6136 results
Cited 11 times since 2014 (1.1 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 42, Issue 2, 19 3 2014, Pages 390-399
Automated left ventricle segmentation in late gadolinium-enhanced MRI for objective myocardial scar assessment.
Tao Q, Piers SR, Lamb HJ, van der Geest RJ
Purpose: To develop and validate an objective and reproducible left ventricle (LV) segmentation method for late gadolinium enhanced (LGE) magnetic resonance imaging (MRI), which can facilitate accurate myocardial scar assessment. Materials and methods: A cohort of 25 ischemic patients and 25 nonischemic patients were included. A four-step algorithm was proposed: first, the Cine-MRI and LGE-MRI volume were globally registered; second, the registered Cine-MRI contours were fitted to each LGE-MRI s...
Abstract
Cited 39 times since 2014 (3.8 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 111, Issue 48, 17 3 2014, Pages 17170-17175
Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry.
Konijnenberg A, Yilmaz D, Ingólfsson HI, Dimitrova A, Marrink SJ, Li Z, Vénien-Bryan C, Sobott F, Koçer A
Mechanosensitive ion channels are sensors probing membrane tension in all species; despite their importance and vital role in many cell functions, their gating mechanism remains to be elucidated. Here, we determined the conditions for releasing intact mechanosensitive channel of large conductance (MscL) proteins from their detergents in the gas phase using native ion mobility-mass spectrometry (IM-MS). By using IM-MS, we could detect the native mass of MscL from Escherichia coli, determine vario...
Abstract
Cited 26 times since 2014 (2.5 per year)
source: EuropePMC
The Journal of clinical investigation,
Volume 124, Issue 12, 17 3 2014, Pages 5159-5174
Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1.
Ali ZA, de Jesus Perez V, Yuan K, Orcholski M, Pan S, Qi W, Chopra G, Adams C, Kojima Y, Leeper NJ, Qu X, Zaleta-Rivera K, Kato K, Yamada Y, Oguri M, Kuchinsky A, Hazen SL, Jukema JW, Ganesh SK, Nabel EG, Channon K, Leon MB, Charest A, Quertermous T, Ashley EA
Angioplasty and stenting is the primary treatment for flow-limiting atherosclerosis; however, this strategy is limited by pathological vascular remodeling. Using a systems approach, we identified a role for the network hub gene glutathione peroxidase-1 (GPX1) in pathological remodeling following human blood vessel stenting. Constitutive deletion of Gpx1 in atherosclerotic mice recapitulated this phenotype of increased vascular smooth muscle cell (VSMC) proliferation and plaque formation. In an i...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 11, 12 2 2014, Pages e112129
Molecular epidemiology of seal parvovirus, 1988-2014.
Bodewes R, Hapsari R, Rubio García A, Sánchez Contreras GJ, van de Bildt MW, de Graaf M, Kuiken T, Osterhaus AD
A novel parvovirus was discovered recently in the brain of a harbor seal (Phoca vitulina) with chronic meningo-encephalitis. Phylogenetic analysis of this virus indicated that it belongs to the genus Erythroparvovirus, to which also human parvovirus B19 belongs. In the present study, the prevalence, genetic diversity and clinical relevance of seal parvovirus (SePV) infections was evaluated in both harbor and grey seals (Halichoerus grypus) that lived in Northwestern European coastal waters from...
Abstract
Cited 8 times since 2014 (0.8 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 85, Issue 3, 12 2 2014, Pages 480-487
Position of Edwards SAPIEN transcatheter valve in the aortic root in relation with the coronary ostia: implications for percutaneous coronary interventions.
Katsanos S, Debonnaire P, van der Kley F, van Rosendael PJ, Joyce E, de Graaf MA, Schalij MJ, Scholte AJ, Bax JJ, Ajmone Marsan N, Delgado V
Objectives: To determine the implications of stable coverage of the coronary ostia by the Edwards SAPIEN valve frame in terms of myocardial ischemia and subsequent percutaneous coronary intervention (PCI), following transcatheter aortic valve implantation (TAVI). Background: Edwards SAPIEN frame is frequently deployed relatively higher than recommended and may overlap the coronary ostia. Methods: A total of 142 patients (age 81 ± 7 years, male 49%) treated with Edwards SAPIEN valve and with mult...
Abstract
Cited 13 times since 2014 (1.3 per year)
source: EuropePMC
Heart rhythm,
Volume 12, Issue 3, 7 1 2014, Pages 533-539
Epicardial leads in adult cardiac resynchronization therapy recipients: a study on lead performance, durability, and safety.
Buiten MS, van der Heijden AC, Klautz RJM, Schalij MJ, van Erven L
Background: Transvenous left ventricular (LV) lead placement for cardiac resynchronization therapy-defibrillator (CRT-D) delivery is unsuccessful in 8% to 10% of cases. These patients might benefit from an epicardial lead. However, data on long-term epicardial lead performance are scarce. Furthermore, extracting an epicardial lead requires a rethoracotomy. Objective: The purpose of this study was to determine data on almost a decade of experience with epicardial leads and investigate the safety...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
Hamostaseologie,
Volume 35, Issue 2, 7 1 2014, Pages 113-120
The role of mast cells in atherosclerosis.
Wezel A, Quax PH, Kuiper J, Bot I
Rupture of an atherosclerotic plaque is the major underlying cause of adverse cardiovascular events such as myocardial infarction or stroke. Therapeutic interventions should therefore be directed towards inhibiting growth of atherosclerotic lesions as well as towards prevention of lesion destabilization. Interestingly, the presence of mast cells has been demonstrated in both murine and human plaques, and multiple interventional murine studies have pointed out a direct role for mast cells in earl...
Abstract
Cited 14 times since 2014 (1.4 per year)
source: EuropePMC
Nutrition and cancer,
Volume 67, Issue 1, 5 1 2014, Pages 137-144
Mechanism of inhibition of CYP1A1 and glutathione S-transferase activities in fish liver by quercetin, resveratrol, naringenin, hesperidin, and rutin.
Arinç E, Yilmaz D, Bozcaarmutlu A
Quercetin, resveratrol, naringenin, hesperidin, and rutin are phenolic compounds/flavonoids that may have roles in the reduction of cancer susceptibility. In this study, in vitro modulatory effects of them were studied on liver CYP1A1 associated 7-ethoxyresorufin-O-deethylase (EROD) activity and glutathione S-transferase (GST) activity of leaping mullet (Liza saliens). All of the phenolic compounds/flavonoids used exerted an inhibitory effect on both EROD and GST activities of fish. Quercetin, r...
Abstract
The Journal of thoracic and cardiovascular surgery,
Volume 148, Issue 5, 4 1 2014, Pages 2440-2442
Reply to the editor.
Grewal N, Gittenberger-de Groot AC, DeRuiter MC
Abstract
Cited 3 times since 2014 (0.3 per year)
source: EuropePMC
JMIR research protocols,
Volume 3, Issue 4, 3 1 2014, Pages e52
Treatment of Infantile Hemangioma in Regional Hospitals With eHealth Support: Evaluation of Feasibility and Acceptance by Parents and Doctors.
de Graaf M, Totté JE, van Os-Medendorp H, van Renselaar W, Breugem CC, Pasmans SG
Background: Since beta blockers became the preferred treatment for infantile hemangiomas (IH), the number of patients eligible for treatment is increasing. Currently treatment of IH with beta blockers is mainly reserved for expert centers, where wait times are lengthening. This demonstrated the need for development of a more efficient and accessible way of providing care for children needing treatment for IH. An eHealth intervention, Hemangioma Treatment Plan (HTP), was developed to treat IH in...
Abstract
Cited 26 times since 2014 (2.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 16, Issue 3, 2 1 2014, Pages 290-299
Leaflet remodelling in functional mitral valve regurgitation: characteristics, determinants, and relation to regurgitation severity.
Debonnaire P, Al Amri I, Leong DP, Joyce E, Katsanos S, Kamperidis V, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Background: Recently, it has been hypothesized that mitral leaflet remodelling may play a role in the pathophysiology of functional mitral regurgitation (FMR). We investigated the characteristics, determinants, and relation of mitral leaflet remodelling to FMR severity. Methods and results: Three-dimensional transoesophageal echocardiographic data of the mitral valve (MV) were studied in 30 patients with FMR ≥ grade 3 (≥3), 24 patients with FMR < grade 3 (
Abstract
Cited 8 times since 2014 (0.8 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 10, Issue 7, 1 1 2014, Pages 884-886
Tools & Techniques - Clinical: 3D transoesophageal echocardiography for selecting and guiding in percutaneous mitral valve repair using MitraClip.
Debonnaire P, Delgado V, Bax JJ, Marsan NA
Abstract
Cited 11 times since 2014 (1.1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 11, 1 1 2014, Pages 484-490
Role of the ECG in initial acute coronary syndrome triage: primary PCI regardless presence of ST elevation or of non-ST elevation.
IJkema BB, Bonnier JJ, Schoors D, Schalij MJ, Swenne CA
The major initial triaging decision in acute coronary syndrome (ACS) is whether or not percutaneous coronary intervention (PCI) is the primary treatment. Current guidelines recommend primary PCI in ST-elevation ACS (STEACS) and initial antithrombotic therapy in non-ST-elevation ACS (NSTEACS). This review probes the question whether this decision can indeed be based on the ECG. Genesis of STE/NSTE ECGs depends on the coronary anatomy, collateral circulation and site of the culprit lesion. Other c...
Abstract
Cited 16 times since 2014 (1.5 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 78, Issue 5, 1 1 2014, Pages 950-960
Evaluation of lecithinized human recombinant super oxide dismutase as cardioprotectant in anthracycline-treated breast cancer patients.
Broeyer FJ, Osanto S, Suzuki J, de Jongh F, van Slooten H, Tanis BC, Bruning T, Bax JJ, Ritsema van Eck HJ, de Kam ML, Cohen AF, Mituzhima Y, Burggraaf J
Aim: Anthracycline-induced cardiotoxicity is (partly) mediated by free radical overload. A randomized study was performed in breast cancer patients to investigate whether free radical scavenger super oxide dismutase (SOD) protects against anthracycline-induced cardiotoxicity as measured by changes in echo, electrocardiography and an array of biomarkers. Method and results: Eighty female, chemotherapy-naïve breast cancer patients (median age 49, range 24-67 years) scheduled for four or five cours...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 11, 1 1 2014, Pages 491-492
Image-guided intramyocardial cell injection: putting a puzzle piece in the right place.
Ramkisoensing AA, Atsma DE
Abstract
Cited 128 times since 2014 (12.3 per year)
source: EuropePMC
Vaccine,
Volume 32, Issue 52, 30 5 2014, Pages 7098-7107
A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human.
van Dissel JT, Joosten SA, Hoff ST, Soonawala D, Prins C, Hokey DA, O'Dee DM, Graves A, Thierry-Carstensen B, Andreasen LV, Ruhwald M, de Visser AW, Agger EM, Ottenhoff TH, Kromann I, Andersen P
Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6 (H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their own, protein antigens cannot sufficiently induce immune responses in humans, and require the addition of an adjuvant system to ensure appropriate delivery and concomitant immune activation. To date no approved adjuvants are available for induction of cellular immunity, which seems essential for a number of vaccines, includ...
Abstract
Cited 44 times since 2014 (4.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 115, Issue 2, 29 5 2014, Pages 234-242
Value of the "TAVI2-SCORe" versus surgical risk scores for prediction of one year mortality in 511 patients who underwent transcatheter aortic valve implantation.
Debonnaire P, Fusini L, Wolterbeek R, Kamperidis V, van Rosendael P, van der Kley F, Katsanos S, Joyce E, Tamborini G, Muratori M, Gripari P, Bax JJ, Marsan NA, Pepi M, Delgado V
A bedside-available transcatheter aortic valve implantation (TAVI)-dedicated prognostic risk score is an unmet clinical need. We aimed to develop such a risk score predicting 1-year mortality post-TAVI and to compare it with the performance of the logistic EuroSCORE (LES) I and LES-II and the Society of Thoracic Surgeons' (STS) score. Baseline variables of 511 consecutive patients who underwent TAVI that were independently associated with 1-year mortality post-TAVI were included in the &quo...
Abstract
Cited 13 times since 2014 (1.3 per year)
source: EuropePMC
Stroke,
Volume 45, Issue 12, 28 4 2014, Pages 3508-3513
Polygenic overlap between kidney function and large artery atherosclerotic stroke.
Holliday EG, Traylor M, Malik R, Bevan S, Maguire J, Koblar SA, Sturm J, Hankey GJ, Oldmeadow C, McEvoy M, Sudlow C, Rothwell PM, Coresh J, Hamet P, Tremblay J, Turner ST, de Andrade M, Rao M, Schmidt R, Crick PA, Robino A, Peralta CA, Jukema JW, Mitchell P, Rosas SE, Wang JJ, Scott RJ, Dichgans M, Mitchell BD, Kao WH, Fox CS, Levi C, Attia J, Markus HS, CKDGen Consortium and the International Stroke Genetics Consortium
Background and purpose: Epidemiological studies show strong associations between kidney dysfunction and risk of ischemic stroke (IS), the mechanisms of which are incompletely understood. We investigated whether these associations may reflect shared heritability because of a common polygenic basis and whether this differed for IS subtypes. Methods: Polygenic models were derived using genome-wide association studies meta-analysis results for 3 kidney traits: estimated glomerular filtration rate us...
Abstract
Cited 13 times since 2014 (1.3 per year)
source: EuropePMC
The Journal of biological chemistry,
Volume 289, Issue 51, 27 4 2014, Pages 35421-35430
Differential complement activation pathways promote C3b deposition on native and acetylated LDL thereby inducing lipoprotein binding to the complement receptor 1.
Klop B, van der Pol P, van Bruggen R, Wang Y, de Vries MA, van Santen S, O'Flynn J, van de Geijn GJ, Njo TL, Janssen HW, de Man P, Jukema JW, Rabelink TJ, Rensen PC, van Kooten C, Cabezas MC
Lipoproteins can induce complement activation resulting in opsonization and binding of these complexes to complement receptors. We investigated the binding of opsonized native LDL and acetylated LDL (acLDL) to the complement receptor 1 (CR1). Binding of complement factors C3b, IgM, C1q, mannose-binding lectin (MBL), and properdin to LDL and acLDL were investigated by ELISA. Subsequent binding of opsonized LDL and acLDL to CR1 on CR1-transfected Chinese Hamster Ovarian cells (CHO-CR1) was tested...
Abstract
Cited 9 times since 2014 (0.9 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 31, Issue 2, 24 4 2014, Pages 369-377
Preprocedural magnetic resonance imaging for image-guided catheter ablation of scar-related ventricular tachycardia.
Tao Q, Piers SR, Lamb HJ, Zeppenfeld K, van der Geest RJ
To present and validate a highly automated MRI analysis workflow for image-guided catheter ablation of scar-related ventricular tachycardia (VT) ablation procedures. A cohort of 15 post-infarction patients underwent MRI prior to VT ablation. The MRI study included a black-blood turbo spin echo sequence for visualizing the aortic root and ostium of the left main (LM) coronary artery, and a 3D late gadolinium enhanced sequence for visualizing the LV anatomy and myocardial scar substrate. Semi-auto...
Abstract
