9618 results
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
The American journal of cardiology,
Volume 241, 11 2 2025, Pages 61-68
Arrhythmogenic Right Ventricular Cardiomyopathy: The Importance of Biventricular Strain in Risk-Stratification.
Chua AP, Laenens D, Sarrazyn C, Lopez-Santi MP, Nabeta T, Myagmardorj R, Bootsma M, Barge-Schaapveld DQCM, Bax JJ, Marsan NA
Despite arrhythmogenic right ventricular cardiomyopathy (ARVC) being predominantly a right ventricular (RV) disease, concomitant left ventricular (LV) involvement has been recognized. ARVC is diagnosed by the RV-centric 2010 Task Force Criteria(TFC) using routine echocardiography, but previous studies have suggested that strain imaging may be more sensitive to detect RV and LV dysfunction. No data however are available regarding the additional value of combining biventricular strain for risk str...
Abstract
Cited 3 times since 2025 (5 per year)
source: EuropePMC
Nature communications,
Volume 16, Issue 1, 10 2 2025, Pages 576
Small-molecule-induced ERBB4 activation to treat heart failure.
Cools JMT, Goovaerts BK, Feyen E, Van den Bogaert S, Fu Y, Civati C, Van Fraeyenhove J, Tubeeckx MRL, Ott J, Nguyen L, Wülfers EM, Van Berlo B, De Vries AAF, Vandersickel N, Pijnappels DA, Audenaert D, Roderick HL, De Winter H, De Keulenaer GW, Segers VFM
Heart failure is a common and deadly disease requiring new treatments. The neuregulin-1/ERBB4 pathway offers cardioprotective benefits, but using recombinant neuregulin-1 as therapy has limitations due to the need for intravenous delivery and lack of receptor specificity. We hypothesize that small-molecule activation of ERBB4 could protect against heart damage and fibrosis. To test this, we conduct a screening of 10,240 compounds and identify eight structurally similar ones (EF-1 to EF-8) that i...
Abstract
American heart journal,
Volume 282, 9 2 2025, Pages 134-145
Increased prevalence of coronary atherosclerosis in cancer survivors: A retrospective matched cross-sectional study with coronary CT angiography.
Polomski EAS, Heemelaar JC, de Ronde MES, Al Jaff AAM, Mertens BJA, van Dijkman PRM, Jukema JW, Antoni ML
Background: Cancer and cancer treatment may accelerate the development of cardiovascular disease. With the improved prognosis of cancer survivors, cardiovascular events are increasing in this patient group. However, it is unknown whether the prevalence of coronary atherosclerosis is increased in patients with a history of cancer. This study aims to evaluate the prevalence and severity of coronary atherosclerosis in different age groups of cancer survivors compared to matched controls. Methods: C...
Abstract
Cited 2 times since 2025 (3.3 per year)
source: EuropePMC
Breast (Edinburgh, Scotland),
Volume 79, 9 2 2025, Pages 103880
Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study.
van Nijnatten RYM, Buijs SM, Agema BC, Fischer RMJ, Moghaddam-Helmantel IG, Contant CME, de Jongh FE, Huijben AMT, Kop M, van der Padt-Pruijsten A, Zuetenhorst HJM, van Schaik RHN, Koch BCP, Jager A, Koolen SLW, Mathijssen RHJ
Tamoxifen is an estrogen-receptor (ER) antagonist, used as adjuvant treatment of ER-positive breast cancer. It is converted by CYP2D6 into endoxifen, its most active metabolite. Patients with endoxifen plasma concentrations
Abstract
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
BMC medical education,
Volume 25, Issue 1, 9 2 2025, Pages 40
Applying principles of adult learning to rural health electives in a medical school curriculum.
Van Schaik L, Develyn T, Kelly K, Yazdabadi A, Scarff C, Harvey W, Wright J
The health disparities between rural and urban populations in Australia, driven by socioeconomic, environmental, and healthcare access factors, highlight the urgent need for rural-focused medical education. The Melbourne Medical School's Rural Health Discovery program addresses this need by integrating adult learning principles within a redesigned curriculum that includes the Rural Health Foundations and Integrating Rural Health topics. These Discovery topics engage medical students from di...
Abstract
Pharmacological research,
Volume 212, 9 2 2025, Pages 107575
GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study.
Magavern EF, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, Noordam R, Chen YI, Seeman TE, Taylor KD, Post WS, Tardif JC, Paul DS, Benjamin EJ, Heard-Costa NL, Vasan RS, Rotter JI, Krauss RM, Jukema JW, Ridker PM, Munroe PB, Caulfield MJ, Chasman DI, Dubé MP, Hitman GA, Warren HR, Genomic Investigation of Statin Therapy Consortium (GIST)
Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response. CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 100...
Abstract
JACC. Advances,
Volume 4, Issue 2, 8 2 2025, Pages 101535
Genetic Predisposition to Coronary Artery Disease: Evaluating Statin Therapy in Elder Populations From PROSPER.
Choi SH, Young R, Koyama S, Jukema JW, Trompet S, Ford I, Natarajan P, Peloso GM
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Langenbeck's archives of surgery,
Volume 410, Issue 1, 8 2 2025, Pages 28
Establishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green.
Tange FP, Peul RC, van den Hoven P, Koning S, Kruiswijk MW, Faber RA, Verduijn PS, van Rijswijk CSP, Galema HA, Hilling DE, van Dijk SPJ, van Ginhoven TM, Keereweer S, Mureau MAM, Feitsma EA, Noltes ME, Kruijff S, Driessen C, Achiam MP, Schepers A, van Schaik J, Mieog JSD, Vahrmeijer AL, Hamming JF, van der Vorst JR
Purpose: Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital tissue perfusion across target tissues using this imaging modality. Methods: Data from five prospective study cohorts conducted in three Dutch academic medical centres between December 2018 and June 2023 was included. Quantitative ana...
Abstract
PloS one,
Volume 20, Issue 1, 8 2 2025, Pages e0313916
Decreased risk-proneness with increasing age in equally raised and kept wolves and dogs.
Jean-Joseph H, Kortekaas K, Range F, Kotrschal K
A basic mechanism of domestication is the selection for fearlessness and acceptance of humans as social partners, which may affect risk-taking behavior and the ability to use humans as social support, both at the behavioural and physiological levels. We combined behavioural observations with heart rate parameters (i.e., HR and heart rate variability, HRV) in equally raised and housed wolves and dogs to assess the responses to food offered in the vicinity of a potential stressor (an unknown spinn...
Abstract
Cited 2 times since 2025 (3.3 per year)
source: EuropePMC
BMJ open,
Volume 15, Issue 1, 6 1 2025, Pages e095392
FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial.
Al-Shakhshir S, Quraishi MN, Mullish B, Patel A, Vince A, Rowe A, Homer V, Jackson N, Gyimah D, Shabir S, Manzoor S, Cooney R, Alrubaiy L, Quince C, van Schaik W, Hares M, Beggs AD, Efstathiou E, Rimmer P, Weston C, Iqbal T, Trivedi PJ
Introduction: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven several pathogenic hypotheses to which the intestinal microbiome is proposed to contribute. Pilot studies of faecal microbiota transplantation (FMT) in PSC and IBD are demonstrated to be safe and associated with increased gut bacterial diversity. However, the longevity of such changes and the impa...
Abstract
Pediatric cardiology,
6 1 2025
Printed Models for Better Prediction of Surgery in Patients with Double Outlet Right Ventricle.
Hoogerbeets SF, Roest AAW, Valverde I, Gomez-Ciriza G, Kroft L, Hazekamp MG
The complex and variable anatomy of complex double outlet right ventricle makes it imperative to understand the spatial anatomic structures to determine whether it is feasible to repair the anomaly in a biventricular or univentricular fashion. Biventricular repair should be aimed for but is not always feasible. Choosing the correct surgical technique is of great importance in surgical planning of biventricular repair. Conventional imaging is typically insufficient to predict feasibility and tech...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 56, 3 1 2025, Pages 101595
Epicardial fat tissue, a hidden enemy against the early recovery of left ventricular systolic function after transcatheter aortic valve implantation.
Anwar HS, Lopez Santi P, Algowhary M, Abdelmegid MAF, Helmy HA, Jukema JW, Ajmone Marsan N, Van Der Kley F
Background: Epicardial fat tissue (EFT) is an active organ that can affect cardiac function and structure through endocrine, paracrine, and proinflammatory mechanisms. We hypothesized that greater thickness of EFT may harm the recovery of left ventricular (LV) systolic function in patients with severe aortic stenosis (AS) and reduced LV ejection fraction (EF ≤ 50 %) undergoing transcatheter aortic valve implantation (TAVI). Methods: A sixty six patients with severe AS and 20 % ≥ LVEF ≤ 50 % who...
Abstract
The Lancet regional health. Europe,
Volume 50, 3 1 2025, Pages 101197
Dynamic association of antimicrobial resistance in urinary isolates of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> between primary care and hospital settings in the Netherlands (2008-2020): a population-based study.
Martínez EP, Verbon A, Schoffelen AF, Altorf-van der Kuil W, van Rosmalen J, ISIS-AR study group
Background: It is unclear whether changes in antimicrobial resistance (AMR) in primary care influence AMR in hospital settings. Therefore, we investigated the dynamic association of AMR between primary care and hospitals. Methods: We studied resistance percentages of Escherichia coli and Klebsiella pneumoniae isolates to co-amoxiclav, ciprofloxacin, fosfomycin, nitrofurantoin and trimethoprim submitted by primary care, hospital outpatient and hospital inpatient settings to the Dutch National AMR...
Abstract
European heart journal. Imaging methods and practice,
Volume 3, Issue 1, 1 1 2025, Pages qyaf066
Cardiovascular imaging in 2024: review of current research and innovations.
Barison A, Timoteo AT, El Messaoudi S, Borodzicz-Jazdzyk S, Moscatelli S, Mandoli GE, Luong C, Levelt E, Ramkisoensing AA, Raisi-Estabragh Z, Antonopoulos A, Moharem-Elgamal S, Liga R, Pontone G, Neglia D
Cardiovascular imaging saw significant advancements in 2024, impacting technology, pathophysiology, and clinical applications. This review provides a comprehensive summary of the most impactful research in cardiovascular imaging published in 2024, highlighting technological advancements, as well as research on ischaemic heart disease, valvular heart disease, cardiomyopathies, and heart failure. It emphasizes the crucial role of artificial intelligence, large-scale studies, and technical improvem...
Abstract
Journal of Crohn's & colitis,
Volume 19, Issue 1, 1 1 2025, Pages jjaf002
Diagnosing Crohn's disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn's disease in perianal fistulas (PREFAB).
Munster LJ, Hanna LN, Hart AL, Tozer PJ, Buskens CJ, van der Bilt JDW, TOpCLASS perianal Crohn’s disease Consortium, the Dutch Initiative on Crohn and Colitis (ICC) and the Initiative on Crohn and Colitis - Surgery (ICC-S)
Background: The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn's disease (CD) in patients with perianal fistula(s) (PAF). Methods: A panel of international experts in the field of proctology/inflammatory bowel disease was invited to participate. In the first round (electronic survey), participants were asked to anonymously provide their opinion probing (1) the relevance and use of clinical characteristics suggestive of under...
Abstract
Vascular biology (Bristol, England),
Volume 7, Issue 1, 1 1 2025, Pages e250001
Lipocalin 2 deficiency impacts angiogenesis after ischemia in vivo and in vitro.
Zhang L, Aref Z, Peters HAB, de Vries MR, Nossent AY, Quax PHA
Therapeutic neovascularization is a promising therapy option for patients with peripheral arterial disease. We followed in time the gene expression after induction of hind limb ischemia in mice with different patterns of blood flow restoration and identified lipocalin 2 (LCN2) as a strongly upregulated factor whose role in neovascularization deserves further investigation. In this study, we investigated the role of LCN2 in angiogenesis using the hind limb ischemia (HLI) model, ex vivo angiogenic...
Abstract
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis,
Volume 31, 1 1 2025, Pages 10760296251347630
Investigation of Two Potential Predictors of Thrombosis Risk in Polycythemia Vera: Hematocrit-to-Hemoglobin Ratio and HALP Score.
Yilmaz D, Akkaya E
Objective: This study aimed to assess the utility of the hematocrit-to-hemoglobin ratio (HHR) and the HALP score in detecting thrombosis history in patients with polycythemia vera (PV). Methods: This retrospective study examined patients diagnosed with PV between January 2013 and December 2022. Demographics, clinical history, PV- and thrombosis-related data, laboratory findings, follow-up duration, and mortality status were retrieved from hospital records. HHR and HALP scores were calculated for...
Abstract
Cited 7 times since 2025 (11.2 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 2, 1 1 2025, Pages 190-214
Definitions of clinical study outcome measures for cardiovascular diseases: the European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart).
Wilkinson C, Bhatty A, Batra G, Aktaa S, Smith AB, Dwight J, Ruciński M, Chappell S, Alfredsson J, Erlinge D, Ferreira J, Guðmundsdóttir IJ, Hrafnkelsdóttir ÞJ, Ingimarsdóttir IJ, Irs A, Jánosi A, Járai Z, Oliveira-Santos M, Popescu BA, Vasko P, Vinereanu D, Yap J, Bugiardini R, Cenko E, Nadarajah R, Sydes MR, James S, Maggioni AP, Wallentin L, Casadei B, Gale CP, Global Cardiovascular Outcomes Consortium and in collaboration with ACNAP, ACVC, EACVI, EAPC, EAPCI, EHRA, ESC Committee for Young CV Professionals, ESC Registry Committee, HFA, ESC Patient Forum and these Working Groups: aorta and peripheral vascular diseases, atherosclerosis and vascular biology, cardiac cellular electrophysiology, cardiovascular pharmacotherapy, cardiovascular regenerative and restorative medicine, cardiovascular surgery, cellular biology of the heart, e-cardiology, myocardial function, pulmonary circulation and right ventricular function and thrombosis
Background and aims: Standardized definitions for outcome measures in randomized clinical trials and observational studies are essential for robust and valid evaluation of medical products, interventions, care, and outcomes. The European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart) project of the European Society of Cardiology aimed to create international data standards for cardiovascular clinical study outcome measures. Methods: The EuroHeart methods for data...
Abstract
Pediatrics international : official journal of the Japan Pediatric Society,
Volume 67, Issue 1, 1 1 2025, Pages e70141
Is it possible to predict the spontaneous reduction of pediatric intussusception using biomarkers?
Ulusoy E, Ulusoy O, Sütçüoğlu N, Küme T, Şık N, Yılmaz D, Duman M
Background: Intussusception is one of the most common causes of acute abdominal pain in childhood. In this study, we hypothesized that alpha-glutathione S-transferase (alpha-GST), intestinal fatty acid-binding protein (IFAB), and inflammatory markers may predict spontaneous reduction in ileocolic intussusceptions, thereby preventing unnecessary interventions. Methods: A single-center, prospective case-control study was conducted in the Pediatric Emergency Department. Patients with ileocolic intu...
Abstract
JAMA dermatology,
Volume 161, Issue 1, 1 1 2025, Pages 12-21
Drug Survival of Dupilumab, Methotrexate, and Cyclosporine A in Children With Atopic Dermatitis.
van der Rijst LP, Kamphuis E, Schuttelaar MLA, Hurmuz R, Seyger MMB, Caron AGM, Zuithoff NPA, Nguyen NT, Kamsteeg M, de Bruin-Weller MS, Pasmans SGMA, Middelkamp-Hup MA, de Graaf M
Importance: Dupilumab, methotrexate (MTX), and cyclosporine A (CsA) are valuable treatment options for pediatric patients with refractory moderate to severe atopic dermatitis (AD). Yet, comparative data on these treatments in pediatric patients are scarce. Objective: To evaluate drug survival of dupilumab, MTX, and CsA, and identify associated predictors in a multicenter daily practice cohort study of pediatric patients with AD. Design, setting, and participants: This multicenter daily practice...
Abstract
