Research

Publications

Below you can find a list of our published research.

6136 results

Cited 11 times since 2015 (1.1 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 17, Issue 9, 2 1 2015, Pages 1383-1390 Incidence and predictors of dormant conduction after cryoballoon ablation incorporating a 30-min waiting period. Compier MG, De Riva M, Dyrda K, Zeppenfeld K, Schalij MJ, Trines SA

Aims: Electrical reconnection after pulmonary vein (PV) isolation is associated with atrial fibrillation (AF) recurrence. Reconnection may already develop within a 30 min waiting period and may only occur as dormant conduction (DC) revealed by adenosine infusion. This study determines incidence and predictors of DC after cryoballoon ablation incorporating a 30 min waiting period and the effect of treating this 'late' DC on 1 year AF-recurrence. Methods and results: Consecutive patients... Abstract

Cited 6 times since 2015 (0.6 per year) source: EuropePMC

Journal of electrocardiology, Volume 48, Issue 4, 1 1 2015, Pages 498-504 Performance of ST and ventricular gradient difference vectors in electrocardiographic detection of acute myocardial ischemia. Treskes RW, Ter Haar CC, Man S, De Jongh MC, Maan AC, Wolterbeek R, Schalij MJ, Wagner GS, Swenne CA

Introduction: Serial analysis could improve ECG diagnosis of myocardial ischemia caused by acute coronary occlusion. Methods: We analyzed ECG pairs of 84 cases and 398 controls. In case-patients, who underwent elective percutaneous coronary intervention, ischemic ECGs during balloon occlusion were compared with preceding non-ischemic ECGs. In control-patients, two elective non-ischemic ECGs were compared. In each ECG the ST vector at the J point and the ventricular gradient (VG) vector was compu... Abstract

Cited 22 times since 2015 (2.2 per year) source: EuropePMC

Atherosclerosis, Volume 241, Issue 1, 1 1 2015, Pages 55-61 HDL cholesterol, leptin and interleukin-6 predict high risk coronary anatomy assessed by CT angiography in patients with stable chest pain. Caselli C, De Graaf MA, Lorenzoni V, Rovai D, Marinelli M, Del Ry S, Giannessi D, Bax JJ, Neglia D, Scholte AJ

Objectives: Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation could predict high risk coronary anatomy at CTA in patients with stable chest pain. Methods: We evaluated a panel of 17 biomarkers in 429 patients (60.3 ± 0.4 years, 268 males) with... Abstract

Cited 15 times since 2015 (1.5 per year) source: EuropePMC

The Journal of general virology, Volume 96, Issue 8, 22 4 2015, Pages 2050-2060 Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data. Lewis NS, Verhagen JH, Javakhishvili Z, Russell CA, Lexmond P, Westgeest KB, Bestebroer TM, Halpin RA, Lin X, Ransier A, Fedorova NB, Stockwell TB, Latorre-Margalef N, Olsen B, Smith G, Bahl J, Wentworth DE, Waldenström J, Fouchier RAM, de Graaf M

Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassort... Abstract

Cited 33 times since 2015 (3.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 65, Issue 18, 22 4 2015, Pages 1954-1959 Predictive value of programmed ventricular stimulation after catheter ablation of post-infarction ventricular tachycardia. Yokokawa M, Kim HM, Baser K, Stevenson W, Nagashima K, Della Bella P, Vergara P, Hindricks G, Arya A, Zeppenfeld K, de Riva Silva M, Daoud EG, Kumar S, Kuck KH, Tilz R, Mathew S, Ghanbari H, Latchamsetty R, Morady F, Bogun FM

Background: A recent meta-analysis demonstrated a survival benefit in post-infarction patients whose ventricular tachycardia (VT) was rendered noninducible by catheter ablation. Furthermore, patients with noninducible VT had a lower VT recurrence rate than did patients whose VT remained inducible after ablation. Objectives: The purpose of this multicenter cohort study was to assess whether noninducibility after VT ablation is independently associated with improved survival. Methods: Data from 1,... Abstract

Cited 2 times since 2015 (0.2 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 12, Issue 6, 21 3 2015, Pages 321-322 Genetics: Genetic risk scores--new promises for drug evaluation. Jukema JW, Trompet S

Abstract

Cited 35 times since 2015 (3.5 per year) source: EuropePMC

PloS one, Volume 10, Issue 4, 17 3 2015, Pages e0124347 Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages. Yıldırım C, Vogel DY, Hollander MR, Baggen JM, Fontijn RD, Nieuwenhuis S, Haverkamp A, de Vries MR, Quax PH, Garcia-Vallejo JJ, van der Laan AM, Dijkstra CD, van der Pouw Kraan TC, van Royen N, Horrevoets AJ

Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients. The inhibiting effect of galectin-2 on arteriogenesis was confirmed in vivo, but the mechanism is largely unknown. In this study we aimed to explore the effects of galectin-2 on monocyte/macrophage phenotype in vitro and vivo, and to identify the receptor by which galectin-... Abstract

Cited 15 times since 2015 (1.5 per year) source: EuropePMC

European heart journal, Volume 36, Issue 31, 16 3 2015, Pages 2079-2086 Secundum atrial septal defect is associated with reduced survival in adult men. Kuijpers JM, van der Bom T, van Riel AC, Meijboom FJ, van Dijk AP, Pieper PG, Vliegen HW, Waskowsky WM, Oomen T, Zomer AC, Wagenaar LJ, Heesen WF, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ

Aims: The identification of sex differences in the prognosis of adults with a secundum atrial septal defect (ASD2) could help tailor their clinical management, as it has in other cardiovascular diseases. We investigated whether disparity between the sexes exists in long-term outcome of adult ASD2 patients. Methods and results: Patients with ASD2 classified as the primary defect were selected from the Dutch national registry of adult congenital heart disease. Survival stratified by sex was compar... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Journal of electrocardiology, Volume 48, Issue 4, 15 3 2015, Pages 490-497 Intra-individual ECG changes over 25 years: How long can elective ECGs be used as reference for acute ischemia detection? De Jongh MC, Ter Haar CC, Man S, Treskes RW, Maan AC, Schalij MJ, Swenne CA

Background: The guidelines advocate, in patients with chest pain, comparison of the acute ECG with a previously made, non-ischemic ECG that serves as a reference, to corroborate the working diagnosis of acute coronary syndrome (ACS). Our approach of this serial comparison is to compute the differences between the ST vectors at the J point and 60 ms thereafter (∆ST(J+0), ∆ST(J+60)) and between the ventricular gradient (VG) vectors (∆VG). In the current study, we investigate if reference ECGs rema... Abstract

Cited 80 times since 2015 (8.1 per year) source: EuropePMC

Molecular psychiatry, Volume 21, Issue 2, 14 2 2015, Pages 189-197 GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C, Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ, Schmidt CO, Mather KA, Chouraki V, Sun Q, Resnick SM, Rose LM, Oldmeadow C, Stewart M, Smith BH, Gudnason V, Yang Q, Mirza SS, Jukema JW, deJager PL, Harris TB, Liewald DC, Amin N, Coker LH, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai N, Becker JT, Jonsdottir MK, Au R, Fehrmann R, Herms S, Nalls M, Zhao W, Turner ST, Yaffe K, Lohman K, van Swieten JC, Kardia S, Knopman DS, Meeks WM, Heiss G, Holliday EG, Schofield PW, Tanaka T, Stott DJ, Wang J, Ridker P, Gow AJ, Pattie A, Starr JM, Hocking LJ, Armstrong NJ, McLachlan S, Shulman JM, Pilling LC, Eiriksdottir G, Scott RJ, Kochan NA, Palotie A, Hsieh YC, Eriksson JG, Penman A, Gottesman RF, Oostra BA, Yu L, DeStefano AL, Beiser A, Garcia M, Rotter JI, Nöthen MM, Hofman A, Slagboom PE, Westendorp R, Buckley

To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time... Abstract

Cited 92 times since 2015 (9.3 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 100, Issue 6, 9 2 2015, Pages 2181-2191 Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. Chaker L, Baumgartner C, den Elzen WP, Ikram MA, Blum MR, Collet TH, Bakker SJ, Dehghan A, Drechsler C, Luben RN, Hofman A, Portegies ML, Medici M, Iervasi G, Stott DJ, Ford I, Bremner A, Wanner C, Ferrucci L, Newman AB, Dullaart RP, Sgarbi JA, Ceresini G, Maciel RM, Westendorp RG, Jukema JW, Imaizumi M, Franklyn JA, Bauer DC, Walsh JP, Razvi S, Khaw KT, Cappola AR, Völzke H, Franco OH, Gussekloo J, Rodondi N, Peeters RP, Thyroid Studies Collaboration

Objective: The objective was to determine the risk of stroke associated with subclinical hypothyroidism. Data sources and study selection: Published prospective cohort studies were identified through a systematic search through November 2013 without restrictions in several databases. Unpublished studies were identified through the Thyroid Studies Collaboration. We collected individual participant data on thyroid function and stroke outcome. Euthyroidism was defined as TSH levels of 0.45-4.49 mIU... Abstract

Cited 19 times since 2015 (1.9 per year) source: EuropePMC

Open heart, Volume 2, Issue 1, 8 2 2015, Pages e000237 Prosthetic aortic valve selection: current patient experience, preferences and knowledge. Korteland NM, Bras FJ, van Hout FM, Kluin J, Klautz RJ, Bogers AJ, Takkenberg JJ

Objective: Current clinical practice guidelines advocate shared decision-making (SDM) in prosthetic valve selection. This study assesses among adult patients accepted for aortic valve replacement (AVR): (1) experience with current clinical decision-making regarding prosthetic valve selection, (2) preferences for SDM and risk presentation and (3) prosthetic valve knowledge and numeracy. Methods: In a prospective multicentre cohort study, AVR patients were surveyed preoperatively and 3 months post... Abstract

Cited 31 times since 2015 (3.1 per year) source: EuropePMC

International journal of epidemiology, Volume 44, Issue 2, 7 1 2015, Pages 604-612 LDL cholesterol still a problem in old age? A Mendelian randomization study. Postmus I, Deelen J, Sedaghat S, Trompet S, de Craen AJ, Heijmans BT, Franco OH, Hofman A, Dehghan A, Slagboom PE, Westendorp RG, Jukema JW

Background: Observational studies in older subjects have shown no or inverse associations between cholesterol levels and mortality. However, in old age plasma low-density lipoprotein cholesterol (LDL-C) may not reflect the lifetime level due to reverse causality, and hence the risk may be underestimated. In the current study, we used an LDL genetic risk score (GRS) to overcome this problem. Methods: A weighted GRS was created using 51 single nucleotide polymorphisms associated with LDL-C levels.... Abstract

Cited 6 times since 2015 (0.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 49, Issue 2, 7 1 2015, Pages 538-44; discussion 544-5 A single-centre 37-year experience with reoperation after primary repair of atrioventricular septal defect. Sojak V, Kooij M, Yazdanbakhsh A, Koolbergen DR, Bruggemans EF, Hazekamp MG

Objectives: To evaluate our experience with patients reoperated after primary repair of atrioventricular septal defect (AVSD) and identify predictors of poor outcome. Methods: Between 1976 and 2014, 69 patients were reoperated after primary repair of partial (n = 28), intermediate (n = 15) or complete (n = 26) AVSD. Results: Median age at first reoperation was 62.4 (range, 1.6-845) months, median interval to first reoperation was 22.3 (range, 0.2-598) months. Main indications for first reoperati... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 42, Issue 5, 7 1 2015, Pages 1297-1304 High-temporal velocity-encoded MRI for the assessment of left ventricular inflow propagation velocity: Comparison with color M-mode echocardiography. Calkoen EE, Marsan NA, Bax JJ, van den Boogaard PJ, Roest AA, de Roos A, Westenberg JJ

Purpose: To develop an alternative method for Vp-assessment using high-temporal velocity-encoded magnetic resonance imaging (VE-MRI). Left ventricular (LV) inflow propagation velocity (Vp) is considered a useful parameter in the complex assessment of LV diastolic function and is measured by Color M-mode echocardiography. Materials and methods: A total of 43 patients diagnosed with ischemic heart failure (61 ± 11 years) and 22 healthy volunteers (29 ± 13 years) underwent Color M-mode echocardiogr... Abstract

Cited 34 times since 2015 (3.4 per year) source: Scopus

JACC. Cardiovascular interventions, Volume 8, Issue 5, 1 1 2015, Pages 670-677 Surgical sutureless and transcatheter aortic valves: hemodynamic performance and clinical outcomes in propensity score-matched high-risk populations with severe aortic stenosis. Kamperidis V, van Rosendael PJ, de Weger A, Katsanos S, Regeer M, van der Kley F, Mertens B, Sianos G, Ajmone Marsan N, Bax JJ, Delgado V

Objectives: In propensity score-matched patients with severe aortic stenosis treated with surgical aortic valve replacement (AVR) with the 3f Enable sutureless prosthesis (Medtronic, Minneapolis, Minnesota) or transcatheter aortic valve replacement (TAVR), the hemodynamic performance of both valves and mid-term survival of patients were evaluated. Background: Data on hemodynamic performance of surgical sutureless bioprostheses in high operative risk patients with aortic stenosis are scarce. Meth... Abstract

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 10, Issue 12, 1 1 2015, Pages 1488-1492 How should I treat recurrent concomitant para-ring and valvular mitral regurgitation after surgical mitral valve repair in a high-risk patient? van Rosendael P, van der Kley F, Martina B, Palmen M, Delgado V, Schillinger W, von Bardeleben RS, Yeo KK, Ho KW, Jack Tan WC

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European heart journal, Volume 36, Issue 14, 1 1 2015, Pages 832-833 The first European Congress on e-Cardiology & e-Health. Bruining N, van der Velde ET, Saner H

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Cited 1 times since 2015 (0.1 per year) source: EuropePMC

World journal for pediatric & congenital heart surgery, Volume 6, Issue 2, 1 1 2015, Pages 298-300 Isolated right subclavian artery with interrupted aortic arch, ventricular septal defect, and left ventricular outflow tract obstruction. Te Hoven AS, Clur SA, Andreu JP, Hazekamp MG

We present two cases of isolated right subclavian artery from the right pulmonary artery (PA) associated with interrupted aortic arch, ventricular septal defect, left ventricular outflow tract obstruction, and 22q11 microdeletion. Both patients were successfully managed with bilateral PA banding initially followed by a modified Yasui operation. Isolation of the subclavian artery is rare but should always be taken into account, especially when bilateral PA banding is considered. The banding must... Abstract

Cited 22 times since 2015 (2.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 10, 31 5 2015, Pages 794-799 Severe tricuspid regurgitation is predictive for adverse events in tetralogy of Fallot. Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ

Objective: Patients with surgically repaired tetralogy of Fallot (rTOF) may develop functional tricuspid regurgitation (TR) due to annulus dilation. Guidelines suggest pulmonary valve replacement (PVR) in patients with rTOF with progressive TR, but data on clinical outcomes are lacking. Our objective was to determine whether TR was predictive for adverse events after PVR. Methods: In this retrospective, multicenter cohort study, patients with rTOF who had undergone PVR after preoperative echocar... Abstract