Research

Publications

Below you can find a list of our published research.

9543 results

Cited 2 times since 2025 (2.3 per year) source: EuropePMC

Langenbeck's archives of surgery, Volume 410, Issue 1, 8 2 2025, Pages 28 Establishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green. Tange FP, Peul RC, van den Hoven P, Koning S, Kruiswijk MW, Faber RA, Verduijn PS, van Rijswijk CSP, Galema HA, Hilling DE, van Dijk SPJ, van Ginhoven TM, Keereweer S, Mureau MAM, Feitsma EA, Noltes ME, Kruijff S, Driessen C, Achiam MP, Schepers A, van Schaik J, Mieog JSD, Vahrmeijer AL, Hamming JF, van der Vorst JR

Purpose: Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital tissue perfusion across target tissues using this imaging modality. Methods: Data from five prospective study cohorts conducted in three Dutch academic medical centres between December 2018 and June 2023 was included. Quantitative ana... Abstract

PloS one, Volume 20, Issue 1, 8 2 2025, Pages e0313916 Decreased risk-proneness with increasing age in equally raised and kept wolves and dogs. Jean-Joseph H, Kortekaas K, Range F, Kotrschal K

A basic mechanism of domestication is the selection for fearlessness and acceptance of humans as social partners, which may affect risk-taking behavior and the ability to use humans as social support, both at the behavioural and physiological levels. We combined behavioural observations with heart rate parameters (i.e., HR and heart rate variability, HRV) in equally raised and housed wolves and dogs to assess the responses to food offered in the vicinity of a potential stressor (an unknown spinn... Abstract

Cited 1 times since 2025 (1.1 per year) source: EuropePMC

Pediatric cardiology, 6 1 2025 Printed Models for Better Prediction of Surgery in Patients with Double Outlet Right Ventricle. Hoogerbeets SF, Roest AAW, Valverde I, Gomez-Ciriza G, Kroft L, Hazekamp MG

The complex and variable anatomy of complex double outlet right ventricle makes it imperative to understand the spatial anatomic structures to determine whether it is feasible to repair the anomaly in a biventricular or univentricular fashion. Biventricular repair should be aimed for but is not always feasible. Choosing the correct surgical technique is of great importance in surgical planning of biventricular repair. Conventional imaging is typically insufficient to predict feasibility and tech... Abstract

Cited 5 times since 2025 (5.7 per year) source: EuropePMC

BMJ open, Volume 15, Issue 1, 6 1 2025, Pages e095392 FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial. Al-Shakhshir S, Quraishi MN, Mullish B, Patel A, Vince A, Rowe A, Homer V, Jackson N, Gyimah D, Shabir S, Manzoor S, Cooney R, Alrubaiy L, Quince C, van Schaik W, Hares M, Beggs AD, Efstathiou E, Rimmer P, Weston C, Iqbal T, Trivedi PJ

Introduction: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven several pathogenic hypotheses to which the intestinal microbiome is proposed to contribute. Pilot studies of faecal microbiota transplantation (FMT) in PSC and IBD are demonstrated to be safe and associated with increased gut bacterial diversity. However, the longevity of such changes and the impa... Abstract

Cited 1 times since 2025 (1.1 per year) source: EuropePMC

International journal of cardiology. Heart & vasculature, Volume 56, 3 1 2025, Pages 101595 Epicardial fat tissue, a hidden enemy against the early recovery of left ventricular systolic function after transcatheter aortic valve implantation. Anwar HS, Lopez Santi P, Algowhary M, Abdelmegid MAF, Helmy HA, Jukema JW, Ajmone Marsan N, Van Der Kley F

Background: Epicardial fat tissue (EFT) is an active organ that can affect cardiac function and structure through endocrine, paracrine, and proinflammatory mechanisms. We hypothesized that greater thickness of EFT may harm the recovery of left ventricular (LV) systolic function in patients with severe aortic stenosis (AS) and reduced LV ejection fraction (EF ≤ 50 %) undergoing transcatheter aortic valve implantation (TAVI). Methods: A sixty six patients with severe AS and 20 % ≥ LVEF ≤ 50 % who... Abstract

Cited 1 times since 2025 (1.1 per year) source: EuropePMC

The Lancet regional health. Europe, Volume 50, 3 1 2025, Pages 101197 Dynamic association of antimicrobial resistance in urinary isolates of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> between primary care and hospital settings in the Netherlands (2008-2020): a population-based study. Martínez EP, Verbon A, Schoffelen AF, Altorf-van der Kuil W, van Rosmalen J, ISIS-AR study group

Background: It is unclear whether changes in antimicrobial resistance (AMR) in primary care influence AMR in hospital settings. Therefore, we investigated the dynamic association of AMR between primary care and hospitals. Methods: We studied resistance percentages of Escherichia coli and Klebsiella pneumoniae isolates to co-amoxiclav, ciprofloxacin, fosfomycin, nitrofurantoin and trimethoprim submitted by primary care, hospital outpatient and hospital inpatient settings to the Dutch National AMR... Abstract

European heart journal. Imaging methods and practice, Volume 3, Issue 1, 1 1 2025, Pages qyaf066 Cardiovascular imaging in 2024: review of current research and innovations. Barison A, Timoteo AT, El Messaoudi S, Borodzicz-Jazdzyk S, Moscatelli S, Mandoli GE, Luong C, Levelt E, Ramkisoensing AA, Raisi-Estabragh Z, Antonopoulos A, Moharem-Elgamal S, Liga R, Pontone G, Neglia D

Cardiovascular imaging saw significant advancements in 2024, impacting technology, pathophysiology, and clinical applications. This review provides a comprehensive summary of the most impactful research in cardiovascular imaging published in 2024, highlighting technological advancements, as well as research on ischaemic heart disease, valvular heart disease, cardiomyopathies, and heart failure. It emphasizes the crucial role of artificial intelligence, large-scale studies, and technical improvem... Abstract

Cited 9 times since 2025 (10.1 per year) source: EuropePMC

European heart journal, Volume 46, Issue 2, 1 1 2025, Pages 190-214 Definitions of clinical study outcome measures for cardiovascular diseases: the European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart). Wilkinson C, Bhatty A, Batra G, Aktaa S, Smith AB, Dwight J, Ruciński M, Chappell S, Alfredsson J, Erlinge D, Ferreira J, Guðmundsdóttir IJ, Hrafnkelsdóttir ÞJ, Ingimarsdóttir IJ, Irs A, Jánosi A, Járai Z, Oliveira-Santos M, Popescu BA, Vasko P, Vinereanu D, Yap J, Bugiardini R, Cenko E, Nadarajah R, Sydes MR, James S, Maggioni AP, Wallentin L, Casadei B, Gale CP, Global Cardiovascular Outcomes Consortium and in collaboration with ACNAP, ACVC, EACVI, EAPC, EAPCI, EHRA, ESC Committee for Young CV Professionals, ESC Registry Committee, HFA, ESC Patient Forum and these Working Groups: aorta and peripheral vascular diseases, atherosclerosis and vascular biology, cardiac cellular electrophysiology, cardiovascular pharmacotherapy, cardiovascular regenerative and restorative medicine, cardiovascular surgery, cellular biology of the heart, e-cardiology, myocardial function, pulmonary circulation and right ventricular function and thrombosis

Background and aims: Standardized definitions for outcome measures in randomized clinical trials and observational studies are essential for robust and valid evaluation of medical products, interventions, care, and outcomes. The European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart) project of the European Society of Cardiology aimed to create international data standards for cardiovascular clinical study outcome measures. Methods: The EuroHeart methods for data... Abstract

Vascular biology (Bristol, England), Volume 7, Issue 1, 1 1 2025, Pages e250001 Lipocalin 2 deficiency impacts angiogenesis after ischemia in vivo and in vitro. Zhang L, Aref Z, Peters HAB, de Vries MR, Nossent AY, Quax PHA

Therapeutic neovascularization is a promising therapy option for patients with peripheral arterial disease. We followed in time the gene expression after induction of hind limb ischemia in mice with different patterns of blood flow restoration and identified lipocalin 2 (LCN2) as a strongly upregulated factor whose role in neovascularization deserves further investigation. In this study, we investigated the role of LCN2 in angiogenesis using the hind limb ischemia (HLI) model, ex vivo angiogenic... Abstract

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Volume 31, 1 1 2025, Pages 10760296251347630 Investigation of Two Potential Predictors of Thrombosis Risk in Polycythemia Vera: Hematocrit-to-Hemoglobin Ratio and HALP Score. Yilmaz D, Akkaya E

Objective: This study aimed to assess the utility of the hematocrit-to-hemoglobin ratio (HHR) and the HALP score in detecting thrombosis history in patients with polycythemia vera (PV). Methods: This retrospective study examined patients diagnosed with PV between January 2013 and December 2022. Demographics, clinical history, PV- and thrombosis-related data, laboratory findings, follow-up duration, and mortality status were retrieved from hospital records. HHR and HALP scores were calculated for... Abstract

Cited 1 times since 2025 (1.1 per year) source: EuropePMC

Pediatrics international : official journal of the Japan Pediatric Society, Volume 67, Issue 1, 1 1 2025, Pages e70141 Is it possible to predict the spontaneous reduction of pediatric intussusception using biomarkers? Ulusoy E, Ulusoy O, Sütçüoğlu N, Küme T, Şık N, Yılmaz D, Duman M

Background: Intussusception is one of the most common causes of acute abdominal pain in childhood. In this study, we hypothesized that alpha-glutathione S-transferase (alpha-GST), intestinal fatty acid-binding protein (IFAB), and inflammatory markers may predict spontaneous reduction in ileocolic intussusceptions, thereby preventing unnecessary interventions. Methods: A single-center, prospective case-control study was conducted in the Pediatric Emergency Department. Patients with ileocolic intu... Abstract

Cited 2 times since 2025 (2.2 per year) source: EuropePMC

JAMA dermatology, Volume 161, Issue 1, 1 1 2025, Pages 12-21 Drug Survival of Dupilumab, Methotrexate, and Cyclosporine A in Children With Atopic Dermatitis. van der Rijst LP, Kamphuis E, Schuttelaar MLA, Hurmuz R, Seyger MMB, Caron AGM, Zuithoff NPA, Nguyen NT, Kamsteeg M, de Bruin-Weller MS, Pasmans SGMA, Middelkamp-Hup MA, de Graaf M

Importance: Dupilumab, methotrexate (MTX), and cyclosporine A (CsA) are valuable treatment options for pediatric patients with refractory moderate to severe atopic dermatitis (AD). Yet, comparative data on these treatments in pediatric patients are scarce. Objective: To evaluate drug survival of dupilumab, MTX, and CsA, and identify associated predictors in a multicenter daily practice cohort study of pediatric patients with AD. Design, setting, and participants: This multicenter daily practice... Abstract

Journal of Crohn's & colitis, Volume 19, Issue 1, 1 1 2025, Pages jjaf002 Diagnosing Crohn's disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn's disease in perianal fistulas (PREFAB). Munster LJ, Hanna LN, Hart AL, Tozer PJ, Buskens CJ, van der Bilt JDW, TOpCLASS perianal Crohn’s disease Consortium, the Dutch Initiative on Crohn and Colitis (ICC) and the Initiative on Crohn and Colitis - Surgery (ICC-S)

Background: The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn's disease (CD) in patients with perianal fistula(s) (PAF). Methods: A panel of international experts in the field of proctology/inflammatory bowel disease was invited to participate. In the first round (electronic survey), participants were asked to anonymously provide their opinion probing (1) the relevance and use of clinical characteristics suggestive of under... Abstract

Tijdschrift voor psychiatrie, Volume 67, Issue 7, 1 1 2025, Pages 403-406 [Systematic decision-making can help in ending long-term treatments]. Poolen F, Verhoeven J, van Schaik DJF, Reinders MJ, van der Wart MT, Vinkers CH

Background: The professional literature places considerable emphasis on the content of treatments, yet relatively little attention is given to their conclusion. When should a treatment be terminated, and how? In practice, there are few guidelines for ending treatment, particularly in the case of long-term interventions that may no longer significantly contribute to further improvement. A careful conclusion is, however, an essential component of any treatment. Due to a lack of attention to the te... Abstract

Digital health, Volume 11, 1 1 2025, Pages 20552076241288724 Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers. van den Brink WJ, Oosterman JE, Smid DJ, de Vries HJ, Atsma DE, Overeem S, Wopereis S

Digital biomarkers are quantifiable and objective indicators of a person's physiological function, behavioral state or treatment response, that can be captured using connected sensor technologies such as wearable devices and mobile apps. We envision that continuous and 24-h monitoring of the underlying physiological and behavioral processes through digital biomarkers can enhance early diagnostics, disease management, and self-care of cardiometabolic diseases. Cardiometabolic diseases, which... Abstract

Cited 3 times since 2024 (3.4 per year) source: EuropePMC

The Canadian journal of cardiology, Volume 41, Issue 5, 31 5 2025, Pages 899-910 The Role of the Axonal Guidance Cue Semaphorin 3A in Innervation of the Postnatal Heart in Health and Disease. Koppel CJ, De Henau CMS, Vreeken D, DeRuiter MC, Jongbloed MRM, van Gils JM

During cardiac development, the heart is innervated by the autonomous nervous system. After development, neurons of the autonomic nervous system have limited capacity for growth and regeneration. However, in recent decades, it has become clear that cardiac nerves can regenerate after cardiac damage. Excessive reinnervation, so-called sympathetic hyperinnervation, may render patients vulnerable to ventricular arrhythmias and heart failure. Several studies have investigated axonal guidance cues as... Abstract

Journal of the Society for Cardiovascular Angiography & Interventions, Volume 4, Issue 2, 31 5 2025, Pages 102492 Navigating Treble Clef Aorta: A Challenge for Transfemoral Transcatheter Aortic Valve Replacement-A Case Report. Anwar HS, Montero-Cabezas JM, Van Der Kley F

Transcatheter aortic valve replacement (TAVR) has emerged as a widely approved intervention for managing severe aortic stenosis. As the number of patients undergoing TAVR continues to rise, certain cases present unique challenges, particularly in relation to vascular access. This report highlights a case of successful transfemoral TAVR performed in a patient with an exceptionally tortuous and elongated aortic arch, characterized by significant curvature reminiscent of the treble clef musical sym... Abstract

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 26 4 2024, Pages 15266028241309267 Diagnostic Performance of the Maximal Systolic Acceleration for Detecting a Significant Stenosis in the Aortoiliac and Popliteal Pathway: A Retrospective Cohort Study. Willems SA, Dolfing SG, van Wissen RC, van der Meer RW, van Schaik J, van der Vorst JR, Schepers A, Hamming JF, Brouwers JJWM

Introduction: Identifying peripheral arterial disease (PAD) remains challenging with currently used bedside tests. The maximal systolic acceleration (ACCmax) is a promising noninvasive parameter measured by duplex ultrasonography and reflects the arterial perfusion proximal to its measurement point. The principal aim of this study was to analyze the diagnostic accuracy of the ACCmax for detecting significant stenosis in different arterial segments, which could be useful in clinical decision-maki... Abstract

Cited 2 times since 2024 (2.2 per year) source: EuropePMC

Allergy, Volume 80, Issue 4, 26 4 2024, Pages 1006-1014 Genotype-Guided Asthma Treatment Reduces Exacerbations in Children: Meta-Analysis of Two Randomized Control Trials. Slob EMA, Vijverberg SJH, Ruffles T, Noij LCE, Biermann J, Brouwer AFJ, van den Brink K, de Bruin-Kok A, Van Ewijk BE, Haarman E, Hammer SC, Hashimoto S, Hogarth F, Jones CJ, Kamps AWA, Kersten ETG, de Kleer I, Lipworth BJ, Littleford R, Mérelle M, Moeller A, Palmer CNA, Pilvinyte K, Rutjes NW, van Schaik RHN, Smith HE, Tavendale R, Terheggen-Lagro SWJ, Turner S, Twisk JWR, Vaessen-Verberne A, Verwaal M, de Vries T, Wesseling J, Pijnenburg MW, Koppelman GH, Mukhopadhyay S, Maitland-van der Zee AH

Background: Long-acting beta2-agonists (LABA) in combination with inhaled corticosteroids (ICS) are commonly used to treat asthma, however, some children lack response to the addition of LABA. This might be partially due to the presence of the Arg16Gly polymorphism, encoded by rs1042713 G>A in the ADRB2 gene. Carrying the A allele (Arg16) at this variant has been associated with an increased risk of exacerbations despite LABA treatment. We investigated whether genotype-guided treatment improv... Abstract

EBioMedicine, Volume 111, 25 4 2024, Pages 105518 Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools. Kokkorakis M, Folkertsma P, Anagnostakis F, Sirotin N, Agarwal M, Shantouf R, Henning RH, Pijl H, Wolffenbuttel BHR, Bax JJ, Atsma DE, Castela Forte J, Mantzoros CS, van Dam S

Background: Coronary artery disease (CAD) comprises one of the leading causes of morbidity and mortality both in the European population and globally. All established clinical risk stratification scores and models require blood lipids and physical measurements. The latest reports of the European Commission suggest that attracting health professionals to collect these data can be challenging, both from a logistic and cost perspective, which limits the usefulness of established models and makes th... Abstract