6125 results
Cited 25 times since 2002 (1.1 per year)
source: EuropePMC
Circulation research,
Volume 91, Issue 10, 1 1 2002, Pages 945-952
Gene transfer of the urokinase-type plasminogen activator receptor-targeted matrix metalloproteinase inhibitor TIMP-1.ATF suppresses neointima formation more efficiently than tissue inhibitor of metalloproteinase-1.
Lamfers ML, Grimbergen JM, Aalders MC, Havenga MJ, de Vries MR, Huisman LG, van Hinsbergh VW, Quax PH
Proteases of the plasminogen activator (PA) and matrix metalloproteinase (MMP) system play an important role in smooth muscle cell (SMC) migration and neointima formation after vascular injury. Inhibition of either PAs or MMPs has previously been shown to result in decreased neointima formation in vivo. To inhibit both protease systems simultaneously, a novel hybrid protein, TIMP-1.ATF, was constructed consisting of the tissue inhibitor of metalloproteinase-1 (TIMP-1) domain, as MMP inhibitor, l...
Abstract
Cited 45 times since 2002 (2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 88, Issue 5, 1 1 2002, Pages 515-519
ECG predictors of ventricular arrhythmias and biventricular size and wall mass in tetralogy of Fallot with pulmonary regurgitation.
Helbing WA, Roest AA, Niezen RA, Vliegen HW, Hazekamp MG, Ottenkamp J, de Roos A, van der Wall EE
Background: In patients with the tetralogy of Fallot, QRS prolongation predicts malignant ventricular arrhythmias. QRS prolongation may result from right ventricular dilatation. The relation of ECG markers to biventricular wall mass and volumes has not been assessed. Objective: To investigate the relations of surface ECG markers of depolarisation and repolarisation to right and left ventricular volume and biventricular wall mass. Methods: 37 Fallot patients (mean (SD) age 17 (9) years) were stud...
Abstract
Cited 18 times since 2002 (0.8 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 124, Issue 5, 1 1 2002, Pages 1038-1040
Bovine jugular vein thrombosis in the Fontan circulation.
Schoof PH, Koch AD, Hazekamp MG, Waterbolk TW, Ebels T, Dion RA
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 9, Issue 6, 1 1 2002, Pages 675-677
Prognostic value of perfusion-FDG mismatch in ischemic cardiomyopathy.
Bax JJ, Visser FC, Poldermans D, Elhendy A, Boersma E, Visser CA, Roelandt JR
Abstract
Cited 14 times since 2002 (0.6 per year)
source: EuropePMC
The New England journal of medicine,
Volume 347, Issue 22, 1 1 2002, Pages 1803-4; author reply 1803-4
Cardiac resynchronization therapy for heart failure.
Bax JJ, Van der Wall EE, Schalij MJ
Abstract
Cited 34 times since 2002 (1.5 per year)
source: EuropePMC
Journal of virology,
Volume 76, Issue 21, 1 1 2002, Pages 10829-10840
Characterization of two new structural glycoproteins, GP(3) and GP(4), of equine arteritis virus.
Wieringa R, de Vries AA, Raamsman MJ, Rottier PJ
Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae of the order Nidovirales. Four envelope proteins have hitherto been identified in EAV particles: the predominant membrane proteins M and G(L), the unglycosylated small envelope protein E, and the nonabundant membrane glycoprotein G(S). In this study, we established that the products of EAV open reading frame 3 (ORF3) and ORF4 (designated GP(3) and GP(4), respectively) are also minor st...
Abstract
Cited 25 times since 2002 (1.1 per year)
source: EuropePMC
American heart journal,
Volume 144, Issue 5, 1 1 2002, Pages 865-869
Assessment of residual myocardial viability in regions with chronic electrocardiographic Q-wave infarction.
Schinkel AF, Bax JJ, Boersma E, Elhendy A, Vourvouri EC, Roelandt JR, Poldermans D
Background: Q waves on the electrocardiogram are often considered to be reflective of irreversibly scarred myocardium due to antecedent transmural myocardial infarction. However, there are some indications that residual viable tissue may be present in Q-wave-infarcted regions. It is clinically relevant to know how many Q-wave regions contain viable tissue because these patients may benefit from revascularization in terms of improvement of function and long-term survival. Methods: Patients (n = 1...
Abstract
Cited 19 times since 2002 (0.9 per year)
source: EuropePMC
Journal of virology,
Volume 76, Issue 21, 1 1 2002, Pages 10734-10744
Efficient generation and amplification of high-capacity adeno-associated virus/adenovirus hybrid vectors.
Gonçalves MA, van der Velde I, Janssen JM, Maassen BT, Heemskerk EH, Opstelten DJ, Knaän-Shanzer S, Valerio D, de Vries AA
Effective gene therapy is dependent on safe gene delivery vehicles that can achieve efficient transduction and sustained transgene expression. We are developing a hybrid viral vector system that combines in a single particle the large cloning capacity and efficient cell cycle-independent nuclear gene delivery of adenovirus (Ad) vectors with the long-term transgene expression and lack of viral genes of adeno-associated virus (AAV) vectors. The strategy being pursued relies on coupling the AAV DNA...
Abstract
Cited 4 times since 2002 (0.2 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 9, Issue 6, 1 1 2002, Pages 587-593
Safety and feasibility of cardiac FDG SPECT following oral administration of Acipimox, a nicotinic acid derivative: Comparison of image quality with hyperinsulinemic euglycemic clamping in nondiabetic patients.
Bax JJ, Visser FC, Poldermans D, Van Lingen A, Elhendy A, Boersma E, Sloof GW, Visser CA
Background: Image quality of cardiac fluorine-18-deoxyglucose (FDG) studies is highly dependent on the metabolic conditions during the study; hyperinsulinemic euglycemic clamping ensures adequate image quality. However, the approach is time-consuming. Data in a small number of patients suggest that oral administration of a nicotinic acid derivative (Acipimox, 250 mg; Byk, The Netherlands) results in good image quality. Methods and results: The safety and image quality of cardiac FDG single photo...
Abstract
Cited 4 times since 2002 (0.2 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 22, Issue 5, 1 1 2002, Pages 802-807
Structural degeneration of pulmonary homografts used as aortic valve substitute underlines early graft failure.
Koolbergen DR, Hazekamp MG, de Heer E, van Hoorn F, Huysmans HA, Bruijn JA, Dion RA
Objectives: The limited availability of donor valves and experimental evidence that pulmonary valves can withstand systemic pressure made us use cryopreserved pulmonary homografts as aortic valve substitutes. We observed a high incidence of early reoperation because of severe graft insufficiency due to cuspal tears. The mid-term results are evaluated in this study and histological analysis of explanted homografts is performed to investigate the cause of graft failure. Methods: From December 1991...
Abstract
Cited 74 times since 2002 (3.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 90, Issue 10, 1 1 2002, Pages 1157-1160
Usefulness of dynamic multislice computed tomography of left ventricular function in unstable angina pectoris and comparison with echocardiography.
Dirksen MS, Bax JJ, de Roos A, Jukema JW, van der Geest RJ, Geleijns K, Boersma E, van der Wall EE, Lamb HJ
Abstract
Cited 44 times since 2002 (2 per year)
source: EuropePMC
Circulation research,
Volume 91, Issue 7, 1 1 2002, Pages 577-584
Accelerated atherosclerosis and calcification in vein grafts: a study in APOE*3 Leiden transgenic mice.
Lardenoye JH, de Vries MR, Löwik CW, Xu Q, Dhore CR, Cleutjens JP, van Hinsbergh VW, van Bockel JH, Quax PH
Vein grafts fail due to development of intimal hyperplasia and accelerated atherosclerosis. Many murine genetic models in which genes are overexpressed, deleted, or mutated have been introduced recently. Therefore, mouse models are very well suited to dissect the relative contribution of different genes in the development of accelerated atherosclerosis. In the present study, we evaluated whether accelerated atherosclerosis in human vein grafts could be mimicked in hypercholesterolemic APOE*3 Lei...
Abstract
Cited 4 times since 2002 (0.2 per year)
source: EuropePMC
Circulation,
Volume 106, Issue 14, 1 1 2002, Pages 1881-1882
Images in cardiovascular medicine. Malignant right coronary artery anomaly detected by magnetic resonance coronary angiography.
Dirksen MS, Langerak SE, de Roos A, Vliegen HW, Jukema JW, Bax JJ, Wielopolski PA, van der Wall EE, Lamb HJ
Abstract
Cited 49 times since 2002 (2.2 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 124, Issue 4, 1 1 2002, Pages 689-697
The pathology of fresh and cryopreserved homograft heart valves: an analysis of forty explanted homograft valves.
Koolbergen DR, Hazekamp MG, de Heer E, Bruggemans EF, Huysmans HA, Dion RA, Bruijn JA
Objective: Tissue degeneration reduces the durability of aortic and pulmonary homograft heart valves. Homograft valves can evoke cellular and humoral immune responses that might be detrimental to the valve tissue. Analyzing explanted homograft valves helps in understanding the different factors that eventually lead to tissue degeneration. Methods: A total of 40 homografts was acquired from patients whose grafts had been explanted because of stenosis (n = 22), insufficiency (n = 8), paravalvular...
Abstract
Cited 6 times since 2002 (0.3 per year)
source: EuropePMC
Cardiology in the young,
Volume 12, Issue 5, 1 1 2002, Pages 474-478
The need for cardiac follow-up in adults with mild congenital cardiac disease.
Kamphuis M, Vliegen HW, Vogels T, Zwinderman KH, van der Wall EE, Verloove-Vanhorick SP, Ottenkamp J
Objective: To discuss the need for continuing cardiac surveillance in adults with hemodynamically insignificant congenital cardiac disease. Methods: In 82 patients with mild congenital cardiac malformations, aged from 17 to 32 years, we investigated the subjective health status, the health-related quality of life, any difficulties encountered in daily life, the regularity of follow-up, current diagnosis, and antibiotic prophylaxis. Results: The subjective health status, and the health-related qu...
Abstract
Cited 158 times since 2002 (7 per year)
source: EuropePMC
Circulation,
Volume 106, Issue 15, 1 1 2002, Pages 1985-1990
In vivo evidence for a role of toll-like receptor 4 in the development of intimal lesions.
Vink A, Schoneveld AH, van der Meer JJ, van Middelaar BJ, Sluijter JP, Smeets MB, Quax PH, Lim SK, Borst C, Pasterkamp G, de Kleijn DP
Background: Inflammation plays an important role in atherogenesis. The toll-like receptor 4 (TLR4) is the receptor for bacterial lipopolysaccharides and also recognizes cellular fibronectin and heat shock protein 60, endogenous peptides that are produced in response to tissue injury. To explore a possible role for this receptor in arterial obstructive disease, we determined the expression of TLR4 in the atherosclerotic arterial wall, including adventitia, and studied the effect of adventitial TL...
Abstract
The international journal of cardiovascular imaging,
Volume 18, Issue 5, 1 1 2002, Pages 353-355
The cavity-to-myocardial count ratio as a marker of left ventricular function.
Bax JJ, Lamb HJ, van der Wall EE
Abstract
Cited 3 times since 2002 (0.1 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 15, Issue 10 Pt 2, 1 1 2002, Pages 1285-1289
Stress echocardiography for risk stratification of patients with chest pain and normal or slightly narrowed coronary arteries.
Bigi R, Cortigiani L, Bax JJ, Colombo P, Desideri A, Sponzilli C, Fiorentini C
One hundred twenty-five patients (60 +/- 10 years old, 60 women) with known (35, previous myocardial infarction) or suspected (90) coronary artery disease (CAD) and no more than 50% coronary stenoses underwent pharmacologic (48 dipyridamole and 77 dobutamine) stress echocardiography (SE) and prospective follow-up (36 +/- 22 months) for cardiac death, nonfatal infarction, and unstable angina. The ability of clinical and SE variables to predict the outcome was assessed by the Cox model. A signific...
Abstract
Cited 87 times since 2002 (3.9 per year)
source: EuropePMC
Blood,
Volume 101, Issue 5, 19 3 2002, Pages 1810-1817
Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix.
Collen A, Hanemaaijer R, Lupu F, Quax PH, van Lent N, Grimbergen J, Peters E, Koolwijk P, van Hinsbergh VW
Adult angiogenesis, associated with pathologic conditions, is often accompanied by the formation of a fibrinous exudate. This temporary matrix consists mainly of fibrin but is intermingled with plasma proteins and collagen fibers. The formation of capillary structures in a fibrinous matrix in vivo was mimicked by an in vitro model, in which human microvascular endothelial cells (hMVECs) seeded on top of a fibrin-10% collagen matrix form capillarylike tubular structures after stimulation with bas...
Abstract
Cited 31 times since 2002 (1.4 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 284, Issue 1, 12 2 2002, Pages H350-7
Impact of pericardial restraint on right atrial mechanics during acute right ventricular pressure load.
Maniar HS, Prasad SM, Gaynor SL, Chu CM, Steendijk P, Moon MR
Optimization of right atrial (RA) mechanics is important for maintaining right ventricular (RV) filling and global cardiac output. However, the impact of pericardial restraint on RA function and the compensatory role of the right atrium to changes in RV afterload remain poorly characterized. In eight open-chest sheep, RA elastance (contractility) and chamber stiffness were measured (RA pressure-volume relations) at baseline and during partial pulmonary artery (PA) occlusion. Data were collected...
Abstract
