Research

Publications

Below you can find a list of our published research.

6131 results

Cited 18 times since 2017 (2.5 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 38, Issue 1, 16 3 2017, Pages 186-194 Statins Promote Cardiac Infarct Healing by Modulating Endothelial Barrier Function Revealed by Contrast-Enhanced Magnetic Resonance Imaging. Leenders GJ, Smeets MB, van den Boomen M, Berben M, Nabben M, van Strijp D, Strijkers GJ, Prompers JJ, Arslan F, Nicolay K, Vandoorne K

Objective: The endothelium has a crucial role in wound healing, acting as a barrier to control transit of leukocytes. Endothelial barrier function is impaired in atherosclerosis preceding myocardial infarction (MI). Besides lowering lipids, statins modulate endothelial function. Here, we noninvasively tested whether statins affect permeability at the inflammatory (day 3) and the reparative (day 7) phase of infarct healing post-MI using contrast-enhanced cardiac magnetic resonance imaging (MRI).... Abstract

Cited 268 times since 2017 (36.7 per year) source: EuropePMC

Circulation, Volume 137, Issue 4, 13 2 2017, Pages 338-350 Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients With Peripheral Artery Disease: Insights From the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk). Bonaca MP, Nault P, Giugliano RP, Keech AC, Pineda AL, Kanevsky E, Kuder J, Murphy SA, Jukema JW, Lewis BS, Tokgozoglu L, Somaratne R, Sever PS, Pedersen TR, Sabatine MS

Background: The PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor evolocumab reduced low-density lipoprotein cholesterol and cardiovascular events in the FOURIER trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk). We investigated the efficacy and safety of evolocumab in patients with peripheral artery disease (PAD) as well as the effect on major adverse limb events. Methods: FOURIER was a randomized trial of evolocumab versus place... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

BMJ open, Volume 7, Issue 11, 12 2 2017, Pages e018833 Barriers and facilitators to learn and improve through morbidity and mortality conferences: a qualitative study. de Vos MS, Hamming JF, Marang-van de Mheen PJ

Objectives: To explore barriers and facilitators to successful morbidity and mortality conferences (M&M), driving learning and improvement. Design: This is a qualitative study with semistructured interviews. Inductive, thematic content analysis was used to identify barriers and facilitators, which were structured across a pre-existing framework for change in healthcare. Setting: Dutch academic surgical department with a long tradition of M&M. Participants: An interview sample of surgeons... Abstract

Cited 9 times since 2017 (1.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 25, Issue 1, 6 1 2017, Pages 39-52 Myocardial perfusion imaging: Lessons learned and work to be done-update. Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W

As the second term of our commitment to Journal begins, we, the editors, would like to reflect on a few topics that have relevance today. These include prognostication and paradigm shifts; Serial testing: How to handle data? Is the change in perfusion predictive of outcome and which one? Ischemia-guided therapy: fractional flow reserve vs perfusion vs myocardial blood flow; positron emission tomography (PET) imaging using Rubidium-82 vs N-13 ammonia vs F-18 Flurpiridaz; How to differentiate micr... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 4, Issue 2, 6 1 2017, Pages 221-227 The Impact of Atrial Fibrillation Clinical Subtype on Mortality. Leung M, van Rosendael PJ, Abou R, Ajmone Marsan N, Leung DY, Delgado V, Bax JJ

Objectives: This study sought to investigate the prognostic implications of the clinical subtype of atrial fibrillation (AF): paroxysmal or persistent. Background: Underlying structural abnormalities of the left atrium may be responsible for the initial clinical presentation of AF in either paroxysmal or persistent form, yet the prognostic implications of the clinical subtype on presentation are unknown. Methods: Over a median of 7 years, 1,773 patients (age 64 ± 12 years, 74% males) with nonval... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

Journal of clinical lipidology, Volume 12, Issue 1, 2 1 2017, Pages 137-144.e1 Mendelian randomization analysis of cholesteryl ester transfer protein and subclinical atherosclerosis: A population-based study. Christen T, Trompet S, Noordam R, Blauw LL, Gast KB, Rensen PCN, Willems van Dijk K, Rosendaal FR, de Mutsert R, Jukema JW, NEO study

Background: Several trials to prevent cardiovascular disease by inhibiting cholesteryl ester transfer protein (CETP) have failed, except Randomized EValuation of the Effects of Anacetrapib through Lipid-modification. Thus far, it is unclear to what extent CETP is causally related to measures of atherosclerosis. Objective: The aim of the article was to study the causal relationship between genetically determined CETP concentration and carotid intima-media thickness (cIMT) in a population-based co... Abstract

Cited 2 times since 2017 (0.3 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 114, 2 1 2017, Pages 50-55 Esophageal ultrasound (EUS) assessment of T4 status in NSCLC patients. Kuijvenhoven JC, Crombag L, Breen DP, van den Berk I, Versteegh MIM, Braun J, Winkelman TA, van Boven W, Bonta PI, Rabe KF, Annema JT

Background: Mediastinal and central large vessels (T4) invasion by lung cancer is often difficult to assess preoperatively due to the limited accuracy of computed tomography (CT) scan of the chest. Esophageal ultrasound (EUS) can visualize the relationship of para-esophageally located lung tumors to surrounding mediastinal structures. Aim: To assess the value of EUS for detecting mediastinal invasion (T4) of centrally located lung tumors. Methods: Patients who underwent EUS for the diagnosis and... Abstract

Cited 33 times since 2017 (4.5 per year) source: EuropePMC

Annals of surgery, Volume 266, Issue 5, 1 1 2017, Pages 898-904 Textbook Outcome: A Composite Measure for Quality of Elective Aneurysm Surgery. Karthaus EG, Lijftogt N, Busweiler LAD, Elsman BHP, Wouters MWJM, Vahl AC, Hamming JF, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit, the Dutch Institute for Clinical Auditing

Objective: To investigate a new composite quality measurement, which comprises a desirable outcome for elective aneurysm surgery, called "Textbook Outcome" (TO). Background: Single-quality indicators in vascular surgery are often not distinctive and insufficiently reflect the quality of care. Methods: All patients undergoing elective abdominal aortic aneurysm repair, registered in the Dutch Surgical Aneurysm Audit between 2014 and 2015 were included. TO was defined as the percentage of... Abstract

Clinical genetics, Volume 92, Issue 5, 1 1 2017, Pages 565 Response to Ciuculete et al. Smit RAJ, le Cessie S, Jukema JW, Trompet S

Abstract

Cited 13 times since 2017 (1.8 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 18, Issue 11, 1 1 2017, Pages 1206-1213 Frequency and angiographic characteristics of coronary microvascular dysfunction in stable angina: a hybrid imaging study. Stenström I, Maaniitty T, Uusitalo V, Pietilä M, Ukkonen H, Kajander S, Mäki M, Bax JJ, Knuuti J, Saraste A

Aims: Coronary microvascular dysfunction (CMD) can cause angina in the absence of obstructive coronary artery disease (CAD). We studied the frequency and angiographic characteristics of CMD in symptomatic patients with suspected stable CAD and identified CMD as diffusely abnormal coronary vasodilator capacity by positron emission tomography (PET) perfusion imaging. Methods and results: We recruited prospectively 189 patients with intermediate pre-test probability of CAD who underwent coronary co... Abstract

Cited 30 times since 2017 (4.1 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 10, Issue 11, 1 1 2017, Pages e005591 Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers. Feola I, Volkers L, Majumder R, Teplenin A, Schalij MJ, Panfilov AV, de Vries AAF, Pijnappels DA

Background: Recently, a new ablation strategy for atrial fibrillation has emerged, which involves the identification of rotors (ie, local drivers) followed by the localized targeting of their core region by ablation. However, this concept has been subject to debate because the mode of arrhythmia termination remains poorly understood, as dedicated models and research tools are lacking. We took a unique optogenetic approach to induce and locally target a rotor in atrial monolayers. Methods and res... Abstract

Cited 1 times since 2017 (0.1 per year) source: EuropePMC

Substance use & misuse, Volume 53, Issue 6, 30 5 2017, Pages 921-930 Effectiveness of Fresh Start: A Randomized Study of a School-Based Program to Retain a Negative Attitude Toward Substance Use in Secondary School Freshmen. Onrust SA, van der Heijden A, Zschämisch AL, Speetjens PAM

Background: The transition to secondary school is linked to more positive attitudes toward substance use, which prelude the moment of first use. Fresh Start is a school-based prevention program for secondary school freshmen (12-13 years old) to retain negative attitudes. Objectives: This study evaluates the effectiveness of Fresh Start on the attitudes toward smoking, alcohol use, and cannabis use, and on multiple secondary outcome measures. In addition, the effect of timing of the program withi... Abstract

Cited 323 times since 2017 (43.9 per year) source: EuropePMC

Nature genetics, Volume 49, Issue 12, 30 5 2017, Pages 1758-1766 Exome-wide association study of plasma lipids in >300,000 individuals. Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC, Boehnke M, Boerwinkle E, Bork-Jensen J, Bottinger EP, Brandslund I, Brown M, Busonero F, Caulfield MJ, Chambers JC, Chasman DI, Chen YE, Chen YI, Chowdhury R, Christensen C, Chu AY, Connell JM, Cucca F, Cupples LA, Damrauer SM, Davies G, Deary IJ, Dedoussis G, Denny JC, Dominiczak A, Dubé MP, Ebeling T, Eiriksdottir G, Esko T, Farmaki AE, Feitosa MF, Ferrario M, Ferrieres J, Ford I, Fornage M, Franks PW, Frayling TM, Frikke-Schmidt R, Fritsche LG, Frossard P, Fuster V, Ganesh SK, Gao W, Garcia ME, Gieger C, Giulianini F, Goodarzi MO, Grallert H, Grarup N, Groop L, Grove ML, Gudnason V, Hansen T, Harris TB, Hayward C, Hirschhorn JN, Holmen OL, Huffman J, Huo Y, Hveem K, Jabeen S, Jackson AU, Jakobsdottir J, Jarvelin MR, Jensen GB, Jørgensen ME, Jukema JW, Justesen JM, Kamstrup PR, Kanoni S, Karpe F, Kee

We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalass... Abstract

Cited 9 times since 2017 (1.2 per year) source: EuropePMC

Pregnancy hypertension, Volume 11, 28 4 2017, Pages 129-135 Assessment of novel cardiovascular biomarkers in women with a history of recurrent miscarriage. Wagner MM, Jukema JW, Hermes W, le Cessie S, de Groot CJM, Bakker JA, van Lith JMM, Bloemenkamp KWM

Objectives: A history of recurrent miscarriage is associated with future cardiovascular disease. The aim of this study was to determine novel cardiovascular biomarkers in women with a history of recurrent miscarriage as this might lead to a better understanding of the association. Study design: Women who visited the recurrent miscarriage clinic at Leiden University Medical Centre (between 2000 and 2010), and had three consecutive miscarriages ≤30 years were invited to participate in this follow-... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 34, Issue 4, 27 4 2017, Pages 495-502 In-stent fractional flow reserve variations and related optical coherence tomography findings: the FFR-OCT co-registration study. Pyxaras SA, Adriaenssens T, Barbato E, Ughi GJ, Di Serafino L, De Vroey F, Toth G, Tu S, Reiber JHC, Bax JJ, Wijns W

We sought to assess in-stent variations in fractional flow reserve (FFR) in patients with previous percutaneous coronary intervention (PCI) and to associate any drop in FFR with findings by optical coherence tomography (OCT) imaging. Suboptimal post-PCI FFR values were previously associated with poor outcomes. It is not known to which extent in-stent pressure loss contributes to reduced FFR. In this single-arm observational study, 26 patients who previously underwent PCI with drug-eluting stent... Abstract

Cited 12 times since 2017 (1.6 per year) source: EuropePMC

European journal of heart failure, Volume 20, Issue 4, 23 4 2017, Pages 803-806 The first titin (c.59926 + 1G > A) founder mutation associated with dilated cardiomyopathy. Hoorntje ET, van Spaendonck-Zwarts KY, Te Rijdt WP, Boven L, Vink A, van der Smagt JJ, Asselbergs FW, van Wijngaarden J, Hennekam EA, Pinto YM, Lekanne Deprez RH, Barge-Schaapveld DQCM, Bootsma M, Regieli J, Hoedemaekers YM, Jongbloed JDH, van den Berg MP, van Tintelen JP

Abstract

Cited 80 times since 2017 (10.8 per year) source: EuropePMC

Nature communications, Volume 8, Issue 1, 13 2 2017, Pages 910 Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T, Barnes CLK, Timmers PRHJ, Shen X, Gandin I, McDaid AF, Hansen TF, Gordon SD, Giulianini F, Boutin TS, Abdellaoui A, Zhao W, Medina-Gomez C, Bartz TM, Trompet S, Lange LA, Raffield L, van der Spek A, Galesloot TE, Proitsi P, Yanek LR, Bielak LF, Payton A, Murgia F, Concas MP, Biino G, Tajuddin SM, Seppälä I, Amin N, Boerwinkle E, Børglum AD, Campbell A, Demerath EW, Demuth I, Faul JD, Ford I, Gialluisi A, Gögele M, Graff M, Hingorani A, Hottenga JJ, Hougaard DM, Hurme MA, Ikram MA, Jylhä M, Kuh D, Ligthart L, Lill CM, Lindenberger U, Lumley T, Mägi R, Marques-Vidal P, Medland SE, Milani L, Nagy R, Ollier WER, Peyser PA, Pramstaller PP, Ridker PM, Rivadeneira F, Ruggiero D, Saba Y, Schmidt R, Schmidt H, Slagboom PE, Smith BH, Smith JA, Sotoodehnia N, Steinhagen-Thiessen E, van Rooij FJA, Verbeek AL, Vermeulen SH, Vollenweider P, Wang Y, Werge T, Whitfield JB, Zonderman AB, Lehtimäki T, Evans MK, Pirastu M, Fuchsberger C, Bert

Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol level... Abstract

Cited 18 times since 2017 (2.4 per year) source: EuropePMC

PloS one, Volume 12, Issue 10, 10 2 2017, Pages e0185820 The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development. de Jong RCM, Ewing MM, de Vries MR, Karper JC, Bastiaansen AJNM, Peters HAB, Baghana F, van den Elsen PJ, Gongora C, Jukema JW, Quax PHA

Objective: Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor kappa-beta (NFκB)-mediated inflammation, which drives post-interventional intimal hyperplasia development. We studied the contributing role of PCAF in post-interventional intimal hyperplasia. Methods and results: PCAF contribution to inflammation and intimal hyperplasia was assessed in leukocytes, macrophages and vascular smoot... Abstract

Cited 12 times since 2017 (1.6 per year) source: EuropePMC

BMC cardiovascular disorders, Volume 17, Issue 1, 10 2 2017, Pages 259 Feasibility and safety of early discharge after transfemoral transcatheter aortic valve implantation - rationale and design of the FAST-TAVI registry. Barbanti M, Baan J, Spence MS, Iacovelli F, Martinelli GL, Saia F, Bortone AS, van der Kley F, Muir DF, Densem CG, Vis M, van Mourik MS, Seilerova L, Lüske CM, Bramlage P, Tamburino C

Background: There is an increasing trend towards shorter hospital stays after transcatheter aortic valve implantation (TAVI), in particular for patients undergoing the procedure via transfemoral (TF) access. Preliminary data suggest that there exists a population of patients that can be discharged safely very early after TF-TAVI. However, current evidence is limited to few retrospective studies, encompassing relatively small sample sizes. Methods: The Feasibility And Safety of early discharge af... Abstract

Cited 13 times since 2017 (1.8 per year) source: Scopus

The American journal of cardiology, Volume 121, Issue 1, 10 2 2017, Pages 86-93 Influence of the Quantity of Aortic Valve Calcium on the Agreement Between Automated 3-Dimensional Transesophageal Echocardiography and Multidetector Row Computed Tomography for Aortic Annulus Sizing. Podlesnikar T, Prihadi EA, van Rosendael PJ, Vollema EM, van der Kley F, de Weger A, Ajmone Marsan N, Naji F, Fras Z, Bax JJ, Delgado V

Accurate aortic annulus sizing is key for selection of appropriate transcatheter aortic valve implantation (TAVI) prosthesis size. The present study compared novel automated 3-dimensional (3D) transesophageal echocardiography (TEE) software and multidetector row computed tomography (MDCT) for aortic annulus sizing and investigated the influence of the quantity of aortic valve calcium (AVC) on the selection of TAVI prosthesis size. A total of 83 patients with severe aortic stenosis undergoing TAV... Abstract