6131 results
Cited 23 times since 2017 (3.1 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 3, Issue 13, 13 2 2017, Pages 1592-1598
Temporal Relationship of Asystole to Onset of Transient Loss of Consciousness in Tilt-Induced Reflex Syncope.
Saal DP, Thijs RD, van Zwet EW, Bootsma M, Brignole M, Benditt DG, van Dijk JG
Objectives: The purpose of this study was to investigate the relationship between the onset of asystole and transient loss of consciousness (TLOC) in tilt-induced reflex syncope and estimate how often asystole was the principal cause of TLOC. Background: The presence of asystole in vasovagal syncope (VVS) may prompt physicians to consider pacemaker therapy for syncope prevention, but the benefit of pacing is limited in VVS. Methods: We evaluated electrocardiography, electroencephalography, blood...
Abstract
Cited 12 times since 2017 (1.6 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 12 2 2017, Pages 11303
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.
Weng LC, Lunetta KL, Müller-Nurasyid M, Smith AV, Thériault S, Weeke PE, Barnard J, Bis JC, Lyytikäinen LP, Kleber ME, Martinsson A, Lin HJ, Rienstra M, Trompet S, Krijthe BP, Dörr M, Klarin D, Chasman DI, Sinner MF, Waldenberger M, Launer LJ, Harris TB, Soliman EZ, Alonso A, Paré G, Teixeira PL, Denny JC, Shoemaker MB, Van Wagoner DR, Smith JD, Psaty BM, Sotoodehnia N, Taylor KD, Kähönen M, Nikus K, Delgado GE, Melander O, Engström G, Yao J, Guo X, Christophersen IE, Ellinor PT, Geelhoed B, Verweij N, Macfarlane P, Ford I, Heeringa J, Franco OH, Uitterlinden AG, Völker U, Teumer A, Rose LM, Kääb S, Gudnason V, Arking DE, Conen D, Roden DM, Chung MK, Heckbert SR, Benjamin EJ, Lehtimäki T, März W, Smith JG, Rotter JI, van der Harst P, Jukema JW, Stricker BH, Felix SB, Albert CM, Lubitz SA
It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent st...
Abstract
Cited 22 times since 2017 (2.9 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 67, Issue 6, 11 2 2017, Pages 1891-1900.e4
Adventitial adipogenic degeneration is an unidentified contributor to aortic wall weakening in the abdominal aortic aneurysm.
Doderer SA, Gäbel G, Kokje VBC, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN
Objective: The processes driving human abdominal aortic aneurysm (AAA) progression are not fully understood. Although antiinflammatory and proteolytic strategies effectively quench aneurysm progression in preclinical models, so far all clinical interventions failed. These observations hint at an incomplete understanding of the processes involved in AAA progression and rupture. Interestingly, strong clinical and molecular associations exist between popliteal artery aneurysms (PAAs) and AAAs; howe...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
European journal of heart failure,
Volume 19, Issue 12, 7 1 2017, Pages 1732-1735
Risk stratification of Asian patients with heart failure and reduced ejection fraction: the effectiveness of the Echo Heart Failure Score.
Bosch L, Carluccio E, Coiro S, Gong L, Sim D, Yeo D, Jaufeerally F, Leong KTG, Ong HY, Pin NT, Richards AM, Arslan F, Ling LH, Lam CSP, Ambrosio G
Abstract
Cited 154 times since 2017 (20.5 per year)
source: EuropePMC
Nature genetics,
Volume 49, Issue 10, 4 1 2017, Pages 1450-1457
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
Zhao W, Rasheed A, Tikkanen E, Lee JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander M, Damrauer S, Small A, Asma S, Imamura M, Yamauch T, Chambers JC, Chen P, Sapkota BR, Shah N, Jabeen S, Surendran P, Lu Y, Zhang W, Imran A, Abbas S, Majeed F, Trindade K, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Mehmood K, Ahmed N, Qureshi IH, Tanveer-Us-Salam, Iqbal W, Malik U, Mehra N, Kuo JZ, Sheu WH, Guo X, Hsiung CA, Juang JJ, Taylor KD, Hung YJ, Lee WJ, Quertermous T, Lee IT, Hsu CC, Bottinger EP, Ralhan S, Teo YY, Wang TD, Alam DS, Di Angelantonio E, Epstein S, Nielsen SF, Nordestgaard BG, Tybjaerg-Hansen A, Young R, CHD Exome+ Consortium, Benn M, Frikke-Schmidt R, Kamstrup PR, EPIC-CVD Consortium, EPIC-Interact Consortium, Michigan Biobank, Jukema JW, Sattar N, Smit R, Chung RH, Liang KW, Anand S, Sanghera DK, Ripatti S, Loos RJF, Kooner JS, Tai ES, Rotter JI, Chen YI, Frossard P, Maeda S, Kadowaki T, Reilly M, Pare G, Melander O, Salomaa V, Rader DJ, Da
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. J...
Abstract
Cited 1 times since 2017 (0.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 70, Issue 13, 1 1 2017, Pages 1681-1682
Patients With an ICD Remain at Risk for Painful Shocks in Last Moments of Life.
Yilmaz D, van der Heijden AC, Thijssen J, Schalij MJ, van Erven L
Abstract
Cited 2171 times since 2017 (289 per year)
source: EuropePMC
European heart journal,
Volume 38, Issue 36, 1 1 2017, Pages 2739-2791
2017 ESC/EACTS Guidelines for the management of valvular heart disease.
Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Muñoz D, Rosenhek R, Sjögren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL, ESC Scientific Document Group
Abstract
Cited 6 times since 2017 (0.8 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 52, Issue 3, 1 1 2017, Pages 418-424
Standards defining a 'Heart Valve Centre': ESC Working Group on Valvular Heart Disease and European Association for Cardiothoracic Surgery Viewpoint.
Chambers JB, Prendergast B, Iung B, Rosenhek R, Zamorano JL, Piérard LA, Modine T, Falk V, Kappetein AP, Pibarot P, Sundt T, Baumgartner H, Bax JJ, Lancellotti P
Abstract
Cited 9 times since 2017 (1.2 per year)
source: EuropePMC
Journal of applied oral science : revista FOB,
Volume 25, Issue 5, 1 1 2017, Pages 515-522
Effects of Syzygium aromaticum, Cinnamomum zeylanicum, and Salvia triloba extracts on proliferation and differentiation of dental pulp stem cells.
Mendi A, Yağci BG, Kiziloğlu M, Saraç N, Yilmaz D, Uğur A, Uçkan D
Introduction: Hypersensitivity, local irritative and cytotoxic effects are known for the chemical components of Syzygium aromaticum and Cinnamomum zeylanicum contained in dental materials. However, there is no intimate data in dentistry using the whole extracts of these plants and introducing new ones. Salvia triloba is a well-known anti-inflammatory plant that correspondingly could be used in several dental traumas. Objectives: We aimed to show and compare the effect of S. aromaticum, C. zeylan...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 18, Issue 9, 1 1 2017, Pages 1041-1048
Three-dimensional transoesophageal echocardiography of the aortic valve and root: changes in aortic root dilation and aortic regurgitation.
Regeer MV, Kamperidis V, Versteegh MIM, Schalij MJ, Marsan NA, Bax JJ, Delgado V
Aims: It has been hypothesized that in response to dilation of the aortic root, the aortic valve cusps may remodel to prevent aortic regurgitation (AR). The aim of the present study was to evaluate the association between aortic cusp dimensions and aortic root geometry. Methods and results: Three-dimensional transoesophageal echocardiography was performed in 40 patients with aortic root dilation (mean age 57 ± 12 years, 75% men, 35% bicuspid aortic valve) and 20 controls with a normal aortic roo...
Abstract
Cited 17 times since 2017 (2.3 per year)
source: EuropePMC
Current treatment options in cardiovascular medicine,
Volume 19, Issue 9, 1 1 2017, Pages 71
Current Challenges in Translating Tissue-Engineered Heart Valves.
Stassen OMJA, Muylaert DEP, Bouten CVC, Hjortnaes J
Opinion statement: Heart valve disease is a major health burden, treated by either valve repair or valve replacement, depending on the affected valve. Nearly 300,000 valve replacements are performed worldwide per year. Valve replacement is lifesaving, but not without complications. The in situ tissue-engineered heart valve is a promising alternative to current treatments, but the translation of this novel technology to the clinic still faces several challenges. These challenges originate from th...
Abstract
Cited 10 times since 2017 (1.3 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 18, Issue 9, 1 1 2017, Pages 969-977
Impact of computed tomography myocardial perfusion following computed tomography coronary angiography on downstream referral for invasive coronary angiography, revascularization and, outcome at 12 months.
van Rosendael AR, Dimitriu-Leen AC, de Graaf MA, van Zwet EW, Jukema JW, Bax JJ, Kroft LJ, Scholte AJ
Aims: The aim of this study was to assess the impact of adding stress computed tomography (CT) myocardial perfusion (CTP) to coronary CT angiography (CTA) on downstream referral for invasive coronary angiography (ICA), revascularization, and outcome in patients presenting with new-onset chest pain. Methods and results: Three hundred and eighty-four patients were referred for cardiac CT. Patients with lesions ≥50% stenosis underwent subsequently stress CTP. Perfusion scans were considered abnorma...
Abstract
Cited 53 times since 2017 (7.1 per year)
source: EuropePMC
Disease models & mechanisms,
Volume 10, Issue 9, 1 1 2017, Pages 1039-1059
Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies.
Brandão KO, Tabel VA, Atsma DE, Mummery CL, Davis RP
It is now a decade since human induced pluripotent stem cells (hiPSCs) were first described. The reprogramming of adult somatic cells to a pluripotent state has become a robust technology that has revolutionised our ability to study human diseases. Crucially, these cells capture all the genetic aspects of the patient from which they were derived. Combined with advances in generating the different cell types present in the human heart, this has opened up new avenues to study cardiac disease in hu...
Abstract
Cited 13 times since 2017 (1.7 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 25, Issue 12, 1 1 2017, Pages 675-681
A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects.
van der Linde IHM, Hiemstra YL, Bökenkamp R, van Mil AM, Breuning MH, Ruivenkamp C, Ten Broeke SW, Veldkamp RF, van Waning JI, van Slegtenhorst MA, van Spaendonck-Zwarts KY, Lekanne Deprez RH, Herkert JC, Boven L, van der Zwaag PA, Jongbloed JDH, Bootsma M, Barge-Schaapveld DQCM
Background: Mutations in the myosin heavy chain 7 (MYH7) gene commonly cause cardiomyopathy but are less frequently associated with congenital heart defects. Methods: In this study, we describe a mutation in the MYH7 gene, c. 5754C > G; p. (Asn1918Lys), present in 15 probands and 65 family members. Results: Of the 80 carriers (age range 0-88 years), 46 (57.5%) had cardiomyopathy (mainly dilated cardiomyopathy (DCM)) and seven (8.8%) had a congenital heart defect. Childhood onset of cardiomyop...
Abstract
Cited 16 times since 2017 (2.1 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 10, Issue 9, 1 1 2017, Pages e005987
Bicuspid Aortic Valve: What to Image in Patients Considered for Transcatheter Aortic Valve Replacement?
Kong WKF, Delgado V, Bax JJ
Abstract
JAMA cardiology,
Volume 2, Issue 9, 1 1 2017, Pages 1047-1048
Bicuspid Aortopathy-Reply.
Delgado V, Kong WKF, Bax JJ
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 25, Issue 9, 1 1 2017, Pages 490-497
Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score.
Montero-Cabezas JM, Karalis I, Wolterbeek R, Kraaijeveld AO, Hoefer IE, Pasterkamp G, Pijls NH, Doevendans PA, Walterberger J, Kuiper J, van Zonneveld AJ, Jukema JW
Background: We need new biomarkers that can predict cardiovascular disease to improve both diagnosis and therapeutic strategies. The CIRCULATING CELLS study was designed to study the role of several cellular mediators of atherosclerosis as biomarkers of coronary artery disease (CAD). An objective and reproducible method for the quantification of CAD extension is required to establish relationships with these potential biomarkers. We sought to analyse the correlation of the SYNTAX score with know...
Abstract
Heart (British Cardiac Society),
Volume 104, Issue 4, 1 1 2017, Pages 332-339
Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography.
Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Müller J, Seebohm G, Paul M, Schäfers K, Stallmeyer B, Schäfers M, Schulze-Bahr E
Objective: We investigated the impact of cardiac presynaptic norepinephrine recycling in patients with long-QT syndrome (LQTS) using positron emission tomography (PET) with 11C-meta-hydroxyephedrine ([11C]mHED-PET). Methods: [11C]mHED-PET was performed in 25 patients with LQTS (LQT1: n=14; LQT2: n=11) and 20 healthy controls and correlated with clinical parameters. [11C]mHED-PET images were analysed for global and regional retention indices (RI) and washout rates (WO) reflecting dynamic paramete...
Abstract
Cited 19 times since 2017 (2.5 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 31 5 2017, Pages 10269
Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure.
Bezhaeva T, Wong C, de Vries MR, van der Veer EP, van Alem CMA, Que I, Lalai RA, van Zonneveld AJ, Rotmans JI, Quax PHA
Arteriovenous access dysfunction is a major cause of morbidity for hemodialysis patients. The pathophysiology of arteriovenous fistula (AVF) maturation failure is associated with inflammation, impaired outward remodeling (OR) and intimal hyperplasia. RP105 is a critical physiologic regulator of TLR4 signaling in numerous cell types. In the present study, we investigated the impact of RP105 on AVF maturation, and defined cell-specific effects of RP105 on macrophages and vascular smooth muscle cel...
Abstract
Cited 4 times since 2017 (0.5 per year)
source: EuropePMC
European radiology,
Volume 28, Issue 2, 30 5 2017, Pages 844-850
Accurate late gadolinium enhancement prediction by early T1- based quantitative synthetic mapping.
van Dijk R, Kuijpers D, Kaandorp TAM, van Dijkman PRM, Vliegenthart R, van der Harst P, Oudkerk M
Objectives: Early synthetic gadolinium enhancement (ESGE) imaging from post-contrast T1 mapping after adenosine stress-perfusion cardiac magnetic resonance (CMR) was compared to conventional late gadolinium enhancement (LGE) imaging for assessing myocardial scar. Methods: Two hundred fourteen consecutive patients suspected of myocardial ischaemia were referred for stress-perfusion CMR. Myocardial infarct volume was quantified on a per-subsegment basis in both synthetic (2-3 min post-gadolinium)...
Abstract
