Research

Publications

Below you can find a list of our published research.

6131 results

Cited 30 times since 2012 (2.4 per year) source: EuropePMC

Frontiers in oncology, Volume 2, 25 4 2012, Pages 77 The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae. Van Rossom S, Op de Beeck K, Franssens V, Swinnen E, Schepers A, Ghillebert R, Caldara M, Van Camp G, Winderickx J

DFNA5 was first identified as a gene responsible for autosomal dominant deafness. Different mutations were found, but they all resulted in exon 8 skipping during splicing and premature termination of the protein. Later, it became clear that the protein also has a tumor suppression function and that it can induce apoptosis. Epigenetic silencing of the DFNA5 gene is associated with different types of cancers, including gastric and colorectal cancers as well as breast tumors. We introduced the wild... Abstract

Cited 92 times since 2012 (7.3 per year) source: EuropePMC

European heart journal, Volume 34, Issue 36, 24 4 2012, Pages 2839-2849 Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction. Reil JC, Hohl M, Reil GH, Granzier HL, Kratz MT, Kazakov A, Fries P, Müller A, Lenski M, Custodis F, Gräber S, Fröhlig G, Steendijk P, Neuberger HR, Böhm M

Aims: In diabetes mellitus, heart failure with preserved ejection fraction (HFPEF) is a significant comorbidity. No therapy is available that improves cardiovascular outcomes. The aim of this study was to characterize myocardial function and ventricular-arterial coupling in a mouse model of diabetes and to analyse the effect of selective heart rate (HR) reduction by If-inhibition in this HFPEF-model. Methods and results: Control mice, diabetic mice (db/db), and db/db mice treated for 4 weeks wit... Abstract

Cited 7 times since 2012 (0.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 14, Issue 3, 19 3 2012, Pages 247-252 Impact of coronary atherosclerosis on the efficacy of radiofrequency catheter ablation for atrial fibrillation. den Uijl DW, Boogers MJ, Compier M, Trines SA, Scholte AJ, Zeppenfeld K, Schalij MJ, Bax JJ, Delgado V

Aims: Coronary atherosclerosis has been associated with the development of atrial fibrillation (AF). However, little is known about the impact of coronary atherosclerosis on the outcome treatment of AF. The aim of this study was to investigate the impact of coronary atherosclerosis on the efficacy of radiofrequency catheter ablation (RFCA) for AF using multi-detector row computed tomography (MDCT). Methods: In 125 consecutive patients undergoing RFCA for AF, a pre-procedural MDCT examination (co... Abstract

Cited 249 times since 2012 (19.7 per year) source: EuropePMC

Circulation, Volume 126, Issue 9, 19 3 2012, Pages 1040-1049 Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Gencer B, Collet TH, Virgini V, Bauer DC, Gussekloo J, Cappola AR, Nanchen D, den Elzen WP, Balmer P, Luben RN, Iacoviello M, Triggiani V, Cornuz J, Newman AB, Khaw KT, Jukema JW, Westendorp RG, Vittinghoff E, Aujesky D, Rodondi N, Thyroid Studies Collaboration

Background: American College of Cardiology/American Heart Association guidelines for the diagnosis and management of heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying the impact of different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events. Methods and results: We performed a pooled analysis of individual participant data usin... Abstract

Cited 284 times since 2012 (22.5 per year) source: EuropePMC

International journal of proteomics, Volume 2012, 18 3 2012, Pages 971907 Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome. Lai RC, Tan SS, Teh BJ, Sze SK, Arslan F, de Kleijn DP, Choo A, Lim SK

Mesenchymal stem cells (MSCs) are used in many of the current stem cell-based clinical trials and their therapeutic efficacy has increasingly been attributed to secretion of paracrine factors. We have previously demonstrated that a therapeutic constituent of this secretion is exosome, a secreted bilipid membrane vesicle of ~50-100 nm with a complex cargo that is readily internalized by H9C2 cardiomyocytes. It reduces infarct size in a mouse model of myocardial ischemia/reperfusion (MI/R) injury.... Abstract

Cited 34 times since 2012 (2.7 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 39, Issue 10, 13 2 2012, Pages 1599-1608 Reproducibility of planar (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in patients with heart failure. Veltman CE, Boogers MJ, Meinardi JE, Al Younis I, Dibbets-Schneider P, Van der Wall EE, Bax JJ, Scholte AJ

Purpose: Despite its high prognostic value, widespread clinical implementation of (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is hampered by a lack of validation and standardization. The purpose of this study was to assess the reliability of planar (123)I-MIBG myocardial scintigraphy in patients with heart failure (HF). Methods: Planar myocardial MIBG images of 70 HF patients were analysed by two experienced and one inexperienced observer. The reproducibility of early and dela... Abstract

Cited 24 times since 2012 (1.9 per year) source: EuropePMC

Atherosclerosis, Volume 224, Issue 1, 13 2 2012, Pages 150-153 A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: the Lipid Treatment Assessment Project 2. Santos RD, Waters DD, Tarasenko L, Messig M, Jukema JW, Chiang CW, Ferrieres J, Foody JM

Objective: This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study. Methods: 9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries. Results: Success rates for non-HDL-C goals were 86% in low, 70% in moderate, and 52% in high-risk patients (63% overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35% vs. 69% in those with ≤200 mg/... Abstract

Cited 144 times since 2012 (11.4 per year) source: EuropePMC

Circulation, Volume 126, Issue 6, 12 2 2012, Pages 720-728 Left bundle-branch block induced by transcatheter aortic valve implantation increases risk of death. Houthuizen P, Van Garsse LA, Poels TT, de Jaegere P, van der Boon RM, Swinkels BM, Ten Berg JM, van der Kley F, Schalij MJ, Baan J, Cocchieri R, Brueren GR, van Straten AH, den Heijer P, Bentala M, van Ommen V, Kluin J, Stella PR, Prins MH, Maessen JG, Prinzen FW

Background: Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and results: Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did and did not develop new LBBB. Of 679 patients analyzed, 387 (57.0... Abstract

Cited 6 times since 2012 (0.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 2, 12 2 2012, Pages 343-354 23Na chemical shift imaging and Gd enhancement of myocardial edema. Aguor EN, van de Kolk CW, Arslan F, Nederhoff MG, Doevendans PA, Pasterkamp G, Strijkers GJ, van Echteld CJ

Myocardial edema can arise in several disease states. MRI contrast agent can accumulate in edematous tissue, which complicates differential diagnosis with contrast-enhanced (CE)-MRI and might lead to overestimation of infarct size. Sodium Chemical Shift Imaging ((23)Na-CSI) may provide an alternative for edema imaging. We have developed a non-infarct, isolated rat heart model with two levels of edema, which was studied with (23)Na-CSI and CE-MRI. In edematous, but viable tissue the extracellular... Abstract

Cited 49 times since 2012 (3.9 per year) source: EuropePMC

Gynecologic oncology, Volume 127, Issue 1, 10 2 2012, Pages 126-130 Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer. Schaafsma BE, van der Vorst JR, Gaarenstroom KN, Peters AA, Verbeek FP, de Kroon CD, Trimbos JB, van Poelgeest MI, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Objective: Near-infrared fluorescence imaging using indocyanine green (ICG) has recently been introduced as a novel technique for sentinel lymph node (SLN) mapping in early-stage cervical cancer. Although preclinical research has shown that ICG adsorbed to human serum albumin (ICG:HSA) improves its performance, the need for HSA has not yet been confirmed in cervical cancer patients. The current randomized study aims to determine whether ICG:HSA offers advantages over using ICG alone. Methods: Ei... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Clinical research in cardiology : official journal of the German Cardiac Society, Volume 102, Issue 1, 6 1 2012, Pages 81-83 An uncommon complication of an aortic root aneurysm. Montero Cabezas JM, de Riva Silva M, Martín Asenjo R, Hernández Hernández F

Abstract

Cited 59 times since 2012 (4.7 per year) source: EuropePMC

PloS one, Volume 7, Issue 7, 6 1 2012, Pages e40058 Integrating macrophages into organotypic co-cultures: a 3D in vitro model to study tumor-associated macrophages. Linde N, Gutschalk CM, Hoffmann C, Yilmaz D, Mueller MM

Tumor progression is controlled by signals from cellular and extra-cellular microenvironment including stromal cells and the extracellular matrix. Consequently, three-dimensional in vitro tumor models are essential to study the interaction of tumor cells with their microenvironment appropriately in a biologically relevant manner. We have previously used organotypic co-cultures to analyze the malignant growth of human squamous cell carcinoma (SCC) cell lines on a stromal equivalent in vitro. In t... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

Brain & development, Volume 35, Issue 4, 5 1 2012, Pages 356-359 Atypical phenotypes of DYT1 dystonia in three children. Yilmaz U, Yüksel D, Atac FB, Yilmaz D, Verdi H, Senbil N

Unlabelled: DYT-1 dystonia is the most common primary dystonia seen in childhood. It is an autosomal dominantly inherited disorder caused by deletion of a GAG triplet in exon 5 of the DYT1 gene. It characteristically starts in a distal limb during late childhood, subsequently spreads to involve other body regions sparing oromandibular muscles. However, clinical presentation can vary remarkably with respect to age, site of onset and progression. In this study we present three early-onset DYT-1 dy... Abstract

Cited 30 times since 2012 (2.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 32, Issue 9, 5 1 2012, Pages 2223-2231 Human ATP-binding cassette G1 controls macrophage lipoprotein lipase bioavailability and promotes foam cell formation. Olivier M, Tanck MW, Out R, Villard EF, Lammers B, Bouchareychas L, Frisdal E, Superville A, Van Berkel T, Kastelein JJ, Eck MV, Jukema JW, Chapman MJ, Dallinga-Thie GM, Guerin M, Le Goff W

Objective: The physiological function of the ATP-binding cassette G1 (ABCG1) transporter in humans is not yet elucidated, as no genetic disease caused by ABCG1 mutations has been documented. The goal of our study was, therefore, to investigate the potential role(s) of ABCG1 in lipid metabolism in humans. Methods and results: Here we report that among the 104 polymorphisms present in the ABCG1 gene, the analysis of the frequent functional rs1893590 and rs1378577 single nucleotide polymorphisms lo... Abstract

Cited 75 times since 2012 (5.9 per year) source: EuropePMC

Annals of surgical oncology, Volume 19, Issue 13, 3 1 2012, Pages 4104-4111 Randomized comparison of near-infrared fluorescence imaging using indocyanine green and 99(m) technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients. van der Vorst JR, Schaafsma BE, Verbeek FP, Hutteman M, Mieog JS, Lowik CW, Liefers GJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Background: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods: Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patien... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

International journal of computer assisted radiology and surgery, Volume 7, Issue 5, 3 1 2012, Pages 753-767 Cardiac MRI visualization for ventricular tachycardia ablation. Godeschalk-Slagboom CJ, van der Geest RJ, Zeppenfeld K, Botha CP

Objective: The integrated visualization of cardiac MRI during a ventricular tachycardia (VT) mapping and ablation procedure would provide improved catheter guidance and tissue assessment. We developed a system for and explored the added value of simultaneous visualization of intracardiac voltage measurements and MRI-derived myocardial scar information during VT ablation procedures. Method: We propose the use of a synchronized 3D and 2D view. In 3D, the catheter will be guided optimally by assess... Abstract

Cited 11 times since 2012 (0.9 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 15, Issue 4, 3 1 2012, Pages 685-689 Serum cortisol concentration with exploratory cut-off values do not predict the effects of hydrocortisone administration in children with low cardiac output after cardiac surgery. Verweij EJ, Hogenbirk K, Roest AA, van Brempt R, Hazekamp MG, de Jonge E

Objectives: Low cardiac output syndrome is common after paediatric cardiac surgery. Previous studies suggested that hydrocortisone administration may improve haemodynamic stability in case of resistant low cardiac output syndrome in critically ill children. This study was set up to test the hypothesis that the effects of hydrocortisone on haemodynamics in children with low cardiac output syndrome depend on the presence of (relative) adrenal insufficiency. Methods: A retrospective study was done... Abstract

Cited 37 times since 2012 (2.9 per year) source: EuropePMC

World journal of gastrointestinal surgery, Volume 4, Issue 7, 1 1 2012, Pages 180-184 Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue. van der Vorst JR, Vahrmeijer AL, Hutteman M, Bosse T, Smit VT, van de Velde CJ, Frangioni JV, Bonsing BA

A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancr... Abstract

Cited 26 times since 2012 (2 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 16, Issue 7, 1 1 2012, Pages 1508-1521 Cardiomyogenic differentiation-independent improvement of cardiac function by human cardiomyocyte progenitor cell injection in ischaemic mouse hearts. den Haan MC, Grauss RW, Smits AM, Winter EM, van Tuyn J, Pijnappels DA, Steendijk P, Gittenberger-De Groot AC, van der Laarse A, Fibbe WE, de Vries AA, Schalij MJ, Doevendans PA, Goumans MJ, Atsma DE

We previously showed that human cardiomyocyte progenitor cells (hCMPCs) injected after myocardial infarction (MI) had differentiated into cardiomyocytes in vivo 3 months after MI. Here, we investigated the short-term (2 weeks) effects of hCMPCs on the infarcted mouse myocardium. MI was induced in immunocompromised (NOD/scid) mice, immediately followed by intramyocardial injection of hCMPCs labelled with enhanced green fluorescent protein (hCMPC group) or vehicle only (control group). Sham-operat... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

Journal of fish biology, Volume 81, Issue 2, 1 1 2012, Pages 750-765 Spawning migrations of the endemic Labeobarbus (Cyprinidae, Teleostei) species of Lake Tana, Ethiopia: status and threats. Anteneh W, Getahun A, Dejen E, Sibbing FA, Nagelkerke LA, De Graaf M, Wudneh T, Vijverberg J, Palstra AP

The reproductive biology of the only known intact species flock of large cyprinids, the 16 Labeobarbus species of Lake Tana (Ethiopia), has been extensively studied for the past two decades. Seven species of Labeobarbus are known to migrate >50 km upstream into tributary rivers for spawning during the rainy season (July to October), whereas eight other species are absent from these rivers and probably developed a new strategy of lacustrine spawning (macro-spatial segregation). One species (L.... Abstract