6131 results
Cited 12 times since 2017 (1.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 120, Issue 11, 30 5 2017, Pages 2008-2016
Usefulness of the CRT-SCORE for Shared Decision Making in Cardiac Resynchronization Therapy in Patients With a Left Ventricular Ejection Fraction of ≤35.
Höke U, Mertens B, Khidir MJH, Schalij MJ, Bax JJ, Delgado V, Ajmone Marsan N
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration...
Abstract
Cited 15 times since 2017 (2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 120, Issue 11, 30 5 2017, Pages 2065-2072
Influence of Aging on Level and Layer-Specific Left Ventricular Longitudinal Strain in Subjects Without Structural Heart Disease.
Abou R, Leung M, Khidir MJH, Wolterbeek R, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
Values for level- (apical, mid, and basal) and layer-based (endocardial, mid-myocardial, and epicardial) left ventricular (LV) longitudinal strain across age are scarce. The present study evaluates the effect of aging on level- and layer-specific LV longitudinal strain in subjects without structural heart disease. A total of 408 subjects (mean age 58 years [range 16 to 91]; 49% men) were evaluated retrospectively. Subjects were divided into equal groups based on age and gender. Subjects with evi...
Abstract
Cited 13 times since 2017 (1.7 per year)
source: EuropePMC
Trials,
Volume 18, Issue 1, 29 5 2017, Pages 402
Mobile phones in cryptogenic strOke patients Bringing sIngle Lead ECGs for Atrial Fibrillation detection (MOBILE-AF): study protocol for a randomised controlled trial.
Treskes RW, Gielen W, Wermer MJ, Grauss RW, van Alem AP, Dehnavi RA, Kirchhof CJ, van der Velde ET, Maan AC, Wolterbeek R, Overbeek OM, Schalij MJ, Trines SA
Background: Recently published randomised clinical trials indicate that prolonged electrocardiom (ECG) monitoring might enhance the detection of paroxysmal atrial fibrillation (AF) in cryptogenic stroke or transient ischaemic attack (TIA) patients. A device that might be suitable for prolonged ECG monitoring is a smartphone-compatible ECG device (Kardia Mobile, Alivecor, San Francisco, CA, USA) that allows the patient to record a single-lead ECG without the presence of trained health care staff....
Abstract
Cited 8 times since 2017 (1.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 25, Issue 3, 28 4 2017, Pages 860-871
Invasive assessment of coronary artery disease.
Pyxaras SA, Wijns W, Reiber JHC, Bax JJ
Coronary artery disease is associated to high mortality and morbidity rates and an accurate diagnostic assessment during heart catheterization has a fundamental role in prognostic stratification and treatment choices. Coronary angiography has been integrated by intravascular imaging modalities, namely intravascular ultrasound and optical coherence tomography, which allow the precise quantification of the atherosclerotic burden of coronary arteries. The hemodynamic relevance of a given coronary s...
Abstract
Cited 30 times since 2017 (4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 104, Issue 7, 28 4 2017, Pages 574-580
Factors associated with coronary artery disease and stroke in adults with congenital heart disease.
Bokma JP, Zegstroo I, Kuijpers JM, Konings TC, van Kimmenade RRJ, van Melle JP, Kiès P, Mulder BJM, Bouma BJ
Objective: To determine factors associated with coronary artery disease (CAD) and ischaemic stroke in ageing adult congenital heart disease (ACHD) patients. Methods: We performed a multicentre case-control study, using data from the national CONgenital CORvitia (CONCOR) registry to identify ACHD patients within five participating centres. Patients with CAD were matched (1:2 ratio) with ACHD patients without CAD on age, CHD defect group and gender. Patients with ischaemic stroke (or transient isc...
Abstract
Cited 14 times since 2017 (1.9 per year)
source: EuropePMC
Scientific reports,
Volume 7, Issue 1, 23 4 2017, Pages 9193
Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload.
Wang JW, Fontes MSC, Wang X, Chong SY, Kessler EL, Zhang YN, de Haan JJ, Arslan F, de Jager SCA, Timmers L, van Veen TAB, Lam CSP, Kleijn DPV
An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic pressure overload is unclear. We sought to evaluate the role of TLR2 in cardiac hypertrophy, fibrosis and dysfunction in sustained pressure overload. We induced pressure overload via transverse aortic constriction (TAC) in TLR2-/- and wild type (WT) mice, and followed temporal changes over 8 weeks. Despite similar increases in heart weight, left...
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 104, Issue 6, 16 3 2017, Pages 454-455
Surgical treatment of Marfan syndrome and related disorders is all about dealing with uncertainties.
Groenink M, Koolbergen DR
Abstract
Cited 5 times since 2017 (0.7 per year)
source: EuropePMC
Journal of clinical lipidology,
Volume 11, Issue 6, 8 2 2017, Pages 1407-1414
Low levels of apolipoprotein-CII in normotriglyceridemic patients with very premature coronary artery disease: Observations from the MISSION! Intervention study.
Hermans MPJ, Bodde MC, Jukema JW, Schalij MJ, van der Laarse A, Cobbaert CM
Background: While the overall acute myocardial infarction rates declined in women and men, premature acute myocardial infarction rates remained stable in men and increased in women. Objective: The purpose of this study was to assess whether baseline apolipoprotein (apo) levels, clinical characteristics, and follow-up of patients with very premature coronary artery disease (CAD) could provide novel clues for the identification of high-risk individuals. Methods: Apos were measured with a validated...
Abstract
Cited 5 times since 2017 (0.7 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 13, Issue 5, 4 1 2017, Pages e564-e571
Call-to-balloon time dashboard in patients with ST-segment elevation myocardial infarction results in significant improvement in the logistic chain.
Hermans MPJ, Velders MA, Smeekes M, Drexhage OS, Hautvast RWM, Ytsma T, Schalij MJ, Umans VAWM
Aims: Timely reperfusion with primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI) patients is associated with superior clinical outcomes. Aiming to reduce ischaemic time, an innovative system for home-to-hospital (H2H) time monitoring was implemented, which enabled real-time evaluation of ischaemic time intervals, regular feedback and improvements in the logistic chain. The objective of this study was to assess the results after implementation...
Abstract
Cited 46 times since 2017 (6.1 per year)
source: EuropePMC
The EMBO journal,
Volume 36, Issue 18, 4 1 2017, Pages 2726-2741
Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.
Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, Schotta G, Abdelsamie AF, Déjardin J, Méchali M, Baldacci G, Sardet C, Cadoret JC, Schepers A, Julien E
Among other targets, the protein lysine methyltransferase PR-Set7 induces histone H4 lysine 20 monomethylation (H4K20me1), which is the substrate for further methylation by the Suv4-20h methyltransferase. Although these enzymes have been implicated in control of replication origins, the specific contribution of H4K20 methylation to DNA replication remains unclear. Here, we show that H4K20 mutation in mammalian cells, unlike in Drosophila, partially impairs S-phase progression and protects from D...
Abstract
Cited 6 times since 2017 (0.8 per year)
source: EuropePMC
Current opinion in lipidology,
Volume 28, Issue 4, 1 1 2017, Pages 361-366
Increasing HDL-C levels with medication: current perspectives.
Smit RA, Jukema JW, Trompet S
Purpose of review: To date, observational studies have repeatedly demonstrated an inverse association between HDL cholesterol (HDL-C) levels and cardiovascular outcomes. Although the efficacy of established HDL-modifying treatment strategies have been examined in multiple large-scale phase III trials, findings from these experimental studies conflict with the hypothesis that HDL-C levels are atheroprotective. In this review, we describe the trial evidence to date, and attempt to place these resu...
Abstract
Cited 25 times since 2017 (3.3 per year)
source: EuropePMC
Cell reports,
Volume 20, Issue 8, 1 1 2017, Pages 1978-1990
Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC
There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to stem cell-derived allografts is necessary for maintaining long-term graft persistence. To model this alloimmunity, humanized mice engrafted with human hematopoietic and immune cells could prove to be useful. In this study, an in-depth analysis of graft-infiltrating human lymphocytes and splenocy...
Abstract
Cited 20 times since 2017 (2.6 per year)
source: EuropePMC
Cardiovascular drugs and therapy,
Volume 31, Issue 4, 1 1 2017, Pages 381-389
MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216.
Reijers JAA, Kallend DG, Malone KE, Jukema JW, Wijngaard PLJ, Burggraaf J, Moerland M
Purpose: Aim of this study was to demonstrate that MDCO-216 (human recombinant Apolipoprotein A-I Milano) does not induce adverse immunostimulation, in contrast to its predecessor, ETC-216, which was thought to contain host cell proteins (HCPs) that elicited an inflammatory reaction. Methods: Data were taken from a clinical trial in which 24 healthy volunteers (HV) and 24 patients with proven stable coronary artery disease (sCAD) received a single intravenous dose of MDCO-216, ranging 5-40 mg/kg...
Abstract
Cited 11 times since 2017 (1.4 per year)
source: EuropePMC
Cardiovascular research,
Volume 113, Issue 10, 1 1 2017, Pages 1186-1197
RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node.
Vicente-Steijn R, Kelder TP, Tertoolen LG, Wisse LJ, Pijnappels DA, Poelmann RE, Schalij MJ, deRuiter MC, Gittenberger-de Groot AC, Jongbloed MRM
Aims: RHOA-ROCK signalling regulates cell migration, proliferation, differentiation, and transcription. RHOA is expressed in the developing cardiac conduction system in chicken and mice. In early development, the entire sinus venosus myocardium, including both the transient left-sided and the definitive sinoatrial node (SAN), has pacemaker potential. Later, pacemaker potential is restricted to the right-sided SAN. Disruption of RHOA expression in adult mice causes arrhythmias including bradycard...
Abstract
Cited 82 times since 2017 (10.8 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 70, Issue 9, 1 1 2017, Pages 1121-1131
Transcatheter Mitral Valve Replacement for Degenerated Bioprosthetic Valves and Failed Annuloplasty Rings.
Yoon SH, Whisenant BK, Bleiziffer S, Delgado V, Schofer N, Eschenbach L, Fujita B, Sharma R, Ancona M, Yzeiraj E, Cannata S, Barker C, Davies JE, Frangieh AH, Deuschl F, Podlesnikar T, Asami M, Dhoble A, Chyou A, Masson JB, Wijeysundera HC, Blackman DJ, Rampat R, Taramasso M, Gutierrez-Ibanes E, Chakravarty T, Attizzani GF, Kaneko T, Wong SC, Sievert H, Nietlispach F, Hildick-Smith D, Nombela-Franco L, Conradi L, Hengstenberg C, Reardon MJ, Kasel AM, Redwood S, Colombo A, Kar S, Maisano F, Windecker S, Pilgrim T, Ensminger SM, Prendergast BD, Schofer J, Schaefer U, Bax JJ, Latib A, Makkar RR
Background: Limited data exist regarding transcatheter mitral valve replacement (TMVR) for patients with failed mitral valve replacement and repair. Objectives: This study sought to evaluate the outcomes of TMVR in patients with failed mitral bioprosthetic valves (valve-in-valve [ViV]) and annuloplasty rings (valve-in-ring [ViR]). Methods: From the TMVR multicenter registry, procedural and clinical outcomes of mitral ViV and ViR were compared according to Mitral Valve Academic Research Consortiu...
Abstract
Cited 44 times since 2017 (5.8 per year)
source: EuropePMC
Emerging infectious diseases,
Volume 23, Issue 8, 1 1 2017, Pages 1359-1354
Global Spread of Norovirus GII.17 Kawasaki 308, 2014-2016.
Chan MCW, Hu Y, Chen H, Podkolzin AT, Zaytseva EV, Komano J, Sakon N, Poovorawan Y, Vongpunsawad S, Thanusuwannasak T, Hewitt J, Croucher D, Collins N, Vinjé J, Pang XL, Lee BE, de Graaf M, van Beek J, Vennema H, Koopmans MPG, Niendorf S, Poljsak-Prijatelj M, Steyer A, White PA, Lun JH, Mans J, Hung TN, Kwok K, Cheung K, Lee N, Chan PKS
Analysis of complete capsid sequences of the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated from a single haplotype since the initial emergence in China in late 2014. Global spread of a sublineage SL2 was identified. A new sublineage SL3 emerged in China in 2016.
Abstract
Cited 3 times since 2017 (0.4 per year)
source: EuropePMC
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Volume 32, Issue 8, 1 1 2017, Pages 1409-1414
Echocardiographic associates of atrial fibrillation in end-stage renal disease.
Hensen LCR, Delgado V, van Wijngaarden SE, Leung M, de Bie MK, Buiten MS, Schalij MJ, Van de Kerkhof JJ, Rabelink TJ, Rotmans JI, Jukema JW, Bax JJ
Background: The prevalence of atrial fibrillation (AF) in end-stage renal disease (ESRD) patients is relatively high. The present study evaluated the association between left atrial (LA) remodelling, including an increased size and myocardial fibrosis, and slow LA conduction and the occurrence of AF. Methods: In 171 ESRD patients enrolled in the Implantable Cardioverter Defibrillators in Dialysis patients (ICD2) trial, the LA dimensions, LA conduction delay [as reflected by the time difference b...
Abstract
Cited 11 times since 2017 (1.4 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 10, Issue 8, 1 1 2017, Pages e005175
Unipolar Endocardial Voltage Mapping in the Right Ventricle: Optimal Cutoff Values Correcting for Computed Tomography-Derived Epicardial Fat Thickness and Their Clinical Value for Substrate Delineation.
Venlet J, Piers SRD, Kapel GFL, de Riva M, Pauli PFG, van der Geest RJ, Zeppenfeld K
Background: Low endocardial unipolar voltage (UV) at sites with normal bipolar voltage (BV) may indicate epicardial scar. Currently applied UV cutoff values are based on studies that lacked epicardial fat information. This study aimed to define endocardial UV cutoff values using computed tomography-derived fat information and to analyze their clinical value for right ventricular substrate delineation. Methods and results: Thirty-three patients (50±14 years; 79% men) underwent combined endocardia...
Abstract
Cited 30 times since 2017 (3.9 per year)
source: EuropePMC
Circulation. Cardiovascular genetics,
Volume 10, Issue 4, 1 1 2017, Pages e001631
<i>Lamin A/C</i>-Related Cardiac Disease: Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation.
Hoorntje ET, Bollen IA, Barge-Schaapveld DQ, van Tienen FH, Te Meerman GJ, Jansweijer JA, van Essen AJ, Volders PG, Constantinescu AA, van den Akker PC, van Spaendonck-Zwarts KY, Oldenburg RA, Marcelis CL, van der Smagt JJ, Hennekam EA, Vink A, Bootsma M, Aten E, Wilde AA, van den Wijngaard A, Broers JL, Jongbloed JD, van der Velden J, van den Berg MP, van Tintelen JP
Background: Interpretation of missense variants can be especially difficult when the variant is also found in control populations. This is what we encountered for the LMNA c.992G>A (p.(Arg331Gln)) variant. Therefore, to evaluate the effect of this variant, we combined an evaluation of clinical data with functional experiments and morphological studies. Methods and results: Clinical data of 23 probands and 35 family members carrying this variant were retrospectively collected. A time-to-event...
Abstract
Cited 37 times since 2017 (4.9 per year)
source: EuropePMC
Circulation. Cardiovascular genetics,
Volume 10, Issue 4, 1 1 2017, Pages e001632
<i>PCSK9</i> Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites.
Kent ST, Rosenson RS, Avery CL, Chen YI, Correa A, Cummings SR, Cupples LA, Cushman M, Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L, Levitan EB, Li X, Liu Y, Post WS, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM, Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL, Wilson JG, Muntner P
Background: PCSK9 loss-of-function (LOF) variants allow for the examination of the effects of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We examined the association of PCSK9 LOF variants with LDL-C and incident coronary heart disease and stroke through a meta-analysis of data from 8 observational cohorts and 1 randomized trial of statin therapy. Methods and results: These 9 studies together included 17 459 blacks with 403 (2.3%) having at least 1 Y142X...
Abstract
