Research

Publications

Below you can find a list of our published research.

6131 results

Cited 43 times since 2011 (3.1 per year) source: EuropePMC

Circulation, Volume 123, Issue 17, 18 3 2011, Pages 1864-1872 Genetic predictors of fibrin D-dimer levels in healthy adults. Smith NL, Huffman JE, Strachan DP, Huang J, Dehghan A, Trompet S, Lopez LM, Shin SY, Baumert J, Vitart V, Bis JC, Wild SH, Rumley A, Yang Q, Uitterlinden AG, Stott DJ, Davies G, Carter AM, Thorand B, Polašek O, McKnight B, Campbell H, Rudnicka AR, Chen MH, Buckley BM, Harris SE, Peters A, Pulanic D, Lumley T, de Craen AJ, Liewald DC, Gieger C, Campbell S, Ford I, Gow AJ, Luciano M, Porteous DJ, Guo X, Sattar N, Tenesa A, Cushman M, Slagboom PE, Visscher PM, Spector TD, Illig T, Rudan I, Bovill EG, Wright AF, McArdle WL, Tofler G, Hofman A, Westendorp RG, Starr JM, Grant PJ, Karakas M, Hastie ND, Psaty BM, Wilson JF, Lowe GD, O'Donnell CJ, Witteman JC, Jukema JW, Deary IJ, Soranzo N, Koenig W, Hayward C

Background: Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. Methods and results: A genome-wide investigation of the genomic correlates of plasma D-dimer levels was conducted among 21 052 European-ancestry adults. Plasma levels of D-dimer were measur... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

Contemporary clinical trials, Volume 32, Issue 4, 17 3 2011, Pages 586-591 Rationale and design of a trial on the role of bosentan in Fontan patients: improvement of exercise capacity? Schuuring MJ, Vis JC, Bouma BJ, van Dijk AP, van Melle JP, Pieper PG, Vliegen HW, Sieswerda GT, Mulder BJ

Background: The Fontan circulation is a palliative procedure performed in patients with complex congenital heart disease (CHD), making transpulmonary blood flow dependent on the systemic venous pressure. In a Fontan circulation a low pulmonary vascular resistance (PVR) is crucial, as is epitomized by the observation that a high PVR is a strong predictor of mortality. Long-term follow-up has shown that PVR may rise many years after the Fontan procedure has been performed, possibly due to micro-em... Abstract

Cited 438 times since 2011 (31.5 per year) source: EuropePMC

Journal of surgical oncology, Volume 104, Issue 3, 14 2 2011, Pages 323-332 The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. Schaafsma BE, Mieog JS, Hutteman M, van der Vorst JR, Kuppen PJ, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the founda... Abstract

ISRN cardiology, Volume 2011, 11 2 2011, Pages 638764 Increased B-type natriuretic Peptide concentration is associated with reduced coronary vasoreactivity in patients with dilated cardiomyopathy but not in healthy young subjects. Sundell J, Engblom E, Koistinen J, Ylitalo A, Laine H, Kalliokoski R, Airaksinen KE, Bax JJ, Knuuti J

Background/Aims. Natriuretic peptides are associated with the cardiovascular disease risk under a range of different circumstances. However, less is known about whether this association is found also in young healthy subjects. Methods. 9 patients with dilated cardiomyopathy and 26 healthy young subjects were studied. The myocardial blood flow measurements were performed basally and during adenosine infusion using PET. Results. S-proBNP concentrations were significantly higher (2153 ± 1964 versus... Abstract

Cited 43 times since 2011 (3.1 per year) source: EuropePMC

The American journal of cardiology, Volume 107, Issue 12, 8 2 2011, Pages 1725-1729 Positive remodeling on coronary computed tomography as a marker for plaque vulnerability on virtual histology intravascular ultrasound. Kröner ES, van Velzen JE, Boogers MJ, Siebelink HM, Schalij MJ, Kroft LJ, de Roos A, van der Wall EE, Jukema JW, Reiber JH, Schuijf JD, Bax JJ

Coronary computed tomographic angiography allows direct evaluation of the vessel wall and thus positive remodeling, which is a marker of vulnerability. The purpose of this study was to assess the association between positive remodeling on computed tomography angiogram (CTA) and vulnerable plaque characteristics on virtual histologic intravascular ultrasound (VH IVUS) images. Forty-five patients (78% men, 58 ± 11 years old) underwent computed tomographic angiography followed by VH IVUS. On CTA, t... Abstract

Cited 18 times since 2011 (1.3 per year) source: EuropePMC

Cellular and molecular life sciences : CMLS, Volume 68, Issue 22, 2 1 2011, Pages 3741-3756 Different roles of the human Orc6 protein in the replication initiation process. Thomae AW, Baltin J, Pich D, Deutsch MJ, Ravasz M, Zeller K, Gossen M, Hammerschmidt W, Schepers A

In eukaryotes, binding of the six-subunit origin recognition complex (ORC) to DNA provides an interactive platform for the sequential assembly of pre-replicative complexes. This process licenses replication origins competent for the subsequent initiation step. Here, we analyze the contribution of human Orc6, the smallest subunit of ORC, to DNA binding and pre-replicative complex formation. We show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6. Biochemical a... Abstract

Cited 9 times since 2011 (0.6 per year) source: EuropePMC

Ocular immunology and inflammation, Volume 19, Issue 2, 1 1 2011, Pages 135-138 Ocular findings in subacute sclerosing panencephalitis. Yuksel D, Sonmez PA, Yilmaz D, Senbil N, Gurer Y

Purpose: The aim of this study was to evaluate the ocular manifestations of subacute sclerosing panencephalitis (SSPE) and to investigate possible risk factors in a relatively large series of patients. Methods: In this prospective study, patients who were diagnosed with SSPE and had undergone ophthalmic examination were included. Results: Of the 59 patients with SSPE, 25 (42.4%) had ocular findings. Ocular involvement was bilateral in 22 (88%) patients. The most characteristic fundus findings in... Abstract

Cited 139 times since 2011 (10 per year) source: EuropePMC

Molecular imaging and biology, Volume 13, Issue 2, 1 1 2011, Pages 199-207 Optical image-guided surgery--where do we stand? Keereweer S, Kerrebijn JD, van Driel PB, Xie B, Kaijzel EL, Snoeks TJ, Que I, Hutteman M, van der Vorst JR, Mieog JS, Vahrmeijer AL, van de Velde CJ, Baatenburg de Jong RJ, Löwik CW

In cancer surgery, intra-operative assessment of the tumor-free margin, which is critical for the prognosis of the patient, relies on the visual appearance and palpation of the tumor. Optical imaging techniques provide real-time visualization of the tumor, warranting intra-operative image-guided surgery. Within this field, imaging in the near-infrared light spectrum offers two essential advantages: increased tissue penetration of light and an increased signal-to-background-ratio of contrast agen... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Cardiology in the young, Volume 21, Issue 2, 1 1 2011 Assessment of proximal right coronary artery and cardiac dimensions with low-dose volumetric computed tomographic angiography in a child. Roest AA, Hazekamp MG, Kroft LJ

Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 18, Issue 2, 1 1 2011, Pages 368-370 Subvalvular hypertrophic calcification of the mitral annulus: [(18)F]FDG-PET-CT, MRI, and echocardiography findings. Persigehl T, Maintz D, Kies P, Heindel W, Schober O, Tiemann K, Rahbar K

Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 18, Issue 2, 1 1 2011, Pages 205-213 Treatment of types II-IV endoleaks by injecting biocompatible elastomer (PDMS) in the aneurysm sac: an in vitro study. Bosman WM, Hinnen JW, van der Steenhoven TJ, de Vries AC, Brom HL, Jacobs MJ, Hamming JF

Purpose: To investigate if an elastomer [polydimethylsiloxane (PDMS)] can be used to effectively treat endoleaks after endovascular aneurysm repair. Methods: A latex aneurysm (36-mm inner diameter sac, 15-mm inner diameter neck) was attached to an in vitro circulation model. The aneurysm was excluded from the circulation by placing an unstented polyester graft. Endoleak types II-IV were created using different setups. While the circulation setup running, the aneurysm was filled with contrast med... Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

Radiology, Volume 260, Issue 1, 1 1 2011, Pages 88-97 Corrected tetralogy of Fallot: comparison of tissue doppler imaging and velocity-encoded MR for assessment of performance and temporal activation of right ventricle. van der Hulst AE, Roest AA, Delgado V, Kroft LJ, Holman ER, Blom NA, Bax JJ, de Roos A, Westenberg JJ

Purpose: To compare velocity-encoded (VE) magnetic resonance (MR) imaging with tissue Doppler imaging to assess right ventricular (RV) peak systolic velocities and timing of velocities in patients with corrected tetralogy of Fallot and healthy subjects. Materials and methods: Local institutional review board approval was obtained; patients or their parents gave informed consent. Thirty-three patients (20 male, 13 female; median age, 12 years; interquartile range [IQR], 11-15 years; age range, 8-... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Minerva cardioangiologica, Volume 59, Issue 2, 1 1 2011, Pages 149-169 Ventricular tachycardia ablation: indications and techniques. Wijnmaalen AP, Zeppenfeld K

Over the last decades indications have broadened and techniques have been developed resulting in an increasing use of catheter ablation for different types of ventricular tachycardia (VT). Due to the high ablation success for non scar-related ventricular arrhythmia (VA) catheter ablation has become a first line therapy for symptomatic idiopathic VA or VA presumed to cause ventricular dysfunction. For the ablation of scar-related VTs individual patient factors and operator experience play an impo... Abstract

Cited 40 times since 2011 (2.9 per year) source: EuropePMC

European heart journal, Volume 32, Issue 9, 1 1 2011, Pages 1161-1170 Manifest disease, risk factors for sudden cardiac death, and cardiac events in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers: determining the best cardiological screening strategy. Christiaans I, Birnie E, Bonsel GJ, Mannens MM, Michels M, Majoor-Krakauer D, Dooijes D, van Tintelen JP, van den Berg MP, Volders PG, Arens YH, van den Wijngaard A, Atsma DE, Helderman-van den Enden AT, Houweling AC, de Boer K, van der Smagt JJ, Hauer RN, Marcelis CL, Timmermans J, van Langen IM, Wilde AA

Aims: We investigated the presence of a clinical diagnosis of hypertrophic cardiomyopathy (HCM), risk factors for sudden cardiac death (SCD), and cardiac events during follow-up in predictively tested-not known to have a clinical diagnosis of HCM before the DNA test-carriers of a sarcomeric gene mutation and associations with age and gender to determine the best cardiological screening strategy. Methods and results: One hundred and thirty-six (30%) of 446 mutation carriers were diagnosed with HC... Abstract

Cited 31 times since 2011 (2.2 per year) source: EuropePMC

PloS one, Volume 6, Issue 3, 31 5 2011, Pages e14783 Modelling the costs and effects of selective and universal hospital admission screening for methicillin-resistant Staphylococcus aureus. Hubben G, Bootsma M, Luteijn M, Glynn D, Bishai D, Bonten M, Postma M

Background: Screening at hospital admission for carriage of methicillin-resistant Staphylococcus aureus (MRSA) has been proposed as a strategy to reduce nosocomial infections. The objective of this study was to determine the long-term costs and health benefits of selective and universal screening for MRSA at hospital admission, using both PCR-based and chromogenic media-based tests in various settings. Methodology/principal findings: A simulation model of MRSA transmission was used to determine... Abstract

Cited 24 times since 2011 (1.7 per year) source: EuropePMC

Clinical genetics, Volume 80, Issue 4, 31 5 2011, Pages 346-353 Critical appraisal of the revised Ghent criteria for diagnosis of Marfan syndrome. Radonic T, de Witte P, Groenink M, de Bruin-Bon RA, Timmermans J, Scholte AJ, van den Berg MP, Baars MJ, van Tintelen JP, Kempers M, Zwinderman AH, Mulder BJ

Marfan syndrome (MFS) is a connective tissue disorder with major features in cardiovascular, ocular and skeletal systems. Recently, diagnostic criteria were revised where more weight was given to the aortic root dilatation. We applied the revised Marfan nosology in an established adult Marfan population to define practical repercussions of novel criteria for clinical practice and individual patients. Out of 180 MFS patients, in 91% (n = 164) the diagnosis of MFS remained. Out of 16 patients with... Abstract

Cited 27 times since 2011 (1.9 per year) source: EuropePMC

Thrombosis research, Volume 128, Issue 1, 30 5 2011, Pages 21-26 A simple non-invasive diagnostic algorithm for ruling out chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism. Klok FA, Surie S, Kempf T, Eikenboom J, van Straalen JP, van Kralingen KW, van Dijk AP, Vliegen HW, Bresser P, Wollert KC, Huisman MV

Background: Our aim was to construct a diagnostic model for ruling out chronic thromboembolic pulmonary hypertension (CTEPH) in symptomatic patients after acute pulmonary embolism (PE) that is based on simple, non-invasive tests. Methods: Plasma levels of various CTEPH associated biomarkers and conventional ECG criteria for right ventricular pressure overload were assessed in 82 consecutive patients with confirmed CTEPH and 160 consecutive patients with a history of PE who were suspected to have... Abstract

Cited 28 times since 2011 (2 per year) source: EuropePMC

European heart journal, Volume 32, Issue 18, 30 5 2011, Pages 2236-2246 Cardiac resynchronization therapy in paediatric and congenital heart disease patients. van der Hulst AE, Delgado V, Blom NA, van de Veire NR, Schalij MJ, Bax JJ, Roest AA, Holman ER

The number of patients with congenital heart disease (CHD) has significantly increased over the last decades. The CHD population has a high prevalence of heart failure during late follow-up and this is a major cause of mortality. Cardiac resynchronization therapy (CRT) may be a promising therapy to improve the clinical outcome of CHD and paediatric patients with heart failure. However, the CHD and paediatric population is a highly heterogeneous group with different anatomical substrates that may... Abstract

Cited 112 times since 2011 (8 per year) source: EuropePMC

European heart journal, Volume 32, Issue 12, 29 5 2011, Pages 1542-1550 Alterations in multidirectional myocardial functions in patients with aortic stenosis and preserved ejection fraction: a two-dimensional speckle tracking analysis. Ng AC, Delgado V, Bertini M, Antoni ML, van Bommel RJ, van Rijnsoever EP, van der Kley F, Ewe SH, Witkowski T, Auger D, Nucifora G, Schuijf JD, Poldermans D, Leung DY, Schalij MJ, Bax JJ

Aims: To identify changes in multidirectional strain and strain rate (SR) in patients with aortic stenosis (AS). Methods and results: A total of 420 patients (age 66.1 ± 14.5 years, 60.7% men) with aortic sclerosis, mild, moderate, and severe AS with preserved left ventricular (LV) ejection fraction [(EF), ≥50%] were included. Multidirectional strain and SR imaging were performed by two-dimensional speckle tracking. Patients were more likely to be older (P < 0.001) and at a worse New York Hea... Abstract

Cited 223 times since 2011 (16 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 8, Issue 5, 29 5 2011, Pages 292-300 Innate immune signaling in cardiac ischemia. Arslan F, de Kleijn DP, Pasterkamp G

Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity related to myocardial infarction is increasing in Western societies. Acute and chronic immune responses elicited by myocardial ischemia have an important role in the functional deterioration of the heart. Research on modulation of the inflammatory responses was focused on effector mediators such as leukocytes. However, increasing evidence indicates that various endogenous ligands that act as 'danger... Abstract