6128 results
Cited 4 times since 2021 (1 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 7, 15 3 2021, Pages 604821
P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3<sup>*</sup>Leiden Mice via Systemic Inhibition of Regulatory T Cells.
de Jong A, de Jong RCM, Peters EA, Arens R, Jukema JW, de Vries MR, Quax PHA
Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficiency affects atherosclerosis via regulation of regulatory Tregs. Method: ApoE3*Leiden (n = 13) and ApoE3*LeidenxPCAF-/- (n = 13) were fed a high-fat diet (HFD) containing 1.25% cholesterol. Systemic FoxP...
Abstract
Cited 25 times since 2021 (6.1 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 107, Issue 21, 15 3 2021, Pages 1725-1730
Sacubitril/valsartan in the treatment of systemic right ventricular failure.
Zandstra TE, Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Tops LF, Schalij MJ, Egorova AD
Objective: Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients. Methods: Data on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circ...
Abstract
Cited 55 times since 2021 (13.3 per year)
source: EuropePMC
Genome biology,
Volume 22, Issue 1, 14 2 2021, Pages 36
SPIN reveals genome-wide landscape of nuclear compartmentalization.
Wang Y, Zhang Y, Zhang R, van Schaik T, Zhang L, Sasaki T, Peric-Hupkes D, Chen Y, Gilbert DM, van Steensel B, Belmont AS, Ma J
We report SPIN, an integrative computational method to reveal genome-wide intranuclear chromosome positioning and nuclear compartmentalization relative to multiple nuclear structures, which are pivotal for modulating genome function. As a proof-of-principle, we use SPIN to integrate nuclear compartment mapping (TSA-seq and DamID) and chromatin interaction data (Hi-C) from K562 cells to identify 10 spatial compartmentalization states genome-wide relative to nuclear speckles, lamina, and putative...
Abstract
Cited 11 times since 2021 (2.7 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 7, 13 2 2021, Pages 1410-1421
Topological Data Analysis of Coronary Plaques Demonstrates the Natural History of Coronary Atherosclerosis.
Hwang D, Kim HJ, Lee SP, Lim S, Koo BK, Kim YJ, Kook W, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Lin FY, Virmani R, Samady H, Stone PH, Narula J, Bax JJ, Shaw LJ, Min JK, Chang HJ
Objectives: This study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA). Background: Coronary CTA can noninvasively assess coronary plaques quantitatively. Methods: Patients who underwent 2 coronary CTAs at a minimum of 24 months' interval were analyzed (n = 1,264). A similarity Mapper network of patients was built by top...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 22, Issue 2, 13 2 2021, Pages E755
Cell-Based Tracers as Trojan Horses for Image-Guided Surgery.
Sier VQ, de Vries MR, van der Vorst JR, Vahrmeijer AL, van Kooten C, Cruz LJ, de Geus-Oei LF, Ferreira V, Sier CFM, Alves F, Muthana M
Surgeons rely almost completely on their own vision and palpation to recognize affected tissues during surgery. Consequently, they are often unable to distinguish between different cells and tissue types. This makes accurate and complete resection cumbersome. Targeted image-guided surgery (IGS) provides a solution by enabling real-time tissue recognition. Most current targeting agents (tracers) consist of antibodies or peptides equipped with a radiolabel for Positron Emission Tomography (PET) an...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
Journal of virology,
Volume 95, Issue 3, 13 2 2021, Pages e01492-20
Human Noroviruses Attach to Intestinal Tissues of a Broad Range of Animal Species.
Villabruna N, Schapendonk CME, Aron GI, Koopmans MPG, de Graaf M
Human noroviruses are the most common nonbacterial cause of gastroenteritis outbreaks, with new variants and genotypes frequently emerging. The origin of these new viruses is unknown; however, animals have been proposed as a potential source, as human noroviruses have been detected in animal species. Here, we investigated the potential of animals to serve as a reservoir of human noroviruses by testing norovirus attachment to formalin-fixed intestinal tissues of a range of potential reservoir ani...
Abstract
Cited 33 times since 2021 (8 per year)
source: EuropePMC
Circulation,
Volume 143, Issue 11, 13 2 2021, Pages 1109-1122
Clinical Efficacy and Safety of Alirocumab After Acute Coronary Syndrome According to Achieved Level of Low-Density Lipoprotein Cholesterol: A Propensity Score-Matched Analysis of the ODYSSEY OUTCOMES Trial.
Schwartz GG, Gabriel Steg P, Bhatt DL, Bittner VA, Diaz R, Goodman SG, Jukema JW, Kim YU, Li QH, Manvelian G, Pordy R, Sourdille T, White HD, Szarek M, ODYSSEY OUTCOMES Committees and Investigators
Background: Recent international guidelines have lowered recommended target levels of low-density lipoprotein cholesterol (LDL-C) for patients at very high risk for major adverse cardiovascular events (MACE). However, uncertainty persists whether additional benefit results from achieved LDL-C levels below the conventional targets. Inferences from previous analyses are limited because patients who achieve lower versus higher LDL-C on lipid-lowering therapy differ in other characteristics prognost...
Abstract
Cited 55 times since 2021 (13.3 per year)
source: EuropePMC
Biomedicines,
Volume 9, Issue 1, 9 2 2021, Pages 57
Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence?
Kurakula K, Smolders VFED, Tura-Ceide O, Jukema JW, Quax PHA, Goumans MJ
Pulmonary arterial hypertension (PAH) is a rare, complex, and progressive disease that is characterized by the abnormal remodeling of the pulmonary arteries that leads to right ventricular failure and death. Although our understanding of the causes for abnormal vascular remodeling in PAH is limited, accumulating evidence indicates that endothelial cell (EC) dysfunction is one of the first triggers initiating this process. EC dysfunction leads to the activation of several cellular signalling path...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
European radiology,
Volume 31, Issue 7, 6 1 2021, Pages 5068-5076
Associations between left ventricular function, vascular function and measures of cerebral small vessel disease: a cross-sectional magnetic resonance imaging study of the UK Biobank.
van Hout MJP, Dekkers IA, Westenberg JJM, Schalij MJ, Scholte AJHA, Lamb HJ
Objectives: Impaired cardiovascular function has been associated with cognitive deterioration; however, to what extent cardiovascular dysfunction plays a role in structural cerebral changes remains unclear. We studied whether vascular and left ventricular (LV) functions are associated with measures of cerebral small vessel disease (cSVD) in the middle-aged general population. Methods: In this cross-sectional analysis of the UK Biobank, 4366 participants (54% female, mean age 61 years) underwent...
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 34, Issue 4, 6 1 2021, Pages 451-452
Left Ventricular Myocardial Work Indices: A Potential Step Forward for the Assessment of Myocardial Performance in Severe Aortic Stenosis: Reply to "Is It Fair to Use the Current Estimation of Myocardial Work in Patients with Significant Aortic Stenosis?"
Fortuni F, Bax JJ, Delgado V, Ajmone Marsan N
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
Health expectations : an international journal of public participation in health care and health policy,
Volume 24, Issue 2, 6 1 2021, Pages 456-467
Patient and public involvement cultures and the perceived impact in the vulnerable context of palliative care: A qualitative study.
Melchior I, van der Heijden A, Stoffers E, Suntjens F, Moser A
Background: Cultural values are crucial to the practice and impact of patient and public involvement (PPI) in research. Objective: To understand different PPI cultures among research teams and the impacts of PPI associated with each culture type. Design: A participatory action research design. Setting and participants: The setting was 10 palliative care research projects. Seventeen patients and members of the public and 31 researchers participated. Intervention: A programme consisting of four co...
Abstract
Circulation. Cardiovascular imaging,
Volume 14, Issue 1, 5 1 2021, Pages e011107
Computed Tomography-Derived Transesophageal Echocardiographic Views: Step Forward for Procedural Planning of Transcatheter Tricuspid Valve Annuloplasty.
Fortuni F, Hirasawa K, Marques AI, Pio SM, Chimed S, Lustosa R, Tjahjadi C, Wang X, Bax JJ, Ajmone Marsan N, Delgado V
Abstract
Cited 83 times since 2021 (20 per year)
source: EuropePMC
Nature communications,
Volume 12, Issue 1, 5 1 2021, Pages 24
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, Isaacs A, Willems SM, Navarro P, Tanaka T, Jackson AU, Montasser ME, O'Connell JR, Bielak LF, Webster RJ, Saxena R, Stafford JM, Pourcain BS, Timpson NJ, Salo P, Shin SY, Amin N, Smith AV, Li G, Verweij N, Goel A, Ford I, Johnson PCD, Johnson T, Kapur K, Thorleifsson G, Strawbridge RJ, Rasmussen-Torvik LJ, Esko T, Mihailov E, Fall T, Fraser RM, Mahajan A, Kanoni S, Giedraitis V, Kleber ME, Silbernagel G, Meyer J, Müller-Nurasyid M, Ganna A, Sarin AP, Yengo L, Shungin D, Luan J, Horikoshi M, An P, Sanna S, Boettcher Y, Rayner NW, Nolte IM, Zemunik T, Iperen EV, Kovacs P, Hastie ND, Wild SH, McLachlan S, Campbell S, Polasek O, Carlson O, Egan J, Kiess W, Willemsen G, Kuusisto J, Laakso M, Dimitriou M, Hicks AA, Rauramaa R, Bandinelli S, Thorand B, Liu Y, Miljkovic I, Lind L, Doney A, Perola M, Hingorani A,
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association stu...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 143, 4 1 2021, Pages 60-66
Influence of Chronic Obstructive Pulmonary Disease on Atrial Mechanics by Speckle Tracking Echocardiography in Patients With Atrial Fibrillation.
Goedemans L, Leung M, van der Bijl P, Abou R, Vo NM, Ajmone Marsan N, Delgado V, Bax JJ
The present study aimed to examine differences in left- and right atrial characteristics between atrial fibrillation (AF) patients with and without chronic obstructive pulmonary disease (COPD). For this, 420 patients (mean age 68 ± 10 years, 73% female) with first diagnosis of AF and baseline echocardiography were included. Of these, 143 COPD patients were compared with 277 patients without COPD matched by age, gender and body surface area. Additionally 38 healthy controls without cardiovascular...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
Journal of periodontology,
Volume 92, Issue 9, 3 1 2021, Pages 1295-1305
Salivary and serum concentrations of monocyte chemoattractant protein-1, macrophage inhibitory factor, and fractalkine in relation to rheumatoid arthritis and periodontitis.
Yilmaz D, Gönüllü E, Gürsoy M, Könönen E, Gürsoy UK
Background: Monocyte chemoattractant protein-1 (MCP-1), macrophage migration inhibitory factor (MIF), and fractalkine are chemokines that are expressed by a variety of cell types to regulate macrophage inflammatory response. The aim of the study was to examine the effects of periodontitis and rheumatoid arthritis (RA) on their serum and salivary concentrations. Methods: Adults with either periodontitis (P, n = 21), or with rheumatoid arthritis (RA, n = 23), or with both diseases (RA+P, n = 23) w...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
BJS open,
Volume 5, Issue 1, 1 1 2021, Pages zraa041
Systematic approach towards reliable estimation of abdominal aortic aneurysm size by ultrasound imaging and CT.
Tomee SM, Meijer CA, Kies DA, le Cessie S, Wasser MNJM, Golledge J, Hamming JF, Lindeman JHN
Background: The management of abdominal aortic aneurysm (AAA) is fully dictated by AAA size, but there are no uniform measurement guidelines, and systematic differences exist between ultrasound- and CT-based size estimation. The aim of this study was to devise a uniform ultrasound acquisition and measurement protocol, and to test whether harmonization of ultrasound and CT readings is feasible. Methods: A literature review was undertaken to evaluate evidence for ultrasound-based measurement of AA...
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 15, Issue 4, 1 1 2021, Pages 322-330
Progression of whole-heart Atherosclerosis by coronary CT and major adverse cardiovascular events.
van Rosendael AR, Lin FY, van den Hoogen IJ, Ma X, Gianni U, Al Hussein Alawamlh O, Al'Aref SJ, Peña JM, Andreini D, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic J, Maffei E, Pontone G, Raff GL, Shin S, Kim YJ, Lee BK, Chun EJ, Sung JM, Lee SE, Han D, Berman DS, Virmani R, Samady H, Stone P, Narula J, Bax JJ, Shaw LJ, Min JK, Chang HJ
Background: The current study aimed to examine the independent prognostic value of whole-heart atherosclerosis progression by serial coronary computed tomography angiography (CCTA) for major adverse cardiovascular events (MACE). Methods: The multi-center PARADIGM study includes patients undergoing serial CCTA for symptomatic reasons, ≥2 years apart. Whole-heart atherosclerosis was characterized on a segmental level, with co-registration of baseline and follow-up CCTA, and summed to per-patient l...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 2, 1 1 2021, Pages 186-187
Predicting left ventricular functional recovery after transcatheter aortic valve implantation with computed tomography-derived extracellular volume.
van der Bijl P, Delgado V, Bax JJ
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
JRSM cardiovascular disease,
Volume 10, 1 1 2021, Pages 20480040211006582
Risk assessment in aortic aneurysm repair by medical specialists versus the American College of Surgeons National Surgical Quality Improvement Program risk calculator outcomes.
van Schaik J, Hers TM, van Rijswijk CS, Schooneveldt MS, Putter H, Eefting D, van der Vorst JR
Objective: The aim of this online clinical vignette-based survey study was to compare risk assessments by vascular surgeons, anaesthesiologists and interventional radiologists involved in treating patients with aortic aneurysms in the Netherlands with the NSQIP risk calculator outcomes. Methods: Participants, recruited using purposive sampling, provided their estimation of the likelihood of postoperative complications and events following aortic surgery in five fictional cases. These cases were...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies,
Volume 22, Issue 1, 1 1 2021, Pages e79-e90
Rhinovirus Detection in the Nasopharynx of Children Undergoing Cardiac Surgery Is Not Associated With Longer PICU Length of Stay: Results of the Impact of Rhinovirus Infection After Cardiac Surgery in Kids (RISK) Study.
Roeleveld PP, Van Rijn AL, de Wilde RBP, van Zwet EW, Wink J, Rozendaal L, Hogenbirk K, Hazekamp MG, Man WH, Sidorov I, Kraakman MEM, Claas ECJ, de Jonge E, Kroes ACM, de Vries JJC
Objectives: To determine whether children with asymptomatic carriage of rhinovirus in the nasopharynx before elective cardiac surgery have an increased risk of prolonged PICU length of stay. Study design: Prospective, single-center, blinded observational cohort study. Setting: PICU in a tertiary hospital in The Netherlands. Patients: Children under 12 years old undergoing elective cardiac surgery were enrolled in the study after informed consent of the parents/guardians. Interventions: The paren...
Abstract
