Research

Publications

Below you can find a list of our published research.

6128 results

Cited 168 times since 2019 (29.2 per year) source: EuropePMC

European heart journal, Volume 40, Issue 24, 1 1 2019, Pages 1975-1986 Clinical applications of machine learning in cardiovascular disease and its relevance to cardiac imaging. Al'Aref SJ, Anchouche K, Singh G, Slomka PJ, Kolli KK, Kumar A, Pandey M, Maliakal G, van Rosendael AR, Beecy AN, Berman DS, Leipsic J, Nieman K, Andreini D, Pontone G, Schoepf UJ, Shaw LJ, Chang HJ, Narula J, Bax JJ, Guan Y, Min JK

Artificial intelligence (AI) has transformed key aspects of human life. Machine learning (ML), which is a subset of AI wherein machines autonomously acquire information by extracting patterns from large databases, has been increasingly used within the medical community, and specifically within the domain of cardiovascular diseases. In this review, we present a brief overview of ML methodologies that are used for the construction of inferential and predictive data-driven models. We highlight seve... Abstract

European heart journal, Volume 40, Issue 22, 1 1 2019, Pages 1749-1751 What was hot at the EHRA2019 Congress. Burri H, Zeppenfeld K

Abstract

Cited 40 times since 2019 (6.9 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 15, Issue 2, 1 1 2019, Pages 147-154 Optimising patient discharge management after transfemoral transcatheter aortic valve implantation: the multicentre European FAST-TAVI trial. Barbanti M, van Mourik MS, Spence MS, Iacovelli F, Martinelli GL, Muir DF, Saia F, Bortone AS, Densem CG, van der Kley F, Bramlage P, Vis M, Tamburino C

Aims: Treatment pathway optimisation in TAVI should include timely patient discharge with a minimised risk for out-of-hospital adverse events. The aim of this study was to define a standardised set of risk criteria that allows a safe and timely discharge, to validate their appropriateness prospectively in different centres and multiple European countries, and to assess post-discharge outcomes. Methods and results: We defined and validated the adequacy of a set of discharge criteria and its abili... Abstract

Cited 10 times since 2019 (1.7 per year) source: Scopus

Behavioural processes, Volume 166, 30 5 2019, Pages 103877 Does socio-ecology drive differences in alertness between wolves and dogs when resting? Kortekaas K, Kotrschal K

Variation in resting behaviour across animals may be driven by adaptations towards their environment. Wolves and dogs seem promising models to examine this idea as they share a common ancestor, but occupy different socio-ecological niches. While wolves generally avoid humans, hunt, defend their territory, and raise offspring cooperatively, most dogs live in human-shaped environments. Hence, we hypothesized wolves to be more alert towards their environment than dogs, i.e. the degree of activation... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 95, Issue 4, 29 5 2019, Pages 686-693 Procedural-related coronary atrial branch occlusion during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction and atrial arrhythmias at follow-up. Montero Cabezas JM, Abou R, Goedemans L, Agüero J, Schalij MJ, Ajmone Marsan N, Fuster V, Ibáñez B, Bax JJ, Delgado V

Objectives: To evaluate the frequency of procedural-related atrial branch occlusion in ST-segment elevation myocardial infarction (STEMI) patients and its association with atrial arrhythmias at 1-year follow-up. Background: Atrial ischemia due to procedural-related coronary atrial branch occlusion in elective percutaneous coronary intervention (PCI) has been associated with atrial arrhythmias. Its role in a STEMI scenario is unknown. Methods: STEMI patients treated with primary PCI were classifi... Abstract

Cited 6 times since 2019 (1 per year) source: EuropePMC

Journal of vascular surgery, Volume 71, Issue 1, 27 4 2019, Pages 242-249 Using maximal systolic acceleration to diagnose and assess the severity of peripheral artery disease in a flow model study. Brouwers JJWM, van Doorn LP, van Wissen RC, Putter H, Hamming JF

Background: Because of the presence of medial calcific sclerosis, both ankle-branchial index and toe pressure measures can yield misleading results when attempting to diagnose peripheral artery disease (PAD). A new ultrasound parameter, maximal systolic acceleration (ACCmax), can be an accurate tool for diagnosing PAD, including in diabetic patients. However, it has not been evaluated thoroughly. The aim of this study was to assess the feasibility of using ACCmax to diagnose and assess the sever... Abstract

Cited 12 times since 2019 (2.1 per year) source: EuropePMC

The American journal of cardiology, Volume 124, Issue 4, 27 4 2019, Pages 604-612 Prevalence and Prognostic Implications of Right Ventricular Dysfunction in Patients With Hypertrophic Cardiomyopathy. Hiemstra YL, Debonnaire P, Bootsma M, Schalij MJ, Bax JJ, Delgado V, Marsan NA

Right ventricular (RV) dysfunction is a well-known prognostic factor in several cardiac diseases. However, the prevalence of RV dysfunction in hypertrophic cardiomyopathy (HC) is unclear and its prognostic value is unknown. This study aims at addressing these issues assessing RV function with speckle tracking echocardiography. In 267 HC patients (52 ± 15 years, 68% male), standard and advanced echocardiographic measurements of RV function were performed including RV 4-chamber longitudinal strain... Abstract

Cited 41 times since 2019 (7.1 per year) source: EuropePMC

Viruses, Volume 11, Issue 5, 25 4 2019, Pages E478 Animals as Reservoir for Human Norovirus. Villabruna N, Koopmans MPG, de Graaf M

Norovirus is the most common cause of non-bacterial gastroenteritis and is a burden worldwide. The increasing norovirus diversity is currently categorized into at least 10 genogroups which are further classified into more than 40 genotypes. In addition to humans, norovirus can infect a broad range of hosts including livestock, pets, and wild animals, e.g., marine mammals and bats. Little is known about norovirus infections in most non-human hosts, but the close genetic relatedness between some a... Abstract

Cited 7 times since 2019 (1.2 per year) source: EuropePMC

Cardiac failure review, Volume 5, Issue 2, 24 4 2019, Pages 99-105 Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials. Spitzer E, Hahn RT, Pibarot P, de Vries T, Bax JJ, Leon MB, Van Mieghem NM

Aortic stenosis is a progressive disease that develops over decades, and once symptomatic and untreated, is associated with poor survival. Transcatheter aortic valve replacement has evolved significantly in the past decade and has expanded its indication from surgically inoperable and high-risk patients to patients with intermediate risk. Assessment of heart failure-related outcomes include the use of functional assessments, disease-specific quality of life surveys and standardised ascertainment... Abstract

Cited 47 times since 2019 (8.1 per year) source: EuropePMC

Circulation, Volume 140, Issue 2, 23 4 2019, Pages 103-112 Effect of Alirocumab on Mortality After Acute Coronary Syndromes. Steg PG, Szarek M, Bhatt DL, Bittner VA, Brégeault MF, Dalby AJ, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Ostadal P, Parkhomenko A, Pordy R, Roe MT, Tricoci P, Vogel R, White HD, Zeiher AM, Schwartz GG

Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12... Abstract

Cited 6 times since 2019 (1 per year) source: EuropePMC

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 21, Issue 1, 16 3 2019, Pages 28 Association of cardiovascular magnetic resonance-derived circumferential strain parameters with the risk of ventricular arrhythmia and all-cause mortality in patients with prior myocardial infarction and primary prevention implantable cardioverter defibrillator. Paiman EHM, Androulakis AFA, Shahzad R, Tao Q, Zeppenfeld K, Lamb HJ, van der Geest RJ

Background: Impaired left ventricular (LV) contraction and relaxation may further promote adverse remodeling and may increase the risk of ventricular arrhythmia (VA) in ischemic cardiomyopathy. We aimed to examine the association of cardiovascular magnetic resonance (CMR)-derived circumferential strain parameters for LV regional systolic function, LV diastolic function and mechanical dispersion with the risk of VA in patients with prior myocardial infarction and primary prevention implantable ca... Abstract

Cited 13 times since 2019 (2.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 13, Issue 1 Pt 1, 15 3 2019, Pages 124-139 Transcatheter Aortic Valve Replacement: Role of Multimodality Imaging in Common and Complex Clinical Scenarios. Bax JJ, Delgado V, Hahn RT, Leipsic J, Min JK, Grayburn P, Sondergaard L, Yoon SH, Windecker S

Transcatheter aortic valve replacement (TAVR) is an established therapy for patients with symptomatic severe aortic stenosis. Technological advances and the learning curve have resulted in better procedural results in terms of hemodynamic valve performance and intermediate-term clinical outcomes. The integration of anatomical and functional information provided by multimodality imaging has improved size selection of TAVR prostheses, permitted better patient selection, and provided new insights i... Abstract

Current cardiovascular imaging reports, Volume 12, Issue 6, 14 2 2019, Pages 24 Coronary Computed Tomography Angiography as a Gatekeeper to Coronary Revascularization: Emphasizing Atherosclerosis Findings Beyond Stenosis. van den Hoogen IJ, van Rosendael AR, Lin FY, Bax JJ, Shaw LJ, Min JK

Purpose of review: Coronary computed tomography angiography (CCTA) is the optimal non-invasive test to rule out coronary artery disease (CAD). Decisions to perform coronary revascularization have traditionally been based upon ischemia testing. This review summarizes the latest observations and trials evaluating the suitability of CCTA to select patients for invasive coronary angiography (ICA) and subsequent revascularization. Recent findings: Recent data shows that beyond stenosis, whole-heart q... Abstract

Cited 13 times since 2019 (2.2 per year) source: EuropePMC

PloS one, Volume 14, Issue 5, 10 2 2019, Pages e0216222 Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease. Ward-Caviness CK, de Vries PS, Wiggins KL, Huffman JE, Yanek LR, Bielak LF, Giulianini F, Guo X, Kleber ME, Kacprowski T, Groß S, Petersman A, Davey Smith G, Hartwig FP, Bowden J, Hemani G, Müller-Nuraysid M, Strauch K, Koenig W, Waldenberger M, Meitinger T, Pankratz N, Boerwinkle E, Tang W, Fu YP, Johnson AD, Song C, de Maat MPM, Uitterlinden AG, Franco OH, Brody JA, McKnight B, Chen YI, Psaty BM, Mathias RA, Becker DM, Peyser PA, Smith JA, Bielinski SJ, Ridker PM, Taylor KD, Yao J, Tracy R, Delgado G, Trompet S, Sattar N, Jukema JW, Becker LC, Kardia SLR, Rotter JI, März W, Dörr M, Chasman DI, Dehghan A, O'Donnell CJ, Smith NL, Peters A, Morrison AC

Background: Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not take advantage of recent genome-wide association studies (GWAS) or multi-variant, pleiotropy robust MR methodologies. Methods and findings: We evaluated evidence for a causal effect of fibrinogen on b... Abstract

Cited 20 times since 2019 (3.4 per year) source: EuropePMC

Journal of arrhythmia, Volume 35, Issue 3, 10 2 2019, Pages 323-484 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N, Aguinaga L, Leite LR, Al-Khatib SM, Anter E, Berruezo A, Callans DJ, Chung MK, Cuculich P, d'Avila A, Deal BJ, Della Bella P, Deneke T, Dickfeld TM, Hadid C, Haqqani HM, Neal Kay G, Latchamsetty R, Marchlinski F, Miller JM, Nogami A, Patel AR, Pathak RK, Saenz Morales LC, Santangeli P, Sapp JL, Sarkozy A, Soejima K, Stevenson WG, Tedrow UB, Tzou WS, Varma N, Zeppenfeld K

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. There... Abstract

Cited 32 times since 2019 (5.5 per year) source: EuropePMC

Heart rhythm, Volume 17, Issue 1, 10 2 2019, Pages e155-e205 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary. Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N, Aguinaga L, Leite LR, Al-Khatib SM, Anter E, Berruezo A, Callans DJ, Chung MK, Cuculich P, d'Avila A, Deal BJ, Della Bella P, Deneke T, Dickfeld TM, Hadid C, Haqqani HM, Kay GN, Latchamsetty R, Marchlinski F, Miller JM, Nogami A, Patel AR, Pathak RK, Saenz Morales LC, Santangeli P, Sapp JL, Sarkozy A, Soejima K, Stevenson WG, Tedrow UB, Tzou WS, Varma N, Zeppenfeld K

Cited 107 times since 2019 (18.4 per year) source: EuropePMC

Heart rhythm, Volume 17, Issue 1, 10 2 2019, Pages e2-e154 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N, Aguinaga L, Leite LR, Al-Khatib SM, Anter E, Berruezo A, Callans DJ, Chung MK, Cuculich P, d'Avila A, Deal BJ, Della Bella P, Deneke T, Dickfeld TM, Hadid C, Haqqani HM, Kay GN, Latchamsetty R, Marchlinski F, Miller JM, Nogami A, Patel AR, Pathak RK, Saenz Morales LC, Santangeli P, Sapp JL, Sarkozy A, Soejima K, Stevenson WG, Tedrow UB, Tzou WS, Varma N, Zeppenfeld K

Annals of vascular surgery, Volume 60, 8 2 2019, Pages 103-111 Toward Optimizing Risk Adjustment in the Dutch Surgical Aneurysm Audit. Lijftogt N, Vahl A, van der Willik EM, Leijdekkers VJ, Wouters MWJM, Hamming JF, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit and the Dutch Institute for Clinical Auditing

Background: To compare hospital outcomes of aortic aneurysm surgery, casemix correction for preoperative variables is essential. Most of these variables can be deduced from mortality risk prediction models. Our aim was to identify the optimal set of preoperative variables associated with mortality to establish a relevant and efficient casemix model. Methods: All patients prospectively registered between 2013 and 2016 in the Dutch Surgical Aneurysm Audit (DSAA) were included for the analysis. Aft... Abstract

Cited 1 times since 2019 (0.2 per year) source: EuropePMC

European journal of preventive cardiology, Volume 26, Issue 13, 2 1 2019, Pages 1430-1432 Gender difference in mitral valve disease: Where is the bias? Marsan NA

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Cited 3 times since 2019 (0.5 per year) source: EuropePMC

Progress in cardiovascular diseases, Volume 62, Issue 3, 2 1 2019, Pages 205-211 Imaging for sudden cardiac death risk stratification: Current perspective and future directions. van der Bijl P, Delgado V, Bax JJ

Sudden cardiac death (SCD) accounts for one fifth of global deaths, and occurs when a trigger (e.g. myocardial ischemia, premature ventricular contraction) interacts with an arrhythmic substrate (e.g. myocardial scar, dilated cardiomyopathy). Multimodality imaging (echocardiographic, cardiac magnetic resonance and nuclear techniques) can potentially visualize many predisposing substrates and triggers. Implantable cardioverter-defibrillator (ICD) is the most effective approach to primary preventi... Abstract