Research

Publications

Below you can find a list of our published research.

6128 results

Cited 5 times since 2020 (1.2 per year) source: EuropePMC

International journal of molecular sciences, Volume 21, Issue 23, 3 1 2020, Pages E9244 Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy. Baganha F, Ritsma L, Quax PHA, de Vries MR

Plaque angiogenesis and plaque hemorrhage are major players in the destabilization and rupture of atherosclerotic lesions. As these are dynamic processes, imaging of plaque angiogenesis, especially the integrity or leakiness of angiogenic vessels, can be an extremely useful tool in the studies on atherosclerosis pathophysiology. Visualizing plaque microvessels in 3D would enable us to study the architecture and permeability of adventitial and intimal plaque microvessels in advanced atherosclerot... Abstract

Cited 14 times since 2020 (3.3 per year) source: EuropePMC

European journal of pediatrics, Volume 180, Issue 2, 2 1 2020, Pages 617-625 Predictive factors for surgical treatment in preterm neonates with necrotizing enterocolitis: a multicenter case-control study. El Manouni El Hassani S, Niemarkt HJ, Derikx JPM, Berkhout DJC, Ballón AE, de Graaf M, de Boode WP, Cossey V, Hulzebos CV, van Kaam AH, Kramer BW, van Lingen RA, Vijlbrief DC, van Weissenbruch MM, Benninga MA, de Boer NKH, de Meij TGJ

Necrotizing enterocolitis (NEC) is one of the most common and lethal gastrointestinal diseases in preterm infants. Early recognition of infants in need for surgical intervention might enable early intervention. In this multicenter case-control study, performed in nine neonatal intensive care units, preterm born infants (< 30 weeks of gestation) diagnosed with NEC (stage ≥ IIA) between October 2014 and August 2017 were divided into two groups: (1) medical (conservative treatment) and (2) surgi... Abstract

Cited 6 times since 2020 (1.4 per year) source: EuropePMC

JACC. Basic to translational science, Volume 5, Issue 12, 2 1 2020, Pages 1228-1239 Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response. Pluijmert NJ, de Jong RCM, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA

Phosphorylcholine monoclonal immunoglobulin G antibody attenuates the immediate post-ischemic inflammatory response by reducing the proinflammatory chemokine (C-C motif) ligand 2 chemokine and circulating Ly-6Chi monocytes. This subsequently enhances the post-ischemic repair process, resulting in limited adverse cardiac remodeling and preservation of cardiac function. Therefore, phosphorylcholine monoclonal immunoglobulin G antibody therapy may be a valid therapeutic approach against myocardial... Abstract

Cited 2 times since 2020 (0.5 per year) source: EuropePMC

Chaos (Woodbury, N.Y.), Volume 30, Issue 12, 1 1 2020, Pages 121107 Universal mechanisms for self-termination of rapid cardiac rhythm. Biasci V, Sacconi L, Cytrynbaum EN, Pijnappels DA, De Coster T, Shrier A, Glass L, Bub G

Excitable media sustain circulating waves. In the heart, sustained circulating waves can lead to serious impairment or even death. To investigate factors affecting the stability of such waves, we have used optogenetic techniques to stimulate a region at the apex of a mouse heart at a fixed delay after the detection of excitation at the base of the heart. For long delays, rapid circulating rhythms can be sustained, whereas for shorter delays, there are paroxysmal bursts of activity that start and... Abstract

Cited 3 times since 2020 (0.7 per year) source: EuropePMC

Atherosclerosis. Supplements, Volume 42, 1 1 2020, Pages e65-e71 Improving lipid management in patients with acute coronary syndrome: The ACS Lipid EuroPath tool. Sionis A, Catapano AL, De Ferrari GM, Dudek D, Jukema JW, Landmesser U, Pirillo A, Schiele F, Zaman A, Zamorano JL

Post-acute coronary syndrome (ACS) patients are at very high risk for recurrent events and mortality, despite the availability of effective pharmacological approaches. In 2018, the ACS EuroPath Survey, performed in collaboration with 555 European cardiologists, identified a sub-optimal LDL-C management in post-ACS patients. Based on these premises, the ACS EuroPath II project led to the development of a self-assessment tool to improve lipid management in these very high risk patients, taking int... Abstract

Cited 16 times since 2020 (3.8 per year) source: EuropePMC

Atherosclerosis. Supplements, Volume 42, 1 1 2020, Pages e49-e58 Lipid-lowering therapy and low-density lipoprotein cholesterol goal achievement in patients with acute coronary syndromes: The ACS patient pathway project. Landmesser U, Pirillo A, Farnier M, Jukema JW, Laufs U, Mach F, Masana L, Pedersen TR, Schiele F, Steg G, Tubaro M, Zaman A, Zamorano P, Catapano AL

Background and aims: Post-acute coronary syndrome (ACS) patients are at very high risk for recurrent events and mortality, despite the availability of effective pharmacological approaches. Aim of this survey was to evaluate the compliance to ESC/EAS guidelines during the management of ACS patients and the effectiveness of secondary prevention in seven European countries. Methods: By means of an online questionnaire, data on 2775 ACS patients (either acute case or follow-up patients) were collect... Abstract

Cited 24 times since 2020 (5.7 per year) source: EuropePMC

JAMA cardiology, Volume 5, Issue 12, 1 1 2020, Pages 1338-1348 Stress Myocardial Perfusion Imaging vs Coronary Computed Tomographic Angiography for Diagnosis of Invasive Vessel-Specific Coronary Physiology: Predictive Modeling Results From the Computed Tomographic Evaluation of Atherosclerotic Determinants of Myocardial Ischemia (CREDENCE) Trial. Stuijfzand WJ, van Rosendael AR, Lin FY, Chang HJ, van den Hoogen IJ, Gianni U, Choi JH, Doh JH, Her AY, Koo BK, Nam CW, Park HB, Shin SH, Cole J, Gimelli A, Khan MA, Lu B, Gao Y, Nabi F, Nakazato R, Schoepf UJ, Driessen RS, Bom MJ, Thompson R, Jang JJ, Ridner M, Rowan C, Avelar E, Généreux P, Knaapen P, de Waard GA, Pontone G, Andreini D, Al-Mallah MH, Lu Y, Berman DS, Narula J, Min JK, Bax JJ, Shaw LJ, CREDENCE Investigators

Importance: Stress imaging has been the standard for diagnosing functionally significant coronary artery disease. It is unknown whether novel, atherosclerotic plaque measures improve accuracy beyond coronary stenosis for diagnosing invasive fractional flow reserve (FFR) measurement. Objective: To compare the diagnostic accuracy of comprehensive anatomic (obstructive and nonobstructive atherosclerotic plaque) vs functional imaging measures for estimating vessel-specific FFR. Design, setting, and... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

European heart journal, Volume 41, Issue 45, 1 1 2020, Pages 4318-4320 The difficult decision of when and in whom to perform isolated tricuspid valve surgery. Delgado V, Ajmone Marsan N, Bax JJ

Abstract

Cited 2 times since 2020 (0.5 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 6, Issue 14, 1 1 2020, Pages 1794-1796 Automated Functional Substrate Mapping: Further Hurdles to Be Cleared. Zeppenfeld K, Porta-Sánchez A

Abstract

Huisarts en wetenschap, Volume 63, Issue 12, 30 5 2020, Pages 27-32 E-health bij poliklinische follow-up van myocardinfarctpatiënten. Treskes R, van Winden L, van Keulen N, van der Velde E, Beeres S, Atsma D, Schalij MJ

Abstract

Cited 2 times since 2020 (0.5 per year) source: EuropePMC

Current cardiology reports, Volume 23, Issue 1, 27 4 2020, Pages 4 Cardiac Sympathetic Innervation Imaging with PET Radiotracers. van der Bijl P, Knuuti J, Delgado V, Bax JJ

Purpose of review: The present article reviews the pathophysiology of cardiac sympathetic denervation, the principles of positron emission tomography (PET) imaging of the sympathetic innervation of the heart and its potential clinical role, based on current and expected future evidence. Recent findings: Imaging of cardiac sympathetic denervation can be performed with radiolabeled noradrenaline analogues, e.g., 11C-hydroxyephedrine. A greater burden of sympathetic denervation carries prognostic s... Abstract

Cited 5 times since 2020 (1.2 per year) source: Scopus

Animals : an open access journal from MDPI, Volume 10, Issue 12, 26 4 2020, Pages E2214 Social Context Influences Resting Physiology in Dogs. Kortekaas K, Kotrschal K

Domestication has affected the social life of dogs. They seem to be less dependent on their pack members than wolves, potentially causing dogs to be more alert towards their environment, especially when resting. Such a response has been found in dogs resting alone compared to wolves in the same situation. However, as this may be influenced by social context, we compared alertness (i.e., degree of activation along the sleep-wake continuum-measured via cardiac parameters) of pack-living and enclos... Abstract

Cited 37 times since 2020 (8.7 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 14, Issue 4, 25 4 2020, Pages 854-866 Neo-LVOT and Transcatheter Mitral Valve Replacement: Expert Recommendations. Reid A, Ben Zekry S, Turaga M, Tarazi S, Bax JJ, Wang DD, Piazza N, Bapat VN, Ihdayhid AR, Cavalcante JL, Blanke P, Leipsic J

With the advent of transcatheter mitral valve replacement (TMVR), the concept of the neo-left ventricular outflow tract (LVOT) was introduced and remains an essential component of treatment planning. This paper describes the LVOT anatomy and provides a step-by-step computed tomography methodology to segment and measure the neo-LVOT while discussing the current evidence and outstanding challenges. It also discusses the technical and hemodynamic factors that play a major role in assessing the neo-... Abstract

Cited 4 times since 2020 (0.9 per year) source: Scopus

Frontiers in psychology, Volume 11, 24 4 2020, Pages 568199 Context-Specific Arousal During Resting in Wolves and Dogs: Effects of Domestication? Jean-Joseph H, Kortekaas K, Range F, Kotrschal K

Due to domestication, dogs differ from wolves in the way they respond to their environment, including to humans. Selection for tameness and the associated changes to the autonomic nervous system (ANS) regulation have been proposed as the primary mechanisms of domestication. To test this idea, we compared two low-arousal states in equally raised and kept wolves and dogs: resting, a state close to being asleep, and inactive wakefulness, which together take up an important part in the time budgets... Abstract

Cited 86 times since 2020 (20.1 per year) source: EuropePMC

Nature genetics, Volume 52, Issue 12, 23 4 2020, Pages 1314-1332 Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindström J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Müller-Nurasyid M, Paré G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepúlveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanáková A, Sulem P, Thériault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E,

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P Abstract

Cited 19 times since 2020 (4.5 per year) source: EuropePMC

ESC heart failure, Volume 8, Issue 1, 23 4 2020, Pages 566-576 Meta-analysis of echocardiographic quantification of left ventricular filling pressure. Jones R, Varian F, Alabed S, Morris P, Rothman A, Swift AJ, Lewis N, Kyriacou A, Wild JM, Al-Mohammad A, Zhong L, Dastidar A, Storey RF, Swoboda PP, Bax JJ, Garg P

Aims: The clinical reliability of echocardiographic surrogate markers of left ventricular filling pressures (LVFPs) across different cardiovascular pathologies remains unanswered. The main objective was to evaluate the evidence of how effectively different echocardiographic indices estimate true LVFP. Methods and results: Design: this is a systematic review and meta-analysis. Data source: Scopus, PubMed and Embase. Eligibility criteria for selecting studies were those that used echocardiography... Abstract

Cited 20 times since 2020 (4.7 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 112, Issue 4, 19 3 2020, Pages 1150-1159 Multiinstitutional Phase 2 Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer. Gangadharan S, Sarkaria IN, Rice D, Murthy S, Braun J, Kucharczuk J, Predina J, Singhal S

Background: Intraoperative molecular imaging (IMI) may improve surgical outcomes during pulmonary resection for lung cancer. A multiinstitutional phase 2 IMI clinical trial was conducted using a near-infrared, folate receptor-targeted contrast agent for lung adenocarcinomas, OTL38. The primary goal was to determine whether OTL38 improved surgeons' ability to identify difficult to find nodules, occult cancers, and positive margins. Methods: Patients with lung nodules received OTL38 (0.025 mg... Abstract

Cited 40 times since 2020 (9.3 per year) source: EuropePMC

Frontiers in nutrition, Volume 7, 19 3 2020, Pages 597600 The Impact of Obesity and Lifestyle on the Immune System and Susceptibility to Infections Such as COVID-19. de Frel DL, Atsma DE, Pijl H, Seidell JC, Leenen PJM, Dik WA, van Rossum EFC

Background: COVID-19 is a global challenge to healthcare. Obesity is common in patients with COVID-19 and seems to aggravate disease prognosis. In this review we explore the link between obesity, chronic disease, lifestyle factors and the immune system, and propose societal interventions to enhance global immunity. Search Strategy and Selection Criteria: We performed three literature searches using the keywords (1) coronavirus AND comorbidities, (2) comorbidities AND immune system, and (3) lifes... Abstract

Cited 29 times since 2020 (6.8 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 14, Issue 1, 18 3 2020, Pages 233-242 The Relationship Between Coronary Calcification and the Natural History of Coronary Artery Disease. Jin HY, Weir-McCall JR, Leipsic JA, Son JW, Sellers SL, Shao M, Blanke P, Ahmadi A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, de Araujo Goncalves P, Shin S, Choi JH, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Chinnaiyan K, Raff G, Al-Mallah MH, Lin FY, Min JK, Sung JM, Lee SE, Chang HJ

Objectives: The aim of the current study was to explore the impact of plaque calcification in terms of absolute calcified plaque volume (CPV) and in the context of its percentage of the total plaque volume at a lesion and patient level on the progression of coronary artery disease. Background: Coronary artery calcification is an established marker of risk of future cardiovascular events. Despite this, plaque calcification is also considered a marker of plaque stability, and it increases in respo... Abstract

Cited 16 times since 2020 (3.7 per year) source: EuropePMC

Journal of the American Heart Association, Volume 9, Issue 23, 16 3 2020, Pages e017094 Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape. Bruijn LE, van den Akker BEWM, van Rhijn CM, Hamming JF, Lindeman JHN

Background Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity. At present, they are subdivided by classic umbrella terms, such as "fibroblasts," "myofibroblasts," "smooth muscle cells," "fibrocytes," "mesangial cells," and "pericytes." However, a discriminative marker-based subclassification has to date not been established. Methods and Results As a fir... Abstract