13 times since 2018 (1.8 per year) source: EuropePMC

Journal of thrombosis and haemostasis : JTH, Volume 16, Issue 3, 19 3 2018, Pages 519-528 Determinants of impaired renal and vascular function are associated with elevated levels of procoagulant factors in the general population. Dekkers IA, de Mutsert R, de Vries APJ, Rosendaal FR, Cannegieter SC, Jukema JW, le Cessie S, Rabelink TJ, Lamb HJ, Lijfering WM

Essentials Why venous thrombosis is more prevalent in chronic kidney disease is unclear. We investigated whether renal and vascular function are associated with hypercoagulability. Coagulation factors showed a procoagulant shift with impaired renal and vascular function. This suggests that renal and vascular function play a role in the etiology of thrombosis. Summary: Background Impaired renal and vascular function have been associated with venous thrombosis, but the mechanism is unclear. Object... Abstract

Cited 17 times since 2018 (2.4 per year) source: EuropePMC

Nutrition & diabetes, Volume 8, Issue 1, 17 3 2018, Pages 6 Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes. van Eyk HJ, van Schinkel LD, Kantae V, Dronkers CEA, Westenberg JJM, de Roos A, Lamb HJ, Jukema JW, Harms AC, Hankemeier T, van der Stelt M, Jazet IM, Rensen PCN, Smit JWA

Background/objectives: Endocannabinoids (ECs) are associated with obesity and ectopic fat accumulation, both of which play a role in the development of cardiovascular disease (CVD) in type 2 diabetes (T2D). The effect of prolonged caloric restriction on ECs in relation to fat distribution and cardiac function is still unknown. Therefore, our aim was to investigate this relationship in obese T2D patients with coronary artery disease (CAD). Subjects/methods: In a prospective intervention study, ob... Abstract

Cited 221 times since 2018 (31 per year) source: EuropePMC

Nature communications, Volume 9, Issue 1, 17 3 2018, Pages 260 Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Jiang X, O'Reilly PF, Aschard H, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakar

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC... Abstract

Cited 16 times since 2018 (2.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 3, 17 3 2018, Pages 476-493 Targeted Imaging for Cell Death in Cardiovascular Disorders. Shekhar A, Heeger P, Reutelingsperger C, Arbustini E, Narula N, Hofstra L, Bax JJ, Narula J

Cell death is desirable in cancer cells and undesirable in organs with limited regenerative potential, like the heart. Cell death comes in many forms, but only apoptosis and to a lesser degree necrosis is currently relevant to the clinical imager. Noninvasive imaging of cell death is an attractive option to understand pathophysiology, track disease activity, and evaluate response to intervention. Apoptosis seems to be the most promising target for imaging cell death, because it could be reversib... Abstract

Cited 7 times since 2018 (1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 9, 17 3 2018, Pages 1362-1364 Regional Left Ventricular Myocardial Mechanics in Degenerative Myxomatous Mitral Valve Disease: A Comparison Between Fibroelastic Deficiency and Barlow's Disease. van Wijngaarden SE, Abou R, Hiemstra YL, Ajmone Marsan N, Bax JJ, Delgado V

Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Pediatric cardiology, Volume 39, Issue 4, 16 3 2018, Pages 690-694 Pulmonary Valve Morphology in Patients with Bicuspid Aortic Valves. Koenraadt WMC, Bartelings MM, Gittenberger-de Groot AC, Bökenkamp R, DeRuiter MC, Schalij MJ, Jongbloed MRM

The aortic and pulmonary valve share a common developmental origin from the embryonic arterial trunk. Bicuspid aortic valve is the most common congenital anomaly and can occur isolated as well as in association with other congenital heart disease (CHD). Data on pulmonary valve morphology in these cases are scarce. In this study, we aimed to determine pulmonary valve morphology in hearts with BAV associated with CHD. In 83 post-mortem heart specimens with BAV and associated CHD, pulmonary valve m... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Patient preference and adherence, Volume 12, 15 3 2018, Pages 119-128 Patients' perceptions of conservative treatment for a small abdominal aortic aneurysm. Tomee SM, Gebhardt WA, de Vries JP, Hamelinck VC, Hamming JF, Lindeman JH

Background: An abdominal aortic aneurysm (AAA) is a progressive, generally symptomless disease that could ultimately result in a fatal rupture. Current guidelines advise conservative follow-up, and preventive surgical repair once the risk of rupture outweighs the cost of repair (55 mm in men). In developed countries, the majority of patients are diagnosed with AAAs less than 55 mm, and so enter a period of conservative surveillance. An important question is how patients perceive and cope with ri... Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

Journal of clinical lipidology, Volume 12, Issue 2, 11 2 2018, Pages 266-276.e3 Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco) genetics. Smit RAJ, Jukema JW, Postmus I, Ford I, Slagboom PE, Heijmans BT, Le Cessie S, Trompet S

In recent years, visit-to-visit variability of serum lipids has been linked to both clinical outcomes and surrogate markers for vascular disease. In this article, we present an overview of the current evidence connecting this intraindividual variability to these outcome measures, discuss its interplay with lipid-lowering treatment, and describe the literature regarding genetic factors of possible interest. In addition, we undertook an explorative genome-wide association analysis on visit-to-visi... Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

Heart rhythm, Volume 15, Issue 5, 8 2 2018, Pages 668-676 Fast nonclinical ventricular tachycardia inducible after ablation in patients with structural heart disease: Definition and clinical implications. Watanabe M, de Riva M, Piers SRD, Dekkers OM, Ebert M, Venlet J, Trines SA, Schalij MJ, Pijnappels DA, Zeppenfeld K

Background: Noninducibility of ventricular tachycardia (VT) with an equal or longer cycle length (CL) than that of the clinical VT is considered the minimum ablation endpoint in patients with structural heart disease. Because their clinical relevance remains unclear, fast nonclinical VTs are often not targeted. However, an accepted definition for fast VT is lacking. The shortest possible CL of a monomorphic reentrant VT is determined by the ventricular refractory period (VRP). Objective: The pur... Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 104, Issue 14, 5 1 2018, Pages 1200-1207 Impact of surgery on presence and dimensions of anatomical isthmuses in tetralogy of Fallot. Kapel GFL, Laranjo S, Blom NA, Hazekamp MG, Schalij MJ, Bartelings MM, Jongbloed MRM, Zeppenfeld K

Objective: In tetralogy of Fallot (TOF), the dominant ventricular tachycardia substrates are slow-conducting anatomical isthmuses. Surgical correction has evolved, which might have influenced isthmus presence and dimensions. Methods: One hundred and forty-two postmortem TOF specimens (84/58 corrected/uncorrected) were studied for isthmus presence. Isthmus 1 is located between the tricuspid annulus and right ventricular (RV) outflow tract (RVOT) patch/RV incision, isthmus 2 between RVOT patch/RV... Abstract